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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Biochemical Advances in Kidney Diseases and Genetics

edited by

Silvio R. De Luka

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1724 | Submission Open

Keywords: pathophysiology; molecular mechanisms; biomarkers; in silico data analysis; image analysis; animal models

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Omics Insights into Stress Responses and Adaptation in Fish

edited by

Zongbin Cui

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1657 | Submission Open

Keywords: fish stress adaptation; environmental stressors; omics integration; molecular mechanisms; functional genomics; epigenetic regulation; systems biology; stress resilience

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Myocardial Disease

edited by

Maicon Landim-Vieira

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1646 | Submission Open

Keywords: cardiac muscle; calcium; sarcomere; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; mitochondria; calmodulin

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action

edited by

Tianfang Wang

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1644 | Submission Open

Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure–function relationships

(This special issue belongs to the Section Molecular Biology)

Molecular and Omics Approaches in Toxicology and Precision Pharmacology

edited by

Mirjana M. Djukić

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1602 | Submission Open

Keywords: toxicology; precision pharmacology; omics technologies; proteomics; mode of action (MoA); mechanism of activity; biomarkers; prediction and modeling

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Reproduction and Reproductive Diseases

edited by

Sung Tae Kim

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1506 | Submission Open

Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering

edited by

Elisa Boanini

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1394 | Submission Open

Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility

(This special issue belongs to the Section Materials Science)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1363 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Anti-Cancer Effects of Natural Products: 2nd Edition

edited by

Moon Nyeo Park

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1359 | Submission Open

Keywords: cancer; natural products; herbal medicine; anticancer therapies; metastasis; recurrence; resistance mechanism; novel biomarker

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Electrochemical Detection Research: A Molecular Insight

edited by

Gastón Pierini

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1359 | Submission Open

Keywords: electrochemical sensors; phenolic compounds; theoretical study; experimental study; nanostructured electrodes

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1323 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Vitamin B6 in Metabolism and Genome Stability

edited by

Fiammetta Verni

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1323 | Submission Open

Keywords: vitamin B6; PLP; DNA damage; metabolism

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Metabolism of Alzheimer’s Disease

edited by

Rebecca Piccarducci

and Maria Letizia Trincavelli

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1309 | Submission Open

Keywords: Alzheimer’s disease; brain metabolism; insulin resistance; lipid metabolism; APOE ε4; metabolic targets; insulin-sensitizing drugs; lifestyle and metabolic interventions

(This special issue belongs to the Section Molecular Neurobiology)

Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1304 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Plant Extracts and Their Biological Activities: In Vitro and In Vivo

edited by

Ângelo Luís

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1279 | Submission Open

Keywords: plant extracts; bioactive compounds; molecular mechanisms; in vitro and in vivo studies; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Comparative Reproductive Physiology

edited by

Heriberto Rodriguez-Martinez

and

Manuel Álvarez-Rodríguez

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1251 | Submission Open

Keywords: andrology; sperm; oocyte; gamete interactions; reproductive morphology; reproductive endocrinology; omics; epigenetics; pregnancy; all animal species

(This special issue belongs to the Section Molecular Biology)

Identification of Predictive Molecular Markers for Cancer Progression, Response to Therapy, and Disease Outcome

edited by

Shadma Fatima

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1232 | Submission Open

Keywords: predictive biomarkers; cancer progression; therapy response; molecular signatures; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Characterization and Biological Function of Marine Biopolymers

edited by

Zahira Belattmania

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1226 | Submission Open

Keywords: marine-based biopolymers; sustainable extractions; polymer characterization; biological functions; marine resources

(This special issue belongs to the Section Materials Science)

Exploring the Functional Activity of Natural Products

edited by

Antonio Speciale

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1221 | Submission Open

Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions

edited by

Adelina-Gabriela Niculescu

and

Ariana Hudita

submission deadline 25 Dec 2026 | Viewed by 1178 | Submission Open

Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease

edited by

Érika Bevilaqua Rangel

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1145 | Submission Open

Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Food Components in Human Health

edited by

Kamila Rachwał

and Klaudia Gustaw

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1103 | Submission Open

Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Regulatory Mechanisms of the Tumor Microenvironment in Human Diseases

edited by

Cornelia Amalinei

and

Adriana Grigoraș

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1078 | Submission Open

Keywords: tumor microenvironment; cytokines; exosomes; non-tumor cells; tumor-associated immune cells; cancer prognosis; cancer diagnosis; oncotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration

edited by Hyun Jin Shin

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1073 | Submission Open

Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Recent Research on Natural Compounds: From Biosynthesis to Application

edited by

Nitin Mantri

submission deadline 25 Dec 2026 | Viewed by 1042 | Submission Open

Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery

(This special issue belongs to the Section Biochemistry)

Emerging Strategies in Tuberculosis Drug Discovery

edited by

Parvesh Singh

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1037 | Submission Open

Keywords: anti-tuberculosis agents; MDR-TB; XDR-TB; drug repurposing; hybrid drugs; high-throughput screening; structure-based drug design; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Advanced in In Silico Methods for Rational Drug Design and Predictive Toxicology

edited by

Gnanendra Shanmugam

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1008 | Submission Open

Keywords: rational drug design; predictive toxicology; molecular modeling; AI in drug discovery; QSAR; molecular docking; ADMET

(This special issue belongs to the Section Molecular Informatics)

Epilepsy: Molecular Neuropharmacology, Calcium Signalling, Neuroinflammation, and Drug Discovery

edited by Maria F. Cano-Abad

submission deadline 25 Dec 2026 | 1 articles | Viewed by 986 | Submission Open

Keywords: epilepsy receptor pharmacology; neurotransmitter receptor modulation; calcium signaling and homeostasis; therapeutic targets in epilepsy; GABAergic and glutamatergic systems

(This special issue belongs to the Section Molecular Neurobiology)

Bioinformatics of Genome Regulation and Structure–2026

edited by

Yuriy L. Orlov

Nikolay A. Kolchanov

and

Anastasia A. Anashkina

submission deadline 25 Dec 2026 | 2 articles | Viewed by 955 | Submission Open

Keywords: bioinformatics; genomics; human genetics; systems biology; AI; e-Health

(This special issue belongs to the Section Molecular Informatics)

Unravelling Molecular Pathways in Ocular Disease and Degeneration

edited by

Zala Lužnik Marzidovšek

submission deadline 25 Dec 2026 | 1 articles | Viewed by 937 | Submission Open

Keywords: molecular mechanisms; ocular disease; biomarkers; therapeutic targets; regenerative; gene therapies; corneal degeneration; retinal degeneration; optic nerve pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Mechanisms of Action of Natural Products

edited by Damião Pergentino De Sousa

submission deadline 25 Dec 2026 | 1 articles | Viewed by 929 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; epilepsy; dementia; pain; essential oils; medicinal plants; alkaloids; flavonoids; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Surfactant Sciences: Design, Synthesis, and Applications

edited by Zakaria Hafidi

submission deadline 25 Dec 2026 | 1 articles | Viewed by 884 | Submission Open

Keywords: surfactants; synthesis; biodegradation; catalysis; biological activity; nanoparticles; design; green chemistry; self-assembly; surface chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels

edited by

Lucie Parent

submission deadline 25 Dec 2026 | Viewed by 878 | Submission Open

Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Curcumin Derivatives and Curcuminoids with Potential Biomedical Applications

edited by

Paola Bonaccorsi

and

Chiara Maria Antonietta Gangemi

submission deadline 25 Dec 2026 | 1 articles | Viewed by 865 | Submission Open

Keywords: curcumin; curcuminoids; synthesis; biomedicine; bioimaging; supramolecular; sensors; photodynamic therapy; antitumor properties; antiviral properties; antibacterial properties; antioxidant properties

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Research on Antioxidant Activity

edited by Agnieszka Filipek

submission deadline 25 Dec 2026 | 1 articles | Viewed by 862 | Submission Open

Keywords: antioxidants; advanced mechanisms of action; signaling pathways; molecular mechanism; biologically active compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Research in Neuroinflammation

edited by Reza Khorooshi

submission deadline 25 Dec 2026 | Viewed by 859 | Submission Open

Keywords: neuroinflammation; central nervous system disorders; neuroimmune interactions; inflammation and neurodegeneration; therapeutic strategies in neurology

(This special issue belongs to the Section Molecular Neurobiology)

Computational and Molecular Advances in Precision Craniofacial Medicine

edited by

Hsiu-Hsia Lin

submission deadline 25 Dec 2026 | Viewed by 857 | Submission Open

Keywords: precision medicine; craniofacial anomalies; artificial intelligence; 3D morphometrics; genomics; transcriptomics; computational modeling; phenotype–genotype correlation; craniofacial surgery; tissue engineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Inflammasome Signaling

edited by

Soren Hayrabedyan

submission deadline 25 Dec 2026 | 1 articles | Viewed by 833 | Submission Open

Keywords: PANoptosis; NLRP6; NLRP12; CARD8; non-immune cells; viral proteins; gasdermin family; inflammasome-independent signaling; inflammaging; MxA inflammasome

(This special issue belongs to the Section Biochemistry)

Biomolecular Stratification in Antiphospholipid Syndrome

edited by

Cristina Belizna

submission deadline 25 Dec 2026 | 1 articles | Viewed by 830 | Submission Open

Keywords: antiphospholipid syndrome; antiphospholipid; stratification; biomolecular; risk stratification; classification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Graphene-Based Nanocomposites

edited by

Oleksandr Ivasenko

submission deadline 25 Dec 2026 | 1 articles | Viewed by 816 | Submission Open

Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering

(This special issue belongs to the Section Molecular Nanoscience)

From ER Stress to Clinical Biomarkers: Integrating Mechanistic Understanding with Diagnostic Innovation

edited by

Maria Francesca Armentano

and

Rocchina Miglionico

submission deadline 25 Dec 2026 | 1 articles | Viewed by 813 | Submission Open

Keywords: unfolded protein response (UPR); circulating biomarkers; extracellular vesicles; translational laboratory medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomass as Feedstock for the Production of High Value-Added Chemicals by Heterogeneous Catalysis

edited by

Cristina García-Sancho

submission deadline 25 Dec 2026 | 2 articles | Viewed by 792 | Submission Open

Keywords: biomass; heterogeneous catalysts; biofuels; bioproducts; platform molecules

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Computational Strategies in Toxicology

edited by

Rajesh Kumar Pathak

and

Vikas Kumar

submission deadline 25 Dec 2026 | 1 articles | Viewed by 790 | Submission Open

Keywords: emerging pollutants; environment; molecular docking; molecular dynamics simulations; QSAR; Omics; PBPK model; predictive toxicology; risk assessment

(This special issue belongs to the Section Molecular Informatics)

Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes

edited by Maria Victoria Preciado

submission deadline 25 Dec 2026 | Viewed by 786 | Submission Open

Keywords: virus evolution; immune response; host–virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics

(This special issue belongs to the Section Molecular Immunology)

Bioactive Peptides: From Discovery and Characterization to Production, Therapeutic Applications, and Mechanistic Elucidation

edited by

José Thalles Lacerda

Taliana Bezerra

and

Luiz Juliano

submission deadline 25 Dec 2026 | 1 articles | Viewed by 765 | Submission Open

Keywords: bioactive peptides; mass spectrometry; machine learning; molecular dynamics simulation; synthetic biology; enzymology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Growth, Development and Secondary Metabolism in Microorganisms

edited by

Francisco Jose Fernandez

and

Ramón O. García-Rico

submission deadline 25 Dec 2026 | Viewed by 758 | Submission Open

Keywords: secondary metabolites; signal transduction; molecular regulation; microbial growth; morphogenesis; microbial metabolites; biotechnological applications; omics technologies

(This special issue belongs to the Section Molecular Microbiology)

Alcohol Metabolism: Molecular, Physiological, and Behavioral Consequences from Basic Research to Translational Applications

edited by Analia G. Karadayian

submission deadline 25 Dec 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: alcohol metabolism; acetaldehyde; mitochondrial dysfunction; oxidative stress; behavioral outcomes; animal models; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Perineuronal Nets and Fear Memories Erasure: State of the Art and Future Directions

edited by

Andrea Poli

submission deadline 25 Dec 2026 | Viewed by 652 | Submission Open

Keywords: perineuronal nets (PNNs); extracellular matrix (ECM); fear erasure; traumatic memories; PTSD; translation research; clinical treatment; therapeutical strategies

(This special issue belongs to the Section Molecular Neurobiology)

HPV Infection and Immune Escape Mechanisms

edited by

Vittorio Unfer

and Elisa Lepore

submission deadline 25 Dec 2026 | Viewed by 647 | Submission Open

Keywords: HPV; persistence; natural molecules; vaccination; genotypes; anal infection; oral infection; co-infection

(This special issue belongs to the Section Molecular Immunology)

Advances in Materials for Water Treatment and Metal/Nutrient Recovery

edited by

Aurora Pat-Espadas

submission deadline 25 Dec 2026 | 1 articles | Viewed by 643 | Submission Open

Keywords: water treatment; wastewater treatment; recalcitrant pollutants; metal recovery; nutrient recovery; molecularly engineered materials; functional materials; adsorption and remediation

(This special issue belongs to the Section Materials Science)

Displaying special issue 1651-1700 on page 34 of 63.

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