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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Compounds in Neurodegenerative Diseases

edited by

Silvia Lima Costa

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1092 | Submission Open

Keywords: bioactive compounds; neurodegenerative diseases; neuroinflammation; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1091 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Innovations in Brain Cancer Research

edited by Vinay K. Sharma

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1077 | Submission Open

Keywords: glioblastomas; astrocytomas; brain tumors; targeted therapies; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Advanced Research in Immunotoxicity and Oxidative Stress

edited by

Soo-Jin Choi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1076 | Submission Open

Keywords: toxicity; macrophage activation; pro-inflammation; anti-inflammation; oxidative stress; foods; food additives; nanomaterials; toxicants; natural compounds

(This special issue belongs to the Section Molecular Toxicology)

Toxicants and Their Effects on Innate Immune Function and Inflammatory Response

edited by

James M. Harper

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1067 | Submission Open

Keywords: ecotoxicology; innate immunity; inflammation; pesticides; plasticizers; pattern-recognition receptors

(This special issue belongs to the Section Molecular Toxicology)

DNA Replication, Damage and Repair in Repeat Instability: Their Role from Bacteria to Genetic Disorders in Humans

edited by

Enrique Viguera

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1058 | Submission Open

Keywords: DNA repeat instability; DNA replication; DNA damage; DNA repair; tandem repeats; trinucleotide repeats; repeat expansion diseases; microsatellite instability; replication slippage; phenotypic variability; bacteria; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1044 | Submission Open

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Lipopolysaccharide in the Health and Disease

edited by

Gen-Ichiro Soma

and Hiroyuki Inagawa

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1001 | Submission Open

Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer

(This special issue belongs to the Section Biochemistry)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 Nov 2025 | 1 articles | Viewed by 973 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 20 Nov 2025 | 1 articles | Viewed by 939 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 20 Nov 2025 | 1 articles | Viewed by 859 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Role of Amyloid in Neurological Diseases

edited by Silvia Purro

submission deadline 20 Nov 2025 | 1 articles | Viewed by 839 | Submission Open

Keywords: amyloid-beta (Aβ ); tau protein; TDP43; synuclein; huntingtin; prion-like mechanisms; amyloid structures; genetic factors; cell-to-cell transmission; pathogenesis mechanisms; protein aggregation; Biomarkers; CNS amyloid clearance and degradation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Orchid Plants: 2nd Edition

edited by Wen‑Chieh Tsai

submission deadline 20 Nov 2025 | 1 articles | Viewed by 835 | Submission Open

Keywords: orchid; genomics; genome; genes; tumor; inflammation; drug; transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 Nov 2025 | 1 articles | Viewed by 829 | Submission Open

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Regulatory Network of Bone Metabolism

edited by

Kazunori Hamamura

submission deadline 20 Nov 2025 | 1 articles | Viewed by 823 | Submission Open

Keywords: osteoblasts; osteoclasts; osteocytes; mesenchymal stem cells; bone metabolism; bone formation; bone resorption

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Aquatic Organisms Models Dedicated to Disease

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Nov 2025 | Viewed by 816 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sulfur-Containing Compounds: Synthesis, Characterization and Antimicrobial or Anticancer Activity

edited by

Paola Bonaccorsi

Chiara Maria Antonietta Gangemi

and

Anna Barattucci

submission deadline 20 Nov 2025 | Viewed by 808 | Submission Open

Keywords: sulfurated compounds; sulfoxides; disulfides; sulfides; thiosulfinates; xanthates; antibacterial; antivirus; anticancer; antimicrobial

(This special issue belongs to the Section Biochemistry)

Applications of Phytochemicals in Drug Synthesis

edited by

Gregorio Peron

submission deadline 20 Nov 2025 | 1 articles | Viewed by 768 | Submission Open

Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Precision Medicine in Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 20 Nov 2025 | Viewed by 737 | Submission Open

Keywords: precision medicine; cancer biomarkers; targeted therapy; genomic profiling; personalized treatment; tumor heterogeneity; molecular diagnostics; clinical research

(This special issue belongs to the Section Molecular Oncology)

Nanodiagnosis and Treatment System for Human Health

edited by

Nan Gao

submission deadline 20 Nov 2025 | 1 articles | Viewed by 717 | Submission Open

Keywords: nanodiagnosis; nanodrugs; nano-antibody; nanosensor; nanoprobe technology

(This special issue belongs to the Section Molecular Nanoscience)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 680 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 635 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Computational Modelling at the Blood–Brain Barrier

edited by Christian Jorgensen

submission deadline 20 Nov 2025 | Viewed by 627 | Submission Open

Keywords: blood– brain barrier models; molecular dynamics simulations; artificial intelligence; CNS penetration predictive models; asymmetric membranes; efflux pumps

(This special issue belongs to the Section Molecular Neurobiology)

Progress in New Agents to Treat Breast Cancer

edited by Eileen Brantley

submission deadline 20 Nov 2025 | 1 articles | Viewed by 624 | Submission Open

Keywords: breast cancer; chemotherapeutic agents; DNA-alkylating drugs; anthracyclines; antimetabolites; taxanes

(This special issue belongs to the Section Molecular Oncology)

Endothelial Dysfunction, Inflammation and Cognition

edited by Christelle Basset and Anne S. Prigent-Tessier

submission deadline 20 Nov 2025 | Viewed by 616 | Submission Open

Keywords: inflammation; endothelial dysfunction; cognition; nitric oxide (NO); BDNF; physical exercise

(This special issue belongs to the Section Molecular Biology)

Molecular Research on PRDM Genes

edited by

Erika Zazzo

Ciro Abbondanza

and

Monica Rienzo

submission deadline 20 Nov 2025 | Viewed by 597 | Submission Open

Keywords: PRDM; cancer; gene expression regulation; epigenetic modifications; proliferation; differentiation; gene expression regulation; apoptosis; cancer biomarkers; cancer diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomic Research in Carcinogenesis, Cancer Progression and Recurrence

edited by

Magdalena Orzechowska

submission deadline 20 Nov 2025 | 1 articles | Viewed by 572 | Submission Open

Keywords: genomic profiling; carcinogenesis; metastasis; recurrence; precision medicine; tumor evolution metrics; sequencing; tumor markers

(This special issue belongs to the Section Molecular Oncology)

Chemical and Biotechnological Strategies to Tailor the Properties of Biomaterials

edited by

Eduardo García-Junceda

and

Julia Revuelta

submission deadline 20 Nov 2025 | 1 articles | Viewed by 568 | Submission Open

Keywords: biomaterial functionalization; green chemistry in biomaterials; biotechnological modification; stimuli-responsive materials; translational biomaterials

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Sprouty Proteins in Cancer

edited by Barbara Hausott and

Lars Klimaschewski

submission deadline 20 Nov 2025 | 1 articles | Viewed by 557 | Submission Open

Keywords: sprouty; tumor growth; apoptosis; migration; signaling

(This special issue belongs to the Section Molecular Biology)

Diabetes: Genetics and Genomics, Hormone Regulation, and Metabolic Control

edited by Maria Stathopoulou

submission deadline 20 Nov 2025 | Viewed by 522 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; monogenic diabetes; polygenic risk factors; gestational diabetes (GDM); maturity-onset diabetes of the young (MODY); latent autoimmune diabetes in adults (LADAs); genome-wide association studies (GWASs); single nucleotide polymorphisms (SNPs); epigenetic modifications in diabetes; insulin production regulation; hormone action and metabolic control; β -cell dysfunction; gene-environment interactions in diabetes; precision medicine in diabetes treatment; genetics; genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nucleolus, Nucleolar Stress, and Ribosome Biogenesis in the Nervous System

edited by

Theologos Michaelidis

submission deadline 20 Nov 2025 | Viewed by 518 | Submission Open

Keywords: nucleolus; nucleolar stress; nucleolar homeostasis; polymerase I; rDNA transcription; ribosome biogenesis; translation; ribosomopathies; apoptosis; autophagy; senescence; neurodegeneration; tumorigenesis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathology and Treatment of Heart Failure

edited by

Giuseppe Armentaro

submission deadline 20 Nov 2025 | 1 articles | Viewed by 505 | Submission Open

Keywords: heart failure; oxidative stress; platelet activation; inflammation; biomarkers; pathophysiology; comorbidities

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 Nov 2025 | Viewed by 498 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

Challenges of Immune Checkpoint Inhibitor Therapy

edited by

Tibor Bakacs

submission deadline 20 Nov 2025 | Viewed by 496 | Submission Open

Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments

edited by

Amit Roy

and

Amrita Chakraborty

submission deadline 20 Nov 2025 | Viewed by 495 | Submission Open

Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms

(This special issue belongs to the Section Molecular Biology)

Molecular Crosstalk Between Bone and Inflammation

edited by Jessica Cottrell

submission deadline 20 Nov 2025 | Viewed by 456 | Submission Open

Keywords: bone; inflammation; immunology; bone metabolism; inflammatory disease

(This special issue belongs to the Section Molecular Immunology)

Genetic Testing and Tailored Treatment for Thyroid Disorders: Molecular Basis and New Trends

edited by

Kyoung Sik Park

submission deadline 20 Nov 2025 | Viewed by 431 | Submission Open

Keywords: thyroid diseases; genetics; personalized medicine; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular, Translational and Clinical Research of Cancer Structural Biomarkers

edited by

Sabine Mai

submission deadline 20 Nov 2025 | Viewed by 427 | Submission Open

Keywords: structural biomarker; extracellular matrix; nuclear organization; discovery research; translational research; clinical research; cancer staging and prognosis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Cancer Models: Development and Applications

edited by

Yong Teng

submission deadline 20 Nov 2025 | Viewed by 424 | Submission Open

Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Pathogenesis of Type 1 Diabetes

edited by

Alessandra Fierabracci

submission deadline 20 Nov 2025 | Viewed by 393 | Submission Open

Keywords: type 1 diabetes; insulin-dependent diabetes mellitus; human leukocyte antigen (HLA); pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Nanomaterials and Molecular Detection in Human Diseases

edited by

Liangcan He

submission deadline 20 Nov 2025 | Viewed by 392 | Submission Open

Keywords: cancer; infectious diseases; neurological diseases; hematological disorders; cardiovascular diseases; nanoparticles; nanodrug delivery; nanoimaging

(This special issue belongs to the Section Materials Science)

Molecular Adaptation Mechanisms of Photosynthesis to Environmental Stress

edited by

Michael Moustakas

submission deadline 20 Nov 2025 | Viewed by 382 | Submission Open

Keywords: photosynthesis; molecular mechanisms; environmental adaptation; climate change; stress physiology; biotic stress; abiotic stress; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology and Chemistry of Mycotoxins and Phytotoxins, 3rd Edition

edited by

Makoto Kimura

submission deadline 20 Nov 2025 | Viewed by 362 | Submission Open

Keywords: aflatoxins; trichothecenes; fumonisins; ochratoxins; host-specific toxins; Alternaria toxins; emerging mycotoxins; biosynthesis; gene cluster; transcriptional regulation; toxicity; modification; ecological role

(This special issue belongs to the Section Molecular Toxicology)

Structure–Activity Relationships Within Pharmaceutical Interactions and the Discovery of Molecular Targets

edited by

Yoshihiro Uesawa

submission deadline 20 Nov 2025 | Viewed by 357 | Submission Open

Keywords: molecular dynamics; docking simulation; QSAR; moleular initiating event

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Signaling Pathways in Neuroinflammatory Disorders

edited by

Martina Schmidt

and

Karim Rafie

submission deadline 20 Nov 2025 | Viewed by 357 | Submission Open

Keywords: blood– brain barrier; inducible pluripotent stem cells; organoids; scaffolds; neuroinflammation; microglia; mitochondria; endothelial cells; drug screening; virus infections; cryo-EM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peptide Receptor Radionuclide Therapy (PRRT) and Targeted Alpha Therapy (TAT) in Cancer

edited by

Behrooz H. Yousefi

submission deadline 20 Nov 2025 | Viewed by 353 | Submission Open

Keywords: novel radiopharmaceutical synthesis; translational research; theranostic studies; manufacturing of radiopharmaceuticals; therapy efficacy; personalized dosimetry

(This special issue belongs to the Section Molecular Oncology)

ROS Signalling and Cell Turnover

edited by

Micol Silic-Benussi

submission deadline 20 Nov 2025 | Viewed by 344 | Submission Open

Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death

(This special issue belongs to the Section Biochemistry)

Molecular Advances in Alcohol Metabolism

edited by Takeshi Haseba

submission deadline 20 Nov 2025 | Viewed by 338 | Submission Open

Keywords: alcohol metabolism; ADH1; ADH3; ADH4; MEOS; catalase; ALDH2; pharmacology and toxicology; ROS; alcohol-related disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Tolerance to Stress

edited by

Xingguo Li

submission deadline 20 Nov 2025 | Viewed by 328 | Submission Open

Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Stem Cell Biology & Regenerative Medicine—2nd Edition

edited by

Rivka Ofir

submission deadline 20 Nov 2025 | Viewed by 309 | Submission Open

Keywords: hiPSC; hES; Crispr; BBB; disease in a dish; neuro-regeneration; pain reliever; scaffold

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1751-1800 on page 36 of 70.

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