Molecular Genetics in the Pathogenesis of Neurological Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 23
Special Issue Editor
Interests: neurogenerative diseases; spinocerebellar ataxia type 3; ataxia; target engagement; protein lowering therapy; genetic modifiers; molecular biomarkers
Special Issue Information
Dear Colleagues,
Over the last two to three decades, genetics has provided new insights into disease genes, risk loci, and genetic modifiers in neurological disorders, leading to the identification of causative genes but also describing changes in disease onset, disease progression, and/or clinical presentation. Accordingly, genetic discoveries are having a profound impact on our understanding of neurological disorders, revealing new levels of complexity. To date, genetics is still a dramatically growing field, incorporating new key technologies (such as long-read or single-cell sequencing technologies), which will ultimately lead to a transformation in our understanding of the genome and the genetic landscape. This will inspire novel diagnostic strategies and personalized medicine, as well as personalized treatment strategies, in neurological disorders.
In this Special Issue, we will focus on the latest developments in neurological and neurodegenerative disorders at the molecular genetic and biochemical research level. We aim to provide a comprehensive overview of the complexity of genetics in the cause and development but also the clinical presentation of neurological and neurodegenerative diseases. We invite researchers in the basic, advanced, and translational neurogenetic research fields or closely related disciplines to contribute original research articles or reviews to this Special Issue.
Dr. Jeannette Hübener-Schmid
Guest Editor
Manuscript Submission Information
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Keywords
- ataxia
- genetic modifier
- genetic landscape
- genomics
- long-read sequencing
- neurodegeneration
- personalized medicine
- personalized treatmen
- polymorphisms
- single cell sequencing
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