Emerging Treatments in Aging-Related Cerebrovascular Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1197
Special Issue Editor
2. Experimental Research Center for Normal and Pathological Aging Director, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: ageing; cerebrovascular diseases; rehabilitation; cell therapies; genomics; proteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is a primary risk factor for cerebrovascular diseases (CVDs), including stroke and vascular dementia, which remain leading causes of disability and mortality worldwide. Recent advances in biomedical research have identified novel therapeutic tools targeting the underlying mechanisms of aging and vascular degeneration.
Author contributions include senolytic drugs that selectively eliminate senescent cells, gene editing technologies such as CRISPR/Cas9 that correct age-related genetic mutations, and RNA-based therapies for modulating inflammatory and metabolic pathways. Stem cell-based interventions, particularly those using induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs), show promise in promoting neurovascular repair and functional recovery post-stroke. Additionally, bioengineered nanocarriers and blood–brain barrier-permeable delivery systems have improved the precision and efficacy of drug administration to affected brain regions. Chronotherapy and circadian modulation are also emerging as tools to optimize treatment timing, aligning interventions with biological rhythms for enhanced outcomes. Together, these therapeutic innovations represent a paradigm shift toward personalized, regenerative, and preventive approaches in treating aging-related cerebrovascular diseases. Continued translational research and clinical trials are essential for fully realizing their potential and ensuring their safe, effective integration into clinical practice.
Prof. Dr. Aurel Popa-Wagner
Guest Editor
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Keywords
- aging
- cerebrovascular diseases
- therapeutic tools
- senolytic drugs
- gene editing technologies
- RNA-based therapies
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