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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Fibrinolytic Factors in Disease
edited by
submission deadline 20 May 2026 | Viewed by 541 | Submission Open
Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1
(This special issue belongs to the Section Molecular Biology)
X-Linked Disorders: Epigenetic and Environmental Modulation of Phenotypes
edited by Yoram Chaiter and
submission deadline 20 May 2026 | Viewed by 529 | Submission Open
Keywords: X-linked disorders; epigenetics; environmental factors; gene expression; clinical manifestations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neuropeptides in Brain Health and Disease: From Molecular Mechanisms to Therapeutic Potential submission deadline 20 May 2026 | 1 articles | Viewed by 483 | Submission Open
Keywords: neuropeptides; brain function; neuroinflammation; regeneration; neurodegeneration; biomarkers; therapy; CNS; brain disorders; demyelination
(This special issue belongs to the Section Molecular Neurobiology)
Recent Advances in the Biological Function of Tyrosinase
edited by
submission deadline 20 May 2026 | Viewed by 467 | Submission Open
Keywords: tyrosinase-related proteins; tyrosinase; melanogenesis; copper; zinc; metal enzymes; tyrosinase inhibitor; pigmentation disorders
(This special issue belongs to the Section Molecular Biology)
Natural Product as Therapeutic Agent: From Molecular Targets to Cellular and Functional Modulation
edited by Su-Yun Lyu
submission deadline 20 May 2026 | 1 articles | Viewed by 466 | Submission Open
Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Potential New Antidepressant Drugs submission deadline 20 May 2026 | Viewed by 461 | Submission Open
Keywords: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems (serotonin; norepinephrine; dopamine); preclinical research (in vitro; in vivo; in silico); psychiatric disorders
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Defects of Naturally Occurring Mutations
edited by Ya-Xiong Tao
submission deadline 20 May 2026 | Viewed by 452 | Submission Open
Keywords: protein misfolding; loss of function; gain of function; pharmacological chaperone; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Interfaces for the Impact of Magnetic Pulses or EMF in Molecular Biology
edited by Richard H. W. Funk
submission deadline 20 May 2026 | Viewed by 436 | Submission Open
Keywords: electromagnetic treatment; magnetic pulses; biological interface; cell biology; molecular biology; signaling cascades; clinical treatment; monitoring; sensors
(This special issue belongs to the Section Molecular Biophysics)
Antituberculous Drugs: Progress and Challenges
edited by Ana Maria Telmo Dias Pereira Vicente Cabral and
submission deadline 20 May 2026 | Viewed by 423 | Submission Open
Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
Cardiomyopathy: From Molecular Pathology to Treatment submission deadline 20 May 2026 | Viewed by 419 | Submission Open
Keywords: obesity; myocardial fibrosis; subclinical myocardial dysfunction; fibrotic remodeling; microRNAs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathogenesis and Treatment of Prostate Cancer submission deadline 20 May 2026 | Viewed by 386 | Submission Open
Keywords: prostate cancer; pathogenesis; genetic mutations; target therapy; surgery; radiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Neurofibromatosis Type 1: From Molecular Insights to Novel Therapies
edited by László Szabó and
submission deadline 20 May 2026 | Viewed by 383 | Submission Open
Keywords: neurofibromatosis type 1; genotype– phenotype analyses; molecular pathogenesis; next-generation sequencing (NGS); molecular targeted therapy; MEK inhibitors; imaging studies
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Understanding Respiratory Virus–Host Interactions
edited by Kun Li
submission deadline 20 May 2026 | Viewed by 359 | Submission Open
Keywords: respiratory viruses; virus– host interactions; molecular mechanisms; viral replication; host– immune response; molecular pathogenesis; molecular signaling; antiviral strategies
(This special issue belongs to the Section Molecular Microbiology)
Molecular Targets and Mechanisms of Innovative Therapies and Natural Adjuvants in Glioblastoma Management
edited by and Fabrizio De Luca
submission deadline 20 May 2026 | Viewed by 357 | Submission Open
Keywords: glioblastoma; targeted therapy; traditional and emerging therapies; signaling pathways; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Advanced Research in Nanophotonics and Biophotonics
edited by
submission deadline 20 May 2026 | Viewed by 351 | Submission Open
Keywords: biophotonics; spectroscopy; light scattering; Raman/FTIR; cancer; Alzheimer's and Parkinson’ s diseases; nanophotonics; plasmonics; nano-biophotonics
(This special issue belongs to the Section Molecular Nanoscience)
The Gene, Genomics, and Molecular Breeding in Cruciferae Plants (3rd Edition)
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 348 | Submission Open
Keywords: Cruciferae plants; genome analysis; genetic dissection; gene function; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Antimicrobial Agents: Mechanisms and Applications submission deadline 20 May 2026 | Viewed by 342 | Submission Open
Keywords: antimicrobial compounds; antibacterial activity; antibiotic resistance; pathogen-tailored therapeutic targeting; novel antimicrobials; molecular aspects of the mechanisms of action of antibacterial substances; effectiveness of antibacterial substances
(This special issue belongs to the Section Biochemistry)
New Advances in Reproductive Immunology and Pathology
edited by Silvia Giugliano
submission deadline 20 May 2026 | Viewed by 341 | Submission Open
Keywords: maternal– fetal immune tolerance; reproductive immunopathology; cytokine signaling in pregnancy; immune-related infertility; metabolome-immune crosstalk; microbiome influence on fertility
(This special issue belongs to the Section Molecular Immunology)
Advanced Research on Comparative Reproductive Physiology submission deadline 20 May 2026 | Viewed by 337 | Submission Open
Keywords: andrology; sperm; oocyte; gamete interactions; reproductive morphology; reproductive endocrinology; omics; epigenetics; pregnancy; all animal species
(This special issue belongs to the Section Molecular Biology)
Microbiome in Cancer: From Pathogenesis to Therapeutic Innovation submission deadline 20 May 2026 | Viewed by 327 | Submission Open
Keywords: microbiome; cancer; anticancer drugs; chemoresistance; immune modulation
(This special issue belongs to the Section Molecular Microbiology)
Heterocyclic Compounds: Molecular Modelling Studies and Pharmacological Investigation submission deadline 20 May 2026 | Viewed by 318 | Submission Open
Keywords: heterocycles; fused heteocycles; synthesis; small-molecules; natural product; drug design; biological studies; molecular modeling
(This special issue belongs to the Section Biochemistry)
Crosstalk Between Bioactive Compounds and Disease
edited by
submission deadline 20 May 2026 | Viewed by 308 | Submission Open
Keywords: bioactive compounds; human health; omics technologies; nanotechnology; drug development
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms Linked to Exercise
edited by Igor Zubrzycki
submission deadline 20 May 2026 | Viewed by 298 | Submission Open
Keywords: molecular mechanisms; exercise adaptations; translational health
(This special issue belongs to the Section Molecular Biology)
Targeted Protein Degradation: From Molecular Mechanisms to Therapeutic Applications
edited by
submission deadline 20 May 2026 | Viewed by 288 | Submission Open
Keywords: targeted protein degradation; ubiquitin– proteasome system; PROTAC; drug design; medicinal chemistry
(This special issue belongs to the Section Molecular Pharmacology)
Latest Molecular Advances in Prostate Cancer
edited by Rejane Maira Góes
submission deadline 20 May 2026 | Viewed by 287 | Submission Open
Keywords: prostate cancer; androgen signaling; metabolic reprogramming; tumor microenvironment; inflammation; immunotherapy; chemoprotection; phytotherapy
(This special issue belongs to the Section Molecular Oncology)
Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders
edited by
submission deadline 20 May 2026 | Viewed by 275 | Submission Open
Keywords: blood– brain barrier; neurodegenerative diseases; Alzheimer’ s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow
(This special issue belongs to the Section Molecular Neurobiology)
AI and Machine Learning in Molecular Biomarker Discovery and Mechanisms of Neurodegenerative Disorders submission deadline 20 May 2026 | Viewed by 273 | Submission Open
Keywords: artificial intelligence (AI); machine learning (ML); biomarker discovery; neurodegenerative disorders; Alzheimer’ s disease (AD); Parkinson’ s disease (PD); dementia; risk prediction models; multi-omics integration; translational bioinformatics
(This special issue belongs to the Section Molecular Neurobiology)
mRNA/miRNAs Network in Diabetes and Its Complications
edited by
submission deadline 20 May 2026 | Viewed by 260 | Submission Open
Keywords: RNA/miRNAs; exosomes; regenerative medicine; translational medicine; adipose tissue biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Application of Hyaluronan in Tissue Healing submission deadline 20 May 2026 | Viewed by 257 | Submission Open
Keywords: wound healing; inflammation; remodeling; chronic wound; wound dressing; scar tissue; sound tissue; biomarkers; chemical modification; crosslinked; biopolymer; biological activity
(This special issue belongs to the Section Macromolecules)
Gut–Brain Axis: Pathophysiological Mechanisms in Neurological Disorders and Metabolic Diseases
edited by
submission deadline 20 May 2026 | Viewed by 257 | Submission Open
Keywords: gut– brain axis; intestinal microbiota; mood diseases; immune system; microbial molecules; behavior; metabolic diseases; signaling pathways; inflammation; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Ataxia submission deadline 20 May 2026 | Viewed by 247 | Submission Open
Keywords: ataxia; molecular mechanisms; repeat expansion disorders; gene discovery; biomarkers; RNA biology; protein aggregation; epigenetics; gene therapy; neurodegeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Effects of Radiation on Human Cells and Tissues submission deadline 20 May 2026 | Viewed by 244 | Submission Open
Keywords: radiation exposure; molecular pathways; inflammation; immune response; biochemical markers; electromagnetic hypersensitivity
(This special issue belongs to the Section Molecular Biology)
Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton
edited by
submission deadline 20 May 2026 | Viewed by 239 | Submission Open
Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane– protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling
(This special issue belongs to the Section Molecular Biology)
ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy
edited by Ilaria Marrocco and
submission deadline 20 May 2026 | Viewed by 238 | Submission Open
Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Male Infertility and Fertility submission deadline 20 May 2026 | Viewed by 231 | Submission Open
Keywords: male infertility; infertility treatment; omics approaches; proteomics; metabolomics; lipidomics; mass spectrometry; signaling pathways; biomarker discovery; reproductive medicine; precision medicine; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Glyco-Based Anticancer Agents
edited by Pedro Colinas
submission deadline 20 May 2026 | Viewed by 226 | Submission Open
Keywords: carbohydrates; cancer; Warburg effect; glycolysis; enzyme inhibitors; transporters inhibitors; docking simulations; tumor microenvironment
(This special issue belongs to the Section Biochemistry)
Role of Nanomaterials in Plant Metabolism
edited by
submission deadline 20 May 2026 | Viewed by 222 | Submission Open
Keywords: nanoparticles; nanomaterials; abiotic stress; photosynthesis; chlorophyll fluorescence; signal molecules; antioxidant activity; chlorophyll fluorescence; photosynthetic machinery; reactive oxygen species; thylakoid membranes; signal molecules; physiological and stressful conditions; plant metabolism
(This special issue belongs to the Section Molecular Nanoscience)
Perineuronal Nets and Fear Memories Erasure: State of the Art and Future Directions
edited by
submission deadline 20 May 2026 | Viewed by 220 | Submission Open
Keywords: perineuronal nets (PNNs); extracellular matrix (ECM); fear erasure; traumatic memories; PTSD; translation research; clinical treatment; therapeutical strategies
(This special issue belongs to the Section Molecular Neurobiology)
Autophagy and Apoptosis in Mammal Cells
edited by Kaja Urbańska and Anna Litwiniuk
submission deadline 20 May 2026 | Viewed by 214 | Submission Open
Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death
(This special issue belongs to the Section Molecular Biology)
Molecular Perspectives in Tissue Engineering and Regenerative Medicine
edited by
submission deadline 20 May 2026 | Viewed by 213 | Submission Open
Keywords: 3D scaffolds; personalized regenerative therapies; tissue engineering; stem cells; bone regeneration; regenerative biomarkers; cell– scaffold interactions; nanomaterials
(This special issue belongs to the Section Molecular Biology)
T Cell Malignancies: Translating Basic Research into Better Therapy submission deadline 20 May 2026 | Viewed by 212 | Submission Open
Keywords: T-Cell malignancies; specific target antigens; gene-targeted therapies
(This special issue belongs to the Section Molecular Oncology)
Omics Approaches to Unravel Plant Responses to Habitat Stresses
edited by
submission deadline 20 May 2026 | Viewed by 209 | Submission Open
Keywords: omics; multi-omics; high-throughput technologies; biotic stress; abiotic stress; environmental stress; crosstalk; translational biology; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Progress in Nanomedicine for Cancer Therapy
edited by Peisheng Xu
submission deadline 20 May 2026 | Viewed by 204 | Submission Open
Keywords: nanomedicine; cancer-targeted therapy; theragnostic; nanodevice
(This special issue belongs to the Section Molecular Nanoscience)
Effects of the Environmental Conditions on Bacterial Growth and Functions
edited by
submission deadline 20 May 2026 | Viewed by 204 | Submission Open
Keywords: bacterial growth; growth conditions; gene expression; bioproducts; biofilm; resistance; population dynamics
(This special issue belongs to the Section Molecular Microbiology)
Latest Research in Neuroinflammation
edited by Reza Khorooshi
submission deadline 20 May 2026 | Viewed by 201 | Submission Open
Keywords: neuroinflammation; central nervous system disorders; neuroimmune interactions; inflammation and neurodegeneration; therapeutic strategies in neurology
(This special issue belongs to the Section Molecular Neurobiology)
The Role of miRNAs in Healthy Lungs and Chronic Lung Diseases
edited by Victor Ruiz
submission deadline 20 May 2026 | Viewed by 199 | Submission Open
Keywords: miRNA; DROSHA; DICER; DGCR8; ADAR; pulmonary fibrosis; COPD; asthma; lung neoplasm
(This special issue belongs to the Section Molecular Biology)
Current and Emerging Therapeutic Approaches for MASLD
edited by
submission deadline 20 May 2026 | Viewed by 198 | Submission Open
Keywords: MASLD; MASH; GLP-1 agonists; anti-inflammatory agents; anti-obesity drugs; FGF-21
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomic and Molecular Insights into Emerging and Reemerging Pathogens
edited by
submission deadline 20 May 2026 | Viewed by 197 | Submission Open
Keywords: pathogens genomic analysis; evolution transmission dynamics; pathogenic mechanisms; viruses; bacteria; fungi; parasites; next-generation sequencing; metagenomics; bioinformatics; genetic variations; adaptive mutations; host– pathogen interactions; emerging pathogens; molecular epidemiology; host immune responses; pathogen genetics
(This special issue belongs to the Section Molecular Immunology)
Advances in Plant-Derived Nanomaterials: From Molecular Mechanisms to Biofortification
edited by
submission deadline 20 May 2026 | Viewed by 195 | Submission Open
Keywords: nanotechnology; green synthesis; sustainable nanomaterials; nano– bio interactions; crop production; plant-based solutions; bio-corona
(This special issue belongs to the Section Molecular Plant Sciences)
Drug and Non-Drug Treatment of Cerebral Diseases
edited by
submission deadline 20 May 2026 | Viewed by 189 | Submission Open
Keywords: cerebral diseases; cerebral ischemia; neonatal hypoxic-ischemic encephalopathy (HIE); neuroprotection; therapeutic hypothermia; neurorehabilitation; oxidative stress; stem cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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