Advances in Molecular Genetics and Molecular Therapy for Gastric Cancers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 32
Special Issue Editor
Special Issue Information
Dear Colleagues,
Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, particularly in East Asia. Recent advances in high-throughput sequencing technologies and molecular pathology have significantly expanded our understanding of the genetic and epigenetic alterations that drive gastric tumorigenesis. Key molecular features such as HER2 amplification, microsatellite instability, Epstein–Barr virus-associated gene expression, and CDH1 alterations have emerged as crucial diagnostic and therapeutic targets. Concurrently, the development of molecular-targeted therapies and immune checkpoint inhibitors has revolutionized the clinical management of gastric cancer.
This Special Issue aims to provide a comprehensive overview of the latest molecular insights and therapeutic strategies in gastric cancer, in line with the journal’s focus on molecular science. It particularly welcomes studies that bridge basic research and clinical applications.
In this Special Issue, original research articles and reviews are welcome. Topics may include, but are not limited to, the following:
- Genomics, epigenomics, and transcriptomics in gastric cancer.
- Biomarker discovery and validation.
- HER2 and immune-related targets.
- Tumor microenvironment and resistance mechanisms.
- Novel molecular therapies and drug development.
We look forward to receiving your contributions.
Dr. Binnari Kim
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gastric cancer
- molecular genetics
- targeted therapy
- tumor microenvironment
- immunotherapy
- biomarkers
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