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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Smart and Sustainable Hydrogels for Environmental Applications
edited by Rolando Chamy
submission deadline 20 May 2026 | Viewed by 17 | Submission Open
Keywords: hydrogel; biomaterials; sustainable materials; regenerative medicine
(This special issue belongs to the Section Materials Science)
The Design, Synthesis, and Application of Functional Porous Materials
edited by Qinhe Pan, and
submission deadline 20 May 2026 | Viewed by 11 | Submission Open
Keywords: porous materials; functional guest species; functionalization; luminescence; electrochemistry; stimulus response; adsorption; sensing; photoelectric; catalysis
(This special issue belongs to the Section Materials Science)
Environmental Microorganisms and Pathogen Infections submission deadline 20 May 2026 | Viewed by 9 | Submission Open
Keywords: environmental microbiome; pathogens; resistance genes; molecular adaptation; microbial interactions; anthropogenic pollution; functional gene expression; ecosystem health
(This special issue belongs to the Section Molecular Microbiology)
Plant Extracts and Their Biological Activities: In Vitro and In Vivo
edited by
submission deadline 20 May 2026 | Viewed by 6 | Submission Open
Keywords: plant extracts; bioactive compounds; molecular mechanisms; in vitro and in vivo studies; biological activities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research and Cellular Biology of Breast Cancer: 2nd Edition submission deadline 20 May 2026 | Viewed by 5 | Submission Open
Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor; immune responses; conventional and biological therapies; blood and tissue biomarkers
(This special issue belongs to the Section Molecular Oncology)
Nutrition of Crustaceans: A Molecular Perspective
edited by
submission deadline 25 May 2026 | Viewed by 96 | Submission Open
Keywords: crustacean nutrition; molecular mechanisms; aquaculture; nutrient metabolism; reproduction
(This special issue belongs to the Section Molecular Biology)
Cutting-Edge Research and Advancements in Neurodegenerative Diseases
edited by Meera Soundararajan
submission deadline 25 May 2026 | Viewed by 69 | Submission Open
Keywords: neurodegenerative disorders; neurons; Alzheimer’ s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington  disease
(This special issue belongs to the Section Molecular Neurobiology)
DNA Damage and Repair Mechanisms in Cancer
edited by
submission deadline 25 May 2026 | Viewed by 52 | Submission Open
Keywords: DNA  damage response  (DDR); genome instability  ; synthethic lethality  ; DNA repair
(This special issue belongs to the Section Molecular Oncology)
Cross-Kingdom Conversations: Deciphering Molecular Interactions in Microorganisms and Plants
edited by Eun-Hae Kwon
submission deadline 25 May 2026 | Viewed by 40 | Submission Open
Keywords: plant– microbe interactions; cross-kingdom signaling; plant growth-promoting microorganisms (PGPMs); molecular communication; synthetic microbial communities (SynComs)
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms in Mucosal Immunity and Inflammatory Diseases
edited by
submission deadline 25 May 2026 | Viewed by 8 | Submission Open
Keywords: mucosal immunity; metabolism; innate memory; trainers and inflammatory stimuli
(This special issue belongs to the Section Molecular Immunology)
Virus Detection and Analysis: Molecular Investigations
edited by
submission deadline 26 May 2026 | Viewed by 87 | Submission Open
Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing
(This special issue belongs to the Section Molecular Microbiology)
Novel Therapeutic Strategies Targeting Cancer Stem Cells
edited by Luciano Vellón
submission deadline 28 May 2026 | Viewed by 71 | Submission Open
Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer
(This special issue belongs to the Section Molecular Oncology)
Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 4177 | Submission Open
Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Materials: Novel Studies and Related Applications
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 748 | Submission Open
Keywords: antimicrobial materials; functional materials; composite materials; contamination; green materials; green technologies; metallic materials; drug resistance; environmental safety; biocompatibility; biodegradability
(This special issue belongs to the Section Materials Science)
Design, Synthesis, and Biological Evaluation of Novel Bioactive Compounds
edited by Monika Wujec and Oleg M. Demchuk
submission deadline 30 May 2026 | Viewed by 539 | Submission Open
Keywords: drug design; organic compounds; heterocyclic compounds; synthetic methodologies; medicinal chemistry; bioactive molecules; pharmaceutical applications; structure– activity relationships (SARs); organic synthesis; natural product
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Evolution of the Vertebrate Immune System
edited by
submission deadline 30 May 2026 | Viewed by 280 | Submission Open
Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias
edited by Yingjie Liu
submission deadline 30 May 2026 | Viewed by 232 | Submission Open
Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies
(This special issue belongs to the Section Molecular Biology)
Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products
edited by Emira D’Amico
submission deadline 30 May 2026 | Viewed by 75 | Submission Open
Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals
(This special issue belongs to the Section Molecular Biology)
Nanostructured Strategies for Bioactive Compounds
edited by
submission deadline 30 May 2026 | Viewed by 68 | Submission Open
Keywords: nanostructure-bioactive interaction; molecular encapsulation mechanisms; metallic nanoparticles (bioactivity); carbon-based nanocarriers; nano/microcapsule delivery systems; bioactive compound stabilisation; structure-activity relationships; molecular release kinetics
(This special issue belongs to the Section Molecular Biology)
Atomic-Scale Design of Li-Ion Battery Materials
edited by
submission deadline 30 May 2026 | Viewed by 67 | Submission Open
Keywords: lithium-ion batteries; atomic-scale design; electrode– electrolyte interface; electrolyte engineering; defect chemistry; solid-state batteries
(This special issue belongs to the Section Materials Science)
Oral Diseases and Oral Soft Tissue Repair
edited by Diana Russo
submission deadline 30 May 2026 | Viewed by 62 | Submission Open
Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytokines and Inflammatory Diseases
edited by
submission deadline 30 May 2026 | Viewed by 57 | Submission Open
Keywords: inflammation; cytokines; interleukin-6; immune diseases; immune signaling; autoimmunity; brain inflammation
(This special issue belongs to the Section Molecular Immunology)
Hormetic Responses of Plants to Environmental Stress
edited by
submission deadline 30 May 2026 | Viewed by 36 | Submission Open
Keywords: hormesis; environmental stress; dose– response; molecular mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Extracellular Matrix Signalling in Health and Disease
edited by
submission deadline 30 May 2026 | Viewed by 32 | Submission Open
Keywords: extracellular; matrix; mechano-transduction; biochemical signalling; cell– matrix interactions; outside-in signalling; matrix remodelling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Engineering Cell-Derived Nanostructures for Therapeutic Delivery
edited by
submission deadline 30 May 2026 | Viewed by 27 | Submission Open
Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions submission deadline 30 May 2026 | Viewed by 27 | Submission Open
Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oral Cancer: From Molecular Mechanisms to Therapeutics
edited by Diana Russo
submission deadline 30 May 2026 | Viewed by 8 | Submission Open
Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology
(This special issue belongs to the Section Molecular Oncology)
Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition submission deadline 31 May 2026 | 4 articles | Viewed by 22439 | Submission Open
Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer
(This special issue belongs to the Section Molecular Pharmacology)
Molecular and Translational Research on Bone Tumors, 2nd Edition submission deadline 31 May 2026 | 2 articles | Viewed by 12618 | Submission Open
Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments submission deadline 31 May 2026 | 2 articles | Viewed by 1322 | Submission Open
Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbiota-Mediated Regulation of Stem Cells in Cancer Initiation, Progression, and Treatment Response submission deadline 31 May 2026 | Viewed by 337 | Submission Open
Keywords: microbiota stem cell cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Infections and Viral Pathogenesis
edited by
submission deadline 31 May 2026 | Viewed by 90 | Submission Open
Keywords: viral pathogenesis; viral– host interactions; viral persistence; long COVID; molecular virology; immune dysregulation; diagnosis; vaccines; oncoviruses; antiviral and gene therapy
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation
edited by Rosanna Avola
submission deadline 31 May 2026 | Viewed by 71 | Submission Open
Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cellular and Molecular Mechanisms of Neuroinflammation submission deadline 31 May 2026 | Viewed by 71 | Submission Open
Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response
(This special issue belongs to the Section Molecular Neurobiology)
Advances in the Pharmacology of Depression and Mood Disorders
edited by
submission deadline 31 May 2026 | Viewed by 70 | Submission Open
Keywords: new antidepressants; rapid antidepressant action; ketamine in depression; glutamatergic antidepressants; psychedelics in depression; 5-HT receptors as targets for antidepressant research; neu-roplasticity and antidepressant action
(This special issue belongs to the Section Molecular Pharmacology)
Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models
edited by
submission deadline 31 May 2026 | Viewed by 63 | Submission Open
Keywords: antimicrobial peptides (AMPs); infectious diseases; drug-induced toxicity; disease models; therapeutic strategies; drug delivery systems
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity
edited by
submission deadline 31 May 2026 | Viewed by 61 | Submission Open
Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function
(This special issue belongs to the Section Molecular Neurobiology)
Microorganisms and Invertebrates in Molecular Dialogue: Mechanisms, Dynamics, and Applications submission deadline 31 May 2026 | Viewed by 60 | Submission Open
Keywords: microorganism– invertebrate interactions; symbiosis; stress tolerance; co-evolution; omics approaches; biotechnological applications
(This special issue belongs to the Section Molecular Microbiology)
Physiological and Molecular Responses of Plants to Drought Stress
edited by
submission deadline 31 May 2026 | Viewed by 49 | Submission Open
Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Materials for Biomedical Applications and Uses submission deadline 31 May 2026 | Viewed by 48 | Submission Open
Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering
(This special issue belongs to the Section Materials Science)
Genetic and Molecular Insights into Aging in Vertebrate Models
edited by Antonio Palladino
submission deadline 31 May 2026 | Viewed by 37 | Submission Open
Keywords: aging; vertebrate models; molecular mechanisms; cellular senescence; translational medicine
(This special issue belongs to the Section Molecular Biology)
Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis
edited by
submission deadline 31 May 2026 | Viewed by 33 | Submission Open
Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design
(This special issue belongs to the Section Macromolecules)
Platelet-Mediated Immune Regulation in Cancer
edited by
submission deadline 31 May 2026 | Viewed by 31 | Submission Open
Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis
(This special issue belongs to the Section Molecular Immunology)
The Role of Ferroptosis in Cancer Biology and Therapy
edited by Alessandra Di Paola and Elvira Pota
submission deadline 31 May 2026 | Viewed by 30 | Submission Open
Keywords: ferroptosis; cancer biology; tumor microenvironment; therapeutic targeting; anticancer immunity; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Metabolic Alterations in Health and Disease: From Molecular Mechanisms to Biomarkers in Clinical Applications submission deadline 31 May 2026 | Viewed by 26 | Submission Open
Keywords: metabolic syndrome; diabetes; oxidative stress; cellular metabolism; biomarkers; molecular pathways; metabolic disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Exploring the Functional Activity of Natural Products
edited by
submission deadline 31 May 2026 | Viewed by 21 | Submission Open
Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights submission deadline 31 May 2026 | Viewed by 19 | Submission Open
Keywords: human virome; molecular virology; functional virology; metagenomics; virus– host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology
(This special issue belongs to the Section Molecular Microbiology)
Molecular Crosstalk in Allergy, Barrier Dysfunction, and Asthma
edited by
submission deadline 31 May 2026 | Viewed by 18 | Submission Open
Keywords: barrier dysfunction; asthma; allergy; molecular pathways; molecular crosstalks
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models
edited by Eugenio Alladio and
submission deadline 31 May 2026 | Viewed by 16 | Submission Open
Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications
(This special issue belongs to the Section Molecular Genetics and Genomics)
Emerging Biomarkers in Cardiovascular Risk Assessment and Myocardial Injury
edited by Beatriz Martín-Carro
submission deadline 31 May 2026 | Viewed by 8 | Submission Open
Keywords: cardiovascular disease; myocardial injury; heart failure; biomarkers; risk stratification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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