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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant–Microbe Interactions: 2nd Edition
edited by Jian Jin
submission deadline 20 Apr 2027 | 6 articles | Viewed by 14793 | Submission Open
Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes
(This special issue belongs to the Section Molecular Plant Sciences)
Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications
edited by Kaiqun Ren and Hui Zou
submission deadline 20 Apr 2027 | 4 articles | Viewed by 14129 | Submission Open
Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Imaging for Cancer Theranostics
edited by and Kai Bao
submission deadline 20 Apr 2027 | 3 articles | Viewed by 8236 | Submission Open
Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials and Antibacterial Materials for Medical Applications
edited by
submission deadline 20 Apr 2027 | 2 articles | Viewed by 2130 | Submission Open
Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings
(This special issue belongs to the Section Materials Science)
Immunoregulation of Abnormal Cell Proliferation: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1072 | Submission Open
Keywords: immune microenvironment; cell proliferation; molecular mechanisms; therapeutic strategies; tumor; autoimmune disease; psoriasis; rheumatoid arthritis; lupus erythematosus; type 1 diabetes; inflammatory bowel disease
(This special issue belongs to the Section Molecular Immunology)
Biomaterials for Dental and Orthopedic Applications, 2nd Edition
edited by
submission deadline 20 Apr 2027 | 1 articles | Viewed by 1007 | Submission Open
Keywords: personalized biomaterials; dental and orthopedic applications; tissue regeneration; 3D biorinting
(This special issue belongs to the Section Materials Science)
Integrative Multi-Omics in Neurodegenerative Diseases: Mechanisms, Biomarkers and Therapeutic Targets
edited by
submission deadline 20 Apr 2027 | Viewed by 27 | Submission Open
Keywords: multi-omics; neurodegenerative diseases; systems biology; biomarkers; precision medicine; transcriptomics; proteomics; metabolomics; epigenomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multidrug-Resistant Bacteria Across One Health Interfaces: Molecular Mechanisms, Dissemination, and Innovative Control Strategies submission deadline 20 Apr 2027 | Viewed by 11 | Submission Open
Keywords: antimicrobial resistance; virulence factors; biofilms; multidrug-resistant bacteria; antimicrobial agents
(This special issue belongs to the Section Molecular Microbiology)
Cellular and Molecular Mechanisms in the Progression of Cardiovascular Diseases
edited by
submission deadline 22 Apr 2027 | Viewed by 64 | Submission Open
Keywords: cardiovascular diseases; molecular mechanisms; cellular signaling; inflammation; oxidative stress; cardiac remodeling; endothelial dysfunction; biomarkers; precision medicine; translational cardiovascular research
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Genomics of Aquatic Crustaceans
edited by , Falin Zhou and Lingbo Ma
submission deadline 23 Apr 2027 | 4 articles | Viewed by 3712 | Submission Open
Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition submission deadline 23 Apr 2027 | 1 articles | Viewed by 1287 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular Biology of Haematology
edited by Valéria Tavares
submission deadline 23 Apr 2027 | 1 articles | Viewed by 861 | Submission Open
Keywords: haematopoiesis; molecular biology; genomics; epigenomics; computational biology; hematologic neoplasms; biomarkers; liquid biopsy; precision medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Innate Immunity and Disease Resistance in Animals
edited by
submission deadline 23 Apr 2027 | Viewed by 470 | Submission Open
Keywords: innate immunity; pathogenic microorganism; animals; pathogenesis; mechanism of disease-resistance; disease-resistant/therapeutic target
(This special issue belongs to the Section Molecular Immunology)
Biosynthetic Pathways, Regulation, and Metabolic Engineering of Plant Bioactive Compounds
edited by
submission deadline 25 Apr 2027 | Viewed by 5 | Submission Open
Keywords: plant bioactive compounds; specialized metabolism; biosynthetic pathways; metabolic regulation; metabolic engineering; synthetic biology; heterologous production; multi-omics
(This special issue belongs to the Section Molecular Plant Sciences)
New Approaches in Molecular and Cellular Cancer Biology: Translating Basic Research to the Clinic submission deadline 29 Apr 2027 | Viewed by 67 | Submission Open
Keywords: cell signaling; proteomics; phosphoproteomics; mass spectrometry; kinase inhibitors; kinase activity; signaling networks; computational biology; peptide receptor antagonists; anticancer and cancer peptides
(This special issue belongs to the Section Molecular Oncology)
Male Infertility: Emerging Trends and Future Directions submission deadline 29 Apr 2027 | Viewed by 59 | Submission Open
Keywords: male infertility; epigenetics; multi-omics; spermatogenesis; assisted reproduction; phytotherapy; artificial intelligence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Inflammasomes
edited by
submission deadline 30 Apr 2027 | 3 articles | Viewed by 4475 | Submission Open
Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis
(This special issue belongs to the Section Molecular Immunology)
Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications
edited by
submission deadline 30 Apr 2027 | 4 articles | Viewed by 4100 | Submission Open
Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety
(This special issue belongs to the Section Molecular Microbiology)
Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 2938 | Submission Open
Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Toxicity Caused by Environmental Pollutants
edited by Ivan Girón-Perez
submission deadline 30 Apr 2027 | 4 articles | Viewed by 2803 | Submission Open
Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity
(This special issue belongs to the Section Molecular Toxicology)
From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 2774 | Submission Open
Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation
(This special issue belongs to the Section Molecular Biology)
Protein–Protein Interactions in Human Cancer
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 2456 | Submission Open
Keywords: protein–protein interactions; protein–protein complexes; human cancer; signal transduction pathways; protein structure and function
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Lipids in Health and Diseases: 2nd Volume
edited by
submission deadline 30 Apr 2027 | 3 articles | Viewed by 2263 | Submission Open
Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism
(This special issue belongs to the Section Biochemistry)
Emerging Therapeutic Strategies and Immunometabolic Pathways in Cancer
edited by Medhi Wangpaichitr
submission deadline 30 Apr 2027 | 2 articles | Viewed by 2234 | Submission Open
Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism
(This special issue belongs to the Section Molecular Immunology)
Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 2130 | Submission Open
Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis
(This special issue belongs to the Section Molecular Immunology)
Mathematical Computation and Modeling in Biology
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1889 | Submission Open
Keywords: mathematical model; computational methods; systemic molecular interaction; machine learning; integrating molecular materials
(This special issue belongs to the Section Molecular Informatics)
Probiotics, Prebiotics, Synbiotics, and Gut Microbial Modulation in Intestinal Health and Disease
edited by Koji Yamamoto
submission deadline 30 Apr 2027 | 3 articles | Viewed by 1227 | Submission Open
Keywords: gut microbiota; probiotics; prebiotics; synbiotics; inter-organ network; intestinal barrier; microbial metabolites; immunoregulation; multi-omics; inflammatory bowel disease; microbiome-based therapy
(This special issue belongs to the Section Molecular Microbiology)
Lipid Metabolic and Signaling Dysregulations: From Molecular Mechanisms to Disease Pathogenesis
edited by Gergana M. Deevska
submission deadline 30 Apr 2027 | 2 articles | Viewed by 1201 | Submission Open
Keywords: lipid signaling; lipid metabolism; lipid homeostasis; metabolic dysregulation; signal transduction; disease pathogenesis
(This special issue belongs to the Section Molecular Biology)
Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 1198 | Submission Open
Keywords: Alzheimer's disease; cerebral amyloid angiopathy; blood–brain barrier; cerebrovascular dysfunction; neuroinflammation; therapeutic development; translational research
(This special issue belongs to the Section Molecular Neurobiology)
New Research on Toxicology Research Models submission deadline 30 Apr 2027 | 1 articles | Viewed by 1035 | Submission Open
Keywords: contaminants of emerging concern; aquatic organisms; in vitro; in vivo; mammalian approaches; mechanisms of toxicity; environmental risk assessment; one health
(This special issue belongs to the Section Molecular Toxicology)
New Insights into Gastroesophageal Tumors
edited by and Luisa Foltran
submission deadline 30 Apr 2027 | 2 articles | Viewed by 988 | Submission Open
Keywords: gastric cancer; esophageal cancer; biomarkers; target therapy; immunotherapy; NGS
(This special issue belongs to the Section Molecular Oncology)
Phytohormones in Plant Responses to Abiotic Stress
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 906 | Submission Open
Keywords: phytohormones; hormone signaling; abiotic stress responses; signaling crosstalk; transcriptional regulation; gene expression; molecular mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Nutrition and Food Science submission deadline 30 Apr 2027 | 1 articles | Viewed by 687 | Submission Open
Keywords: molecular nutrition; functional foods; bioactives; food matrix; nutrient bioavailability; digestion kinetics; gut microbiota; nutritional functionality; food structure–function relationships; food reformulation; food science
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Stem Cell and Epigenetic Regulation in Regenerative Medicine
edited by
submission deadline 30 Apr 2027 | Viewed by 605 | Submission Open
Keywords: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; gene expression; cell–environment interactions; conditioned medium; secreted factors; epigenetic modification
(This special issue belongs to the Section Molecular Biology)
Research in Nutritional Physiology and Gut Microbiome
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 541 | Submission Open
Keywords: nutritional physiology; gut microbiome; microbial metabolites; nutrient sensing; metabolic homeostasis; gut–brain axis; prebiotics; probiotics; molecular nutrition
(This special issue belongs to the Section Bioactives and Nutraceuticals)
DNA Damage and Repair Mechanisms in Cancer Development
edited by
submission deadline 30 Apr 2027 | Viewed by 309 | Submission Open
Keywords: DNA damage response and repair; DNA replication; genome instability; drug resistance; targeted therapy; cellular senescence; innate immunity; nucleic acid homeostasis
(This special issue belongs to the Section Molecular Oncology)
Advances in Plant Transporters and Tolerance Proteins
edited by Kun Qiao
submission deadline 30 Apr 2027 | Viewed by 272 | Submission Open
Keywords: heavy metal; transporter; antioxidant; ornamental plants and horticulture; ion transport; phytoremediation; biofortification
(This special issue belongs to the Section Molecular Plant Sciences)
Forward in Vasculitis: Genetics and Beyond, 2nd Edition
edited by
submission deadline 30 Apr 2027 | Viewed by 232 | Submission Open
Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Plant–Soil–Microbe Interactions Under Abiotic Stress submission deadline 30 Apr 2027 | Viewed by 184 | Submission Open
Keywords: abiotic stress; microbial metabolites; molecular signaling; plant–microbe interactions; plant stress tolerance; rhizosphere microbiome; stress-responsive genes
(This special issue belongs to the Section Molecular Plant Sciences)
Biochemical Mechanisms of the Gut–Brain Axis: Microbial Metabolites, Barrier Integrity, and Neuroimmune Signaling submission deadline 30 Apr 2027 | Viewed by 129 | Submission Open
Keywords: gut–brain axis; gut microbiota; microbial metabolites; intestinal barrier integrity; neuroimmune signaling; host-microbiome interactions; microbiome-brain communication; neuroinflammation; multi-omics; microbiome-based therapeutics
(This special issue belongs to the Section Molecular Biology)
Targeting Membrane Proteins: Structure, Function, and Dynamic Relationships
edited by Ki-Young Lee
submission deadline 30 Apr 2027 | Viewed by 110 | Submission Open
Keywords: membrane proteins; conformational dynamics; allosteric regulation; signal transduction; drug discovery; cryo-electron microscopy; nuclear magnetic resonance spectroscopy; artificial intelligence; membrane mimetics
(This special issue belongs to the Section Molecular Biology)
Advanced Research on Functional Genomics and Genome Editing in Plants submission deadline 30 Apr 2027 | Viewed by 23 | Submission Open
Keywords: CRISPR/Cas; genome editing; functional genomics; plant biotechnology; gene regulation; base editing; prime editing; gene overexpression; multi-omics; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Melanoma: Molecular Mechanism and Therapy, 2nd Edition
edited by
submission deadline 30 May 2027 | 3 articles | Viewed by 4143 | Submission Open
Keywords: melanoma progression; melanoma metastasis; molecular background; targeted therapies; immunotherapy; acquired drug resistance; prognostic and predictive markers; therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Molecular Evolution of the Vertebrate Immune System
edited by
submission deadline 30 May 2027 | 1 articles | Viewed by 1427 | Submission Open
Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics
(This special issue belongs to the Section Molecular Biology)
Agronomic Regulation of Crop Environmental Adaptation and Grain Safety: Physiological and Molecular Mechanisms
edited by and
submission deadline 30 May 2027 | Viewed by 26 | Submission Open
Keywords: agronomic management; environmental adaptation; molecular regulation; physiological and biochemical mechanisms; crop quality formation; plant-soil-microbe interactions; heavy metal detoxification; nitrogen-use efficiency; photosynthetic efficiency
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biology on Environmental Microorganisms
edited by
submission deadline 31 May 2027 | 3 articles | Viewed by 1916 | Submission Open
Keywords: environmental microbiology; metagenomics; microbial interactions; phage–host dynamics; horizontal gene transfer; biogeochemical cycles; antimicrobial resistance; single-cell methods; microbiome engineering; environmental biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Advanced Drug Delivery Systems: From Nanocarrier Design to Translation submission deadline 31 May 2027 | Viewed by 123 | Submission Open
Keywords: nanocarriers; stimuli-responsive; targeted delivery; biocompatibility; scale-up; nanomedicine
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms Linking Environmental Pollutant Exposure to Human Health and Development submission deadline 31 May 2027 | Viewed by 88 | Submission Open
Keywords: environmental pollutants; molecular toxicology; developmental toxicology; particulate matter; metals and metalloids; pesticides; persistent organic pollutants; PFAS; environmental pharmaceuticals; microplastics; nanoplastics; mixture toxicity; adverse outcome pathways; human biomonitoring; toxicokinetics; oxidative stress; genotoxicity; epigenetics; endocrine disruption; neurodevelopment; human health risk assessment
(This special issue belongs to the Section Molecular Toxicology)
Drought‑Stress‑Induced Physiological and Molecular Changes in Plants
edited by
submission deadline 31 May 2027 | Viewed by 2 | Submission Open
Keywords: drought stress; abiotic stress; physiological response; reactive oxygen species; osmotic adjustment; molecular regulation; transcription factors; signal transduction; plant adaptation; omics; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Polymeric Biomaterials: From Molecular Engineering to Biomedical Applications submission deadline 1 Jun 2027 | Viewed by 51 | Submission Open
Keywords: polymeric biomaterials; biodegradable polymers; molecular design; AI-driven materials design; structure–property relationships; biomolecule–material interactions; biocompatibility; drug delivery systems; tissue engineering; regenerative medicine
(This special issue belongs to the Section Materials Science)
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