Advances in Oral Cancer Invasion and Metastasis Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 1
Special Issue Editor
Special Issue Information
Dear Colleagues,
Invasion and metastasis are defining processes in the progression of oral cancer; understanding their molecular and tissue-level bases is essential for advancing tumor biology. Recent progress has clarified mechanisms underlying these events, including the role of tumor-associated macrophages, lymphocytes, and stromal components in shaping the tumor microenvironment. Parallel studies on epithelial–mesenchymal plasticity, extracellular vesicle communication, and pre-metastatic niche formation have deepened insight into tumor adaptation and dissemination. Integrating molecular biology with pathology has highlighted the significance of invasion patterns, perineural and lymphovascular infiltration, and the influence of biomechanical signals such as YAP/TAZ signaling.
This Special Issue, “Advances in Oral Cancer Invasion and Metastasis Research”, invites a broad range of contributions, including original research articles and reviews that advance mechanistic, molecular, and histopathological understanding of invasion and metastatic processes. Topics of particular interest include single-cell and spatial omics; molecular pathology and quantitative histology; macrophage and stromal cell biology; epithelial–mesenchymal plasticity and cytoskeletal regulation; extracellular vesicles and intercellular signaling; biomechanical and mechanotransduction studies; organotypic, ex vivo, and animal models that probe tissue-level behavior; and the development or validation of molecular/histological assays and biomarkers. We particularly encourage studies that use molecular, cellular, and tissue-based approaches or that tightly link histopathology with underlying mechanisms to illuminate the biology of oral cancer invasion and metastasis.
Dr. Kiyofumi Takabatake
Guest Editor
Manuscript Submission Information
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Keywords
- oral cancer
- invasion and metastasis
- molecular mechanisms
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