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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health

edited by

Giusy Rita Caponio

and

Graziana Difonzo

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2776 | Submission Open

Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Autoimmune Diseases: From Molecular Mechanisms to Therapeutic Innovations

edited by

Paula Sandrin-Garcia

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2717 | Submission Open

Keywords: autoimmunity; biological biomarkers; personalized therapies; biologics and JAK inhibitors; CAR-T cell therapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Dialogues in the Tumor Microenvironment: Mechanisms, Methods and Therapeutic Implications

edited by

José M. Muñoz-Félix

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2625 | Submission Open

Keywords: tumor microenvironment; blood vessels; immune cells; spatial transcriptomics; histology

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances and Insights into Liver Diseases: Second Edition

edited by

Jacek Baj

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2536 | Submission Open

Keywords: liver; hepatocellular carcinoma; cancer; hepatitis cirrhosis; encephalopathy; non-alcoholic fatty liver disease; autoimmune diseases; Wilson’s disease; fatty liver disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Prevention of Infectious Diseases

edited by

Marília Andreza Da Silva Ferreira

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2483 | Submission Open

Keywords: host–pathogen interactions; molecular diagnostics; infectious diseases; emerging and reemerging pathogens; prevention; diagnosis; molecular epidemiology; omics; molecular surveillance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced In Vitro Systems for Mechanistic Toxicology

edited by

João Pedro Silva

and

Félix Carvalho

submission deadline 31 Mar 2027 | 3 articles | Viewed by 2463 | Submission Open

Keywords: mechanistic toxicology; organ-on-chip; microphysiological systems; human iPSC models; organoids; AI/ML modeling; multi-omics; high-content screening; 3D cell cultures

(This special issue belongs to the Section Molecular Toxicology)

From Synapse to Substance Use: Endocannabinoids and Cannabinoid Receptors in Brain Plasticity and Addiction Circuits

edited by Balapal S. Basavarajappa

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2446 | Submission Open

Keywords: anandamide; cannabis; alcohol; drug abuse; plasticity; neurotransmitters; cell-types; reward system

(This special issue belongs to the Section Molecular Neurobiology)

Hidradenitis Suppurativa: Molecular Mechanisms and Therapeutic Strategies

edited by

Lucas André Cavalcanti Brandão

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2432 | Submission Open

Keywords: hidradenitis suppurativa; molecular mechanisms; therapeutic strategies; pathophysiology; autoinflammatory disorders; immunology; dermatology inflammation; skin disease; molecular pathways; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular, Immune and Molecular Pathways of Injury and Disease in Forensic and Legal Medicine

edited by

Sorin Hostiuc

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2374 | Submission Open

Keywords: molecular autopsy; cellular injury pathways; ischemia and hypoxia markers; molecular profiling of fatal injuries; forensic genetics and toxicogenomic

(This special issue belongs to the Section Molecular Biology)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2356 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Genetic Advances in Neurobiology of Health and Disease

edited by

Efthimios M. C. Skoulakis

and Katerina Papanikolopoulou

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2328 | Submission Open

Keywords: genomics; proteins; proteomics; signaling

(This special issue belongs to the Section Molecular Neurobiology)

Neuroblastoma: Advances in Molecular Pathogenesis and Therapy

edited by Paola Fadda and

Simona Dedoni

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2311 | Submission Open

Keywords: neuroblastoma; molecular pathogenesis; MYCN; ALK; epigenetics; non-coding RNAs; tumor microenvironment; immunotherapy; targeted therapy; precision medicine

(This special issue belongs to the Section Molecular Oncology)

New Insights into Intercellular Communication and Signal Transduction

edited by

Dongki Yang

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2275 | Submission Open

Keywords: intercellular communication; signal transduction; extracellular vesicles (EVs); exosomes; tunneling nanotubes (TNTs); cytokines; hormonal signaling; neurotransmitters; mechanotransduction; immune signaling

(This special issue belongs to the Section Molecular Biology)

Smart and Sustainable Delivery Systems for Natural Compounds in Health and Nutrition

edited by Raffaele Conte

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2272 | Submission Open

Keywords: natural bioactive compounds; smart delivery systems; sustainable nutrition; biopolymer-based carriers; microfluidics and green technologies; controlled and targeted release; functional foods and nutraceuticals; one health approach

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Discovery and Development of Functional Ingredients for Anti-Aging, Cognitive Enhancement and Skin Health

edited by

Sung-Joon Lee

and Jinbyung Park

submission deadline 31 Mar 2027 | 3 articles | Viewed by 2246 | Submission Open

Keywords: bioactive compounds; anti-aging; cognitive performance; skin health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovative Biomaterials for Advanced Applications in Regenerative Medicine and Drug Delivery

edited by

Calogero Fiorica

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2219 | Submission Open

Keywords: biomaterials; drug delivery; regenerative medicine; stimuli-responsive polymers; 3D scaffolds; micro-nanocarriers

(This special issue belongs to the Section Materials Science)

Molecular Insight into Retinal Diseases: 2nd Edition

edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2189 | Submission Open

Keywords: faricimab; modified cerebrolysin; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond Drivers and Suppressors: Investigating Upstream Regulators of Cell Death

edited by

Damian Kołat

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2169 | Submission Open

Keywords: cell death; driver genes; suppressor genes; upstream regulators; gene expression; in silico; in vitro; in vivo

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Stroke

edited by

Hee-Jung Song

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2145 | Submission Open

Keywords: stroke; microglia; neuroinflammation; molecular mechanisms; ischemic injury

(This special issue belongs to the Section Molecular Neurobiology)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2138 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making

edited by

Maria Beatrice Morelli

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2114 | Submission Open

Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity

(This special issue belongs to the Section Molecular Oncology)

Anti-Inflammatory Drugs: New and Old Compounds with Novel Delivery Systems Contributing to Improve the Treatment of Inflammatory Diseases

edited by S. Gorzalczany

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1951 | Submission Open

Keywords: inflammation; new compounds; novel formulation; mechanism of action; biological drug; arthritis; inflammatory bowel disease

(This special issue belongs to the Section Molecular Biology)

The Role of Selenium in Human Health and Disease

edited by

Youcef M. Rustum

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1926 | Submission Open

Keywords: selenium; oxidative stress; immune modulation; cancer prevention and therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules: 2nd Edition

edited by

Dong-Sung Lee

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1916 | Submission Open

Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Progress in Peptidic Protease Inhibitors

edited by

Roberta Ettari

and Carla Di Chio

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1875 | Submission Open

Keywords: peptide inhibitors; infectious diseases; cancer; metabolic disorders; neurological disorders; inflammation

(This special issue belongs to the Section Biochemistry)

Metals in Human Diseases: From Molecular Mechanisms to Innovative Therapies

edited by

Jacek Baj

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1845 | Submission Open

Keywords: metallomics; trace elements; metal homeostasis; metal-induced toxicity; bioinorganic chemistry; chelation therapy; metal-based therapeutics; ICP-MS/LA-ICP-MS; neurodegeneration and metals; environmental metal exposure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond the Resolution Revolution: The Next Era of Cryo-EM and Structural Biology

edited by

Gaya P. Yadav

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1840 | Submission Open

Keywords: cryo-electron microscopy (cryo-EM); membrane protein structure; cryo-tomography and 3D reconstruction; advances in sample vitrification; structure-guided drug discovery; lipid–protein dynamics; innovations in cryo-EM methodology

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Health and Disease: From Physiology to Therapeutics

edited by

Yohan Seo

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1827 | Submission Open

Keywords: ion channels; cellular homeostasis; chronic diseases; cancer; inflammation; therapeutic targets; drug resistance; channel modulators; translational medicine

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Nutrients and Oxidative Stress

edited by

Duško P. Blagojević

submission deadline 31 Mar 2027 | 4 articles | Viewed by 1745 | Submission Open

Keywords: oxidative stress; redox regulation; reactive oxygen species; antioxidants; nutrients; functional food

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Infectious and Immunoinflammatory Mechanisms of Alzheimer's Disease

edited by Hiroshi Nakanishi

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1737 | Submission Open

Keywords: Alzheimer's Disease; amyloid; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Antimicrobial Resistance

edited by

Dan-Alexandru Țoc

and

Carmen Costache

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1715 | Submission Open

Keywords: antimicrobial resistance; MRSA; ESBL-producing bacteria; carbapenem-resistant enterobacterales (CRE); vancomycin-resistant enterococci (VRE); linezolid resistance; novel antibiotic combinations; resistance mechanisms; horizontal gene transfer; molecular epidemiology

(This special issue belongs to the Section Molecular Pharmacology)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1699 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Neuroprotective Drug Development and Therapeutic Applications

edited by Jolanta Helena Kotlińska

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1636 | Submission Open

Keywords: neuropharmacology; neuroprotective drugs; dopaminergic and glutamatergic signaling; endocannabinoid system; neurodevelopmental and stress-related disorders

(This special issue belongs to the Section Molecular Neurobiology)

Non-Coding RNAs as Key Regulators in Human Disease Processes

edited by

Beatrice Polini

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1624 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pancreatic Ductal Adenocarcinoma: Unveiling Pathogenic Mechanisms and Pioneering Novel Therapeutic Strategies

edited by

Elena Astanina

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1623 | Submission Open

Keywords: pancreatic ductal adenocarcinoma; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Recent Research in Cerebellar Development and Disease

edited by Maryam Rahimi-Balaei

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1585 | Submission Open

Keywords: cerebellar development; cerebellum; neural development; neurogenesis; neuronal migration; cerebellar malformations

(This special issue belongs to the Section Molecular Neurobiology)

Eukaryotic Mitogenomes: Key Insights

edited by

Yuri Kartavtsev

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1535 | Submission Open

Keywords: eukaria; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Oral Health: Disease and Medicine

edited by Norio Sogawa

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1510 | Submission Open

Keywords: oral health; disease; molecular medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Systemic Sclerosis

edited by

Filomena Napolitano

and

Nunzia Montuori

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1484 | Submission Open

Keywords: systemic sclerosis; autoimmune disease; fibrosis; vasculopathy; immune dysregulation; fibroblasts; endothelial dysfunction; epigenetics; transcriptomics; biomarkers

(This special issue belongs to the Section Molecular Biology)

Fractalkine (CX3CL1) and Its Chemoattractant and Adhesion Molecule Properties in Health and Disease, 2nd Edition

edited by Dariusz Szukiewicz

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1463 | Submission Open

Keywords: fractalkine; transmembrane fractalkine; soluble fractalkine; fractalkine receptor; CX3CL1-CX3CR1 signaling; inflammation; chemokine; cell adhesion; chemotaxis; immune response; angiogenesis; implantation; atherosclerosis; carcinogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pregnancy-Related Complications: Molecular Pathogenesis and Therapeutic Strategies

edited by

Alicia E. Damiano

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1436 | Submission Open

Keywords: pregnancy-related complications; placental dysfunction; maternal-fetal communication; extracellular vesicles; translational research; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy: A Double-Edged Sword in Disease Pathogenesis and Cancer Progression

edited by

Antonio Ieni

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1433 | Submission Open

Keywords: autophagy; cancer therapy resistance; tumor microenvironment; immunometabolism

(This special issue belongs to the Section Molecular Biology)

Advances in Research of Estrogen Receptors in Health and Diseases

edited by

Maciej Iek Skrzypczak

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1406 | Submission Open

Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders

(This special issue belongs to the Section Biochemistry)

Oral and Esophageal Disorders: Molecular Induction/Promotion, Treatment, and Prevention

edited by

Takanobu Takata

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1398 | Submission Open

Keywords: oral disorders; esophageal disorders; stomatitis; esophagitis; lifestyle-related diseases; advanced glycation-end products; modern European medicines; traditional medicines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Photophysics and Photochemistry in Biological Molecules

edited by

María Alicia Biasutti

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1393 | Submission Open

Keywords: photochemistry; photodegradation; Reactive Oxygen Species (ROS); emerging contaminants; bioremediation; biomolecules; carotenoids; enzymes; fatty acids; DNA; RNA; photodynamic therapy; fluorescence; photosynthesis; phototoxicity; photosensitizers

(This special issue belongs to the Section Biochemistry)

Plant Epigenetic Memory Under Abiotic Stress

edited by

Md Mezanur Rahman

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1388 | Submission Open

Keywords: plant epigenetics; epigenetic memory; abiotic stress; DNA methylation; histone modification; chromatin remodeling; transgenerational inheritance; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Plant–Microbe Interactions

edited by

Daowan Lai

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1368 | Submission Open

Keywords: plant–microbe interactions; plant defense; pathogenicity; genetics; biochemistry; artificial intelligence; synthetic biology; symbiosis; plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Precision Medicine for Cancer-Associated Thrombosis: The Role of Biomarkers

edited by Darko Antic

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1359 | Submission Open

Keywords: biomarkers; precision medicine; cancer-associated thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by

Ricardo Emilio Fretes

and María I. De La Calle

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1331 | Submission Open

Keywords: placental barrier; maternal–fetal interface; pregnancy pathologies; vertical transmission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Methodological Advances in Phytochemical Analysis

edited by

Mehmet Yaman

and

Kadir Uğurtan YILMAZ

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1331 | Submission Open

Keywords: advanced phytochemical profiling; high-resolution mass spectrometry; green extraction methodologies; chemometric data processing; bioactive metabolite elucidation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 2701-2750 on page 55 of 63.

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