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Hidradenitis Suppurativa: Molecular Mechanisms and Therapeutic Strategies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1625

Special Issue Editor


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Guest Editor
Department of Pathology, Federal University of Pernambuco, Recife 50670-901, Brazil
Interests: molecular pathologies; genomics and omics; autoinflammatory disorders

Special Issue Information

Dear Colleagues,

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder marked by painful nodules, abscesses, and scarring, with a significant impact on quality of life. Despite advances, its molecular mechanisms remain incompletely understood, and effective therapies are limited. This IJMS Special Issue aims to highlight recent insights into the genetic, immunological, and microbial contributors to HS pathogenesis, as well as innovative therapeutic approaches. We welcome contributions that explore novel molecular targets, biomarkers, and treatment strategies. By integrating basic, translational, and clinical research, this Special Issue seeks to advance our understanding and management of HS at a mechanistic and therapeutic level. This Special Issue is supervised by Dr. Lucas André Cavalcanti Brandão, with assistance from Dr. Sergio Crovella (Federal University of Pernambuco).

Dr. Lucas André Cavalcanti Brandão
Guest Editor

Manuscript Submission Information

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Keywords

  • hidradenitis suppurativa
  • molecular mechanisms
  • therapeutic strategies
  • pathophysiology
  • autoinflammatory disorders
  • immunology
  • dermatology inflammation
  • skin disease
  • molecular pathways
  • targeted therapy

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Published Papers (1 paper)

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12 pages, 972 KB  
Review
Targeting Neutrophil Function as Therapy for Hidradenitis Suppurativa
by Eric Meldrum and John R. Ingram
Int. J. Mol. Sci. 2026, 27(4), 2076; https://doi.org/10.3390/ijms27042076 - 23 Feb 2026
Cited by 1 | Viewed by 1334
Abstract
Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterized by painful nodules, abscesses, and epithelialized tunnels, predominantly affecting flexural regions. With a global prevalence of approximately 1%, HS has a significant negative impact on quality of life. Multi-omics and histopathology studies [...] Read more.
Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterized by painful nodules, abscesses, and epithelialized tunnels, predominantly affecting flexural regions. With a global prevalence of approximately 1%, HS has a significant negative impact on quality of life. Multi-omics and histopathology studies have revealed a complex interplay between innate and adaptive immunity in HS, with neutrophils emerging as important drivers of inflammation. While therapies targeting TNF-α and IL-17 isoforms offer a degree of benefit, significant unmet need remains. Neutrophil signatures in HS lesions and the circulation underscore the rationale for selective modulation of neutrophil function. Strategies advancing through clinical trials include inhibition of chemokine-mediated trafficking, neutrophil serine protease inactivation and suppression of neutrophil extracellular traps (NETs), which amplify inflammatory and autoimmune responses. These emerging therapies mark a significant shift toward targeted neutrophil modulation, offering new opportunities to improve outcomes for patients with HS. Full article
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