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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

TRP Channels: Mechanisms, Functions, and Therapeutic Implications

edited by

Stefan Mergler

submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open

Keywords: transient receptor potential (TRP) channels; calcium signaling; ion channels; tissue homeostasis; receptor activation

(This special issue belongs to the Section Biochemistry)

Advances in Angiogenesis—from Molecular Drivers to Clinical Implications

edited by

Claudiu N. Lungu

and

Subhash C. Basak

submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open

Keywords: angiogenesis; pro-angiogenic molecules; vascular endothelial growth factor (VEGF); fibroblast growth factors (FGFs); angiopoietins; vascular morphogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology and the Genetic Breeding of Aquatic Animals: Breakthroughs and Challenges (2nd Edition)

edited by

Hongyan Xu

submission deadline 31 Oct 2025 | Viewed by 86 | Submission Open

Keywords: transgenic; genetic breeding; omics; gene expression and regulation; aquatic animals

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Skeletal Muscle Adaptation

edited by

Michele Salanova

submission deadline 31 Oct 2025 | Viewed by 85 | Submission Open

Keywords: skeletal muscle; adaptive responses; muscle physiology; genomics; transcriptomics; proteomics; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Perineuronal Nets and Fear Memories Erasure: State of the Art and Future Directions

edited by

Andrea Poli

submission deadline 31 Oct 2025 | Viewed by 82 | Submission Open

Keywords: perineuronal nets (PNNs); extracellular matrix (ECM); fear erasure; traumatic memories; PTSD; translation research; clinical treatment; therapeutical strategies

(This special issue belongs to the Section Molecular Neurobiology)

Current Molecular Advances in Apoptosis

edited by

Mariarosaria Boccellino

and

Davide Viggiano

submission deadline 31 Oct 2025 | Viewed by 82 | Submission Open

Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin

(This special issue belongs to the Section Biochemistry)

Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement

edited by

Amelia Salimonti

submission deadline 31 Oct 2025 | Viewed by 82 | Submission Open

Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Omics Approaches to Unravel Plant Responses to Habitat Stresses

edited by

Claudia Uhde-Stone

submission deadline 31 Oct 2025 | Viewed by 81 | Submission Open

Keywords: omics; multi-omics; high-throughput technologies; biotic stress; abiotic stress; environmental stress; crosstalk; translational biology; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Adsorption Materials: From Design to Application

edited by Qi Liu

submission deadline 31 Oct 2025 | Viewed by 80 | Submission Open

Keywords: functional adsorption materials; molecular design; selective adsorption

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 31 Oct 2025 | Viewed by 79 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene– environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tolerance Mechanisms of Plants Against Abiotic Stresses

edited by

Ilektra Sperdouli

submission deadline 31 Oct 2025 | Viewed by 79 | Submission Open

Keywords: abiotic stress; oxidative stress; plant adaptation; physiological mechanisms; molecular mechanisms; morphological mechanisms; biochemical mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Biomaterials: Molecular Design and Applications

edited by

Yuxin Zhang

submission deadline 31 Oct 2025 | Viewed by 78 | Submission Open

Keywords: biomaterials; molecular design; biomedical applications

(This special issue belongs to the Section Materials Science)

Exploring Rare Diseases: Genetic, Genomic and Metabolomic Advances: 2nd Edition

edited by

Judit Bene

and

Kinga Hadzsiev

submission deadline 31 Oct 2025 | Viewed by 76 | Submission Open

Keywords: rare diseases; genotype– phenotype analyses; NGS; mass spectrometry; biomarker discovery; molecular targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

In Silico Approaches to Drug Design and Discovery

edited by

Alejandro Speck-Planche

submission deadline 31 Oct 2025 | Viewed by 75 | Submission Open

Keywords: chemoinformatics; computational de novo design and generative AI methods; machine learning; deep learning; molecular modeling; pharmacophore modeling; molecular docking; molecular dynamics; QSAR/QSPR; virtual screening

(This special issue belongs to the Section Molecular Informatics)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 31 Oct 2025 | Viewed by 73 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders

edited by

Amal Kaddoumi

submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; Alzheimer’ s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow

(This special issue belongs to the Section Molecular Neurobiology)

Neuropeptides in Brain Health and Disease: From Molecular Mechanisms to Therapeutic Potential

edited by

Alessandro Castorina

submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open

Keywords: neuropeptides; brain function; neuroinflammation; regeneration; neurodegeneration; biomarkers; therapy; CNS; brain disorders; demyelination

(This special issue belongs to the Section Molecular Neurobiology)

The Gene, Genomics, and Molecular Breeding in Cruciferae Plants (3rd Edition)

edited by

Maoteng Li

submission deadline 31 Oct 2025 | Viewed by 71 | Submission Open

Keywords: Cruciferae plants; genome analysis; genetic dissection; gene function; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Molecular Research in Cardiology and Treatment Approaches

edited by Ludger Hauck

submission deadline 31 Oct 2025 | Viewed by 71 | Submission Open

Keywords: TAp63; EzH2; histone methyltransferase; cardiomyocyte proliferation; myocardial infarction; heart regeneration; heart repair; epigenetic regulation; cardiac regeneration; Skp2-p27KIP1 pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Electrochemical Nanomaterials for Energy and Catalysis

edited by

Sankar Sekar

submission deadline 31 Oct 2025 | Viewed by 70 | Submission Open

Keywords: advanced micro- and nanomaterials for electrochemical applications; electrochemical energy storage; electrocatalysis; photoelectrochemical water splitting; electrochemical sensors; supercapacitor; batteries; nanocomposites and functionalized materials; energy storage and conversion application; natural resources-based materials

(This special issue belongs to the Section Molecular Nanoscience)

Quantum Chemical Intelligence: New Horizons of Molecular Structure and Reactivity

edited by

Mihai V. Putz

submission deadline 31 Oct 2025 | Viewed by 69 | Submission Open

Keywords: chemical bond and bonding; quantum states and measurements; chemical reactivity; valence models; complex coordination; reaction coordinates and paths; bio-nano-materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nano-Biomaterials and Biotechnology for Biomedicine and Tissue Regeneration

edited by

Laura Giannotti

submission deadline 31 Oct 2025 | Viewed by 68 | Submission Open

Keywords: nano-biomaterials; regenerative medicine; tissue engineering; drug delivery systems; bioactive interfaces

(This special issue belongs to the Section Materials Science)

Advances in Nano-Based Drug Delivery and Theranostic Systems

edited by

Mukesh Meher

and

Yapei Zhang

submission deadline 31 Oct 2025 | Viewed by 67 | Submission Open

Keywords: nanoparticles; smart drug/gene delivery; multifunctional nanoparticles; theranostics; targeted therapy; molecular imaging; cancer

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms in Rare and Hereditary Vascular Diseases

edited by

Antonino Tuttolomondo

submission deadline 31 Oct 2025 | Viewed by 65 | Submission Open

Keywords: Klippel– Trenaunay syndrome; Parkes– Weber syndrome; CLOVES syndrome; Proteus syndrome; hereditary hemorrhagic telangiectasia; blue rubber bleb nevus syndrome; COL4A1/A2-related disorders; CADASIL; Fabry disease; cerebral amyloid angiopathy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nano-Biomaterials for Biomedicine and Tissue Regeneration

edited by

Silvia Barbon

and

Elena Stocco

submission deadline 31 Oct 2025 | Viewed by 65 | Submission Open

Keywords: nanostructured biomaterials; cell-scaffold interactions; drug delivery systems; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Current and Emerging Therapeutic Approaches for MASLD

edited by

Chrysoula Boutari

submission deadline 31 Oct 2025 | Viewed by 64 | Submission Open

Keywords: MASLD; MASH; GLP-1 agonists; anti-inflammatory agents; anti-obesity drugs; FGF-21

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Development, Characterization and Applications of Novel Polymeric Materials and Composites: 2nd Edition

edited by

Daniel Dumitru Banciu

and

Xiao Hu

submission deadline 31 Oct 2025 | Viewed by 64 | Submission Open

Keywords: diagnosis; therapy; polymers; composite materials; theoretical model

(This special issue belongs to the Section Materials Science)

Advanced Plant Molecular Responses to Abiotic Stresses: 2nd Edition

edited by

Dong-Gwan Kim

submission deadline 31 Oct 2025 | Viewed by 64 | Submission Open

Keywords: abiotic stress responses (heat; drought; salinity; nutrient deficiency; oxygen quality; flooding; light; etc.); genetically modified plants; CRISPR/Cas-mediated stress overcome; microplastic/nanoparticle stresses; bioinformatic studies; miRNAs and other noncoding RNAs involved in abiotic stresses in plants; secondary metabolite synthesis

(This special issue belongs to the Section Molecular Plant Sciences)

miRNA in Human Diseases

edited by

Anna Valentino

submission deadline 31 Oct 2025 | Viewed by 64 | Submission Open

Keywords: microRNA; gene regulation; disease biomarkers; miRNAs expression profiling; miRNA-based therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mitochondria-Associated Non-Coding RNAs

edited by

Verónica A. Burzio

, Jaime E. Villegas and

Sam Das

submission deadline 31 Oct 2025 | Viewed by 61 | Submission Open

Keywords: mitochondrial-encoded ncRNAs; mitochondrial miRNAs; mitochondrial lncRNAs; mitochondrial circRNAs; nuclear-encoded mitochondrial ncRNAs

(This special issue belongs to the Section Molecular Biology)

Emerging Treatments in Aging-Related Cerebrovascular Diseases

edited by

Aurel Popa-Wagner

submission deadline 31 Oct 2025 | Viewed by 60 | Submission Open

Keywords: aging; cerebrovascular diseases; therapeutic tools; senolytic drugs; gene editing technologies; RNA-based therapies

(This special issue belongs to the Section Molecular Neurobiology)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 31 Oct 2025 | Viewed by 58 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Molecular Genetics of Head and Neck Cancer

edited by

Jacek Kabziński

submission deadline 31 Oct 2025 | Viewed by 56 | Submission Open

Keywords: head and neck cancer; molecular genetics; tumor heterogeneity; driver mutations; epigenetic alterations; non-coding RNAs; oncogenes and tumor suppressors; gene expression profiling; genomic instability; biomarkers for diagnosis and therapy

(This special issue belongs to the Section Molecular Oncology)

New Trends in Green Synthesis of Nanomaterials

edited by Rocío Redón

submission deadline 31 Oct 2025 | Viewed by 56 | Submission Open

Keywords: nanoparticles; cytotoxicity; drug delivery; nanomaterials; green synthesis

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Brain Cancer

edited by

Gerardo Caruso

submission deadline 31 Oct 2025 | Viewed by 56 | Submission Open

Keywords: brain tumor biomarkers; genomic and epigenomic alterations; microenvironment; targeted therapies; angiogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Lipopolysaccharide as a Drug Target

edited by

Martina Schmidt

submission deadline 31 Oct 2025 | Viewed by 55 | Submission Open

Keywords: tissue barriers; neuroinflammation; macrophages; microglia; organoids; scaffolds; infections; cry-EM

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Targets of Disease—Changing Treatment Strategies for Parkinson's Disease

edited by

Chung-Yin Lin

submission deadline 31 Oct 2025 | Viewed by 55 | Submission Open

Keywords: Parkinson’ s disease; therapeutic targets; potential treatments; molecular targets; drug delivery; neurodegenerative disease

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Genetics in the Pathogenesis of Neurological Disorders

edited by Jeannette Hübener-Schmid

submission deadline 31 Oct 2025 | Viewed by 53 | Submission Open

Keywords: ataxia; genetic modifier; genetic landscape; genomics; long-read sequencing; neurodegeneration; personalized medicine; personalized treatmen; polymorphisms; single cell sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Antitumor Agents from Natural Source

edited by Fábio Ferreira Perazzo

submission deadline 31 Oct 2025 | Viewed by 52 | Submission Open

Keywords: natural products; cancer; medicinal plants; phytochemistry; fermented compounds; isolated compounds; tumor; in vitro; in vivo; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Current Research on Applications and Effects of Bioactive Components in Rheumatoid Arthritis

edited by David Fox and

James J. Moon

submission deadline 31 Oct 2025 | Viewed by 52 | Submission Open

Keywords: RA; synovium; FLS; synovial fluid; microbiome; autoimmunity; DMARD; joint inflammation; joint damage; nanoparticle

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Porous Polymers

edited by Bolin Ji

submission deadline 31 Oct 2025 | Viewed by 52 | Submission Open

Keywords: porous organic polymer; covalent organic framework; adsorption and separation of gases; energy storage materials; water treatment; antimicrobial; fluorescence imaging; tumor treatment

(This special issue belongs to the Section Materials Science)

Advances in Sex Hormones

edited by

Cheryl Anne Frye

submission deadline 31 Oct 2025 | Viewed by 51 | Submission Open

Keywords: neurosteroids; selective estrogen receptor β modulators (SERMs); selective androgen receptor modulators (SARMs); non-genomic; estriol; gut health; cardiovascular disease; stroke; lordosis; prostate; cognition; addiction; nutrition; oxytocin

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Computational and Molecular Advances in Precision Craniofacial Medicine

edited by

Hsiu-Hsia Lin

submission deadline 31 Oct 2025 | Viewed by 51 | Submission Open

Keywords: precision medicine; craniofacial anomalies; artificial intelligence; 3D morphometrics; genomics; transcriptomics; computational modeling; phenotype– genotype correlation; craniofacial surgery; tissue engineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Molecular Research in Plant Secondary Metabolism

edited by

Andrey Marchev

submission deadline 31 Oct 2025 | Viewed by 50 | Submission Open

Keywords: plants; plant in vitro systems; secondary metabolism; metabolite profiling and fingerprinting; sustainable production; elicitation; metabolic engineering; CRISPR/Cas; molecular targets

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Leukemia

edited by Juan Manuel Mejia-Arangure

submission deadline 31 Oct 2025 | Viewed by 49 | Submission Open

Keywords: leukemia; molecular biology; genetic testing; epigenomics; targeted therapy; precision medicine; diagnostic techniques; molecular pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Treatment in Gastrointestinal Cancers

edited by

Dani Ran Castillo

submission deadline 31 Oct 2025 | Viewed by 49 | Submission Open

Keywords: gastrointestinal cancers; tumor microenvironment; immune regulation; biomarkers; therapeutic resistance; liquid biopsy; targeted therapy; immune checkpoint inhibitors; epigenetic regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unveiling the Functional Microbiomes of the Ocean: From Genes to Ecosystem Services

edited by

Sergey Dobretsov

and

Daniel Rittschof

submission deadline 31 Oct 2025 | Viewed by 48 | Submission Open

Keywords: microbiome; symbiosis; community organization; functional diversity; communication; microbial functions; metagenomics; metabolomics; transcriptomics; proteomics; biogeochemical cycling; biofouling; ocean health; marine biotechnology; microbial ecology

(This special issue belongs to the Section Molecular Microbiology)

Fish and Amphibians: Exploring Genetic, Developmental, and Endocrine Mechanisms

edited by

Gad Degani

submission deadline 31 Oct 2025 | Viewed by 46 | Submission Open

Keywords: gene expression; fish physiology; amphibian development; endocrine regulation; comparative genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart

edited by

Ofer Binah

submission deadline 31 Oct 2025 | Viewed by 44 | Submission Open

Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1551-1600 on page 32 of 69.

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