New Discoveries in Virus–Cytoskeleton Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 46
Special Issue Editor
Interests: HIV; AIDS; SARS-CoV-2; COVID-19; Zika virus; emerging viruses; immunology; pharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Viruses employ diverse strategies to bypass cytoskeletal barriers—such as actin filaments (AFs), intermediate filaments (IFs), and microtubules (MTs)—to complete their lifecycle. By manipulating cytoskeletal organization and dynamics through adaptor proteins, molecular motors, and viral accessory factors, they facilitate viral entry, intracellular transport, and virion release. Initial infection often involves viral proteins binding to host receptors, inducing cytoskeletal modelling to form fusion pores or membrane invaginations for entry. Following internalization, viral capsids hijack cytoskeletal transport systems, guided by host adaptors, motors, and viral components, to reach specific organelles or the nucleus. In later stages, viruses alter cytoskeletal dynamics to establish viral replication factories and direct progeny transport to the cell periphery for assembly, budding, and maturation. This Special Issue seeks to compile research elucidating how viruses exploit cytoskeletal networks during infection, with a focus on mechanisms driving pathogenesis, highlighting potential therapeutic strategies to disrupt viral infection cycles.
Dr. Agustín Valenzuela-Fernández
Guest Editor
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Keywords
- viruses
- cytoskeleton dynamics
- actin, tubulin and intermediate filaments
- infection
- pathogenesis
- therapies
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