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Sulfur-Containing Compounds: Synthesis, Characterization and Antimicrobial or Anticancer Activity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1146

Special Issue Editors


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Dipartimento di Scienze Chimiche Biologiche Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, 98166 Messina, Italy
Interests: organic synthesis; luminescent probes; carbohydrates; BODIPY; curcumin; sulfenic acids
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
ChiBioFarAm Department, University of Messina, 98166 Messina, Italy
Interests: organic synthesis; luminescent probes; carbohydrates; bioactive compounds; oligo phenylene ethynylene; sulfenic acids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this new Special Issue that will focus on sulfur-containing compounds. Sulfurated molecules are often found in nature, and their biological roles make them important scaffolds in medicinal and pharmacological chemistry as well as in materials science and organic synthesis. The C-S bond is present in a wide range of active compounds, and for this reason, researchers have turned their attention to the development of efficient methods of forming such C-S bonds. Organic sulfur compounds are very effective in preventing various pathological human diseases; they act as gene modulators of some key regulating factors, are involved in the maintenance of cellular redox homeostasis, and possess antioxidant activity that is able to counterbalance the increased oxidative stress associated with many degenerative diseases. Sulfides, known also as thioethers, disulfides, sulfoxides, and thiosulfinates, are a sulfurated functional group found in nature; they are an integral part of many biologically active molecules such as antibiotics and antitumor drugs.

In this Special Issue, we wish to involve authors who would like to communicate their work on various aspects of sulfur-containing compounds, their synthesis (i.e., updated conventional methodologies or unconventional synthetic pathways), their characterization (which may be after the purification of natural sources), their nutraceutical properties, their role in the development of novel drugs, and their potential application in the biomedical antimicrobial and anticancer fields. The formation of C-S bonds is the main focus of this SI; we are confident that each new sulfurated molecule may have potential applicability.

We welcome the submission of original research articles, short communications, reviews, and featured articles to this Special Issue. Research areas may include (but are not limited to) organic chemistry, pharmaceuticals, food, natural products, therapeutics, phytochemistry, and inflammatory processes.

We look forward to receiving your contributions.

Prof. Dr. Paola Bonaccorsi
Dr. Chiara Maria Antonietta Gangemi
Dr. Anna Barattucci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sulfurated compounds
  • sulfoxides
  • disulfides
  • sulfides
  • thiosulfinates
  • xanthates
  • antibacterial
  • antivirus
  • anticancer
  • antimicrobial

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Published Papers (1 paper)

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Research

29 pages, 5540 KB  
Article
Scaffold-Hopping Design and Synthesis of Thieno[3,2-d]pyrimidines: Anticancer Activity, Apoptosis Induction, and In Silico Inhibition of CDKs
by Zukela Ruzi, Anvarjon Buronov, Lifei Nie, Azizbek Nasrullaev, Zarifa Murtazaeva, Rustamkhon Kuryazov, Jiangyu Zhao, Thomas Efferth, Haji Akber Aisa and Khurshed Bozorov
Int. J. Mol. Sci. 2025, 26(17), 8528; https://doi.org/10.3390/ijms26178528 - 2 Sep 2025
Viewed by 217
Abstract
Two series of tricyclic thieno[3,2-d]pyrimidines were synthesized, achieving yields of up to 97%. The tricyclic thieno[3,2-d]pyrimidines examined in this study are synthetic analogs of the deoxyvasicinone alkaloids, where the thiophene ring substitutes for the benzene ring. A systematic investigation [...] Read more.
Two series of tricyclic thieno[3,2-d]pyrimidines were synthesized, achieving yields of up to 97%. The tricyclic thieno[3,2-d]pyrimidines examined in this study are synthetic analogs of the deoxyvasicinone alkaloids, where the thiophene ring substitutes for the benzene ring. A systematic investigation was conducted on the scaffold-hopping strategy of these alkaloids, emphasizing the selective synthesis and anticancer properties of thieno[3,2-d]pyrimidines. The anticancer evaluation was performed on human cancer cell lines, specifically cervical HeLa and colon HT-29 carcinoma cells. Additional bioassays included cell migration analyses, cell cycle progression, apoptosis, and molecular docking analyses. Furthermore, molecular docking studies showed that the most active small molecule 6e is likely to disrupt the cell cycle process through targeting CDKs (Cyclin-dependent kinases), leading to the inhibition of tumor cell proliferation. Full article
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