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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Regulation of Plant Growth and Protection (2nd Edition)
edited by and
submission deadline 30 Jun 2026 | Viewed by 194 | Submission Open
Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Molecular Genetics and Molecular Therapy for Gastric Cancers
edited by
submission deadline 30 Jun 2026 | Viewed by 168 | Submission Open
Keywords: gastric cancer; molecular genetics; targeted therapy; tumor microenvironment; immunotherapy; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials and Nanotechnology in Cancer Therapy and Regenerative Medicine
edited by Manoochehr Rasekh
submission deadline 30 Jun 2026 | Viewed by 152 | Submission Open
Keywords: biomaterials; nanoparticle drug delivery; cancer therapy; stimuli-responsive nanocarriers; targeted therapeutics; regenerative medicine; tissue engineering; theranostics
(This special issue belongs to the Section Materials Science)
Nanodrug Bioavailability and Biocompatibility in Cancer and CNS Disorders submission deadline 30 Jun 2026 | Viewed by 146 | Submission Open
Keywords: nanomedicine; bioavailability; biocompatibility; tumor microenvironment; Blood– Brain Barrier; targeted drug delivery; neurodegenerative diseases
(This special issue belongs to the Section Molecular Nanoscience)
Unraveling Neurodevelopmental Disorders: A Molecular Perspective
edited by Marija-Magdalena Petrinovic
submission deadline 30 Jun 2026 | Viewed by 99 | Submission Open
Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanism and Therapeutics in Human Cancer
edited by
submission deadline 30 Jun 2026 | Viewed by 96 | Submission Open
Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer
(This special issue belongs to the Section Molecular Oncology)
From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities
edited by and Beata Marciniak
submission deadline 30 Jun 2026 | Viewed by 94 | Submission Open
Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets
(This special issue belongs to the Section Molecular Biology)
Molecular Discoveries in Pharmacogenetics: From Bench to Bedside submission deadline 30 Jun 2026 | Viewed by 88 | Submission Open
Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Human Liver Diseases: 3rd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 86 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); alcoholic steatohepatitis (ASH); Wilson’ s disease; hemochromatosis; viral hepatitis; autoimmune hepatitis; hepatocellular carcinoma; signaling pathways; molecular mechanisms; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitigating Metal Toxicity: Contaminated Environment, Animal Studies and Human Health submission deadline 30 Jun 2026 | Viewed by 81 | Submission Open
Keywords: heavy metal toxicity; heavy metal pollution; heavy metal bioaccumulation and interactions; health risk; mechanistic analysis; dysregulation of cellular homeostasis; natural plant bioactive compounds; human diseases; environmental pollution; in vitro/animal studies; innovative strategies; polyoxometalates (POMs); metal-organic frameworks (MOFs)
(This special issue belongs to the Section Molecular Toxicology)
Thermogenic Adipocytes and Skeletal Muscle: Novel Molecular Targets for the Treatment of Diabetes and Obesity
edited by
submission deadline 30 Jun 2026 | Viewed by 73 | Submission Open
Keywords: metabolic diseases; obesity; type 2 diabetes; molecular signaling pathway
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Latest Research Progress of Biomaterial Modification
edited by
submission deadline 30 Jun 2026 | Viewed by 72 | Submission Open
Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices
(This special issue belongs to the Section Materials Science)
Preparation and Applications of Colloidal Emulsions
edited by
submission deadline 30 Jun 2026 | Viewed by 63 | Submission Open
Keywords: emulsions; fabrication; characterization; applications; encapsulation; delivery systems
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into the Stability and Degradation of Perovskite Solar Cells
edited by
submission deadline 30 Jun 2026 | Viewed by 56 | Submission Open
Keywords: perovskite; thin films; solar cells; PCE; stability; molecular structure evolution (perovskite); perovskite precursor molecular design
(This special issue belongs to the Section Materials Science)
Anesthetics and Neurovascular Health: Molecular Pathways
edited by Gabriele Melegari
submission deadline 30 Jun 2026 | Viewed by 44 | Submission Open
Keywords: neurovascular paths; blood– brain barrier (BBB) and anesthesia; neurovascular coupling; perioperative neuroprotection; neuroinflammation; endothelial dysfunction; cerebral autoregulation; cerebral blood flow; perioperative brain health
(This special issue belongs to the Section Molecular Neurobiology)
Gynaecological Diseases: From Emergence to Translational Medicine
edited by
submission deadline 30 Jun 2026 | Viewed by 41 | Submission Open
Keywords: gynaecological diseases; reproductive biology; endometriosis; ovarian dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Leukemia in the Omics Era: From Mechanisms to Therapies
edited by Marco Rossi
submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: FLT3 inhibitors; JAK inhibitors; BTK inhibitors; BCL 2 inhibitors; BTK degraders; menin inhibitors; IDH inibitors
(This special issue belongs to the Section Molecular Oncology)
Recent Trends in Metal-Organic and Covalent Organic Frameworks
edited by
submission deadline 30 Jun 2026 | Viewed by 38 | Submission Open
Keywords: metal– organic frameworks; covalent organic frameworks; porous materials; electrocatalysis; sustainable energy systems; adsorption; supercapacitors
(This special issue belongs to the Section Materials Science)
Advances in Alzheimer’s Disease
edited by
submission deadline 30 Jun 2026 | Viewed by 36 | Submission Open
Keywords: Alzheimer’ s Disease; amyloid beta; molecular target
(This special issue belongs to the Section Molecular Neurobiology)
Reproductive Endocrinology Research: 2nd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 33 | Submission Open
Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advanced Functional Materials for Catalysis and Storage
edited by
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: functional materials; energy catalysis; small molecule conversion; energy storage
(This special issue belongs to the Section Materials Science)
Advances in Polymeric Nanomaterials in Medicine
edited by Prabhanjan Giram
submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open
Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies
(This special issue belongs to the Section Molecular Nanoscience)
Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer
edited by Xuming Mao
submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open
Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology
(This special issue belongs to the Section Molecular Immunology)
Viral Infections and Host Antiviral Responses: Molecular Mechanisms and Molecular Regulation
edited by Hong Jia
submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open
Keywords: antiviral immunity; viral entry; host– virus interaction; innate immunity; interferon signaling; viral immune evasion; non-coding RNAs; post-translational modifications; molecular therapeutics; viral pathogenesis
(This special issue belongs to the Section Molecular Microbiology)
Ovarian Insufficiency: From Molecular Pathology to Novel Therapeutic Approach
edited by Aleksandar Ljubić
submission deadline 30 Jun 2026 | Viewed by 21 | Submission Open
Keywords: ovarian insufficiency; premature ovarian insufficiency; molecular pathology; regenerative medicine; stem cell therapy; platelet-rich plasma; epigenetics; intraovarian treatment; ovarian stem cells; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liposome-Related Nanotechnology and Lipid-Based Nanocarriers
edited by
submission deadline 30 Jun 2026 | Viewed by 18 | Submission Open
Keywords: liposomes; lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; nanocarriers; drug delivery; controlled release
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights and Therapeutic Advances in Atherosclerosis
edited by
submission deadline 30 Jun 2026 | Viewed by 17 | Submission Open
Keywords: atherosclerosis; molecular mechanisms; lipid metabolism; inflammation; endothelial dysfunction; RNA therapeutics; nanomedicine; cardiovascular disease; biomarkers; translational medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
From Drug Design to Mechanistic Understanding and Resistance
edited by
submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open
Keywords: drug resistance; drug discovery; targeted protein degradation; systems pharmacology; structural biology
(This special issue belongs to the Section Molecular Pharmacology)
Plant Secondary Metabolites and Their Regulatory Mechanisms
edited by
submission deadline 30 Jun 2026 | Viewed by 14 | Submission Open
Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches
(This special issue belongs to the Section Molecular Plant Sciences)
Next-Generation Disease Models for Neuropsychiatric Disorders: Organoids, iPSC-Derived Circuits, and Gene Editing
edited by Masaru Tanaka
submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSC); neural stem cells; CRISPER-CAS systems (CRISPR); neuropsychiatric disorders; neurodevelopmental disorders; synaptic transmission; neuroinflammation; drug discovery; animal disease models
(This special issue belongs to the Section Molecular Neurobiology)
Plant Molecular Ecology and Genomic Perspectives
edited by
submission deadline 1 Jul 2026 | Viewed by 261 | Submission Open
Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Physiopathological Role of Hypoxia submission deadline 10 Jul 2026 | Viewed by 47 | Submission Open
Keywords: hypoxia; cell metabolism; inflammation; tumor microenvironment; cancer progression; EMT; chronic inflammation; obesity; inflammatory microenvironment; storage disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Breast Cancer: From Molecular Mechanism to Therapeutic Strategy
edited by
submission deadline 10 Jul 2026 | Viewed by 43 | Submission Open
Keywords: breast cancer; molecular mechanisms; therapeutic strategies; tumor microenvironment; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Structure and Characterization of Optical Materials
edited by
submission deadline 10 Jul 2026 | Viewed by 20 | Submission Open
Keywords: luminescence; structure modification; spectroscopy; measurement techniques; Kerr effect; Faraday effects; doping; molecular structure
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Mechanism of Circadian Rhythm
edited by Rosângela Vieira de Andrade
submission deadline 20 Jul 2026 | 3 articles | Viewed by 27865 | Submission Open
Keywords: circadian cycle; exercise; aging; clock genes; health
(This special issue belongs to the Section Molecular Biology)
Interplay Between the Human Microbiome and Diseases submission deadline 20 Jul 2026 | 9 articles | Viewed by 15826 | Submission Open
Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition
edited by
submission deadline 20 Jul 2026 | 5 articles | Viewed by 10703 | Submission Open
Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass submission deadline 20 Jul 2026 | 2 articles | Viewed by 7692 | Submission Open
Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization
(This special issue belongs to the Section Biochemistry)
Bone Metabolism and Bone Diseases
edited by
submission deadline 20 Jul 2026 | 4 articles | Viewed by 4764 | Submission Open
Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Placental Pathology
edited by and Ana Correia-Branco
submission deadline 20 Jul 2026 | 3 articles | Viewed by 4579 | Submission Open
Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Strategies in Cancer Therapy submission deadline 20 Jul 2026 | 1 articles | Viewed by 2951 | Submission Open
Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Addiction submission deadline 20 Jul 2026 | 2 articles | Viewed by 2717 | Submission Open
Keywords: addiction; dependence; neurobiology; reward; neuroplasticity; biostatistics
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular Biology on Mycobacteria: 2nd Edition
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 2475 | Submission Open
Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Sjögren's Syndrome, 4th Edition submission deadline 20 Jul 2026 | 2 articles | Viewed by 1786 | Submission Open
Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Supplements and Drug-Based Strategies in Neonatal and Paediatric Health submission deadline 20 Jul 2026 | 1 articles | Viewed by 1387 | Submission Open
Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota– host interactions; infectious diseases in children; neurodevelopmental disorders; drug– nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms Governing Lipid Metabolism in Health and Disease submission deadline 20 Jul 2026 | 1 articles | Viewed by 1257 | Submission Open
Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1246 | Submission Open
Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database
(This special issue belongs to the Section Molecular Pharmacology)
Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer
edited by Rebecca Chin
submission deadline 20 Jul 2026 | 2 articles | Viewed by 1221 | Submission Open
Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids
(This special issue belongs to the Section Molecular Oncology)
Recent Nanotechnology in Drug Delivery
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1198 | Submission Open
Keywords: smart nanoparticles; hybrid nanomaterial; functionalization; drug targeting; liposome; cubosome; polypeptide; polymers; biomolecules; cancer; vaccine; antimicrobial; antiparasite; antioxidant; immunomodulatory; genetic therapy; nanomedicine
(This special issue belongs to the Section Molecular Nanoscience)
Nanoparticle-Based Biosensors and Their Applications
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1091 | Submission Open
Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
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