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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Molecular Pathogenesis of Gastrointestinal Malignancies with Implications for Diagnosis and Therapy

edited by Laura Necula

submission deadline 31 Jan 2026 | 1 articles | Viewed by 758 | Submission Open

Keywords: gastrointestinal cancers; biomarkers; early diagnosis; circulating molecules; non-invasive tests

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Protein–Ligand Interactions

edited by

Qiaomei Sun

submission deadline 31 Jan 2026 | 1 articles | Viewed by 742 | Submission Open

Keywords: interaction; protein– ligand; computer simulation; docking; molecular simulation

(This special issue belongs to the Section Biochemistry)

Integrative Omics Strategies for Biomarker Discovery and Mechanistic Insights into Disease

edited by

Xinxin Song

submission deadline 31 Jan 2026 | 1 articles | Viewed by 642 | Submission Open

Keywords: integrative omics; biomarker discovery; cancer signaling networks; drug resistance; phosphoproteomics; multi-omics integration; systems biology; translational research

(This special issue belongs to the Section Molecular Informatics)

Novel Mechanisms of Receptor Activation

edited by

Zong Jie Cui

submission deadline 31 Jan 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

Molecular Design and Functional Applications of Polysaccharide Composites

edited by

Magdalena Krystyjan

Gohar Khachatryan

and

Karen Khachatryan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 610 | Submission Open

Keywords: polysaccharide composites; molecular design; functional applications

(This special issue belongs to the Section Materials Science)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 31 Jan 2026 | Viewed by 602 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Inner Ear Disorders: From Molecular Mechanisms to Treatment

edited by

Srdjan Vlajkovic

submission deadline 31 Jan 2026 | 1 articles | Viewed by 586 | Submission Open

Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Zoonotic Diseases: Current Advances and Perspectives

edited by

Gabriela Goujgoulova

submission deadline 31 Jan 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: emerging zoonoses; re-emerging zoonoses; zoonotic pathogens; control strategies and measures; animal and public health; worldwide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Fibrosis and Oral Cancers: From Molecular Targets to Therapeutics

edited by Ila Pant

submission deadline 31 Jan 2026 | Viewed by 552 | Submission Open

Keywords: OSF; oral cancer; myofibroblast activation; collagen homeostasis; cancer stem cells; immunotherapy; monoclonal antibodies; DNA or RNA based targeted therapy; small molecule inhibitors; targeted nano-delivery systems; resistance to targeted therapies; molecular targets; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Genetic and Metabolic Molecular Research of Lysosomal Storage Disease: 5th Edition

edited by

Grzegorz Wegrzyn

submission deadline 31 Jan 2026 | 1 articles | Viewed by 541 | Submission Open

Keywords: lysosomal storage diseases; molecular mechanisms of genetic disorders metabolic diseases; accumulation of macromolecules in cells; enzyme replacement therapy; hematopoietic stem cell transplantation gene therapy; substrate reduction therapy; translational research; novel therapies for genetic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Progression of Innate Immunity in Tuberculosis Infections

edited by

Octavio Miguel Rivero-Lezcano

submission deadline 31 Jan 2026 | 1 articles | Viewed by 512 | Submission Open

Keywords: macrophage; neutrophil; innate lymphoid cells; NK cells; mucosal associated invariant T (MAIT) cells; phagocytosis; trained innate immunity; collectins; autophagy; mucociliary clearance; NETosis

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Thromboinflammation

edited by Ana B. Arroyo

submission deadline 31 Jan 2026 | Viewed by 483 | Submission Open

Keywords: thromboinflammation; coagulation; inflammation; immune system; sepsis; stroke; autoimmune diseases; cancer; hematology; biomarkers; translational medicine

(This special issue belongs to the Section Molecular Immunology)

Plant Responses to Abiotic Stress: Mechanisms and Adaptations

edited by

Shalini Tiwari

and

Lam-Son Phan Tran

submission deadline 31 Jan 2026 | Viewed by 466 | Submission Open

Keywords: salinity stress; heat and cold stress; oxidative stress; signal transduction; stress-responsive genes; antioxidant defence mechanisms; hormonal regulation; molecular adaptation; epigenetic regulation; plant-microbe interaction; crop improvement; stress-resilient plants

(This special issue belongs to the Section Molecular Plant Sciences)

Structure, Properties, and Applications of Carbon Materials

edited by

Javier Arcibar-Orozco

submission deadline 31 Jan 2026 | 1 articles | Viewed by 458 | Submission Open

Keywords: carbon-based structures; diamonds; carbon quantum dots; carbon composites; graphene; nanotubes

(This special issue belongs to the Section Materials Science)

Molecular Insights into Recent Research in Composite Materials

edited by Aboulfazl Barati

submission deadline 31 Jan 2026 | Viewed by 457 | Submission Open

Keywords: composite materials; molecular-level structure– property relationships; polymer nanocomposites; interfacial interactions; sustainable and biodegradable composites; hybrid organic– inorganic systems

(This special issue belongs to the Section Materials Science)

Research Progress of Fluorescent Proteins in Molecular Biology

edited by Matteo Grenzi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 445 | Submission Open

Keywords: fluorescence microscopy; fluorescence live-cell imaging; quantitative imaging; fluorescent biosensors; in vivo imaging; innovative fluorescence microscopy techniques

(This special issue belongs to the Section Molecular Biology)

Advances in Melanoma Immunotherapy and Molecular Mechanisms of Drug Resistance, Second Edition

edited by Antonino Guerrisi and

Italia Falcone

submission deadline 31 Jan 2026 | Viewed by 441 | Submission Open

Keywords: melanoma; targeted therapy; immunotherapy; precision medicine; biomarkers; omics technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Medicinal Plants and Natural Products: Second Edition

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 31 Jan 2026 | 1 articles | Viewed by 434 | Submission Open

Keywords: medicinal plants; natural products; phytochemistry; bioactive substances; medicinal properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms Related to Exercise

edited by Giorgia Scarfò

submission deadline 31 Jan 2026 | 1 articles | Viewed by 429 | Submission Open

Keywords: exercise; mitochondrial biogenesis; intracellular pathways; inflammation; oxidative stress; hypertrophy; metabolism angiogenesis

(This special issue belongs to the Section Molecular Biology)

Autoimmune Diseases: From Molecular Mechanisms to Therapeutic Innovations

edited by

Paula Sandrin-Garcia

submission deadline 31 Jan 2026 | 1 articles | Viewed by 418 | Submission Open

Keywords: autoimmunity; biological biomarkers; personalized therapies; biologics and JAK inhibitors; CAR-T cell therapy

(This special issue belongs to the Section Molecular Immunology)

Biopolymer-Based Materials: Synthesis, Characterization and Applications for a Sustainable Future

edited by

Agnieszka Feliczak-Guzik

and

Agata Wawrzyńczak

submission deadline 31 Jan 2026 | 1 articles | Viewed by 370 | Submission Open

Keywords: biodegradable polymers; biopolymers; biopolymer-based composite materials; synthesis and characterization of biopolymer materials; applications of biopolymers and biopolymer-based composites

(This special issue belongs to the Section Materials Science)

Fine-Tuning Proteostasis: Insights into Ubiquitination and Deubiquitination Pathways

edited by

Kwang-Hyun Baek

submission deadline 31 Jan 2026 | Viewed by 335 | Submission Open

Keywords: deubiquitination; homeostasis; posttranslational modification; proteasomal degradation; protein quality control; proteolysis; proteostasis; signaling pathway; small molecule; ubiquitin-proteasome system; ubiquitination

(This special issue belongs to the Section Biochemistry)

Breaking Barriers in Drug Discovery: Novel Methodologies and Mechanisms of Action

edited by Likun Gong,

Qiuping Qin

and Jing Chen

submission deadline 31 Jan 2026 | 1 articles | Viewed by 304 | Submission Open

Keywords: new approach methodologies (NAMs); in silico; in vitro; in vivo; in chemico; drug discovery; computational modeling; artificial intelligence (AI); high-throughput screening (HTS); high-throughput imaging (HTI); bioassay; omics; cell cultures; tissue engineering; organ engineering; therapeutic target; mechanism of drug action

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Strategies for Melanoma Immunotherapy

edited by

Andrzej Mackiewicz

and

Piotr Rutkowski

submission deadline 31 Jan 2026 | Viewed by 278 | Submission Open

Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Food Science: From Nutritional Value to Safety Evaluation

edited by

Mariachiara Bianco

submission deadline 31 Jan 2026 | 1 articles | Viewed by 274 | Submission Open

Keywords: nutraceutical; food safety; analytical methods; novel foods; food analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Heterocyclic Bioactive Compounds: Design, Synthesis and Biological Evaluation

edited by

Lilia Matei

submission deadline 31 Jan 2026 | Viewed by 259 | Submission Open

Keywords: heterocyclic compounds; drug design; medicinal chemistry; bioactive molecules; structure– activity relationships; synthetic methodologies; molecular mechanisms of action; pharmacological evaluation; therapeutic agents

(This special issue belongs to the Section Biochemistry)

Coordination Chemistry: From Fundamental Principles to Multifunctional Applications

edited by

Kiril B. Gavazov

submission deadline 31 Jan 2026 | Viewed by 255 | Submission Open

Keywords: coordination compounds; metal– ligand interactions; ligand design and synthesis; spectroscopic characterization; coordination geometry; molecular architecture; ion-association complexes; supramolecular chemistry; catalysis and activation mechanisms; functional materials; metal– organic frameworks; magnetism in coordination compounds; redox-active complexes; environmental and green chemistry applications; sensors and molecular devices; bioinorganic chemistry; medicinal coordination chemistry; theoretical and computational coordination chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 31 Jan 2026 | Viewed by 249 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 31 Jan 2026 | Viewed by 240 | Submission Open

Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics; metabolomics; proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Brain Tumor Research and Treatment

edited by

Daniele Armocida

and

Davide Barbagallo

submission deadline 31 Jan 2026 | Viewed by 230 | Submission Open

Keywords: brain tumor; gliomas; brain metastases; translational research; molecular biology

(This special issue belongs to the Section Molecular Oncology)

Advances in Research of Estrogen Receptors in Health and Diseases

edited by

Maciej Iek Skrzypczak

submission deadline 31 Jan 2026 | Viewed by 225 | Submission Open

Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders

(This special issue belongs to the Section Biochemistry)

Emerging Therapeutic Potential of Organic Compound in Diseases

edited by

Katarzyna Kotwica-Mojzych

submission deadline 31 Jan 2026 | Viewed by 206 | Submission Open

Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Role of Cytoskeletal Proteins in Diseases

edited by

Urko Del Castillo

submission deadline 31 Jan 2026 | Viewed by 200 | Submission Open

Keywords: cytoskeleton; microtubules; actin filaments; intermediate filaments; neurodegeneration; cancer metastasis; cell migration; cellular mechanotransduction; cytoskeletal remodeling

(This special issue belongs to the Section Molecular Biology)

Pregnancy-Related Complications: Molecular Pathogenesis and Therapeutic Strategies

edited by

Alicia E. Damiano

submission deadline 31 Jan 2026 | Viewed by 188 | Submission Open

Keywords: pregnancy-related complications; placental dysfunction; maternal-fetal communication; extracellular vesicles; translational research; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Long COVID Biology and Epidemiology: Predisposition, Molecular Mechanisms and Diagnostics

edited by Eduardo José Melo dos Santos

submission deadline 31 Jan 2026 | Viewed by 185 | Submission Open

Keywords: long COVID; genetic predisposing; long COVID epidemiology; pathogenesis; immunology of long COVID; long COVID etiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Angiogenesis Research: From Novel Compounds to Mechanistic Insights and Therapeutic Strategies

edited by Juliana Luporini Dreyfuss

submission deadline 31 Jan 2026 | Viewed by 181 | Submission Open

Keywords: angiogenesis; vascular endothelial growth factor (VEGF); novel compounds; endothelial cells; drug development; advanced molecular biology; omics technologies; innovation

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Molecular Imaging and Therapy

edited by

Xuyi Yue

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: molecular imaging; therapy; clinical translation; precision medicine; radiotheranostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Macrophage Metabolic Reprogramming in Inflammation

edited by

Ricardo Sánchez-Rodríguez

and

Roberta Angioni

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages

(This special issue belongs to the Section Molecular Immunology)

Breakthroughs in Anti-Cancer Agents Discovery

edited by

Giulia Bononi

submission deadline 31 Jan 2026 | Viewed by 176 | Submission Open

Keywords: medicinal chemistry; drug discovery; cancer; anti-cancer agents; synthesis; bioactive molecules; biological evaluation; computational drug discovery; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Advances in Animal Nutrition and Muscle Biology

edited by Usuk Jung

submission deadline 31 Jan 2026 | Viewed by 175 | Submission Open

Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis

(This special issue belongs to the Section Molecular Biology)

Cardiomyocytes Among Physiology and Pathophysiology: Molecular Insights and Therapeutic Implications

edited by Rosetta Ragusa and

Chiara Caselli

submission deadline 31 Jan 2026 | Viewed by 174 | Submission Open

Keywords: sarcomere; metabolic stress; epigenetic mechanisms; exercise; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Combinatorial Strategies in Anti-Obesity Therapeutics

edited by

James Ernest Blevins

and

Pawel K. Olszewski

submission deadline 31 Jan 2026 | Viewed by 169 | Submission Open

Keywords: obesity; high-fat diet; rodents; pharmacotherapy; body weight; food intake

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Retinal Diseases: 2nd Edition

edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo

submission deadline 31 Jan 2026 | Viewed by 166 | Submission Open

Keywords: faricimab; modified cerebrolysin; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products and Compounds in Anticancer Drug Discovery

edited by

Diana I. Ivanova

submission deadline 31 Jan 2026 | Viewed by 163 | Submission Open

Keywords: antitumor plant compounds; antitumor plant-derived products; cellular pathways for natural drug apoptosis induction; chromatography of antitumor plant metabolites; modern technologies for recovery of plant anticancer substances; nanotechnology based natural anticancer drug products; plant-derived antitumor drug-protein interactions

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Functional Nanomaterials, Nanomedicines and Biosensors Based on Nucleic Acids

edited by

Yuancong Xu

and Peng Cao

submission deadline 31 Jan 2026 | Viewed by 163 | Submission Open

Keywords: nucleic acids; functional nanomaterials; nanomedicine; biosensors; DNA nanotechnology; delivery systems; self-assembly; biomedical imaging; clinical applications; diagnostics

(This special issue belongs to the Section Molecular Nanoscience)

Health-Promoting Benefits of Natural Products and Functional Foods, 2nd Edition

edited by

Emad Al-Dujaili

submission deadline 31 Jan 2026 | Viewed by 161 | Submission Open

Keywords: natural products; functional foods; health promotion; nutrigenomics; evidence-based preventive healthcare; phytochemicals; biomarkers; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Unraveling Cell–Cell and Cell–Matrix Interactions: Novel Morphological and Molecular Insights

edited by

José Freni

submission deadline 31 Jan 2026 | Viewed by 161 | Submission Open

Keywords: DGC; sarcoglycans; cell– cell interactions; cell– matrix interactions; morphological analysis; molecular analysis; molecular pathogenesis; translational studies

(This special issue belongs to the Section Molecular Biology)

Regulation of the Intestinal Barrier and the Brain-Gut Microbiota Axis: Role of Age, Gender, and Sex

edited by

Elzbieta M. Sajdel-Sulkowska

submission deadline 31 Jan 2026 | Viewed by 160 | Submission Open

Keywords: age; brain– gut microbiota axis; intestinal barrier; fetal; gender; sex

(This special issue belongs to the Section Molecular Biology)

3D Scaffolds for Tissue Engineering: Challenges and Breakthroughs

edited by