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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Photophysics and Photochemistry in Biological Molecules

edited by

María Alicia Biasutti

submission deadline 31 Aug 2026 | Viewed by 526 | Submission Open

Keywords: photochemistry; photodegradation; Reactive Oxygen Species (ROS); emerging contaminants; bioremediation; biomolecules; carotenoids; enzymes; fatty acids; DNA; RNA; photodynamic therapy; fluorescence; photosynthesis; phototoxicity; photosensitizers

(This special issue belongs to the Section Biochemistry)

Exploring the New Cancer Biomarkers: Progress and Prospects

edited by

Marcelo José Barbosa Silva

submission deadline 31 Aug 2026 | Viewed by 523 | Submission Open

Keywords: prevention; diagnostic; prognostic; response; liquid biopsy; image biomarkers; clinicopathological biomarkers

(This special issue belongs to the Section Molecular Oncology)

Precision Medicine in Cancer: Biomarker and Bioinformatics Research

edited by

Youping Deng

and

Shaoqiu Chen

submission deadline 31 Aug 2026 | 1 articles | Viewed by 516 | Submission Open

Keywords: precision medicine; cancer biomarkers; bioinformatics; multi-omics; machine learning; tumor heterogeneity

(This special issue belongs to the Section Molecular Informatics)

Plant Extracts and Bioactive Molecules with Potential Benefits for Human Health—2nd Edition

edited by

Violeta Popovici

and

Cerasela Elena Gîrd

submission deadline 31 Aug 2026 | Viewed by 508 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive phytocompound identification and quantification; pharmacological activity; health benefits; phytotherapy; plant-based diet; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Animal Reproduction and Development: Current Issues and Future Perspectives

edited by

Kamil Janelt

submission deadline 31 Aug 2026 | 1 articles | Viewed by 492 | Submission Open

Keywords: reproductive and developmental biology; molecular and cellular mechanisms; gene regulation and epigenetics; physiology and metabolic regulation; biotechnology and translational research

(This special issue belongs to the Section Molecular Biology)

Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy

edited by

Dominique Delmas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 491 | Submission Open

Keywords: lipid metabolism; degenerative diseases; cardiovascular pathologies; neurodegeneration; inflammation; autoimmunity; cancer; lipid droplets; bioactive molecules; drug repositioning; oxidative stress; mitochondrial dysfunction; inflammatory processes

(This special issue belongs to the Section Biochemistry)

Medicinal Plants: Molecular Dissection of Active Compounds

edited by

Moxian Chen

and

Abazar Ghorbani

submission deadline 31 Aug 2026 | 1 articles | Viewed by 469 | Submission Open

Keywords: medicinal plants; active compounds; secondary metabolites; biosynthetic pathways; metabolic regulation; terpenoids; flavonoids; multi-omics; metabolic engineering; bioactivity

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers, 4rd Edition

edited by

Andrzej Kutner

Geoffrey Brown

and Enikö Kallay

submission deadline 31 Aug 2026 | Viewed by 461 | Submission Open

Keywords: drug design and discovery antimicrobial drugs; antiviral drugs; antibiotics; cancer prevention and treatment molecular modeling; molecular mechanisms; crystallography preclinical studies; pharmacokinetics; pharmacodynamics; pharmacognosy drug-protein interactions nuclear receptors; receptor agonists and antagonists; stem cells; activity profiling; vaccines; markers; and diagnostics drug carriers; dosage form; anti-crystal engineering; nanoparticles; dissolution testing

(This special issue belongs to the Section Molecular Pharmacology)

New Insights in Microalgae and Cyanobacteria-Derived Bioactive Compounds

edited by

Tarik Aanniz

submission deadline 31 Aug 2026 | 1 articles | Viewed by 455 | Submission Open

Keywords: microalgal bioactive compounds; cyanobacterial bioactive compounds; mechanisms of action; structure–activity relationship; antimicrobial activity; anti-inflammatory agents; anticancer compounds; neuroprotective agents; nutraceuticals; therapeutic applications; biotechnological production

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research Trends on Enzyme Structure, Dynamics, and Mechanisms of Action

edited by

Amarendra Nath Maity

submission deadline 31 Aug 2026 | 1 articles | Viewed by 454 | Submission Open

Keywords: enzyme mechanism; enzyme dynamics; metalloenzymes; cofactor; X-ray crystallography; cryo-electron microscopy; QM/MM; DFT; EPR; drug target

(This special issue belongs to the Section Biochemistry)

Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery

edited by

Betty Revon Liu

submission deadline 31 Aug 2026 | Viewed by 439 | Submission Open

Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Oral and Esophageal Disorders: Molecular Induction/Promotion, Treatment, and Prevention

edited by

Takanobu Takata

submission deadline 31 Aug 2026 | 1 articles | Viewed by 435 | Submission Open

Keywords: oral disorders; esophageal disorders; stomatitis; esophagitis; lifestyle-related diseases; advanced glycation-end products; modern European medicines; traditional medicines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Depression: From Molecular Basis to Therapy—3rd Edition

edited by

Terezia Kiskova-Simkova

submission deadline 31 Aug 2026 | Viewed by 414 | Submission Open

Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Translational Research on Late-Life Cognitive and Neuropsychiatric Disorders

edited by

Ioannis Liampas

submission deadline 31 Aug 2026 | Viewed by 413 | Submission Open

Keywords: dementia; Alzheimer’s disease; mild cognitive impairment; mild behavioral impairment; movement disorders; Parkinson’s disease; biomarkers; neurogenetics; molecular research

(This special issue belongs to the Section Molecular Neurobiology)

Innovations in Avian Reproduction: From Basic Science to Application

edited by

Ali Aygun

submission deadline 31 Aug 2026 | Viewed by 396 | Submission Open

Keywords: avian reproduction; reproductive physiology and technologies; incubation management; embryonic development; genetic approaches in reproduction; candidates genes of reproduction; nutrition and reproduction; genetic regulation of reproduction traits; GWAS in reproduction; avian sperm cryopreservation

(This special issue belongs to the Section Molecular Biology)

Recent Molecular Insights into Alzheimer's Disease

edited by

Giulia Sita

submission deadline 31 Aug 2026 | Viewed by 393 | Submission Open

Keywords: neurodegeneration; neuroprotection; pharmacology; toxicology; Alzheimer’s disease; neuroinflammation; aging

(This special issue belongs to the Section Molecular Neurobiology)

Antioxidants and Redox Biomarkers: Beneficial and Harmful Effects on Human Health

edited by

Ramona D'Amico

submission deadline 31 Aug 2026 | Viewed by 384 | Submission Open

Keywords: antioxidants; redox homeostasis; oxidative stress; redox biomarkers; redox balance; molecular pathways; human health

(This special issue belongs to the Section Molecular Biology)

From Tryptophan to Circadian and Neurochemical Regulators: The Serotonin-Melatonin Pathway

edited by

Anna Cieslinska

submission deadline 31 Aug 2026 | Viewed by 379 | Submission Open

Keywords: tryptophan metabolism; serotonin; melatonin; indoleamines; circadian rhythm; neurotransmission; metabolites; gut–brain axis; chronobiology; metabolomics

(This special issue belongs to the Section Molecular Biology)

The Role of Endocrine Disruptors in Cancer

edited by Andrea Randi

submission deadline 31 Aug 2026 | Viewed by 374 | Submission Open

Keywords: endocrine disruptors; cancer; chronic exposure; cell proliferation; cancer progression; signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Precision Medicine in Cancer: Organoid Models and Integrated Omics Profiling

edited by Gavin Robert Oliver and Carlton C Barnett

submission deadline 31 Aug 2026 | Viewed by 370 | Submission Open

Keywords: organoids; rare cancer; new approach methodologies; oncology; precision medicine; functional precision medicine; multiomics; genomics; transcriptomics; epigenomics

(This special issue belongs to the Section Molecular Oncology)

Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges

edited by

Alessandra Micera

and

Filippo Biamonte

submission deadline 31 Aug 2026 | Viewed by 358 | Submission Open

Keywords: gut microbiota; brain; eye diseases; neuroinflammation; neurodegeneration; chronic inflammation; chronic pain; probiotics; gastrointestinal disorders; metabolic diseases; machine learning; artificial intelligence

(This special issue belongs to the Section Molecular Neurobiology)

Current Challenges and Emerging Opportunities in Breast Cancer Immunotherapy

edited by María Florencia Mercogliano

submission deadline 31 Aug 2026 | Viewed by 354 | Submission Open

Keywords: breast cancer; tumor microenvironment; immunotherapy; immune evasion; therapy resistance; immune modulation; immune checkpoint inhibitors; antibody–drug conjugates; biomarkers, cell-based therapies

(This special issue belongs to the Section Molecular Immunology)

Traumatic Brain Injury and Alzheimer's Disease: From Pathogenesis to Therapy

edited by

Dimitrios Kanakis

submission deadline 31 Aug 2026 | Viewed by 350 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD); neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Nutrition from Cereal Foods: Molecular Perspectives

edited by

Yakindra Timilsena

submission deadline 31 Aug 2026 | Viewed by 346 | Submission Open

Keywords: cereal nutrition; molecular bioavailability; plant proteins; foodomics; grain processing; bioactive compounds; gut microbiome; nutraceuticals; food matrices; sustainable foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application of Metabolomics in Health and Human Diseases: Diagnostic, Therapeutic, Nutritional and Nutraceutical Perspectives

edited by

Barbara Tomasello

and Francesco Bellia

submission deadline 31 Aug 2026 | Viewed by 344 | Submission Open

Keywords: metabolomics; metabolomic profile biomarkers; preclinical studies; clinical studies; drug and nutraeuticals biological activities; precision medicine; personalized medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Transcription Factors and Chromatin Modifiers in Gene Regulation

edited by Takashi Ito

submission deadline 31 Aug 2026 | Viewed by 339 | Submission Open

Keywords: transcription; chromatin; epigenetics; enhancers; promoters; histone modification; gene expression; regulatory complexes; nuclear organization; cell fate regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mechanisms and Pathways of Actions for Nutritional Effects on Brain Health

edited by

Fahimeh Martami

submission deadline 31 Aug 2026 | Viewed by 318 | Submission Open

Keywords: brain health; neuroplasticity; neurotransmission; neuroinflammation; oxidative stress; brain metabolism

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Infection Immunology

edited by

Arturo Contis-Montes De Oca

submission deadline 31 Aug 2026 | Viewed by 311 | Submission Open

Keywords: neuro-infection; innate immunity; immunopathology; microbiome-immune axis; chronic in-flammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Placental Function and Pregnancy Complications

edited by Jezid Miranda

submission deadline 31 Aug 2026 | Viewed by 310 | Submission Open

Keywords: placental biology; pregnancy complications; preeclampsia; fetal growth restriction; angiogenic markers; maternal–fetal immunity; fetal growth; trophoblast; implementation; precision obstetrics; maternal mortality

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Updates on Oral Potentially Malignant Disorders: From Pathogenesis to Treatment

edited by

Takahiro Abe

submission deadline 31 Aug 2026 | Viewed by 308 | Submission Open

Keywords: oral potentially malignant disorders; oral leukoplakia; oral erythroplakia; oral lichen planus/oral lichenoid lesions; oral submucous fibrosis; oral epithelial dysplasia; malignant transformation risk; biomarkers; imaging/diagnostic support; genomic or epigenomic factor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometriosis: Contemporary Insights and Emerging Perspectives

edited by

Márcia Mendonça Carneiro

submission deadline 31 Aug 2026 | Viewed by 306 | Submission Open

Keywords: endometrisis; infertility; chronic pelvic pain

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Heterocyclic Compounds: Synthesis, Design, and Biological Activity—2nd Edition

edited by

Josef Jampilek

submission deadline 31 Aug 2026 | Viewed by 306 | Submission Open

Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms in Cardiovascular and Metabolic Diseases: Effective and Potential Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 31 Aug 2026 | Viewed by 305 | Submission Open

Keywords: molecular mechanisms; cardiovascular diseases; metabolic diseases; microRNAs; circRNAs; long non-coding RNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural-Derived Bioactive Compounds in Disease Treatment, 2nd Edition

edited by

Marilena Gilca

and

Adelina Vlad

submission deadline 31 Aug 2026 | Viewed by 297 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advancements in Cancer Immunotherapy

edited by

Pritam Sadhukhan

submission deadline 31 Aug 2026 | Viewed by 296 | Submission Open

Keywords: immune checkpoint inhibitor; PD-1 inhibitor; PDL-1 inhibitor; CTLA-4 inhibitor; B7H3 inhibitors; CAR-T cell therapy; nanotechnology in immunotherapy; tumor microenvironment remodeling

(This special issue belongs to the Section Molecular Oncology)

Immune Responses as the Central Determinant of Gene Therapy Outcomes

edited by

Manoj Pandey

submission deadline 31 Aug 2026 | Viewed by 295 | Submission Open

Keywords: innate and adaptive immune sensing; TLR signaling; complement activation; antigen presentation; T‑cell cytotoxicity; humoral immunity (IgG, IgM, IgA); pediatric immunology; rare disease; lysosomal storage disease; neuroinflammation; immunomodulatory therapies; complement inhibitors

(This special issue belongs to the Section Molecular Immunology)

Advances in Calcium Signaling: Physiological Roles and Implications for Disease

edited by

Adán Dagnino-Acosta

and

Luis Castro-Sánchez

submission deadline 31 Aug 2026 | Viewed by 290 | Submission Open

Keywords: calcium signaling; intracellular calcium; calcium homeostasis; calcium channels; muscle physiology; signal transduction; calcium-related diseases; mitochondrial calcium; genetic control of calcium signaling

(This special issue belongs to the Section Molecular Biology)

Emerging Biomarkers in Airway Diseases: From Epigenetic Regulation to Cellular Stress Pathways

edited by

Giusy Daniela Albano

submission deadline 31 Aug 2026 | Viewed by 288 | Submission Open

Keywords: airway diseases; asthma; chronic obstructive pulmonary disease; chronic rhinosinusitis; virus-associated airway disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases: 2nd Edition

edited by

Niels Schaft

submission deadline 31 Aug 2026 | Viewed by 286 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

DNA Damage and Repair Mechanisms in Cancer Development

edited by

Mengfan Tang

submission deadline 31 Aug 2026 | Viewed by 279 | Submission Open

Keywords: DNA damage response and repair; DNA replication; genome instability; drug resistance; targeted therapy; cellular senescence; innate immunity; nucleic acid homeostasis

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Advanced Diagnostic Technologies in Hair Disorders

edited by Maria Fernanda Reis Gavazzoni-Dias

submission deadline 31 Aug 2026 | Viewed by 277 | Submission Open

Keywords: inflammatory hair disorders; scarring and non-scarring alopecias; trichoscopy and scalp pathology; immunologic mechanisms in hair loss

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibiotic Resistance: Recent Developments and Future Prospects

edited by

Awais Ghaffar

submission deadline 31 Aug 2026 | Viewed by 275 | Submission Open

Keywords: antimicrobial resistance detection; microbial ecology; shotgun metagenomics; genome-resolved metagenomics; microbiome analysis; resistome characterization; One Health

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Neuropharmacology: From Molecular Design to Preclinical Models

edited by

Jana Tchekalarova

and Miroslav A. Rangelov

submission deadline 31 Aug 2026 | Viewed by 273 | Submission Open

Keywords: neuropharmacology; drug discovery; molecular modeling; preclinical models

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Schwannomas: So-Called Benign Nervous System Tumors

edited by Sheila Mansouri

submission deadline 31 Aug 2026 | Viewed by 271 | Submission Open

Keywords: schwannoma; omics technology; liquid biopsy; tumour imaging; artificial intelligence; cell biology; tumour microenvironment; model organisms; organoids

(This special issue belongs to the Section Molecular Oncology)

Gut Microbiota and Host Immune Interactions in Inflammatory Diseases

edited by

Tomomi Kuwahara

submission deadline 31 Aug 2026 | Viewed by 271 | Submission Open

Keywords: gut microbiota; host–microbe interactions; innate and adaptive immunity; microbial metabolites; short-chain fatty acids; intestinal dysbiosis; inflammatory bowel disease (IBD); metabolic syndrome; autoimmune diseases; gut–organ axis; microbiome-targeted therapies

(This special issue belongs to the Section Molecular Microbiology)

Research on Genomics of Crop Stress Tolerance

edited by

Xi Zhu

submission deadline 31 Aug 2026 | Viewed by 269 | Submission Open

Keywords: crop stress tolerance; genomic research; molecular mechanisms; multi-omics approaches; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research on Host–Oral Bacteria Interactions in Periodontal Pathogenesis

edited by

Ana María Fernández Presas

submission deadline 31 Aug 2026 | Viewed by 269 | Submission Open

Keywords: periodontitis; Porphyromonas gingivalis; biofilms; cytokines; dysbiosis; quorum sensing; gingipains; alveolar bone therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Impact of Maternal Diet and Nutrition on Infant Neurodevelopment

edited by

Ana Sofia Vallés

submission deadline 31 Aug 2026 | Viewed by 260 | Submission Open

Keywords: nutrition; neurodevelopment; molecular mechanisms; epigenetics; neuroinflammation; metabolic programming; brain development; developmental origins of health and disease; pregnancy; maternal diet

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research in Cannabinoid Therapeutics: Novel Insights and Products

edited by

Daniela Sedan

and Dario Andrinolo

submission deadline 31 Aug 2026 | Viewed by 257 | Submission Open

Keywords: cannabinoids; acidic cannabinoids; entourage effect; full spectrum; endocannabinoid system; endocannabinoidome; endocannabinoids; endocannabinoid-like compounds; cannabis derivatives; endocannabinoidome receptors

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Starch-Based Composite Systems

edited by

Angel H. Cabrera-Ramirez

submission deadline 31 Aug 2026 | Viewed by 256 | Submission Open

Keywords: starch-based composites; biopolymer materials; hydrogels and aerogels; controlled release systems; biodegradable packaging; nanocomposites; structure–property relationships; functional biomaterials; pharmaceutical excipients; sustainable materials

(This special issue belongs to the Section Macromolecules)

Displaying special issue 551-600 on page 12 of 64.

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