Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editors
Interests: Neuromediators; Ocular Diseases; Biomarkers; Epigenetics; Genetic Variants
Special Issues, Collections and Topics in MDPI journals
Interests: Neurodegeneration; Cerebellum; Testosterone; Cell Migration; Immunohistochemistry; Cellular Neuroscience Molecular Neurobiology; Neural Plasticity; Steroids; Brain; Estrogens; Neuroscience; Biochemistry Stereology; Neurobiology; Nutritional medicine.
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
This Special Issue will explore the emerging role of the intestinal microbiota in modulating the brain–eye axis, examining both healthy conditions and the context of chronic neuroinflammatory and neurodegenerative disorders. We will highlight recent advances in the identification of molecular and biochemical markers and targets across these systems, with a particular emphasis on the expression of gene variants, proteins, and transcripts, as well as on the non-coding long and short RNAs involved in the signal pathway activation and receptor signaling.
Special attention will be given to the integration of artificial intelligence and machine learning approaches in differential diagnostics. These tools have the potential to support personalized medicine by identifying the most effective microbiota-driven interventions based on individual profiles.
Finally, this collection will present innovative therapeutic stragtegies informed by microbiota research, paving the way for improved diagnostic precision and better patient outcomes in neurological diseases.
Dr. Alessandra Micera
Dr. Filippo Biamonte
Guest Editors
Manuscript Submission Information
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Keywords
- gut microbiota
- brain
- eye diseases
- neuroinflammation
- neurodegeneration
- chronic inflammation
- chronic pain
- probiotics
- gastrointestinal disorders
- metabolic diseases
- machine learning
- artificial intelligence
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