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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Application of Pulsed Electric Fields in Cancer Therapy
edited by Siqi Guo
submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open
Keywords: pulsed electric fields; cancer therapy; ablation; minimally invasive; tumor microenvironment; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Cutting-Edge Carbon-Based Nanomaterials for Biomedical and Environmental Innovations
edited by Roberto Romeo
submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open
Keywords: carbon-based nanomaterials; carbon dots; biochar; graphene derivatives; biomedical applications; environmental monitoring; sustainable nanotechnology; smart sensors
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into Cardiomyopathy
edited by
submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open
Keywords: cardiomyopathy; inflammation; molecular mechanisms; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms, Pathogenesis, and Novel Therapeutic Strategies in Cardiovascular Disease, 2nd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 48 | Submission Open
Keywords: aneurysm pathobiology; vascular remodeling; extracellular matrix degradation; inflammatory signaling pathways; molecular targets for therapy; autophagy; macrophage; inflammation; immune cell regulation; age-related diseases; therapeutic implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Compounds in Cancer Drugs Treatment and Prevention
edited by
submission deadline 31 Mar 2026 | Viewed by 47 | Submission Open
Keywords: natural compounds; cancer prevention; cancer treatment; drug resistance; secondary metabolites; anticancer agents; molecular mechanisms; clinical trials; drug delivery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nanocomplexes and Drug Delivery Systems for Cancer Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 47 | Submission Open
Keywords: nanocomplexes; drug delivery systems; cancer therapy; nanocarriers; stimuli-responsive systems; theranostics; biomolecules delivery; tumor microenvironment; personalized medicine; multidrug resistance
(This special issue belongs to the Section Molecular Nanoscience)
Recent Genetic Insights into Neurodevelopmental Disorders
edited by Maria Cristina Aspromonte and Emanuela Dazzo
submission deadline 31 Mar 2026 | Viewed by 46 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder; intellectual disability; attention deficit hyperactivity disorder; epilepsy; motor disorders; chromosomal rearrangements; genetic variant; integrative omics approaches
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Oral Cancer Invasion and Metastasis Research
edited by Kiyofumi Takabatake
submission deadline 31 Mar 2026 | Viewed by 46 | Submission Open
Keywords: oral cancer; invasion and metastasis; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Reprogramming of Mitochondrial Signalling and Metabolism in Cancers submission deadline 31 Mar 2026 | Viewed by 45 | Submission Open
Keywords: mitochondrial dynamic; mitochondrial biogenesis; mitochondrial transfer; mitochondrial targeting; mitophagy; oxidative metabolism; mtDNA; ROS; oncometabolism
(This special issue belongs to the Section Molecular Oncology)
Neuroblastoma: Advances in Molecular Pathogenesis and Therapy
edited by Paola Fadda and
submission deadline 31 Mar 2026 | Viewed by 45 | Submission Open
Keywords: neuroblastoma; molecular pathogenesis; MYCN; ALK; epigenetics; non-coding RNAs; tumor microenvironment; immunotherapy; targeted therapy; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Bioactive Compounds Targeting Metabolic Disorders: Molecular Mechanisms and Translational Applications
edited by
submission deadline 31 Mar 2026 | Viewed by 44 | Submission Open
Keywords: bioactive compounds; obesity; type 2 diabetes; insulin resistance; adipose tissue; gut microbiota; inflammation; oxidative stress; nutraceuticals; molecular nutrition
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Immunotherapies of Solid Tumors
edited by
submission deadline 31 Mar 2026 | Viewed by 44 | Submission Open
Keywords: immune; solid tumors; anti-tumor; molecular pathways; immunotherapy; tumor microenvironment; checkpoint; CAR T cell; adoptive cell
(This special issue belongs to the Section Molecular Immunology)
Latest Advances in Pituitary Endocrinology
edited by and Cristina Lamas
submission deadline 31 Mar 2026 | Viewed by 42 | Submission Open
Keywords: pituitary tumors; hypopituitarism; growth and puberty disorders; acromegaly; Cushing’ s disease and silent corticotroph tumors; silent pituitary tumors; hypophysitis; molecular endocrinology and transcription factors; hormone resistance; precision endocrinology
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Developing the Coupling or De-Coupling of Osteoclastogenesis vs. Osteogenesis at the Osteoimmune Interface
edited by Andy Yen-Tung Teng
submission deadline 31 Mar 2026 | Viewed by 41 | Submission Open
Keywords: bone and immune cells; osteoclasts vs. osteoblasts; interactions between osteoclasts and osteoblasts; osteoimmune interactions in health and/or disease; developmental lineages or pathways of osteoclastogenesis; coupling and/or de-coupling (or crosstalk) for osteoclastogenesis and/or osteogenesis; biomaterials and/or bio-mimics for bone genesis and/or loss
(This special issue belongs to the Section Molecular Immunology)
Neurological and Neurodevelopmental Disorders: Models, Drugs and Technologies
edited by Su-Yun Lyu
submission deadline 31 Mar 2026 | Viewed by 38 | Submission Open
Keywords: neurodevelopmental disorders; disease modeling; molecular mechanisms; neurological; precision medicine; individualized therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Viral Infections and Cancer: Recent Advances and Future Perspectives (2nd Edition)
edited by
submission deadline 31 Mar 2026 | Viewed by 38 | Submission Open
Keywords: virus; infection; cancer; immune response
(This special issue belongs to the Section Molecular Oncology)
Solid Tumours in Focus: Tissue Biomarkers and Spatial Technologies in Cancer Pathology
edited by Kathryn Pennel
submission deadline 31 Mar 2026 | Viewed by 36 | Submission Open
Keywords: biomarkers; cancer pathology; spatial biology; molecular mechanisms; tumour microenvironment; cell signalling and communication
(This special issue belongs to the Section Molecular Oncology)
DNA Repair Mechanisms in Neurological Disorders
edited by Camila Araújo Bernardino Garcia
submission deadline 31 Mar 2026 | Viewed by 36 | Submission Open
Keywords: DNA repair; somatic mosaicism; focal cortical dysplasia; epilepsy genetics; cortical malformations; neurodevelopmental disorders; genomic instability; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Nanomaterials in Biomedicine, Microbiology and Tissue Engineering submission deadline 31 Mar 2026 | Viewed by 34 | Submission Open
Keywords: nanomaterials; nanotechnology; biomedicine; microbiology; tissue regeneration
(This special issue belongs to the Section Materials Science)
Advances in Antimicrobial Resistance: Molecular and Biochemical Perspectives
edited by
submission deadline 31 Mar 2026 | Viewed by 32 | Submission Open
Keywords: antimicrobial resistance mechanisms; molecular basis of resistance; metabolic reprogramming in bacteria; biofilm formation and regulation; resistance gene expression and regulation
(This special issue belongs to the Section Molecular Microbiology)
Natural Product-Based Therapeutics: Molecular Mechanisms and Cellular Modulation
edited by Mario Garcia-Dominguez
submission deadline 31 Mar 2026 | Viewed by 31 | Submission Open
Keywords: natural products; molecular mechanisms; cellular modulation; molecular targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unraveling the Molecular Landscape of Systemic Lupus Erythematosus
edited by Yoshinori Matsumoto
submission deadline 31 Mar 2026 | Viewed by 26 | Submission Open
Keywords: systemic lupus erythematosus; autoimmunity; molecular mechanisms; immune regulation; type I interferon; biomarkers; multi-omics; signal transduction; precision medicine; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Skin Cancer: Molecular Drivers, Biomarkers, Non-Invasive Diagnostics and Therapeutic Strategies
edited by , and Giulia Veronesi
submission deadline 31 Mar 2026 | Viewed by 23 | Submission Open
Keywords: melanoma; skin cancers; immunotherapy; targeted therapy; liquid biopsy; non-invasive diagnostics techniques; miRNA; genomic
(This special issue belongs to the Section Molecular Oncology)
Advances in Immunotherapy for Cancer: From Molecular Basis to Novel Biomarkers and Therapeutic Targets—2nd Edition submission deadline 31 Mar 2026 | Viewed by 20 | Submission Open
Keywords: tumor microenvironment; immune suppression; metabolic and molecular mechanisms of resistance to therapy; tumor immune escape; immunotherapy; immune checkpoint inhibitors; cancer vaccination; tumor-infiltrating cells; biomarkers; tumor antigens; cancer metabolism
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Breast Cancer Immunology and Immunotherapy
edited by Tamara Gulić
submission deadline 31 Mar 2026 | Viewed by 18 | Submission Open
Keywords: breast cancer; immunology; tumor microenvironment; immunotherapy tumor infiltrating lymphocytes; innate immunology; immune-checkpoint inhibitors; immunotherapy; biomarkers; targeted therapies
(This special issue belongs to the Section Molecular Immunology)
Microenviromental Signalling in Tumorigenesis and Anti-Cancer Drugs Resistance
edited by
submission deadline 5 Apr 2026 | Viewed by 156 | Submission Open
Keywords: tumor microenvironment; cancer cell signaling; paracrine and autocrine mechanisms; cancer drug resistance; oncogenic pathways; immune checkpoints; cancer immune evasion; cancer-associated fibroblasts; tumor-infiltrating lymphocytes; onco-immunology; CAR-T
(This special issue belongs to the Section Molecular Oncology)
Research on Drug Delivery in Health and Disease submission deadline 10 Apr 2026 | Viewed by 40 | Submission Open
Keywords: precision medicine; nanomedicine; targeted delivery; biomarkers; personalized therapy; adaptive systems; AI-driven drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
New Insights in Tumor Immunity
edited by
submission deadline 20 Apr 2026 | 10 articles | Viewed by 34052 | Submission Open
Keywords: tumor immunity; tumor evolution; tumor antigens; immune surveillance; cancer immunoediting; tumor microenvironment; immunotherapies; immune checkpoints; tumor-specific lymphocytes
(This special issue belongs to the Section Molecular Immunology)
Molecular Biology of Cancer—Implications for Diagnosis and Treatment: 3rd Edition submission deadline 20 Apr 2026 | 16 articles | Viewed by 30164 | Submission Open
Keywords: genomics; epigenetics; translational research; oncology precision medicine
(This special issue belongs to the Section Molecular Oncology)
Recent Research in Gut Microbiota–Gut–Brain Axis
edited by Ying Han
submission deadline 20 Apr 2026 | 5 articles | Viewed by 29878 | Submission Open
Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; short-chain fatty acid; immune pathway; vagus nerve; neuropsychiatric disorders; depression
(This special issue belongs to the Section Molecular Biology)
Molecular and Physiological Mechanisms of Exercise
edited by Zoran Nikolovski
submission deadline 20 Apr 2026 | 3 articles | Viewed by 17996 | Submission Open
Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 17462 | Submission Open
Keywords: tendinopathy; tendon pain; stiffness; physical disability; etiopathogenesis; molecular mechanisms; tendon reattachment; tendon repair; advanced molecular tools; omics techniques; biophysical therapies; novel biomaterials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Wound Healing: 2nd Edition submission deadline 20 Apr 2026 | 7 articles | Viewed by 16181 | Submission Open
Keywords: management of wounds; nanobiomaterials; infection control; chronic wounds; biofilm infections; wound dressings; tissue engineering; wound healing
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Molecular Mechanisms Underlying Kidney Diseases: Pathophysiology and Therapeutic Targets, 2nd Edition submission deadline 20 Apr 2026 | 7 articles | Viewed by 15706 | Submission Open
Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Dysfunction: A Metabolic, Cardiovascular, Neurodegenerative and Neuromuscular Issue: 2nd Edition
edited by , and Claudia Nesti
submission deadline 20 Apr 2026 | 5 articles | Viewed by 14456 | Submission Open
Keywords: bioenergetics; mitochondrial disorders; biomarkers; OxPhos complexes; mitochondrial DNA; aging; neurodegenerative diseases; cardiovascular diseases; metabolic diseases; therapies to counteract mitochondrial dysfunction TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Metabolism of Ameloblasts in Tooth Development
edited by Maiko Suzuki and Yong Hee Patricia Chun
submission deadline 20 Apr 2026 | 6 articles | Viewed by 13451 | Submission Open
Keywords: ameloblasts; amelogenesis; metabolism; gene regulation; amelogenesis imperfecta; SCPP; enamel hypomineralization; tooth epithelial stem cells
(This special issue belongs to the Section Molecular Biology)
Natural Compounds for Counteracting GI and Liver Diseases submission deadline 20 Apr 2026 | 5 articles | Viewed by 13410 | Submission Open
Keywords: natural compounds; gastrointestinal diseases; liver diseases; pharmacological potential
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights into Immune Dysregulation Disorders
edited by
submission deadline 20 Apr 2026 | 6 articles | Viewed by 12914 | Submission Open
Keywords: immune dysregulation disorders; autoimmune conditions; primary immunodeficiencies; autoinflammatory disorders
(This special issue belongs to the Section Molecular Immunology)
Pediatric Diseases: From Molecular Mechanisms to Novel Therapeutic Strategies
edited by
submission deadline 20 Apr 2026 | 5 articles | Viewed by 12799 | Submission Open
Keywords: congenital abnormalities; genetic disease; molecular mechanism; therapeutic agents; maternal and fetal medicine; pediatric diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viruses as Therapeutic Tools: Medical and Biotechnological Applications
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 11992 | Submission Open
Keywords: molecular virology; virus– host interactions; immunology; gene therapy vectors; vaccines; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Galectins (Gals), 2nd Edition
edited by
submission deadline 20 Apr 2026 | 8 articles | Viewed by 11649 | Submission Open
Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers
(This special issue belongs to the Section Molecular Biology)
New Advances in Epigenetics and Epigenomics
edited by Vicki Maltby
submission deadline 20 Apr 2026 | 4 articles | Viewed by 11084 | Submission Open
Keywords: epigenetics; epigenomics; multi-omics; epitranscriptomics; single cell
(This special issue belongs to the Section Molecular Genetics and Genomics)
Plant-Derived Bioactive Compounds for Pharmacological Applications submission deadline 20 Apr 2026 | 6 articles | Viewed by 10893 | Submission Open
Keywords: plant-derived bioactive compounds; pharmacological applications; antioxidant activity; anti-inflammatory agents; antimicrobial properties; neuroprotective effects; drug discovery; high-throughput screening; extraction and isolation techniques; structural characterization; CRISPR technology; genome editing; bioprocess engineering; bioreactor production; therapeutic potential; metabolite profiling
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Boosting the Production of Bioactive Compounds: Biotechnology and Metabolic Engineering of Medicinal Plants submission deadline 20 Apr 2026 | 5 articles | Viewed by 10824 | Submission Open
Keywords: bioactive compounds; plant tissue culture; elicitors; metabolic engineering; gene expression; medicinal plants; metabolic pathway; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights in Neurodegeneration submission deadline 20 Apr 2026 | 5 articles | Viewed by 10508 | Submission Open
Keywords: neurodegeneration; molecular mechanisms; protein aggregation; neuroinflammation; oxidative stress; mitochondrial dysfunction; Alzheimer’ s disease; Parkinson’ s disease; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Physiological Functions and Pathological Effects of Microglia
edited by Hiroshi Nakanishi
submission deadline 20 Apr 2026 | 4 articles | Viewed by 10485 | Submission Open
Keywords: circadian clock; homeostasis; immune response; microglia; neurodegenerative diseases; neuroinflammation; neuropsychiatric disorders; neuromodulation; phagocytosis; synaptic pruning
(This special issue belongs to the Section Molecular Neurobiology)
The Role of RNAs in Cancers: Recent Advances
edited by Roman Beňačka
submission deadline 20 Apr 2026 | 4 articles | Viewed by 10144 | Submission Open
Keywords: cancer cells; carcinogenesis; mRNAs; ncRNAs; lncRNAs; miRNAs; circRNAs; piRNAs; RNA-based diagnostics; RNA-based therapy
(This special issue belongs to the Section Molecular Oncology)
New Insights into the Immunopathology of Autoimmune and Drug Induced Liver Injury
edited by Eleni Geladari
submission deadline 20 Apr 2026 | 2 articles | Viewed by 9943 | Submission Open
Keywords: liver disease; liver injury; immune system; immune dysregulation
(This special issue belongs to the Section Molecular Immunology)
Molecular Insight into Skin Infection and Inflammation
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 9912 | Submission Open
Keywords: skin infection; skin inflammation; inflammatory skin diseases; atopic dermatitis; skin microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomarkers in Cancer Immunology
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 9664 | Submission Open
Keywords: immunotherapy; adoptive cell transfer; CAR-T cells; immune checkpoint inhibitors; tumor microenvironment; extracellular vesicles; biomarkers; miRNA; DNA
(This special issue belongs to the Section Molecular Immunology)
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