Molecular Insights into Heredity and Metabolism of Osteosarcoma

Dear Colleagues,

Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, characterized by aggressive local growth and a high propensity for metastasis. Despite advances in multimodal therapy, long-term survival remains limited, and little progress has been achieved in the past decades. Increasing evidence indicates that the biological heterogeneity of osteosarcoma arises not only from genetic alterations but also from metabolic rewiring that enables tumor adaptation to hypoxia, nutrient stress, and therapeutic pressure. The interplay between heredity and metabolism has thus emerged as a critical frontier in understanding tumor initiation, progression, and treatment resistance in osteosarcoma.

This Special Issue, Molecular Insights into Heredity and Metabolism of Osteosarcoma, aims to highlight novel discoveries at the interface of genetics and metabolism. We welcome contributions that explore inherited predispositions, somatic mutations, epigenetic regulation, and metabolic remodeling, as well as their implications for tumor biology and therapeutic strategies. By integrating molecular pathology, preclinical models, and translational approaches, this collection seeks to provide a comprehensive view of how genetic and metabolic factors shape osteosarcoma. Ultimately, our goal is to foster interdisciplinary dialogue and inspire innovative approaches that can improve outcomes for patients facing this devastating disease.

Prof. Dr. Hiroki Kuniyasu
Prof. Dr. Kanya Honoki
Guest Editors

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