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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer

edited by

Daniel Gabriel Pons

submission deadline 20 Sep 2026 | 5 articles | Viewed by 8840 | Submission Open

Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Bee Products and Their Flavonoids: Recent Advances in Molecular Mechanisms, Therapeutic Applications, and Innovative Delivery Systems

edited by

Nada Orsolic

and

Maja Jazvinšćak Jembrek

submission deadline 20 Sep 2026 | 2 articles | Viewed by 8619 | Submission Open

Keywords: honeybee products; flavonoids; bioactive compounds; biological activity; pharmacological activity; health benefits; side effects; disease prevention; antioxidant activity; apitherapy; nutritional properties; innovative technical approaches

(This special issue belongs to the Section Molecular Biology)

Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition

edited by

Jasmin Knopf

submission deadline 20 Sep 2026 | 3 articles | Viewed by 8239 | Submission Open

Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs

(This special issue belongs to the Section Molecular Immunology)

New Advances in Metabolic Engineering and Synthetic Biology of Yeasts

edited by

Justyna Ruchała

submission deadline 20 Sep 2026 | 1 articles | Viewed by 8222 | Submission Open

Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Abiotic Stress in Plants: Physiological and Molecular Responses

edited by Edyta Zdunek-Zastocka

submission deadline 20 Sep 2026 | 9 articles | Viewed by 8031 | Submission Open

Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Darío Acuña-Castroviejo

submission deadline 20 Sep 2026 | 6 articles | Viewed by 7921 | Submission Open

Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption

(This special issue belongs to the Section Molecular Biology)

Recent Advances in New Biomarkers for Cancers

edited by

Maria Panagopoulou

submission deadline 20 Sep 2026 | 6 articles | Viewed by 7641 | Submission Open

Keywords: biomarkers; cancer research; liquid biopsy; epigenetic and genetic biomarkers; precision oncology; diagnosis; prognosis; prediction

(This special issue belongs to the Section Molecular Oncology)

Pathophysiological Insights, Biomarkers and New Therapeutic Strategies in Immune-Mediated Disorders and Neurodegenerative Diseases

edited by

Eleonora Virgilio

submission deadline 20 Sep 2026 | 3 articles | Viewed by 7508 | Submission Open

Keywords: neurodegeneration; neuroimmunology; inflammation; biomarkers; treatment; pathophysiology; multiple sclerosis; myasthenia gravis; neurodegenerative disease

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Heart Failure: From Bench to Bedside

edited by

Nadia Aspromonte

submission deadline 20 Sep 2026 | 4 articles | Viewed by 7248 | Submission Open

Keywords: heart failure; cardiac biomarkers; medical therapy; molecular pathways; prognosis; target therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Forensic Toxicology

edited by

Angelo Montana

submission deadline 20 Sep 2026 | 1 articles | Viewed by 7196 | Submission Open

Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro, in vivo, and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Toxicology)

New Insights into Network Pharmacology

edited by

Mi Hye Kim

submission deadline 20 Sep 2026 | 4 articles | Viewed by 7192 | Submission Open

Keywords: network pharmacology; traditional medicine; drug discovery; computational biology; molecular mechanisms; protein–protein interaction; enrichment analysis; herb–compound–gene network

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Forensics and the Genetic Foundations of Forensic Biology

edited by

Laura Caine

submission deadline 20 Sep 2026 | 3 articles | Viewed by 7148 | Submission Open

Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of Bone Biology and Bone Tissue: 2nd Edition

edited by

Giovanna Iezzi

submission deadline 20 Sep 2026 | 5 articles | Viewed by 7065 | Submission Open

Keywords: bone; stem cells; immunomodulation; biomaterials; bone regeneration; bone repair; bone diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives

edited by

Luca Mastorino

submission deadline 20 Sep 2026 | 2 articles | Viewed by 7064 | Submission Open

Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into the Environmental Toxicity of Contaminants and Risk Mitigation Strategies

edited by

Barbara Mognetti

and

Tiziana Cappello

submission deadline 20 Sep 2026 | 4 articles | Viewed by 7039 | Submission Open

Keywords: microplastic toxicity; environmental pollutants; molecular mechanisms; cell metabolic pathways; in vivo, in vitro, and in silico models; pollutant interactions; risk mitigation strategies

(This special issue belongs to the Section Molecular Toxicology)

The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition)

edited by

Vassilis Athanasiadis

submission deadline 20 Sep 2026 | 4 articles | Viewed by 7004 | Submission Open

Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancements and Trends in Plant Genomics

edited by Rongbin Hu

submission deadline 20 Sep 2026 | 5 articles | Viewed by 6823 | Submission Open

Keywords: plant; genomics; next-generation sequencing; third-generation sequencing; CRISPR-Cas

(This special issue belongs to the Section Molecular Plant Sciences)

Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy

edited by

M. Letizia Motti

submission deadline 20 Sep 2026 | 3 articles | Viewed by 6812 | Submission Open

Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules

(This special issue belongs to the Section Molecular Oncology)

Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy

edited by

Dong Min Lee

submission deadline 20 Sep 2026 | 2 articles | Viewed by 6675 | Submission Open

Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Neurodegenerative Diseases: Molecular Mechanisms, Drug Targets and Therapeutic Strategies

edited by

Andrea Kwakowsky

submission deadline 20 Sep 2026 | 2 articles | Viewed by 6133 | Submission Open

Keywords: beta amyloid peptide; tau protein; alpha-synuclein protein; huntingtin protein; autophagy; neuromodulators; neurotrophins; natural compounds; neuroinflammation; vascular dysfunction; neuronal death; drug development; therapeutic biomarkers; blood–brain barrier; small-molecule therapeutics

(This special issue belongs to the Section Molecular Neurobiology)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 20 Sep 2026 | 5 articles | Viewed by 6100 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Sep 2026 | 4 articles | Viewed by 5980 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

New Horizons in Structure and AI-Based Drug Design

edited by

Huiyong Sun

submission deadline 20 Sep 2026 | 2 articles | Viewed by 5975 | Submission Open

Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design

(This special issue belongs to the Section Molecular Informatics)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 20 Sep 2026 | 2 articles | Viewed by 5933 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Plant Cell/Organ Structure and Function Research

edited by

Bartosz Płachno

submission deadline 20 Sep 2026 | 4 articles | Viewed by 5783 | Submission Open

Keywords: leaf development; root development; plant cell ultrastructure; plant morphogenesis; plant organs and bacteria, fungi and animal interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Application of Mass Spectrometry and Chromatography in Biomedicine: 2nd Edition

edited by

Giovanni Ventura

submission deadline 20 Sep 2026 | 5 articles | Viewed by 5540 | Submission Open

Keywords: mass spectrometry; chromatography; LC-MS; GC-MS; biomarker discovery; pharmaceuticals; metabolomics; proteomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Advances in Natural Antioxidants in Human Health and Diseases

edited by

Eman M. Othman

submission deadline 20 Sep 2026 | 3 articles | Viewed by 5288 | Submission Open

Keywords: oxidative stress and diseases; antioxidants; natural products

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Diagnostics and Therapeutic Targets in Bladder Cancer (Second Edition)

edited by

Hideki Furuya

submission deadline 20 Sep 2026 | 4 articles | Viewed by 5280 | Submission Open

Keywords: non-muscle invasive bladder cancer; muscle-invasive bladder cancer; metastatic bladder cancer; diagnostic biomarkers; therapeutic targets; early detection; progression biomarkers; liquid biopsy; genomic profiling; proteomics; metabolomics; imaging biomarkers; multi-omics; targeted therapy; immunotherapy; antibody–drug conjugates; DNA damage response; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia

edited by Fabrizio Barbetti

submission deadline 20 Sep 2026 | 3 articles | Viewed by 5153 | Submission Open

Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Latest Development of Molecular Research in Animal Nutrition

edited by

Mohammad Moniruzzaman

submission deadline 20 Sep 2026 | 3 articles | Viewed by 5121 | Submission Open

Keywords: animal nutrition; molecular biology; microbiome; feed efficiency; sustainable aquaculture; proteomics; metabolomics; molecular mechanisms; metabolic regulation; disease resistance

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism of Immune Response

edited by Marisa Mariel Fernández

submission deadline 20 Sep 2026 | 5 articles | Viewed by 5084 | Submission Open

Keywords: training of the innate immune response; antigen recognition; cell migration; autoimmune processes; cell differentiation; tolerance; molecular responses of epithelial cells to foreign stimuli; alterations in immune checkpoints; modulation of immune responses; mechanisms of hypersensitivity

(This special issue belongs to the Section Molecular Immunology)

Current Advances in Immuno-Oncology

edited by Gratiela Grădișteanu Pircălabioru

submission deadline 20 Sep 2026 | 3 articles | Viewed by 5019 | Submission Open

Keywords: immuno-oncology; tumor microenvironment; immune checkpoint inhibitors; CAR-T cells; adoptive cell therapy; cancer vaccines; oncolytic viruses; tumor immune evasion; immunometabolism; biomarkers; tumor immunology; microbiome and cancer

(This special issue belongs to the Section Molecular Oncology)

Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment, 2nd Edition

edited by

Barbara Bażanów

and Dominika Marta Stygar

submission deadline 20 Sep 2026 | 3 articles | Viewed by 4965 | Submission Open

Keywords: viral infections; virus mutations; molecular diagnostic methods; antiviral drugs/preparations; viral diseases; physiological mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Mechanism Research on Listeria monocytogenes and Its Control

edited by

Irene Martín Tornero

submission deadline 20 Sep 2026 | 1 articles | Viewed by 4942 | Submission Open

Keywords: Listeria monocytogenes; virulence; biofilm; pathogenicity; control; prevention; food safety

(This special issue belongs to the Section Molecular Microbiology)

Medicinal Mechanisms of Biologically Active Compounds in Cancer

edited by

Karthik Gourishetti

submission deadline 20 Sep 2026 | 2 articles | Viewed by 4729 | Submission Open

Keywords: biologically active compounds; cancer treatment; apoptosis; tumor growth; natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 20 Sep 2026 | 2 articles | Viewed by 4548 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

The Role of Trace Elements in Nutrition and Health, 2nd Edition

edited by Jie Feng

submission deadline 20 Sep 2026 | 4 articles | Viewed by 4518 | Submission Open

Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience

edited by Matteo Di Segni and Rossella Ventura

submission deadline 20 Sep 2026 | 2 articles | Viewed by 4356 | Submission Open

Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Immune Response to Virus Infection and Vaccines

edited by

Giulia Matusali

submission deadline 20 Sep 2026 | 2 articles | Viewed by 4259 | Submission Open

Keywords: immunogenicity; emerging pathogen vaccination; molecular and cellular determinants of vaccine responses in immunocompromised individuals; predictive markers of immune response; laboratory methods to dissect immune responses to infections and vaccinations

(This special issue belongs to the Section Molecular Immunology)

Plant Metabolism and Natural Product Biosynthesis

edited by

Andrej Frolov

submission deadline 20 Sep 2026 | 3 articles | Viewed by 4228 | Submission Open

Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Ion Transporters and Channels

edited by

Yoshinori Marunaka

submission deadline 20 Sep 2026 | 1 articles | Viewed by 4072 | Submission Open

Keywords: ion transporter; ion channel; proton; interstitial fluid pH; Na+ channels; K+ channels; Cl− channels; ENaC; CALHM

(This special issue belongs to the Section Biochemistry)

Damage to Plants and Microorganisms Caused by Heavy Metal Toxicity

edited by

Xiaomeng Chen

submission deadline 20 Sep 2026 | 2 articles | Viewed by 4067 | Submission Open

Keywords: metal; oxidative stress; stress response; molecular function; gene regulation; metabolic regulation; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Phenolics and Polyphenols 2025

edited by

Davide Barreca

submission deadline 20 Sep 2026 | 2 articles | Viewed by 4062 | Submission Open

Keywords: phenolic metabolism; biological activities; stability to food processing; elicitation; methods of analysis; dietary supplements; nutraceutical ingredients; non-thermal processing; extraction and purification

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Quantum Chemical Approaches for Investigating Reaction Mechanisms in Organic Chemistry

edited by

Robert O'Reilly

submission deadline 20 Sep 2026 | 3 articles | Viewed by 4044 | Submission Open

Keywords: organic chemistry; biochemistry; density functional theory; coupled cluster theory; free radicals; reaction mechanisms; transition states

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Pathophysiology and Molecular Mechanisms of Cardiovascular, Cardiometabolic, and Cardiorenal Diseases

edited by

Carmine Savoia

submission deadline 20 Sep 2026 | 2 articles | Viewed by 4019 | Submission Open

Keywords: heart failure; cardiorenal syndrome; oxidative stress; inflammation; endothelial dysfunction; fibrosis and remodeling; mitochondrial function and energy metabolism; insulin resistance; epigenetics and microRNAs; biomarkers and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Towards Complex Molecular Cancer Therapies

edited by

Luba Hunáková

submission deadline 20 Sep 2026 | 1 articles | Viewed by 3866 | Submission Open

Keywords: precision medicine; immune system harnessing; targeted therapies; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh

(This special issue belongs to the Section Molecular Oncology)

Drugs—from Chemical Structure to Biological Activity

edited by

Sravani Sana

submission deadline 20 Sep 2026 | 1 articles | Viewed by 3825 | Submission Open

Keywords: hit molecule; lead optimization; drug design; virtual screening; molecule descriptors; structure–activity relationship; pharmacokinetic/ADME profile; in vitro biological activity

(This special issue belongs to the Section Molecular Pharmacology)

Applications of Bioinformatics in Human Disease

edited by Maria Rosaria De Filippo

submission deadline 20 Sep 2026 | 3 articles | Viewed by 3695 | Submission Open

Keywords: bioinformatics; omics data; machine learning; biomarker prediction

(This special issue belongs to the Section Molecular Informatics)

Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition

edited by

Bruna Scaggiante

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3686 | Submission Open

Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing

(This special issue belongs to the Section Molecular Oncology)

Molecular Synapse: Diversity, Function and Signaling

edited by Leonora Balaj

submission deadline 20 Sep 2026 | 2 articles | Viewed by 3666 | Submission Open

Keywords: synaptic signaling; synaptic plasticity; brain disorders; synapse diversity; molecular composition of synapse

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 51-100 on page 2 of 63.

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