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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Perspectives in Steroidomics
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4544 | Submission Open
Keywords: steroidomics; steroids; pathophysiology; physiology; diagnostics; treatment; prediction; prognosis; LC-MS/MS; GC-MS/MS
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Diabetic Bone Disease: New Insights into Molecular Mechanisms and Therapeutic Approaches
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 4536 | Submission Open
Keywords: diabetic bone disease; molecular mechanisms; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Male Infertility and Sperm Biology
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4421 | Submission Open
Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Biology)
Natural Compounds: Structural Diversity, Modifications, and Biological Activities
edited by Tomasz Pospieszny
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4295 | Submission Open
Keywords: bile acids; molecular research; biological activity; natural products; steroids
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4273 | Submission Open
Keywords: oral squamous cell carcinoma; epigenetics; molecular genetics; gene expression targeted therapy; molecular biomarkers
(This special issue belongs to the Section Molecular Oncology)
Cell and Molecular Perspectives in Breast Cancer
edited by Seungbaek Lee
submission deadline 20 Jan 2026 | 1 articles | Viewed by 4220 | Submission Open
Keywords: breast cancer; molecular biology; cell biology; biomarker; novel therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Insights into Molecular Mechanisms of Pulmonary Pathology
edited by Qiaozhen Liu
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4215 | Submission Open
Keywords: fibrosis; infection; COPD; asthma; IPF; pneumonia; lung cancer; molecular mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Applications of Machine Learning in Bioinformatics and Biomedicine
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4190 | Submission Open
Keywords: bioinformatics; computational biology; machine learning; deep learning; AI for biology
(This special issue belongs to the Section Molecular Informatics)
Research and Innovations in Green Monomers and Macromolecular Materials submission deadline 20 Jan 2026 | 2 articles | Viewed by 4167 | Submission Open
Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products
(This special issue belongs to the Section Materials Science)
Advances and Emerging Trends in Marine Natural Products
edited by Rafael Alexandre Faria da Costa Félix and
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4071 | Submission Open
Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights into Lipodystrophy submission deadline 20 Jan 2026 | 2 articles | Viewed by 3988 | Submission Open
Keywords: lipodystrophy; adipogenesis; animal models; lipid metabolism; therapeutic targets; insulin signaling pathways; adipose tissue
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective
edited by Andra Valentina Krauze
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3987 | Submission Open
Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights
(This special issue belongs to the Section Molecular Informatics)
Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer submission deadline 20 Jan 2026 | 3 articles | Viewed by 3912 | Submission Open
Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hormone Metabolism and Signaling in Human Health and Disease
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3903 | Submission Open
Keywords: hormone metabolism; signaling pathways; pathophysiology; molecular and cellular biology; diseases originating from hormone disorders; hormonal therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pathophysiology and Treatment of Congenital Neuromuscular Disorders
edited by Johan Lindqvist
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3707 | Submission Open
Keywords: nemaline myopathy; hereditary neuromuscular disorder; genetic mutations; pathogenesis; pathophysiology; therapy; myofilament dysfunction; congenital neuromuscular disorders; congenital muscular dystrophy; spinal muscular atrophy; Duchenne muscular dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hemophilia: From Pathophysiology to Novel Therapies
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3566 | Submission Open
Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of HLA (Human Leucocyte Antigen) in Human Diseases submission deadline 20 Jan 2026 | 2 articles | Viewed by 3477 | Submission Open
Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Biology and Targeted Therapies in Leukemias
edited by Fabio Stagno and
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3396 | Submission Open
Keywords: molecular biology; target therapy; leukemia; TKI; BCL-2; FLT3; CAR-T cells; CML
(This special issue belongs to the Section Molecular Oncology)
Lipid Peroxidation and Protein Carbonylation in Human Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3358 | Submission Open
Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes
(This special issue belongs to the Section Biochemistry)
Current Research for Heart Disease Biology and Therapeutics (Third Edition)
edited by Claudia Kusmic
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3336 | Submission Open
Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Targets in Gastrointestinal Diseases
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3319 | Submission Open
Keywords: molecular pathways; gastrointestinal cancers; inflammatory bowel disease; targeted therapies; microbiota; gene editing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oxidative Stress Responses in Cardiovascular Diseases
edited by Vladimir Jakovljevic
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3292 | Submission Open
Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Clostridial and Related Neurotoxins, 3rd Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3256 | Submission Open
Keywords: botulinum neurotoxin; BoNT; toxicity; molecular mechanisms; recombinant; derivative; clostridium botulinum
(This special issue belongs to the Section Molecular Toxicology)
Molecular Advances in Understanding Plant-Microbe Interactions submission deadline 20 Jan 2026 | 2 articles | Viewed by 3254 | Submission Open
Keywords: phytomicrobiome; symbiosis; pathogen resistance; microbial signalling
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Plant Stress submission deadline 20 Jan 2026 | 3 articles | Viewed by 3250 | Submission Open
Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression
(This special issue belongs to the Section Molecular Plant Sciences)
Hematologic Diseases: Molecular Insights and Novel Methods
edited by and Samantha Bruno
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3177 | Submission Open
Keywords: hematologic malignancies; high-throughput technologies; omics data; biomarkers; drug resistance; minimal residual disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Dynamics Simulations of Protein Structures
edited by Alfonso Trezza
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3168 | Submission Open
Keywords: molecular dynamics simulations; protein structure analysis; computational methods in structural biology; bioinformatics and drug discovery; protein– ligand interactions
(This special issue belongs to the Section Molecular Biophysics)
Genomics of Human Disease
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3162 | Submission Open
Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Molecular Research of Cartilage: 2nd Edition
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2973 | Submission Open
Keywords: articular cartilage; cartilage lesions; tissue engineering; cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms: New Insights into the Pathogenesis of Neonatal Disorders
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2938 | Submission Open
Keywords: neonate; neonatal infections; molecular and cellular mechanisms; necrotizing enterocolitis; immature immune system; neonatal inflammation; epigenetic modification; regulatory RNAs; bronchopulmonary dysplasia; neonatal hypoxic– ischemic injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches
edited by Magaly Martinez-Ferrer
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2869 | Submission Open
Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker
(This special issue belongs to the Section Molecular Oncology)
Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies
edited by Hanna Mysliwiec
submission deadline 20 Jan 2026 | 3 articles | Viewed by 2808 | Submission Open
Keywords: psoriasis; pathogenesis; lipid metabolism disturbances; metabolic syndrome; systemic comorbidities; epigenetics; therapeutic strategies; biologic treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cell Envelope Biogenesis and, Molecular Strategies to Maintain Cellular Homeostasis in Bacteria submission deadline 20 Jan 2026 | 3 articles | Viewed by 2744 | Submission Open
Keywords: LpxC and the regulation of LPS; periplasmic protein folding; disulfide bond formation; BAM proteins and assembly of outer membrane proteins; periplasmic protease DegP (HtrA); lipopolysaccharide assembly; LPS modifications and diversity; LPS and phospholipid trafficking; bacterial virulence factors; antibiotic resistance; extracytoplasmic function sigma factors; regulatory RNAs; two-component systems; lipid A and its modification
(This special issue belongs to the Section Molecular Microbiology)
Dysregulation of Bone Health–a Matter of Several Culprits
edited by Ana Gomes
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2725 | Submission Open
Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Lymphocytic Leukemia: Molecular Pathologies and Therapeutic Strategies
edited by Tang Her Jaing
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2701 | Submission Open
Keywords: chronic lymphocytic leukemia; genomic landscapes; precision medicine; clinical trials; biomarker
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Resistance Mechanisms in Biotechnology: From Extremes to Applications
edited by Giovanni Gallo and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2688 | Submission Open
Keywords: microorganism resistance systems; extreme environments; molecular adaptation; genetic pathways; biotechnological applications; industrial biotechnology; environmental remediation; extremophiles; stress tolerance; evolutionary adaptations
(This special issue belongs to the Section Molecular Microbiology)
Exploring New Field in Hydrocolloids Research and Applications
edited by , Cristina Elena Dinu-Pirvu and
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2669 | Submission Open
Keywords: drug delivery systems; controlled-release; targeted delivery; wound healing; tissue engineering; bioadhesive agents; transdermal patches; mucoadhesive hydrogels; ophthalmic preparations; oral disintegrating films; gastroretentive systems; rheology modifiers; textural characteristics; stabilizing agents; encapsulation for protection and stability (drugs; probiotics and bioactive compounds); 3D bioprinting; nutraceutical delivery
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments
edited by Angelo Delmonte and Alberto Verlicchi
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2640 | Submission Open
Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies 
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Epilepsy and Epileptogenesis—2nd Edition
edited by and Barbara Miziak
submission deadline 20 Jan 2026 | 3 articles | Viewed by 2600 | Submission Open
Keywords: epilepsy; antiseizure; anti-epileptogenic drugs; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Innovative Strategies in the Design and Development of Anticancer Agents
edited by Sanjay Kumar
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2594 | Submission Open
Keywords: chemotherapy; biomimetic; natural product analogs; prodrugs; nanodrugs; drug release
(This special issue belongs to the Section Molecular Pharmacology)
Autophagy and Kidney Diseases
edited by Francesco Reggiani
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2583 | Submission Open
Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structure, Function and Dynamics in Proteins: 3rd Edition
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2559 | Submission Open
Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray
(This special issue belongs to the Section Molecular Biology)
Bone Development and Regeneration—4th Edition
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2543 | Submission Open
Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials
(This special issue belongs to the Section Molecular Biology)
Protein Networks and Their Signaling submission deadline 20 Jan 2026 | 1 articles | Viewed by 2484 | Submission Open
Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design
(This special issue belongs to the Section Molecular Biology)
Biofunctionalization of Metals for Medical Application: Molecular Aspects
edited by and Xiaoming Zhang
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2470 | Submission Open
Keywords: biofunctionalization; medical applications; nanomaterials; nanofunctionalized materials; molecular mechanisms; bacterial membranes; membrane polarity; bacterial resistance
(This special issue belongs to the Section Molecular Nanoscience)
Recent Advances in Molecular Mechanisms of Bacterial Resistance and Antibiotic Therapy
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2428 | Submission Open
Keywords: bacterial resistance; antibiotics; antimicrobials; “ superbugs” ; clinical strains; laboratory induced-bacteria; antimicrobial peptides; antimicrobial combinations; hybrid antibiotics; repurposing drugs; anti-virulence agents; immune modulators; toxin neutralizers
(This special issue belongs to the Section Molecular Microbiology)
Latest Advances in Nanoparticles for Modern Biomedicine (2nd Edition) submission deadline 20 Jan 2026 | 2 articles | Viewed by 2427 | Submission Open
Keywords: nanoparticles; nanotherapeutics; nanomedicine; biomedicine; selective targeting of nanoparticles
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms of Bone Injury and Bone Tissue Regeneration
edited by Nasim Golafshan
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2332 | Submission Open
Keywords: bone formation; osteoblast diffrentiation; cell-based materials
(This special issue belongs to the Section Materials Science)
Precision Medicine Approaches to Antifibrotic Therapy
edited by Karim Daliri
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2207 | Submission Open
Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research in Alzheimer’s Disease: Advances and Perspectives
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2168 | Submission Open
Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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