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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondrial Signaling Pathways in Inflammation and Diseases

edited by

Francesca Oppedisano

and

Cristina Algieri

submission deadline 30 Apr 2026 | Viewed by 101 | Submission Open

Keywords: mitochondria; cell metabolism; inflammatory mitochondrial signalling; metabolic pathways; mitochondrial dysfunction; mtDNA; cGAS-STING pathway; NLRP3 inflammasome; human pathology

(This special issue belongs to the Section Biochemistry)

Peptides in Healthcare and Beyond: Emerging Roles in Skincare, Nutrition, Medicine, and Animal Health

edited by

Jiazhong Li

and Lijing Fang

submission deadline 30 Apr 2026 | Viewed by 101 | Submission Open

Keywords: peptides; efficacy; healthcare; skincare; nutrition; medicine; animal health

(This special issue belongs to the Section Biochemistry)

Extracellular Vesicles—New Kids on the Block in Liquid Biopsy

edited by Christa Nöhammer

submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open

Keywords: extracellular vesicles; biological fluids; liquid biopsy; multi-omics; biomarkers; EV technologies

(This special issue belongs to the Section Molecular Biology)

Next-Generation Antimicrobials and Anticancer Agents: From Natural to Synthetic Compounds

edited by

Manuela E. Crisan

and Roxana Popescu

submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open

Keywords: bioactive molecules; natural products; synthetic compounds; molecular design; antimicrobial agents; anticancer agents; drug-resistant infections; drug discovery

(This special issue belongs to the Section Biochemistry)

Cariovascular Diseases: From Molecular Mechanisms to Therapeutics

edited by

Paul Quax

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: yocardial infarction and cardiac regeneration; microvasculature in cardiovascular health and disease; gender specific aspects of cardiovascular disease; heart failure; aneurysm formation and dissection; vascular remodeling (restenosis; atherosclerosis; angioegenesis); valve failure; replacement or regeneration; atherosclerosis; imaging; new therapeutic options including non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Targets in Cancers: 4th Edition

edited by

Elena Levantini

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Green Synthesis of Biomaterials Using Plant Extracts with Potential Application in Medicine and Biotechnology

edited by

Divine Yufetar Shyntum

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: green synthesis; biomaterials; antimicrobial activity; plant-mediated green synthesis; biomedical application; antibiotic resistance

(This special issue belongs to the Section Materials Science)

Emerging Topics in Polymeric Nanoparticles

edited by

Andrei Honciuc

and

Mirela Honciuc

submission deadline 30 Apr 2026 | Viewed by 86 | Submission Open

Keywords: polymeric nanoparticles; nanostructured materials; functional polymers; Janus particles; self-assembly; drug delivery; environmental remediation; microplastics; biodegradability; nanomedicine; green synthesis; adsorbents; life cycle assessment; surface functionalization; smart materials; biocompatibility; environmental impact; bioaccumulation; responsive polymers; hybrid nanomaterials

(This special issue belongs to the Section Macromolecules)

Impact of Exercise on Molecular and Cellular Processes in the CNS

edited by

Philippe De Deurwaerdere

and Hélène Gréa

submission deadline 30 Apr 2026 | Viewed by 86 | Submission Open

Keywords: physical exercise; plasticity; neurotransmission; metabolism; neuroinflammation; glia; epigenetic; CNS disease; animal models; humans

(This special issue belongs to the Section Molecular Biology)

Gut Microbiota-Derived Metabolites in Human Health and Disease

edited by Zeneng Wang

submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open

Keywords: microbiome; microbiota; gut; metabolomics; health; disease; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Gene Therapy for Ocular Diseases: Mechanisms, Advances and Therapeutic Applications

edited by Jiang-Hui Wang

submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open

Keywords: AAV; capsid engineering; gene therapy; retinal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Estrogen Therapy for CNS Diseases

edited by

Istvan Merchenthaler

submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open

Keywords: estrogen; central nervous system (CNS) diseases; neurodegenerative disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bone Health: From Molecular Mechanisms to Therapeutics

edited by

Farasat Zaman

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: bone growth; chondrocytes; osteoporosis; fractures; inflammation; cancer; nutrition; stress; biomechanics; biotechnology; bioengineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Structure and Function of Nuclear Receptors

edited by

Elza Fonseca

submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open

Keywords: transcription factors; endocrine disorders; ligands; xenobiotics; pharmacology; modelling; drug design; evolution; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Molecular, Genetic and Genomic Insights into Marine Organisms: From Mechanisms to Ecology

edited by Yaron Tikochinski

submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open

Keywords: marine genomics; molecular ecology; population genetics; transcriptomics; conservation genomics; eDNA; functional genomics; environmental stress; phylogeography; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Zebrafish Model in Animal and Human Health Research, 3rd Edition

edited by

Marta Anna Szychlinska

and Federica Scalia

submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open

Keywords: zebrafish; environmental toxicology; predictive toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microplastics, Gut Microbiome and Human Health

edited by

Ying Zhang

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: microplastics; gut microbiome; dysbiosis; intestinal barrier; immunotoxicity; metabolic inflammation; na-noplastics; molecular mechanisms

Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 3rd Edition

edited by

Jarosław Nuszkiewicz

and

Alina Woźniak

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: oxidative stress; redox homeostasis; reactive oxygen species (ROS); redox signaling; antioxidants and defense mechanisms; metabolic regulation; inflammation and redox imbalance; mitochondrial dysfunction; biomarkers of oxidative stress; therapeutic redox modulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Current Research on Autophagy in Aging and Age Related Diseases

edited by

Tímea Sigmond

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria

(This special issue belongs to the Section Biochemistry)

Regulatory Mechanism and Network of Abiotic Stress-Response in Plants: 3rd Edition

edited by

Yong-Hwan Moon

submission deadline 30 Apr 2026 | Viewed by 76 | Submission Open

Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

Intermittent Hypoxia: Physiological and Biomedical Perspectives

edited by

Teresa Carbonell Camós

Olga Tura-Ceide

and Norma Alva

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: altitude training; cardiovascular adaptation; endothelial dysfunction; EPO; intermittent hypoxia conditioning programs; HIF-1; neuroplasticity; obstructive sleep apnea; oxidative stress; pulmonary hypertension

(This special issue belongs to the Section Molecular Biology)

Molecular Insights and Therapeutic Innovations in Neuromuscular Diseases

edited by

Virginia Arechavala Gomeza

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: neuromuscular disorders; molecular mechanisms; gene therapies; RNA therapies; small molecules

(This special issue belongs to the Section Molecular Neurobiology)

Mitochondria: Not Just Powerhouse of the Cell

edited by

Kailash Chandra Mangalhara

submission deadline 30 Apr 2026 | Viewed by 73 | Submission Open

Keywords: mitochondrial nucleic acid; mitonuclear communication; mito-ER communication; mito-lysosome communication; mitochondria in cancer; mitochondrial metabolic disorders; mitochondria in inflammation

(This special issue belongs to the Section Molecular Biology)

Novel Advances in Ataxia-Telangiectasia

edited by David Coman

submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open

Keywords: ataxia-telangiectasia; ATM; metabolism; mitochondrial dysfunction; DNA repair; natural history; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Antibiotic Resistance/Tolerance

edited by

Mara Di Giulio

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: antibiotic resistance; biofilm; innovative antimicrobial strategies and compounds; synergistic actions; One Health; bacterial tolerant phenotypes; resistant pathogenic microorganisms; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Multi-Target and Synergistic Therapeutic Strategies in Modern Drug Discovery

edited by

Vincenzo Piccolo

submission deadline 30 Apr 2026 | Viewed by 69 | Submission Open

Keywords: multi-target and synergistic therapeutic strategies; drug design; combination therapy; polypharmacology; drug re-purposing

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Plant-Pathogen Interactions: The Role of Effectors and Host Targets

edited by

Muhammad Asif

submission deadline 30 Apr 2026 | Viewed by 68 | Submission Open

Keywords: plant immunity; effector proteins; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); NLR receptors; plant-microbe interactions; susceptibility; secreted virulence factors; signal transduction; host manipulation

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring the Chemistry of 2D Transition Metal Carbides and Nitrides (MXenes): Synthesis Methods and Surface Chemistry

edited by

Hyunho Kim

submission deadline 30 Apr 2026 | Viewed by 66 | Submission Open

Keywords: synthesis optimization of non-Al MAX phase; wet chemical etching of non-Al MAX phase; molten salt etching of non-Al MAX phase; surface modification of MXenes; colloidal stability of MXenes; solution process of MXenes

(This special issue belongs to the Section Materials Science)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 30 Apr 2026 | Viewed by 66 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

The Role of Dopamine Neurotransmission in Schizophrenia

edited by

Mirian Akemi Furuie Hayashi

submission deadline 30 Apr 2026 | Viewed by 66 | Submission Open

Keywords: schizophrenia; dopamine; dopaminergic system; neurotransmission; psychosis; pathophysiology; molecular psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Breast Cancer and Hormone Receptors: Molecular Insights

edited by

Alkistis Papatheodoridi

and

Antonella Muscella

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: hormone receptor-positive breast cancer; estrogen receptor (ER); progesterone receptor (PR); endocrine therapy resistance; breast cancer genomics; molecular biomarkers; transcriptomic profiling; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Crosstalk Between Metabolic Dysregulation and Neuropsychiatric Disorders: Novel Therapeutic Perspectives

edited by Aleksandra Szopa and Anna D. Serefko

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut– brain axis; innovative therapeutic strategies; natural compounds; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer

edited by

Elisa Dalla Pozza

and

Ilaria Dando

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

Multi-Omic Data Integration in Oncology

edited by Hung-Yu Lin and

Hsing-Ju Wu

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: bioinformatics; multi-omics at bulk level; single-cell omics; spatial multi-omics; metabolomics; proteomics; pharmacogenomics; tumor microenvironment; tumor molecular profiling; therapy resistance

(This special issue belongs to the Section Molecular Informatics)

Emerging Metabolomics Techniques and Applications

edited by Jun Han

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: metabolomics; lipidomics; bioinformatics; micro-extraction; chemical derivatization; liquid chromatography-mass spectrometry (LC-MS); matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); gas chromatography-mass spectrometry (GC-MS); metabolic profiling; biomarker assay

(This special issue belongs to the Section Molecular Informatics)

Novel Diagnostic and Theragnostic Strategies in Brain Tumors

edited by Andrea Cimini and Laura Travascio

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: brain tumor; novel diagnostic and theragnostic approaches; neuro-oncology; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms, Epigenetics and Therapeutics in Liver Cirrhosis

edited by Ana Soledad Sandoval-Rodríguez

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: liver cirrhosis; molecular pathogenesis; fibrosis and inflammation; epigenetics; hepatocellular carcinoma (HCC); viral hepatitis; molecular mechanism; hepatic nutrition; therapeutic targets; translational hepatology; MASLD; ALD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair

edited by Rebeca Illescas Montes

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: fibroblast; wound healing; inflammation; tissue repair; immune– stromal crosstalk; extracellular matrix remodeling; myofibroblast; regenerative medicine; exosomes; biomaterials

(This special issue belongs to the Section Molecular Immunology)

New Insight into Pathogen Stress Effects on Plant Structure and Metabolism

edited by

Edmund Kozieł

and

Katarzyna Otulak-Kozieł

submission deadline 30 Apr 2026 | Viewed by 62 | Submission Open

Keywords: plant– pathogen interaction; innate immunity; ultrastructure; plant defense systems; plant physiology; signal transduction; resistance genes

(This special issue belongs to the Section Molecular Plant Sciences)

Precision Nutrition and Cancer: Molecular Insights into Cancer Prevention and Development

edited by

Da Pan

submission deadline 30 Apr 2026 | Viewed by 62 | Submission Open

Keywords: precision nutrition; cancer prevention; cancer development; nutrigenomics; personalized diets; tumor metabolism; dietary interventions

(This special issue belongs to the Section Molecular Oncology)

Mechanisms of Genotoxicity Induced by Environmental Mutagens—Focus on Nanoparticles and Micro/Nanoplastics

edited by

Ricard Marcos

and Susana Pastor

submission deadline 30 Apr 2026 | Viewed by 62 | Submission Open

Keywords: genotoxicity; DNA damage; chromosome damage; DNA repair; comet assay; micronucleus assay; mechanisms; environmental pollutants; micro/nanoplastics; nanoparticles

(This special issue belongs to the Section Molecular Toxicology)

Involvement of Connexin-, Pannexin-, and Innexin-Based Hemichannels in Physiological Functions of Diverse Tissues

edited by

Juan Carlos Saéz

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: connexin; pannexin; innexin; hemichannel; permeant ions

(This special issue belongs to the Section Molecular Biology)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

Endometrial Cancer: From Molecular Mechanisms to Treatment

edited by Ursula Catena

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: endometrial cancer; molecular mechanisms; biomarkers; targeted therapy; immunotherapy; genomics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Heredity and Metabolism of Osteosarcoma

edited by

Hiroki Kuniyasu

and

Kanya Honoki

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: osteosarcoma; clinical imaging; genetics; epigenetics; metabolism; signal transduction; stemness; pathology; metastasis; novel druggable target

(This special issue belongs to the Section Molecular Oncology)

3D Printing and Biomaterials for Hearing and Balance Restoration

edited by

Chenkai Dai

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: hearing; balancing; 3D printing; biomaterial

(This special issue belongs to the Section Materials Science)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

The Structure, Function, and Application of Zinc Finger Proteins

edited by

Sabrina Esposito

submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open

Keywords: zinc finger proteins: structure; function and properties; applications; protein folding and dynamics; environmental contaminants and metal ions exposure; uptake; toxicity; molecular recognition and signal transduction; mechanisms of action and effects of abnormal zinc finger proteins on human health; zinc finger proteins as drug targets

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2751-2800 on page 56 of 66.

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