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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bee Products and Their Flavonoids: Recent Advances in Molecular Mechanisms, Therapeutic Applications, and Innovative Delivery Systems

edited by

Nada Orsolic

and

Maja Jazvinšćak Jembrek

submission deadline 20 Mar 2026 | Viewed by 120 | Submission Open

Keywords: honeybee products; flavonoids; bioactive compounds; biological activity; pharmacological activity; health benefits; side effects; disease prevention; antioxidant activity; apitherapy; nutritional properties; innovative technical approaches

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research

edited by

Paola Muggeo

submission deadline 20 Mar 2026 | Viewed by 120 | Submission Open

Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies

(This special issue belongs to the Section Molecular Oncology)

Skin Diseases: From Molecular Mechanisms to Pathology, 2nd Edition

edited by

Alessandro Terrinoni

submission deadline 20 Mar 2026 | Viewed by 115 | Submission Open

Keywords: skin diseases; immunology; genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

HPV Infection and Immune Escape Mechanisms

edited by

Vittorio Unfer

and Elisa Lepore

submission deadline 20 Mar 2026 | Viewed by 111 | Submission Open

Keywords: HPV; persistence; natural molecules; vaccination; genotypes; anal infection; oral infection; co-infection

(This special issue belongs to the Section Molecular Immunology)

Arthritis: From Molecular Basis to Therapy

edited by Cinzia Rotondo

submission deadline 20 Mar 2026 | Viewed by 108 | Submission Open

Keywords: comorbidities; biomarkers; inflammation; autoimmune disease; systemic disease; arthritis; autoimmune disease; psoriasis; axial involvement; biological drugs; target synthetic DMARDs; pathogenesis; rheumatoid arthritis; spondyloarthritis; psoriatic arthritis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Biomaterials for Advanced Applications in Regenerative Medicine and Drug Delivery

edited by

Calogero Fiorica

submission deadline 20 Mar 2026 | Viewed by 102 | Submission Open

Keywords: biomaterials; drug delivery; regenerative medicine; stimuli-responsive polymers; 3D scaffolds; micro-nanocarriers

(This special issue belongs to the Section Materials Science)

Genetic Diversity, Founder Effects, and Migration in Neurodegeneration: Molecular and Population Perspectives

edited by

Dasiel Oscar Borroto-Escuela

submission deadline 20 Mar 2026 | Viewed by 102 | Submission Open

Keywords: neurodegeneration; population genetics; founder effects; genetic diversity; migration and disease risk; spinocerebellar ataxia; Alzheimer’ s disease; Parkinson’ s disease; genetic epidemiology; underrepresented populations

(This special issue belongs to the Section Molecular Neurobiology)

Current Research on Colloidal Emulsions: Preparation and Applications

edited by Alexander Djerdjev

submission deadline 20 Mar 2026 | Viewed by 85 | Submission Open

Keywords: emulsion formulation and stability; nano-; micro-; and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil– water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology

(This special issue belongs to the Section Materials Science)

Musculoskeletal Development and Skeletal Pathophysiologies, 3rd Edition

edited by

Elizabeth W. Bradley

submission deadline 20 Mar 2026 | Viewed by 79 | Submission Open

Keywords: musculoskeletal development; growth plate; endochondral ossification; intramembranous ossification; osteoporosis; osteoarthritis; bone; cartilage; osteoblast; osteoclast; chondrocyte

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Biomaterials in Human Diseases

edited by

Satoshi Komasa

submission deadline 20 Mar 2026 | Viewed by 75 | Submission Open

Keywords: implant; bone substitute material; titanium; zirconia; biomaterials; in vitro; in vivo

(This special issue belongs to the Section Materials Science)

Drug Discovery and Preclinical Pharmacology for Cognitive and Neuropsychiatric Disorders in Aging

edited by

Malgorzata Zaremba

submission deadline 20 Mar 2026 | Viewed by 74 | Submission Open

Keywords: aging brain; neural aging; neurodegeneration; neuropsychiatric disorders; late-life psychiatric disorders; dementia syndromes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Toxicology of Nano- and Microplastics: Mechanisms of Cellular Disruption and Biochemical Pathways

edited by Ioannis Alexandros Charitos

submission deadline 20 Mar 2026 | Viewed by 72 | Submission Open

Keywords: nanoplastics; microplastics (NMP); toxicology; toxicological impact; human health; human microbiota; metabolome

(This special issue belongs to the Section Molecular Toxicology)

Cytokines in Inflammatory Signaling: 3rd Edition

edited by

Waipo Chong

and

Daniela Novick

submission deadline 20 Mar 2026 | Viewed by 71 | Submission Open

Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Research Advances in Common and Rare Pediatric Diseases

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 20 Mar 2026 | Viewed by 66 | Submission Open

Keywords: pediatric diseases; diagnosis; therapeutic targets; molecular mechanisms; pediatric pathology; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Dry Eye Syndrome, Second Edition

edited by Maria Jesus Giráldez-Fernández

submission deadline 20 Mar 2026 | Viewed by 64 | Submission Open

Keywords: dry eye disease; tear film osmolarity; tear film; artificial tear substitutes; biological tear substitutes; tear fluid biomarkers; tear film lipid layer; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; ocular surface inflammation; cytokines; histological analysis; pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autoimmune Diseases: A Swing Dance of Immune Cells, 3rd Edition

edited by

Balik Dzhambazov

submission deadline 20 Mar 2026 | Viewed by 64 | Submission Open

Keywords: autoimmune diseases; antigens/autoantigens; post-translational modifications; antigen processing and presentation; shared epitopes; molecular mimicry; autoantibodies; immune signaling; animal models; therapeutic agents

(This special issue belongs to the Section Molecular Immunology)

The Role of Long Non-Coding RNAs in Cancer Metastasis and Drug Resistance

edited by

Tulasigeri M. Totiger

submission deadline 20 Mar 2026 | Viewed by 50 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); cancer metastasis; drug resistance; epithelial– mesenchymal transition (EMT); tumor microenvironment; chemoresistance mechanisms; RNA-based therapeutics; gene regulation; functional genomics; biomarkers in cancer

(This special issue belongs to the Section Molecular Oncology)

Liver Disease and Primary Liver Cancer: Translational Advances and Therapeutic Perspectives

edited by

Cristian Turato

submission deadline 20 Mar 2026 | Viewed by 47 | Submission Open

Keywords: liver disease; hepatocellular carcinoma; cholangiocarcinoma; molecular mechanisms; translational research; 3D models and organoids; biomarkers and therapeutic strategies; MASH/MASLD: pathogenesis; diagnosis; and management; primary liver cancer: pathogenesis; detection; and treatment; inflammation in liver disease; 3D liver models; microbiota and liver disease; mechanisms of damage and repair: ischemia-reperfusion injury; cellular pathology in acute and chronic liver damage of different origin; biomarkers in liver disease: emerging methods and potential applications; immunology in the liver— from homeostasis to disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Genetic and Epigenetic Alterations in Age-Related Diseases

edited by

Valerio Caputo

and

Andrea Latini

submission deadline 25 Mar 2026 | Viewed by 563 | Submission Open

Keywords: genomics; epigenetic modifications; age-related pathologies; neurodegeneration; dysmetabolism; spatial omics; 3D genome; genetic variants; telomere length; mitochondrial DNA; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy

edited by

Wei Dai

submission deadline 25 Mar 2026 | Viewed by 113 | Submission Open

Keywords: nasopharyngeal carcinoma (NPC); epstein– barr virus (EBV); cancer epigenomics; virus– host interaction; tumor microenvironment (TME); immunotherapy; targeted therapy; biomarker; metastasis; radiotherapy resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glial Cells in Brain and Eye: Emerging Mechanisms and Functions in Health and Disease

edited by

Mario E. Guido

submission deadline 25 Mar 2026 | Viewed by 113 | Submission Open

Keywords: glial cells; brain & eye (retina); health & disease; neuronal regulation; therapeutic strategies; CNS; glia biology; cellular interactions

(This special issue belongs to the Section Molecular Biology)

Molecular Engineering of Antimicrobial Agents: From Structure-Function Insights to Combinatorial Therapies

edited by Mingrui Liao

submission deadline 25 Mar 2026 | Viewed by 104 | Submission Open

Keywords: antimicrobial amphiphiles; antimicrobial resistance; structure– activity relationship; synergistic antimicrobial therapy; drug delivery systems

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Central Nervous System Inflammatory Demyelinating Diseases

edited by Yong Guo

submission deadline 25 Mar 2026 | Viewed by 72 | Submission Open

Keywords: central nervous system; autoimmune; demyelination; inflammation; multiple sclerosis; pathology

(This special issue belongs to the Section Molecular Neurobiology)

The Expanding Genetic Landscape of Parkinson's Disease

edited by Christos Koros and

Vasilios C. Constantinides

submission deadline 25 Mar 2026 | Viewed by 71 | Submission Open

Keywords: Parkinson’ s disease; monogenic; polygenic risk score; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Prostate Cancer: Molecular Mechanisms and Targeting

edited by

Guoliang Li

submission deadline 25 Mar 2026 | Viewed by 29 | Submission Open

Keywords: prostate cancer; androgen receptor; therapy resistance; epigenetics; tumor microenvironment; molecular signaling; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Pulmonary Fibrosis: Molecular Mechanisms and Therapeutic Strategies

edited by

Barbara Ruaro

submission deadline 28 Mar 2026 | Viewed by 135 | Submission Open

Keywords: machine learning; pulmonary fibrosis; interstitial lung diseases; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular-Level Insights into Retinal Vascular Disorders

edited by

Nikhlesh Singh

submission deadline 28 Mar 2026 | Viewed by 79 | Submission Open

Keywords: retina; retinal neovascularization; diabetic retinopathy; retinopathy of prematurity; VEGF; blood– retinal barrier

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer

edited by Radka S. Stoyanova

submission deadline 28 Mar 2026 | Viewed by 58 | Submission Open

Keywords: prostate cancer; molecular biomarkers; imaging; non-invasive biomarkers; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Advances in Enzyme Inhibitors: Mechanisms, Applications, and Future Perspectives

edited by

Clemente Capasso

and

Valeria Pittalà

submission deadline 30 Mar 2026 | 5 articles | Viewed by 11770 | Submission Open

Keywords: enzyme inhibitors; drug design; drug discovery; drug therapy; resistance mechanisms; cancer; drug delivery systems; biocatalysts; enzymes in industrial applications

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapies of Brain Tumors

edited by Oana Alexandru

submission deadline 30 Mar 2026 | 4 articles | Viewed by 10187 | Submission Open

Keywords: brain tumors; molecular mechanisms; signal transduction; cell proliferation; apoptosis; targeted therapies; chemotherapy; radiotherapy

(This special issue belongs to the Section Molecular Oncology)

Neuroprotective Effects of Food Ingredients

edited by

Elena Ibáñez

and

Alejandro Cifuentes

submission deadline 30 Mar 2026 | 4 articles | Viewed by 5749 | Submission Open

Keywords: neuroprotection; Parkinson; Alzheimer; bioactive compounds; agri-food by-products; chemical characterization; foodomics; metabolomics; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Diagnostics and Genomics of Tumors, 2nd Edition

edited by

Petra Korać

submission deadline 30 Mar 2026 | 3 articles | Viewed by 775 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advanced Oxidation Processes and Biodegradation for Emerging Contaminants Treatment: 2nd Edition

edited by

Chengdu Qi

submission deadline 30 Mar 2026 | 1 articles | Viewed by 611 | Submission Open

Keywords: advanced oxidation processes; persistent organic compounds; water pollution control; biodegradation; emerging contaminants; water treatment; wastewater treatment; toxicity assessment

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Role of the Epithelial Mesenchymal Transition in Cancer Development and Invasiveness

edited by

Elisabetta Aldieri

submission deadline 30 Mar 2026 | Viewed by 537 | Submission Open

Keywords: epithelial mesenchymal transition; EMT; cancer; epithelial protein; mesenchymal phenotype; therapeutic approach

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapeutic Targets in Systemic Vasculitis

edited by Andrés González-García

submission deadline 30 Mar 2026 | 1 articles | Viewed by 257 | Submission Open

Keywords: vasculitis; ANCA-associated vasculitis; EGPA; complement activation; molecular immunopathogenesis; endothelial dysfunction; cytokine signaling; biomarkers; therapeutic targets; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Antitumoral Properties of Natural and Synthetic Compounds

edited by

Manuel Valenzuela-Valderrama

submission deadline 30 Mar 2026 | Viewed by 236 | Submission Open

Keywords: anticancer agents; natural compounds; synthetic compounds; molecular mechanisms; translational research

(This special issue belongs to the Section Molecular Pharmacology)

Metallopharmaceuticals: Current Trends and Future Perspectives in Cancer Immunoediting

edited by

Marialuisa Piccolo

and

Claudia Riccardi

submission deadline 30 Mar 2026 | Viewed by 197 | Submission Open

Keywords: metal-based drugs; anticancer activity; mechanisms of action; tumor microenvironment; immune cell regulation; cancer immunity; metal– protein interactions; metal– nucleic acid interactions

(This special issue belongs to the Section Molecular Pharmacology)

Domestic Animal Genetics, Genomics, and Molecular Breeding

edited by

Ke Wang

submission deadline 30 Mar 2026 | Viewed by 165 | Submission Open

Keywords: genomic selection; molecular breeding; domestic animals; functional genomics; genetic improvement; product quality; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

Obesity: From Molecular Mechanisms to Clinical Aspects—2nd Edition

edited by

Bunzo Matsuura

submission deadline 30 Mar 2026 | Viewed by 137 | Submission Open

Keywords: food intake; physical activity; adipose tissue; adipokines; gut hormones; nervous system; gut– brain axis; bariatric surgery; inflammation and immune response; genetics and epigenetics

Molecular Pathways to Infertility

edited by

Apostolos Kaponis

submission deadline 30 Mar 2026 | Viewed by 129 | Submission Open

Keywords: infertility; molecules; meiotic arrest; premature ovarian insufficiency; sperm function; progesterone resistance; mitochondrial dysfunction; epigenetic dysregulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Inflammation and Cancer Immunity

edited by

Hyuk Soon Kim

submission deadline 30 Mar 2026 | Viewed by 120 | Submission Open

Keywords: immune regulation; inflammation; cancer immunity; immunotherapy; cytokine signaling; therapeutic targets; immune evasion; antibody-based therapy; histamine; drug repositioning

(This special issue belongs to the Section Molecular Immunology)

Molecular Aspects of the Quality and Biological Diversity of Oocytes of Different Species—A Challenge for Reproductive Applications

edited by Krzysztof Papis

submission deadline 30 Mar 2026 | Viewed by 113 | Submission Open

Keywords: molecular determinants of oocyte quality; developmental competence; in vitro maturation (IVM); follicular fluid composition; reproductive biotechnology; assisted reproductive technologies (ART); comparative oocyte biology; artificial intelligence in reproduction

(This special issue belongs to the Section Molecular Biology)

Immune Microenvironment and Tissue Remodeling in Oral Diseases and Oral Cancer

edited by

Aiman Ali

submission deadline 30 Mar 2026 | Viewed by 106 | Submission Open

Keywords: immune microenvironment; oral cancer; oral diseases; tissue remodeling; molecular signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Research on Stress Signaling in Embryonic Development

edited by

Poongodi Geetha-Loganathan

and Norihisa Higashihori

submission deadline 30 Mar 2026 | Viewed by 103 | Submission Open

Keywords: stress signaling; embryonic development; morphogenesis; signal transduction; teratogenesis

(This special issue belongs to the Section Molecular Biology)

Nitrogen-Containing Heterocycles and Their Biological Applications

edited by

Stella Manta

submission deadline 30 Mar 2026 | Viewed by 92 | Submission Open

Keywords: nitrogen-based heterocycles; synthesis; pharmaceuticals; biological activities

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Pathophysiology of Nerve Regeneration

edited by Fabian Szepanowski and Mark Stettner

submission deadline 30 Mar 2026 | Viewed by 77 | Submission Open

Keywords: nerve injury; nerve inflammation; autoimmune neuropathies; immune-mediated neuropathies; polyneuropathies; peripheral neuroinflammation; nerve regeneration; Schwann cell; Schwann cell differentiation; repair Schwann cell

(This special issue belongs to the Section Molecular Neurobiology)

Research of Emerging Mechanisms in Neuronal Signaling

edited by Dongshu Du

submission deadline 30 Mar 2026 | Viewed by 77 | Submission Open

Keywords: neuronal signaling; astrocytes and microglia; extracellular vesicles; ephaptic coupling; tunneling nanotubes; primary cilium; local mRNA translation; cognition; behavior; physiology; psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Updates on Metal Ions and Related Complexes in Molecular Biology and Biochemistry

edited by

Makan Golizeh

submission deadline 30 Mar 2026 | Viewed by 76 | Submission Open

Keywords: biochemistry; homeostasis; metal ions; metal ion complexes; metallomics; molecular biology; molecular pathogenesis; quantification; systems biology; toxicity

(This special issue belongs to the Section Biochemistry)

Down Syndrome: From Molecular Mechanisms to Therapeutic Strategies

edited by Amy Feldman Lewanda

submission deadline 30 Mar 2026 | Viewed by 75 | Submission Open

Keywords: down syndrome; Trisomy 21; molecular mechanisms; therapeutic strategies; neurodegeneration; comorbidities; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Animal Molecular Genetics

edited by

Jarosław Króliczewski

submission deadline 30 Mar 2026 | Viewed by 72 | Submission Open

Keywords: epigenetics; functional genomics; gene expression; gene polymorphism; genetic diseases; genetic techniques and assays; genome-wide association; genetic markers; quantitative genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 2151-2200 on page 44 of 65.

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