Advances in Molecular Genetics of Head and Neck Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 2
Special Issue Editor
Interests: molecular diagnostics; molecular basis of diseases; cancer genetics and epigenetics; metabolomics; oncogenes and tumor suppressor genes
Special Issue Information
Dear Colleagues,
Head and neck cancer (HNC) encompasses a biologically and clinically diverse group of malignancies affecting the oral cavity, pharynx, and larynx. Despite advances in surgical techniques, radiotherapy, and systemic treatments, survival outcomes—particularly for advanced-stage disease—remain suboptimal. A more detailed understanding of the molecular and genetic drivers of HNC is critical to developing more effective and personalized therapeutic strategies.
This Special Issue focuses on recent advances in the molecular genetics of head and neck cancer. We invite original research articles and comprehensive reviews that explore the genetic and epigenetic alterations involved in HNC development and progression. Topics of interest include driver mutations, chromosomal instability, dysregulated signaling pathways, tumor suppressors, oncogenes, and non-coding RNAs.
We also welcome studies that employ next-generation sequencing, transcriptomics, or other multi-omics approaches to characterize tumor heterogeneity, identify molecular subtypes, and discover novel biomarkers for diagnosis, prognosis, or treatment response. Research that investigates the interaction between genetic alterations and the tumor microenvironment or mechanisms of therapy resistance is particularly encouraged.
By highlighting cutting-edge research in this field, this Special Issue aims to enhance our understanding of the molecular underpinnings of HNC and support the development of improved diagnostic tools and targeted treatments.
Dr. Jacek Kabziński
Guest Editor
Manuscript Submission Information
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Keywords
- head and neck cancer
- molecular genetics
- tumor heterogeneity
- driver mutations
- epigenetic alterations
- non-coding RNAs
- oncogenes and tumor suppressors
- gene expression profiling
- genomic instability
- biomarkers for diagnosis and therapy
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