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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bacterial Infections: Unraveling Pathogenesis, Resistance, and Therapeutic Frontiers

edited by

Jagoda Jablonska

submission deadline 31 Dec 2025 | 1 articles | Viewed by 944 | Submission Open

Keywords: antimicrobial resistance; host– pathogen interactions; bacterial molecular pathogenesis; therapeutic target discovery

(This special issue belongs to the Section Molecular Microbiology)

Molecular Breeding for Important Economic Traits in Livestock

edited by

Dawei Wei

and

Syed Haidar Abbas Raza

submission deadline 31 Dec 2025 | Viewed by 933 | Submission Open

Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement

(This special issue belongs to the Section Molecular Biology)

Advances in Plant RNA Biology: Non Coding RNAs in Plant Development, Defense, and Adaptation

edited by

Andrew Eamens

submission deadline 31 Dec 2025 | 1 articles | Viewed by 878 | Submission Open

Keywords: plant RNA biology; regulatory RNA; non-coding RNA; small RNA (including miRNAs and siRNAs); RNA interacting proteins; plant development; plant pathogen defense; plant environmental stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Plasma in Seed and Plant Treatment

edited by

Ricardo Molina

and

Karina Balestrasse

submission deadline 31 Dec 2025 | 1 articles | Viewed by 844 | Submission Open

Keywords: seed; plant; plasma; germination; dormancy; sterilization; reactive oxygen species; reactive nitrogen species; molecular mechanism; growth promotion; essential oils; plant stem cells; seed coating and pelleting

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Trends in Enzymology

edited by

Francesco Malatesta

submission deadline 31 Dec 2025 | Viewed by 839 | Submission Open

(This special issue belongs to the Section Biochemistry)

Next Generation Sequencing in Human Diseases

edited by

Manuel Muro

submission deadline 31 Dec 2025 | 1 articles | Viewed by 800 | Submission Open

Keywords: NGS; single-cell analysis; metagenomics; forensic DNA analysis; precision medicine; genetic diagnostics; transplant monitoring; cell-free DNA; new allele and variant discovery

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications

edited by

Joško Osredkar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 799 | Submission Open

Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Gut Microbiota—Its Role and Molecular Mechanisms in Nutritional Health

edited by

Xi Ma

and Peng Tan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 768 | Submission Open

Keywords: gut microbiota; microbiome; mucosal immunity; probiotics; omics; dysbiosis; microbiota– host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

State-of-the-Art Electrochemical Reaction Technologies

edited by

Cornelia Bandas

and

Carmen Lǎzǎu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 728 | Submission Open

Keywords: energy storage; electrochemical sensors; electrocatalysis; supercapacitors; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Chelating Ligands in Therapeutics: Recent Advances and Future Directions

edited by

Matteo Mori

and

Fiorella Meneghetti

submission deadline 31 Dec 2025 | Viewed by 679 | Submission Open

Keywords: metal complexes; chelation therapy; chelating agents; diagnostic imaging; metal detoxification; chelation pharmacokinetics

(This special issue belongs to the Section Biochemistry)

Plant Responses to Microorganisms and Insects

edited by

Sumit Jangra

submission deadline 31 Dec 2025 | 1 articles | Viewed by 660 | Submission Open

Keywords: biotic stresses; crop protection; signaling molecules; transcriptomics; proteomics; microRNAs; resistance mechanism; plant– microbe– vector interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Medicinal Plants in Drug Discovery: Unveiling Potential Applications and Molecular Mechanisms

edited by Abdelhakim Bouyahya

submission deadline 31 Dec 2025 | 1 articles | Viewed by 637 | Submission Open

Keywords: bioactive compounds; pharmacodynamic; clinical efficacy; chemotherapeutic drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Carbon Fiber, Carbon Nanofiber for Composites: Synthesis, Processing, Molecular Structure, Characterization, and Application

edited by Tridung Ngo

submission deadline 31 Dec 2025 | Viewed by 624 | Submission Open

Keywords: carbon fiber; carbon nanofiber; nanotube; carbon fiber composites; synthesis; advanced manufacturing; characterization; recent advancements; applications

(This special issue belongs to the Section Materials Science)

Emerging Trends of Quantum Mechanics, Computational Chemistry, and Spectroscopy in Physical Chemistry

edited by

Dongho Kim

submission deadline 31 Dec 2025 | Viewed by 603 | Submission Open

Keywords: quantum theory; computational chemistry; spectroscopy

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular and Electrochemical Mechanisms of Metal Corrosion

edited by

Mehrdad Faraji

submission deadline 31 Dec 2025 | 1 articles | Viewed by 603 | Submission Open

Keywords: metal corrosion; molecular mechanisms; electrochemistry; surface chemistry; corrosion inhibitors; passivation

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Drug Synthesis Reactions: From Bench to Breakthroughs

edited by

Hadia Almahli

submission deadline 31 Dec 2025 | Viewed by 595 | Submission Open

Keywords: organic synthesis; sustainability; scale-up synthesis; bio-orthogonal reactions; flow chemistry; green chemistry; natural product scaffolds; electrochemical synthesis; chemoenzymatic synthesis; automated and high-throughput synthesis

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Entomology of Insects of Economic Importance: Advanced Molecular Approaches for Insect Pest Management

edited by

T. G. Emyr Davies

submission deadline 31 Dec 2025 | Viewed by 575 | Submission Open

Keywords: molecular entomology; insect pests; agricultural pests; disease vectors; beneficial insects; CRISPR; RNA interference; genome-wide approaches; computational biology; nanotechnology

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Prostate Cancer, 2nd Edition

edited by

Yaser Gamallat

submission deadline 31 Dec 2025 | 1 articles | Viewed by 556 | Submission Open

Keywords: prostate cancer; molecular biology; genomics; biomarkers; signaling pathways; precision medicine; treatment resistance; epigenetics; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design of Polymer Composites for Biomedical Applications

edited by

Valentina Vassallo

submission deadline 31 Dec 2025 | Viewed by 533 | Submission Open

Keywords: biocompatibility; polymers; biomaterials; tissue regeneration; mesenchymal cells; wound healing

(This special issue belongs to the Section Materials Science)

Detrimental and Beneficial Roles of Glial Cells After Neural Disorders

edited by

Walace Gomes-Leal

submission deadline 31 Dec 2025 | Viewed by 513 | Submission Open

Keywords: neuroprotection; neuroinflammation; cell therapy; microglia; astrocytes; oligodendrocytes; Janus face; double-edged sword

(This special issue belongs to the Section Molecular Neurobiology)

Microbial Metagenomics: From Basic Science to Biotechnological Applications

edited by Rafael Antonio Rojas-Herrera

submission deadline 31 Dec 2025 | Viewed by 414 | Submission Open

Keywords: metagenomic; microbial ecology; bioremediation; ecological resilience; extremozyme bioprospecting; biodiversity

(This special issue belongs to the Section Molecular Microbiology)

Functional Microbiomes and the Organization of Marine Communities: Molecular Biological Insights

edited by

Daniel Rittschof

submission deadline 31 Dec 2025 | Viewed by 378 | Submission Open

Keywords: marine communities; functional microbiomes; exoenzymes; chemical communication; organization of complex ecosystems

(This special issue belongs to the Section Molecular Microbiology)

Advances in Pathophysiology and Treatment of Atherosclerosis

edited by Graziano Riccioni

submission deadline 31 Dec 2025 | Viewed by 367 | Submission Open

Keywords: atherosclerosis; pathogenetic pathway; targeted therapies; cardiovascular disease; plaque development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gene Regulation and Neurotoxicity in Alcohol Related Pathologies

edited by

Stefano Casalotti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 288 | Submission Open

Keywords: alcohol; ethanol; gene expression; neurotoxicity; epigenetics; polymorphisms; neu-rons; glial cell; plasticity

(This special issue belongs to the Section Molecular Neurobiology)

Synthetic Lethality Strikes: Outsmarting Cancer with Precision Medicine

edited by

Stefania Butini

submission deadline 31 Dec 2025 | Viewed by 285 | Submission Open

Keywords: synthetic lethality; precision medicine; DDR modulators; non-DDR modulators; cancer; BRCA; PARP; RAD51; RAD52

(This special issue belongs to the Section Molecular Oncology)

Microtubule Cytoskeleton, Motor Proteins, and Other Cytoskeleton-Associated Proteins

edited by

Tibor Szénási

submission deadline 31 Dec 2025 | Viewed by 276 | Submission Open

Keywords: microtubule cytoskeleton; motor proteins (kinesins and dyneins); cytoskeleton-associated proteins; cytoskeletal “ cross-talk” ; intracellular transport; cellular signaling and regulation; cellular processes (mitosis; migration; and polarity)

(This special issue belongs to the Section Biochemistry)

Advances in Dendritic Cell-Based Immunotherapy of Cancer

edited by Helena Haque Chowdhury and Matjaz Jeras

submission deadline 31 Dec 2025 | Viewed by 253 | Submission Open

Keywords: DC-based immunotherapy of cancer; immunostimulatory dendritic cell (DC) generation; dosage and routes of DC administration; body distribution of DCs post-application; frequency and duration of DC applications; tumour immunosuppressive mechanisms’ modulation; combinatorial DC-based anticancer immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Decoding Cardiovascular Disease: From Molecular Mechanisms to Clinically Translational Innovations

edited by Lisa Kitasato

submission deadline 31 Dec 2025 | Viewed by 248 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; translational research; biomarkers; cardiac remodeling; oxidative stress; inflammation; precision medicine; systems biology; regenerative cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular, Cellular Mechanism of Oxidative Stress in Physiological and Pathophysiological Conditions, 2nd Edition

edited by Dominika Marta Stygar

submission deadline 31 Dec 2025 | Viewed by 239 | Submission Open

Keywords: oxidative stress; inflammation; obesity; civilization; diseases; molecular mechanism; cellular mechanism; biomarkers; bacterial and viral diseases; environmental stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Early Diagnosis and Advanced Therapies of Genetic Disorders

edited by

Milen Velinov

submission deadline 31 Dec 2025 | Viewed by 239 | Submission Open

Keywords: genetic disorders; rare diseases; disease diagnostics; therapeutic targets; gene variants

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Review Papers in “Materials Science” Section

edited by

David P. Mills

submission deadline 31 Dec 2025 | Viewed by 235 | Submission Open

Keywords: biomaterials; coatings; materials phenomena; machine learning; nanocomposites; artificial intelligence

(This special issue belongs to the Section Materials Science)

The Role of Iron in Human Physiology: Molecular Mechanisms and Therapeutic Applications

edited by

Alireza Morovat

submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; transferrin; metabolic regulation; cell signaling; cellular processes; mitochondrial function; stress response; inflammation; ferroptosis; gene regulation; disorders

(This special issue belongs to the Section Molecular Biology)

Fractalkine (CX3CL1) and Its Chemoattractant and Adhesion Molecule Properties in Health and Disease, 2nd Edition

edited by Dariusz Szukiewicz

submission deadline 31 Dec 2025 | Viewed by 220 | Submission Open

Keywords: fractalkine; transmembrane fractalkine; soluble fractalkine; fractalkine receptor; CX3CL1-CX3CR1 signaling; inflammation; chemokine; cell adhesion; chemotaxis; immune response; angiogenesis; implantation; atherosclerosis; carcinogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Antimicrobial Peptides with Anticancer Activity

edited by

Esther Imperlini

submission deadline 31 Dec 2025 | Viewed by 214 | Submission Open

Keywords: antimicrobial peptides; cytotoxicity; selective anticancer drugs; omics approaches; anticancer peptide action

(This special issue belongs to the Section Biochemistry)

Immunological Control of Vascular Plasticity: Insights into Arteriogenesis, Angiogenesis, and Atherosclerosis

edited by

Elisabeth Deindl

and

Hector A. Cabrera-Fuentes

submission deadline 31 Dec 2025 | Viewed by 213 | Submission Open

Keywords: vascular plasticity; arteriogenesis; angiogenesis; atherosclerosis; immune modulation; inflammation and vascular remodeling; translational vascular immunology; smooth muscle cell-/endothelial cell proliferation; sterile inflammation; collateral artery growth

(This special issue belongs to the Section Molecular Immunology)

Systemic Lupus: Molecular Research, New Biomarkers and Novel Therapy

edited by Juan Pablo Mackern-Oberti

submission deadline 31 Dec 2025 | Viewed by 207 | Submission Open

Keywords: lupus; biomarkers; autoimmunity; inflammation; therapy; treatment; endocrine; prolactin; stress; T cell and B cell activation; T cell and B cell proliferation; antigenic immunosuppression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein-Targeted Therapeutics: Functional Modulation in Disease Pathways

edited by

Sung-Kun (Sean) Kim

submission deadline 31 Dec 2025 | Viewed by 200 | Submission Open

Keywords: protein-targeted therapeutics; proteins inhibitors; ligand binding; conformational changes

(This special issue belongs to the Section Biochemistry)

Synthesis and Structural Studies of Potential Anticancer Drugs

edited by Janusz Madaj

submission deadline 31 Dec 2025 | Viewed by 197 | Submission Open

Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Natural Products in Cancer Prevention and Treatment—Second Edition

edited by

Simona Serini

and

Gabriella Calviello

submission deadline 31 Dec 2025 | Viewed by 192 | Submission Open

Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Nitric Oxide in Cardiovascular System

edited by

Elena Grossini

submission deadline 31 Dec 2025 | Viewed by 185 | Submission Open

Keywords: heart; nitric oxide; oxidative stress; pathways; protection; therapy; vascular

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Genetics and Genomics of Neurodevelopmental Disorders

edited by

Elisabetta Bolognesi

and

Franca Rosa Guerini

submission deadline 31 Dec 2025 | Viewed by 182 | Submission Open

Keywords: neurodevelopmental disorders; genetics; molecular biology; biomarkers; epigenetics; precision medicine; rare variants; common variants; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Pathophysiology of Peripheral Neuropathies and Neuromuscular Disorders

edited by

Eleonora Galosi

submission deadline 31 Dec 2025 | Viewed by 181 | Submission Open

Keywords: peripheral neuropathies; neuromuscular disorders; small fiber neuropathy; neuropathic pain; nerve regeneration; molecular pathways; next-generation sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Basis of Oral Immunology

edited by

Kenichi Kumagai

submission deadline 31 Dec 2025 | Viewed by 179 | Submission Open

Keywords: oral immunology; oral mucosa; immune tolerance; oral microbiome; oral diseases; periodontium; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Advances in Stem Cell Biology and Translational Medicine

edited by Yangluowa Qu

submission deadline 31 Dec 2025 | Viewed by 177 | Submission Open

Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research

(This special issue belongs to the Section Molecular Biology)

Advances in Neuropharmacology in Neurodegenerative Disorders

edited by

Ichiro Kawahata

submission deadline 31 Dec 2025 | Viewed by 177 | Submission Open

Keywords: neuropharmacology; neurodegenerative disorders; cognitive dysfunction; motor dysfunction; drug discovery; neuroprotection; neurogenesis; brain plasticity; biomarkers; AI (artificial intelligence)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeted Peptide Drugs for Metabolic Diseases

edited by

Lukasz Buldak

submission deadline 31 Dec 2025 | Viewed by 174 | Submission Open

Keywords: metabolic disorders; peptide drugs; MASLD; receptor targeting; lipid regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Discoveries in Virus–Cytoskeleton Regulation

edited by