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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances Related to Bone Regeneration

edited by

Gianluigi Pasta

and

Virginie Sottile

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2316 | Submission Open

Keywords: bone regeneration; bone extracellular matrix; regenerative medicine; biomaterials

(This special issue belongs to the Section Molecular Biology)

Advances in Design, Synthesis and Applications of Peptide Nucleic Acid

edited by

Maria Moccia

, Concetta Avitabile and

Annalisa Masi

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1836 | Submission Open

Keywords: PNA; nucleic acid analog; molecular design; synthesis; delivery system; therapeutics; diagnostic

(This special issue belongs to the Section Molecular Biology)

Macro- and Micronutrients in Health and Diseases

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 30 Jul 2025 | 1 articles | Viewed by 854 | Submission Open

Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Elucidating How Chondrocytes Maintain Cartilage Stability

edited by James A. Martin

submission deadline 30 Jul 2025 | Viewed by 198 | Submission Open

Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix

(This special issue belongs to the Section Molecular Biology)

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

edited by Masahiro Terada

submission deadline 31 Jul 2025 | Viewed by 113 | Submission Open

Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity

(This special issue belongs to the Section Molecular Biology)

NURR1 Biology in Neurological Disorders and Other Diseases

edited by

Ángel Juan García-Yagüe

submission deadline 31 Jul 2025 | Viewed by 104 | Submission Open

Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles: Unraveling Molecular Pathways for Targeted Therapy

edited by

Ssang-Goo Cho

submission deadline 31 Jul 2025 | Viewed by 100 | Submission Open

Keywords: stem cells; cellular reprogramming; extracellular vesicles; exosomes; targeted therapy; regenerative medicine; rejuvenation; anti-inflammation therapy; pain syndrome

(This special issue belongs to the Section Molecular Biology)

Galectins (Gals), 2nd Edition

edited by

Luciano Pirone

submission deadline 10 Aug 2025 | 4 articles | Viewed by 2605 | Submission Open

Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Therapies Barriers and Opportunities

edited by

O’neil W. Guthrie

submission deadline 15 Aug 2025 | Viewed by 124 | Submission Open

Keywords: gene therapy; gene editing; RNA therapy; RNA editing; protein therapy; stem cells; cell therapy; genomics; proteomics; molecular pathology

(This special issue belongs to the Section Molecular Biology)

Molecular Links between Sensory Nerves, Inflammation, and Pain 3.0

edited by

Zsuzsanna Helyes

and

Szőke Éva

submission deadline 20 Aug 2025 | 5 articles | Viewed by 15045 | Submission Open

Keywords: sensory neuropeptides; inflammation; neurogenic inflammation; pain; arthritis; colitis; neuropathy; migraine; novel drug targets; TRP channels; neuroinflammation

(This special issue belongs to the Section Molecular Biology)

Exercise and Health: Cellular and Molecular Perspectives

edited by

Annamaria Mancini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 13630 | Submission Open

Keywords: promoting health; anti-inflammatory action; anti-ageing action; mental health; mitochondrial adaptation; cellular function; regulation of gene expression; metabolic response to exercise

(This special issue belongs to the Section Molecular Biology)

Computational Molecular Biology of Metabolic Pathways and Signal Transduction Pathways

edited by Ralf Herwig

submission deadline 20 Aug 2025 | 8 articles | Viewed by 12881 | Submission Open

Keywords: computational genomics; computational structural and molecular biology; molecular dynamics simulations; artificial intelligence; AI-driven drug design and development; molecular modeling; computer-aided drug design; computational proteomics; computational and theoretical chemistry

(This special issue belongs to the Section Molecular Biology)

Advanced Research on Protein Structure and Protein Dynamics

edited by

Robert T. Youker

submission deadline 20 Aug 2025 | 5 articles | Viewed by 10469 | Submission Open

Keywords: allostery; receptor; kinase; protein folding; simulations; X-ray crystallography; NMR; super-resolution imaging; fluorescence fluctuation techniques; thermodynamic; enzyme; catalysis; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Molecular and Cellular Research in Ophthalmology

edited by Zala Lužnik Marzidovšek

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9976 | Submission Open

Keywords: eye disease; ophthalmology; molecular mechanisms; cellular mechanism; stem cell therapy; tissue engineering; gene therapy

(This special issue belongs to the Section Molecular Biology)

The Na, K-ATPase in Health and Disease

edited by

Liora Shoshani

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9713 | Submission Open

Keywords: Na+; K+-ATPase; α -subunit; β -subunit; γ subunits; FXYD

(This special issue belongs to the Section Molecular Biology)

Autophagy and Cellular Oxidative Stress: Molecular Mechanisms and Diagnostic Biomarkers

edited by Ramona D’Amico and

Daniela Impellizzeri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8955 | Submission Open

Keywords: autophagy; oxidative stress; biomarkers; acute and chronic diseases; molecular pathways; ROS; mitophagy

(This special issue belongs to the Section Molecular Biology)

The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence

edited by

Angelo Montana

and

Margherita Neri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8720 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Wound Healing: 2nd Edition

edited by

Alina Maria Holban

and

Carmen Curutiu

submission deadline 20 Aug 2025 | 6 articles | Viewed by 8614 | Submission Open

Keywords: management of wounds; nanobiomaterials; infection control; chronic wounds; biofilm infections; wound dressings; tissue engineering; wound healing

(This special issue belongs to the Section Molecular Biology)

Latest Advances in Reproduction Biology

edited by Clara Malo

submission deadline 20 Aug 2025 | 8 articles | Viewed by 8180 | Submission Open

Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology

(This special issue belongs to the Section Molecular Biology)

Stress Response Research: Yeast as Models: 2nd Edition

edited by

Cristina Mazzoni

and

Sergio Giannattasio

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8178 | Submission Open

Keywords: yeast; stress response; genetic disease; age-related disease; cell factory

(This special issue belongs to the Section Molecular Biology)

Biomolecular Basis of Life Processes

edited by

Janusz Błaszczyk

submission deadline 20 Aug 2025 | 3 articles | Viewed by 7929 | Submission Open

Keywords: energy metabolism; bone-muscle interaction; ATP signalling; calcium– phosphate signalling; metabolic syndrome; aging; cellular turnover; cancers

(This special issue belongs to the Section Molecular Biology)

Signaling Molecules Involved in Gametes Development, Differentiation and Fertilization, 2nd Edition

edited by

Sergio Minucci

and

Massimo Venditti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7224 | Submission Open

Keywords: spermatogenesis; oogenesis; spermatozoa; oocyte; fertilization; acrosome reaction; fertility; epidydimal transit; endocrine disrupting chemicals; testicular and ovarian cancer

(This special issue belongs to the Section Molecular Biology)

Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction

edited by

Gundula Schulze-Tanzil

submission deadline 20 Aug 2025 | 5 articles | Viewed by 6259 | Submission Open

Keywords: cartilage; tendon; ligament; anterior cruciate ligament; bioprinting; scaffold; bioreactor; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Aug 2025 | 2 articles | Viewed by 6251 | Submission Open

Keywords: antioxidants; metabolic pathways; oxidative stress; cellular homeostasis; redox signaling; energy metabolism; lipid metabolism; therapeutic strategies; chronic diseases

(This special issue belongs to the Section Molecular Biology)

Targeting Oxidative Stress for Disease: 2nd Edition

edited by

Nada Orsolic

and

Maja Jazvinšćak Jembrek

submission deadline 20 Aug 2025 | 6 articles | Viewed by 5896 | Submission Open

Keywords: oxidants and free radical production; physiological activities of free radicals; detrimental effects of free radicals on human health; ROS and ROS-mediated cellular signaling; pathophysiology of oxidative stress; biomarkers of oxidative stress; chronic degenerative diseases; therapeutic approaches targeting oxidative stress; biochemical/molecular targets of chronic diseases; exogenous antioxidants and human health; flavonoids and redox biology in the pathophysiology of diseases; pro-oxidative role of antioxidants: double-sided sword; prooxidant agents in therapy

(This special issue belongs to the Section Molecular Biology)

Using Model Organisms to Study Complex Human Diseases

edited by

Roberto Piergentili

submission deadline 20 Aug 2025 | 6 articles | Viewed by 5886 | Submission Open

Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Mitochondria: Transport of Metabolites Across Biological Membranes

edited by

Graziantonio Lauria

and

Rosita Curcio

submission deadline 20 Aug 2025 | 2 articles | Viewed by 5687 | Submission Open

Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis

(This special issue belongs to the Section Molecular Biology)

Advances in Bioactive Molecules

edited by

Helena P. Felgueiras

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4898 | Submission Open

Keywords: antimicrobial profile; drug discovery; tissue regeneration; analytical techniques; chemical synthesis; high-throughput screening; therapeutic development; surface functionalization; biomaterial integration; bio-based

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Therapeutic Targets in Acute Settings: Ischemic and Traumatic Brain Injuries

edited by Hylde Zirpoli

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4760 | Submission Open

Keywords: ischemic brain injury; traumatic brain insult; cell-type specific molecular mechanisms; therapy; target discovery; repurposing; efficacy studies; new drug formulations; high-throughput technologies; proteomics; metabolomics; microarray; next-generation sequencing; BBB disruption; gliosis; neuronal loss; neurobehavior; age-related molecular mechanisms in brain injury

(This special issue belongs to the Section Molecular Biology)

Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles

edited by Tong Ming Liu and Xiaoman Luo

submission deadline 20 Aug 2025 | 2 articles | Viewed by 4609 | Submission Open

Keywords: mesenchymal stem cells; extracellular vesicles; MSCs; MSC-EVs; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Induced Pluripotent Stem and Extracellular Vesicles in Biomedicine

edited by

Ylenia Della Rocca

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Aug 2025 | 1 articles | Viewed by 4549 | Submission Open

Keywords: induced pluripotent stem; embryonic stem cells; extracellular vesicles; tissue development; translational medicine

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Eye Development, Health, and Disease

edited by Thirumalini Vaithianathan and

T. J. Hollingsworth

submission deadline 20 Aug 2025 | 1 articles | Viewed by 4467 | Submission Open

Keywords: eye development; eye health and disease; ion channels; channelopathies; physiology; computational technology; molecular modeling; molecular biology tools; pharmacology; systems genetics

(This special issue belongs to the Section Molecular Biology)

New Molecular Perspectives in Crustacean Neuroendocrinology

edited by

Tomer Ventura

submission deadline 20 Aug 2025 | 3 articles | Viewed by 2999 | Submission Open

Keywords: neuroendocrinology; neuropeptides; functional genomics; arthropods development and reproduction; crustacean aquaculture

(This special issue belongs to the Section Molecular Biology)

Research on Transcriptional Regulation in Reproductive Biology

edited by

Anna Nynca

submission deadline 20 Aug 2025 | 2 articles | Viewed by 2962 | Submission Open

Keywords: reproductive biology; molecular research; transcriptional regulations; signaling pathways; gene expression; cell biology

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Crustacean Aquaculture

edited by Tom Levy and

Tomer Ventura

submission deadline 20 Aug 2025 | 3 articles | Viewed by 2433 | Submission Open

Keywords: androgenic gland; aquaculture; crustaceans; disease management; gene silencing; genetic modification; monosex; selective breeding; sex reversal; yield improvement

(This special issue belongs to the Section Molecular Biology)

MicroRNAs and Other Non-Coding RNAs as Regulators, Biomarkers, and Therapeutic Targets, 2nd Edition

edited by

Wan Lee

submission deadline 20 Aug 2025 | 1 articles | Viewed by 2429 | Submission Open

Keywords: non-coding RNAs; microRNA; lncRNA; circRNA; piRNA; biomarker; therapeutic target

(This special issue belongs to the Section Molecular Biology)

Non-Coding RNA in Physiology and Pathophysiology: Second Edition

edited by Maria Rosaria Tumolo

submission deadline 20 Aug 2025 | 2 articles | Viewed by 2197 | Submission Open

Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging

(This special issue belongs to the Section Molecular Biology)

Latest Molecular Advances in Autophagy

edited by

Gloria Riitano

submission deadline 20 Aug 2025 | 2 articles | Viewed by 2078 | Submission Open

Keywords: autophagy; lipid rafts; Beclin 1; autoimmune diseases; cancer; clock genes; CLOCK

(This special issue belongs to the Section Molecular Biology)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1497 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

New Insights into Embryonic Development

edited by

Jacek Z. Kubiak

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1487 | Submission Open

Keywords: embryonic development; molecular mechanisms; cellular mechanisms; model embryos; genetic

(This special issue belongs to the Section Molecular Biology)

Microsatellite Instability (MSI) and Mismatch Repair Deficient (dMMR)-Related Diseases: From Detection Methods to Practice

edited by Federica Zito Marino

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1311 | Submission Open

Keywords: microsatellite instability (MSI); mismatch repair deficient (dMMR); immunotherapy; next-generation sequencing (NGS); immunohistochemistry (IHC); polymerase chain reaction (PCR); MSI-positive tumors

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research of Kidney Diseases

edited by Andrea Angioi

submission deadline 20 Aug 2025 | Viewed by 753 | Submission Open

Keywords: molecular genetics; kidney disease; biomarkers; cellular signaling; target therapeutics; innovative treatments

(This special issue belongs to the Section Molecular Biology)

Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Darío Acuña-Castroviejo

submission deadline 20 Aug 2025 | 1 articles | Viewed by 695 | Submission Open

Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption

(This special issue belongs to the Section Molecular Biology)

Molecular Biological Determination of Physical Injury

edited by

Sorin Hostiuc

submission deadline 20 Aug 2025 | 1 articles | Viewed by 567 | Submission Open

Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Application of NMR Spectroscopy to Study Structure and Dynamics of Proteins

edited by Harindranath Kadavath

submission deadline 20 Aug 2025 | Viewed by 541 | Submission Open

Keywords: proteins; dynamics; NMR spectroscopy; structure– dynamics– function; protein folding; protein– protein interactions; in-cell NMR; biomolecular structure; intrinsically disordered proteins (IDPs)

(This special issue belongs to the Section Molecular Biology)

Mechanisms of Protein–Ligand Interactions in Therapies for Lifestyle Diseases and Their Complications

edited by Agnieszka Szkudlarek

submission deadline 20 Aug 2025 | Viewed by 486 | Submission Open

Keywords: chronic diseases and their complications; protein– ligand interactions; protein modifications; therapeutic efficacy; binding affinity; serum proteins; pharmaceutical applications; biomedical research

(This special issue belongs to the Section Molecular Biology)

Yeast Models in Genetic and Molecular Research

edited by

Ee Sin Chen

submission deadline 20 Aug 2025 | Viewed by 447 | Submission Open

Keywords: yeast; genome; epigenetics; chemogenomics; DNA repair

(This special issue belongs to the Section Molecular Biology)

Experimental Models and Applications in Muscle Regeneration

edited by

Daiva Bironaite

submission deadline 20 Aug 2025 | Viewed by 427 | Submission Open

Keywords: stem cells; internal and external stimuli; scaffolds; signaling systems; muscle regeneration mechanisms

(This special issue belongs to the Section Molecular Biology)

Exploring the Impact of the Biological Clock on Health and Disease

edited by

Bojlul Bahar

submission deadline 20 Aug 2025 | Viewed by 405 | Submission Open

Keywords: circadian rhythm; inflammation; oxidative stress; energy balance; metabolic syndrome; ageing; cancer; diabetes; obesity; entrainment; synchrony; melatonin

(This special issue belongs to the Section Molecular Biology)

Nrf1/2/3 and Other Antioxidant Transcription Factors in Health and Disease

edited by

Eleonora Stanca

submission deadline 20 Aug 2025 | Viewed by 141 | Submission Open

Keywords: transcription factor; oxidative stress; NRF1/2; NRF3; NFkB; P53; antioxidant-response elements; neurologial diseases; metabolic diseases; cancer

(This special issue belongs to the Section Molecular Biology)

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