Molecular Insights and Therapeutic Advances in Atherosclerosis

Dear Colleagues,

Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, driven by complex interactions among lipid metabolism, inflammation, endothelial dysfunction, and genetic factors. Rapid advances in molecular biology, multi-omics technologies, and targeted therapeutics are transforming our understanding of atherogenesis and enabling the development of more precise diagnostic and treatment strategies.

This Special Issue aims to highlight cutting-edge research elucidating the molecular mechanisms that initiate and propagate atherosclerotic disease, as well as emerging therapeutic approaches designed to halt or reverse its progression. We welcome original research articles, reviews, and perspectives that advance current knowledge and foster innovation in translational and clinical applications.

Topics of interest include, but are not limited to, the following:

• Molecular and cellular mechanisms underlying plaque formation, progression, and instability;
• Lipid metabolism, lipoprotein biology, and regulatory pathways;
• Inflammatory and immune signaling in vascular pathology;
• Endothelial and smooth muscle cell biology;
• Novel biomarkers and diagnostic strategies;
• Gene- and RNA-based therapeutics, nanoparticle delivery systems, and targeted interventions;
• Preclinical models and translational studies;
• Systems biology, multi-omics, and computational approaches in atherosclerosis.

This Special Issue seeks to provide a comprehensive platform for advancing molecular insights and accelerating therapeutic breakthroughs in atherosclerosis.

Dr. Zhu Bo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.