Pulmonary Hypertension: From Molecular Pathophysiology to New Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 22
Special Issue Editor
Interests: infectious diseases; schistosomiasis; Schistosoma; COVID-19; pulmonary hypertension; inflammation
Special Issue Information
Dear Colleagues,
Pulmonary hypertension (PH) is a progressive and life-threatening condition characterized by elevated pulmonary arterial pressure and vascular remodeling. Despite therapeutic advances, PH continues to pose significant clinical challenges, with limited curative options and poor long-term outcomes. Understanding the molecular mechanisms driving PH is essential to developing more effective and targeted therapies.
This special issue, “Pulmonary Hypertension: From Molecular Pathophysiology to New Therapeutic Approaches”, invites contributions that explore the disease from its molecular roots to innovative treatment strategies. We particularly encourage research focused on molecular-level mechanisms such as endothelial dysfunction, smooth muscle proliferation, inflammation, and metabolic alterations. Emerging technologies in genomics, proteomics, and single-cell analysis are shedding new light on the cellular and molecular dynamics of the pulmonary vasculature, offering promising avenues for discovery.
In addition to basic science, we welcome translational and clinical studies that propose novel therapeutic approaches. These may include pharmacologic agents targeting specific signaling pathways, gene- and cell-based therapies, and strategies that personalize treatment based on molecular profiling. Contributions addressing early diagnosis, risk stratification, and biomarkers are also of high interest.
By bringing together diverse perspectives—from molecular biology to clinical innovation—this Special Issue aims to foster interdisciplinary collaboration and accelerate progress in PH research. We invite researchers, clinicians, and industry partners to submit original articles, reviews, and perspectives that will contribute to a deeper understanding of PH and inspire new directions in its management.
Dr. Claudia Mikael
Guest Editor
Manuscript Submission Information
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Keywords
- pulmonary hypertension
- molecular pathophysiology
- vascular remodelling
- targeted therapies
- translational research
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