Mitochondria: Not Just Powerhouse of the Cell
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 12
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria are no longer viewed as mere “powerhouses of the cell,” but as dynamic signaling organelles that integrate metabolic, immunologic, and stress responses to regulate cellular homeostasis and fate. This Special Issue aims to provide a holistic view of recent advances redefining mitochondrial biology beyond ATP generation. Mitochondria coordinate diverse processes such as ROS signaling, apoptosis, innate immune activation, and epigenetic regulation through metabolite flux and post-translational modifications, and their dysfunction drives cancer, neurodegeneration, metabolic disease, and aging. This collection will feature original research and reviews exploring mitochondrial dynamics and quality control; mitonuclear communication; mitochondrial nucleic acids in immune signaling; and organelle crosstalk with the ER, lysosome, and nucleus. It will also highlight innovations in mitochondrial imaging, multi-omics, and genome editing that reveal new regulatory mechanisms. By integrating insights from molecular biology, metabolism, and immunology, this Special Issue will position mitochondria as central hubs of cellular communication, emphasizing their pivotal role in linking metabolic states to immune and stress responses, and their potential as therapeutic targets in complex diseases.
Dr. Kailash Chandra Mangalhara
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrial nucleic acid
- mitonuclear communication
- mito-ER communication
- mito-lysosome communication
- mitochondria in cancer
- mitochondrial metabolic disorders
- mitochondria in inflammation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
