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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making

edited by

Maria Beatrice Morelli

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1071 | Submission Open

Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity

(This special issue belongs to the Section Molecular Oncology)

Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment

edited by

Deborah J. Good

submission deadline 20 Jul 2026 | Viewed by 514 | Submission Open

Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials

(This special issue belongs to the Section Bioactives and Nutraceuticals)

G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition

edited by

Joanna Filipowska

submission deadline 20 Jul 2026 | 1 articles | Viewed by 466 | Submission Open

Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode

(This special issue belongs to the Section Molecular Pharmacology)

Nucleic Acid Aptamers in Molecular Medicine

edited by

Silvia Catuogno

submission deadline 20 Jul 2026 | Viewed by 402 | Submission Open

Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery

(This special issue belongs to the Section Molecular Biology)

Neuronal Differentiation: From Pathology to Therapeutic Strategies

edited by

Marzia Lecchi

submission deadline 20 Jul 2026 | Viewed by 351 | Submission Open

Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Medical Microbiology and Infectious Diseases: The Role of Artificial Intelligence and Machine Learning

edited by

Alberto Rizzo

submission deadline 20 Jul 2026 | Viewed by 208 | Submission Open

Keywords: molecular diagnostics; pathogen genomics; antimicrobial resistance; host– pathogen interaction; infectious diseases surveillance; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Informatics)

Non-Coding RNAs as Key Regulators in Human Disease Processes

edited by

Beatrice Polini

submission deadline 20 Jul 2026 | Viewed by 168 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathophysiology of Chronic Lung Diseases: Mechanisms and Therapeutics

edited by Gary C. Mouradian

submission deadline 20 Jul 2026 | Viewed by 154 | Submission Open

Keywords: chronic lung disease; vagal sensory neurons; inflammation; airway remodeling; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Molecular Research on Photocatalytic Applications

edited by Hassan Ait Ahsaine

submission deadline 20 Jul 2026 | Viewed by 138 | Submission Open

Keywords: photocatalysis; photocatalytic degradation; molecular catalysts; photocatalysts; functional materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Natural Product-Inspired Anticancer Drug Development

edited by

Erzsébet Mernyák

submission deadline 20 Jul 2026 | Viewed by 133 | Submission Open

Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

From Biology to Biomechanics: Molecular Advances in Orthodontic Remodeling and Acceleration

edited by

Marcin Derwich

and

Alessandra Lucchese

submission deadline 20 Jul 2026 | Viewed by 122 | Submission Open

Keywords: orthodontic tooth movement; bone remodeling; root resorption; molecular mechanisms; inflammatory response; corticotomy-assisted orthodontics; biomechanics; periodontal ligament; cellular signaling; accelerated orthodontic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regenerative Medicine for Tendon: Harnessing Stem Cell Potential

edited by

Maria Camilla Ciardulli

submission deadline 20 Jul 2026 | Viewed by 117 | Submission Open

Keywords: stem cells; endogenic differentiation; three-dimensional in vitro tendon models; immunomodulation; biomimetic scaffolds; in vivo tendon models; dynamic cultures

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Airway Diseases: Molecular Basis and Advanced Therapeutics

edited by

S. Lorraine Martin

submission deadline 20 Jul 2026 | Viewed by 105 | Submission Open

Keywords: chronic airway diseases; asthma; chronic obstructive pulmonary disease (COPD); cystic fibrosis; bronchiectasis; pulmonary fibrosis; airway remodeling; cytokines; inflammation; immune dysregulation; mucociliary clearance; microbiome; epithelial– mesenchymal transition (EMT); molecular mechanisms; biomarkers; proteases; protease inhibitors; precision medicine; targeted therapeutics; RNA-based and gene therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Rhizospheric Microbial Interactions

edited by

Jelena Lozo

submission deadline 20 Jul 2026 | Viewed by 102 | Submission Open

Keywords: plant– microorganism interactions; rhizosphere community; secretory systems; secondary metabolites; volatile compounds

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Natural Compounds in the Prevention and Treatment of Human and Veterinary Diseases

edited by

Fabiana Superti

and

Anna Scotto D'Abusco

submission deadline 20 Jul 2026 | Viewed by 54 | Submission Open

Keywords: bioactive natural substances; nutraceuticals; drug discovery; drug resistance; inflammation; antioxidant; health promotion; prevention; treatment; synergistic effect; molecular mechanism; computational analysis; repurposed molecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Evolving Landscape of Cardiovascular Pathophysiology

edited by

Pooja Shivshankar

submission deadline 25 Jul 2026 | Viewed by 60 | Submission Open

Keywords: biomarker discovery in cardiovascular pathophysiology; precision diagnostics-novel contrast agents combined with PET/CT; MRI; machine learning/AI and clinical implementations in cardiology; cardio-metabolic disease; inflammation and immunity in cardiovascular diseases; mechanisms of non-coding RNAs and microRNAs in cardiac diseases; translational research in large animals bridging the rodent re-search with human pathophysiology; targeted therapies- genetic therapies/gene editing approach (CRISPR); stem cell therapies; and therapeutic mRNA and siRNA-based approaches

(This special issue belongs to the Section Biochemistry)

Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 30 Jul 2026 | Viewed by 110 | Submission Open

Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Drug Resistance and Therapeutic Targets

edited by

Sanjay K. Srivastava

submission deadline 30 Jul 2026 | Viewed by 105 | Submission Open

Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies

(This special issue belongs to the Section Molecular Oncology)

Advances in Bone Homeostasis

edited by

John Kelly Smith

submission deadline 30 Jul 2026 | Viewed by 88 | Submission Open

Keywords: bone remodeling; osteoblasts and osteoclasts; osteoimmunology; osteometabolism; signaling pathways; bone diseases; epigenetic regulation; extracellular vesicles; mechanotransduction; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms Underlying Abiotic Stress Tolerance in Plants: From Gene Regulation to Adaptive Traits

edited by Shijiang Cao

submission deadline 30 Jul 2026 | Viewed by 53 | Submission Open

Keywords: forest molecular biology; tree physiology; plant developmental biology; plant-microbe interactions; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Phytochemicals and Antioxidants on Health and Disease Modulation

edited by Natalia Kurhaluk

submission deadline 30 Jul 2026 | Viewed by 28 | Submission Open

Keywords: phytochemical bioactive compounds; antioxidant mechanisms; oxidative stress modulation; chronic disease prevention; inflammatory signalling pathways; molecular health effects; bioavailability and metabolism; flavonoid biological activity; polyphenol therapeutic potential; disease modulation strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Role of Proteomics in Human Diseases and Infections: 2nd Edition

edited by

Mahamud Ur Rashid

submission deadline 30 Jul 2026 | Viewed by 25 | Submission Open

Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host– pathogen interactions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunoregulatory Mechanisms of Gut Microbiota

edited by

José Fachi

submission deadline 30 Jul 2026 | Viewed by 14 | Submission Open

Keywords: gut microbiota; mucosal immunity; host– microbe interactions; immune homeostasis; dysbiosis; microbial metabolites; short-chain fatty acids; barrier function; colitis

(This special issue belongs to the Section Molecular Microbiology)

Immunoregulation of Abnormal Cell Proliferation: Molecular Mechanisms and Therapeutic Strategies

edited by

Xingkang Wu

submission deadline 30 Jul 2026 | Viewed by 12 | Submission Open

Keywords: immune microenvironment; cell proliferation; molecular mechanisms; therapeutic strategies; tumor; autoimmune disease; psoriasis; rheumatoid arthritis; lupus erythematosus; type 1 diabetes; inflammatory bowel disease

(This special issue belongs to the Section Molecular Immunology)

Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition

edited by

De-Guo Han

submission deadline 31 Jul 2026 | 1 articles | Viewed by 531 | Submission Open

Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms

edited by

Seong-Hee Maria Ko

submission deadline 31 Jul 2026 | 1 articles | Viewed by 471 | Submission Open

Keywords: metabolic syndrome; single-nucleotide polymorphism (SNP); genome-wide association study (GWAS); copy number variation; diet; metabolomics; nutritional genetics; lipid metabolism; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cell–Cell Communication Through Extracellular Vesicles

edited by Federica Fratini

submission deadline 31 Jul 2026 | Viewed by 300 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Selected Papers from the HSG-2025 Conference

edited by

Marsel Kabilov

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: metagenomics; genomics; metabarcoding; next-generation sequencing; transcriptomics; translatomics; NGS data analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Bioactive Natural Products: From Molecular Mechanisms to Biological Function

edited by

Noureddine El Aouad

submission deadline 31 Jul 2026 | Viewed by 40 | Submission Open

Keywords: natural products; molecular mechanism; biological activities; drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathogenesis and Novel Therapeutic Targets in Oncologic Cardiotoxicity

edited by

Marco Tana

submission deadline 31 Jul 2026 | Viewed by 29 | Submission Open

Keywords: cardiotoxicity; CTRCD; heart failure; HFrEF; HFpEF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of GPCR Signaling

edited by

Kyeong-Man Kim

submission deadline 31 Jul 2026 | Viewed by 22 | Submission Open

Keywords: biased signaling; allosteric modulation; receptor conformations; spatiotemporal signaling; allosteric modulation; receptor trafficking; signaling networks; structure-based drug design

(This special issue belongs to the Section Biochemistry)

Molecular Advances in Glomerular Diseases, 2nd Edition

edited by

Gian Marco Ghiggeri

submission deadline 31 Jul 2026 | Viewed by 21 | Submission Open

Keywords: glomerulonephritis; proteinuria; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Eukaryotic Mitogenomes: Key Insights

edited by

Yuri Kartavtsev

submission deadline 31 Jul 2026 | Viewed by 19 | Submission Open

Keywords: eukaria; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations

(This special issue belongs to the Section Molecular Biology)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 1 Aug 2026 | Viewed by 82 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 10 Aug 2026 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Aug 2026 | 6 articles | Viewed by 13109 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4744 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Genomics in Translational Medicine

edited by

Cornelia Braicu

, Oana Zanoaga and

Ștefan Strilciuc

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4730 | Submission Open

Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Seed Development and Germination

edited by

Sławomir Borek

Łukasz Wojtyla

and

Małgorzata Garnczarska

submission deadline 20 Aug 2026 | 3 articles | Viewed by 4501 | Submission Open

Keywords: seed aging; seed development; seed dormancy; seed germination; seed metabolism; seed preservation; seed priming; seed responses to stress

(This special issue belongs to the Section Molecular Plant Sciences)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1436 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Decoding the Microbial Influence on Host Gene Expression

edited by

Damian Kołat

and

Mateusz Kciuk

submission deadline 20 Aug 2026 | 1 articles | Viewed by 329 | Submission Open

Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo

(This special issue belongs to the Section Molecular Microbiology)

Molecular Aspects of Diabetes and Its Complications

edited by

Giuseppe Murdolo

submission deadline 20 Aug 2026 | Viewed by 183 | Submission Open

Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipopolysaccharide as a Drug Target

edited by

Martina Schmidt

submission deadline 20 Aug 2026 | Viewed by 123 | Submission Open

Keywords: tissue barriers; neuroinflammation; macrophages; microglia; organoids; scaffolds; infections; cry-EM

(This special issue belongs to the Section Molecular Pharmacology)

Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms

edited by

Eugenia Mata-Greenwood

submission deadline 20 Aug 2026 | Viewed by 76 | Submission Open

Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Aug 2026 | Viewed by 70 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities

edited by

Anthony Lemarié

submission deadline 30 Aug 2026 | Viewed by 30 | Submission Open

Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape

(This special issue belongs to the Section Molecular Neurobiology)

MiRNA Stromal Interaction in the Tumor Microenvironment

edited by

Kurt Sartorius

submission deadline 30 Aug 2026 | Viewed by 26 | Submission Open

Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System

edited by

Hirotaka Sakamoto

submission deadline 31 Aug 2026 | Viewed by 526 | Submission Open

Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus