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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 10 Aug 2026 | 1 articles | Viewed by 1707 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Metals and Metal Ions in Human Health, Diseases, and Environment

edited by

Agnieszka Scibior

Juan Llopis

and

Manuel Aureliano

submission deadline 20 Aug 2026 | 7 articles | Viewed by 17375 | Submission Open

Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution

(This special issue belongs to the Section Molecular Biology)

New Advances in Cancer Genomics

edited by

Yoshihito Kano

submission deadline 20 Aug 2026 | 8 articles | Viewed by 13393 | Submission Open

Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)

edited by

Elisabetta Palazzo

submission deadline 20 Aug 2026 | 7 articles | Viewed by 12750 | Submission Open

Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models

(This special issue belongs to the Section Molecular Biology)

Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Ligia Petrica

submission deadline 20 Aug 2026 | 6 articles | Viewed by 12314 | Submission Open

Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress

(This special issue belongs to the Section Molecular Biology)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Aug 2026 | 8 articles | Viewed by 11817 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Obesity: From Cellular Mechanism to Potential Molecular Therapies

edited by

Veronica Jimenez

submission deadline 20 Aug 2026 | 4 articles | Viewed by 8095 | Submission Open

Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer

(This special issue belongs to the Section Molecular Biology)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 Aug 2026 | 1 articles | Viewed by 8087 | Submission Open

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition

edited by

Jyotshna Kanungo

submission deadline 20 Aug 2026 | 5 articles | Viewed by 7484 | Submission Open

Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders

(This special issue belongs to the Section Molecular Biology)

Fish Nutrition, Biochemical Pathways, and Physiological Adaptations

edited by Paula Simó-Mirabet and Fernando Naya-Català

submission deadline 20 Aug 2026 | 2 articles | Viewed by 6497 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

Progress in Adipokines Research in Cardiovascular Health and Diseases

edited by

Morris Karmazyn

submission deadline 20 Aug 2026 | 4 articles | Viewed by 5842 | Submission Open

Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function, structure, and integrity; adipokines and cardiovascular inflammation; adipokines, adiposity, and cardiovascular disease in obesity

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Regenerative and Anti-Aging Medicine

edited by

Takayuki Yoshimoto

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3637 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs); platelet-rich plasma (PRP); placenta; organoid; secretome; exosome; senolytics; nicotinamide mononucleotide (NMN); nicotinamide adenine dinucleotide+ (NAD+)

(This special issue belongs to the Section Molecular Biology)

The Role of Ion Channels in Health and Disease

edited by

Joohyun Nam

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3328 | Submission Open

Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology

(This special issue belongs to the Section Molecular Biology)

Molecular Studies on Wnt Signaling

edited by Katalin Mészáros

submission deadline 20 Aug 2026 | 2 articles | Viewed by 3059 | Submission Open

Keywords: Wnt signaling pathway; inhibitor; cancer; treatment; drugs

(This special issue belongs to the Section Molecular Biology)

Effects of Radiation in Health and Disease

edited by

Raffaella Lazzarini

submission deadline 20 Aug 2026 | 4 articles | Viewed by 2284 | Submission Open

Keywords: extremely low-frequency magnetic fields; proteins and gene interaction; ionizing and non-ionizing radiations

(This special issue belongs to the Section Molecular Biology)

From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension

edited by

Swati Dabral

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2151 | Submission Open

Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation

(This special issue belongs to the Section Molecular Biology)

Advances in Stem Cell Biology and Translational Medicine

edited by Yangluowa Qu

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2078 | Submission Open

Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research

(This special issue belongs to the Section Molecular Biology)

Rewriting Medicine: Stem Cells and Regeneration

edited by

Tadahisa Sugiura

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2064 | Submission Open

Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1972 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

Telocytes: Unraveling Their Roles in Health and Disease

edited by

Sanda Cretoiu

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1770 | Submission Open

Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells

(This special issue belongs to the Section Molecular Biology)

Research Progress of Fluorescent Proteins in Molecular Biology

edited by Matteo Grenzi

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1679 | Submission Open

Keywords: fluorescence microscopy; fluorescence live-cell imaging; quantitative imaging; fluorescent biosensors; in vivo imaging; innovative fluorescence microscopy techniques

(This special issue belongs to the Section Molecular Biology)

Animal Reproductive Biology and Genetic Breeding

edited by Chang Wu and Fangzhou Hu

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1472 | Submission Open

Keywords: genetic breeding; genetic variation; phenotype analysis; reproductive barrier; hybridization; multomics analysis

(This special issue belongs to the Section Molecular Biology)

Systems Approaches to Diabetic Complications

edited by

Paola Pontrelli

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1237 | Submission Open

Keywords: diabetes; diabetic complications; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Biology)

Crucial Role of Intestinal Barriers and Their Impact on the Gut–Brain Axis in Health and Disease: Addressing Future Therapies

edited by

Elzbieta M. Sajdel-Sulkowska

submission deadline 20 Aug 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: age; brain–gut microbiota axis; intestinal barrier; fetal; gender; sex

(This special issue belongs to the Section Molecular Biology)

Recent Research in RNA–Protein Networks

edited by Hidenori Tani

submission deadline 20 Aug 2026 | 1 articles | Viewed by 813 | Submission Open

Keywords: machine learning; bioinformatics; ribonucleoprotein; RNA–protein complex; alternative splicing; RNA stability; RNA localization

(This special issue belongs to the Section Molecular Biology)

Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment

edited by

Marco Fiore

submission deadline 20 Aug 2026 | Viewed by 801 | Submission Open

Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress

(This special issue belongs to the Section Molecular Biology)

Stem Cell and Epigenetic Regulation in Regenerative Medicine

edited by

Giuseppe Garroni

submission deadline 20 Aug 2026 | Viewed by 580 | Submission Open

Keywords: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; gene expression; cell–environment interactions; conditioned medium; secreted factors; epigenetic modification

(This special issue belongs to the Section Molecular Biology)

Ion Regulation in Human Pathophysiology

edited by

Lars Kaestner

submission deadline 20 Aug 2026 | Viewed by 439 | Submission Open

Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes

(This special issue belongs to the Section Molecular Biology)

Dermatological Perspectives on Connective Tissue Diseases

edited by

Yoshihide Asano

submission deadline 20 Aug 2026 | Viewed by 427 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjögren’s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications

edited by Karl M Thompson

submission deadline 20 Aug 2026 | Viewed by 388 | Submission Open

Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics

(This special issue belongs to the Section Molecular Biology)

Decoding Protein Structure and Protein Dynamics in Cancer

edited by

Umesh Kalathiya

and

Monikaben Padariya

submission deadline 20 Aug 2026 | Viewed by 349 | Submission Open

Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Current Research on Lipidomics

edited by

Agata Kot-Wasik

submission deadline 25 Aug 2026 | 1 articles | Viewed by 2328 | Submission Open

Keywords: lipids ; hyphenated chromatography–mass spectrometry ; biological samples ; sample preparation

(This special issue belongs to the Section Molecular Biology)

Muscle Atrophy Molecular Signaling Regulation

edited by

Tatiana Kostrominova

submission deadline 25 Aug 2026 | 1 articles | Viewed by 860 | Submission Open

Keywords: skeletal muscle atrophy; loss of mass and contractile force; molecular signaling pathways

(This special issue belongs to the Section Molecular Biology)

Autophagy: A Double-Edged Sword in Disease Pathogenesis and Cancer Progression

edited by

Antonio Ieni

submission deadline 30 Aug 2026 | 1 articles | Viewed by 1249 | Submission Open

Keywords: autophagy; cancer therapy resistance; tumor microenvironment; immunometabolism

(This special issue belongs to the Section Molecular Biology)

Targeting Oxidative Stress: New Insights into Disease Pathogenesis, Emerging Preventive Strategies and Novel Therapeutic Approaches

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1239 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; natural oxidative stress modulators; novel preventive/therapeutic strategies; ageing; cardiovascular diseases; regenerative medicine; neurodegeneration; environmental exposure; cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Placental Function and Pregnancy Complications

edited by

Yoshinori Moriyama

submission deadline 30 Aug 2026 | Viewed by 403 | Submission Open

Keywords: placenta; placental dysfunction; pregnancy complications; preeclampsia; fetal growth restriction; placental immunology

(This special issue belongs to the Section Molecular Biology)

Developmental Biology: Computational and Experimental Approaches, 3rd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 31 Aug 2026 | 6 articles | Viewed by 4197 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations; fertilization; zygote; cell cycle; stem cell; meristem; cell layer; tissue; embryo; multicellular organism; ontogenesis; morphogenesis; life cycle; molecular mechanism; signal transduction; gene regulation; gene networks; cellular process; differentiation; migration; segmentation; high-resolution 3D-map; real-time in silico simulator; developmental hourglass; transcriptome ontogenetic switch; developmental abnormality; premature aging; neurodegeneration; tumorigenesis; atherogenesis; autoimmunity; induced pluripotent cell; wound healing; regeneration; assisted reproductive technologies; epigenetic reprogramming; predictive preventive personalized participatory (4P) medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Zoology: 2nd Edition

edited by

Valeria Maselli

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2852 | Submission Open

Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoology

(This special issue belongs to the Section Molecular Biology)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2235 | Submission Open

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

Techniques and Applications of Forensic Molecular Biology: From Pathology to Clinical Practice

edited by

Angelo Montana

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2081 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro, in vivo, and in silico models; hypoxic–ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Intermittent Hypoxia and Physiological Effects: Interplay Between Oxidative Stress, Inflammation, and Autonomic Dysregulation

edited by

Rodrigo L. Castillo

and

Esteban G. Figueroa

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1518 | Submission Open

Keywords: intermittent hypoxia; cardiovascular and pulmonary effects; oxidative stress; autonomic dysfunction; neuroinflammation; renal effects; animal models

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Health and Disease: From Physiology to Therapeutics

edited by

Yohan Seo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1514 | Submission Open

Keywords: ion channels; cellular homeostasis; chronic diseases; cancer; inflammation; therapeutic targets; drug resistance; channel modulators; translational medicine

(This special issue belongs to the Section Molecular Biology)

Metabolic Sensing and Adaptive Stress Responses in Aging and Chronic Disease

edited by Mark Slevin

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1426 | Submission Open

Keywords: metabolic sensing; aging and healthspan; exercise physiology; AMPK–mTOR signaling; autophagy and mitophagy; redox biology; mitochondrial quality control; cellular stress adaptation; chronic disease prevention; inflammaging

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Metabolic Bone Disorders

edited by

Harish K. Datta

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1259 | Submission Open

Keywords: metabolic bone disease; bone cells; rare diseases; genetics; molecular biology; skeletal development disorders

(This special issue belongs to the Section Molecular Biology)

Advances in Vascular Function, Senescence and Remodeling: A New Direction for Therapeutic Approach to Prevent CVDs

edited by

Gautham Yepuri

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1100 | Submission Open

Keywords: vascular dysfunction; senescence; endothelial cells; small molecules; anti-aging; cardiovascular diseases; sudden death

(This special issue belongs to the Section Molecular Biology)

Lipid Metabolic and Signaling Dysregulations: From Molecular Mechanisms to Disease Pathogenesis

edited by Gergana M. Deevska

submission deadline 31 Aug 2026 | 2 articles | Viewed by 970 | Submission Open

Keywords: lipid signaling; lipid metabolism; lipid homeostasis; metabolic dysregulation; signal transduction; disease pathogenesis

(This special issue belongs to the Section Molecular Biology)

Animal Reproduction and Development: Current Issues and Future Perspectives

edited by

Kamil Janelt

submission deadline 31 Aug 2026 | 1 articles | Viewed by 592 | Submission Open

Keywords: reproductive and developmental biology; molecular and cellular mechanisms; gene regulation and epigenetics; physiology and metabolic regulation; biotechnology and translational research

(This special issue belongs to the Section Molecular Biology)

Innovations in Avian Reproduction: From Basic Science to Application

edited by

Ali Aygun

submission deadline 31 Aug 2026 | Viewed by 412 | Submission Open

Keywords: avian reproduction; reproductive physiology and technologies; incubation management; embryonic development; genetic approaches in reproduction; candidates genes of reproduction; nutrition and reproduction; genetic regulation of reproduction traits; GWAS in reproduction; avian sperm cryopreservation

(This special issue belongs to the Section Molecular Biology)

From Tryptophan to Circadian and Neurochemical Regulators: The Serotonin-Melatonin Pathway

edited by

Anna Cieslinska

submission deadline 31 Aug 2026 | Viewed by 405 | Submission Open

Keywords: tryptophan metabolism; serotonin; melatonin; indoleamines; circadian rhythm; neurotransmission; metabolites; gut–brain axis; chronobiology; metabolomics

(This special issue belongs to the Section Molecular Biology)

Advances in Calcium Signaling: Physiological Roles and Implications for Disease

edited by

Adán Dagnino-Acosta

and

Luis Castro-Sánchez

submission deadline 31 Aug 2026 | Viewed by 314 | Submission Open

Keywords: calcium signaling; intracellular calcium; calcium homeostasis; calcium channels; muscle physiology; signal transduction; calcium-related diseases; mitochondrial calcium; genetic control of calcium signaling

(This special issue belongs to the Section Molecular Biology)

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