Erosive vulvar lichen planus (VLP) is a chronic T-cell-mediated inflammatory disorder characterized by painful mucosal erosions, recurrent disease, scarring, and incomplete responses to anti-inflammatory therapy. Persistent epithelial injury, basemen...
Background: Skin aging processes impair biochemical, structural, and physical properties, leading not only to aesthetic changes but also to the impairment of skin barrier functions. Although the biological efficacy of isolated phytic acid is well doc...
Background: Central centrifugal cicatricial alopecia (CCCA) is a progressive scarring alopecia that disproportionately impacts Black women. Although research interest in CCCA has grown over time, trends among the most influential publications and the...
Phimosis, the inability to retract the prepuce over the glans penis, is one of the most common reasons for referral of boys to pediatric surgeons and urologists, yet the great majority of cases represent a normal developmental stage rather than true...
Background: Tattooing has become increasingly prevalent worldwide; however, data on its epidemiology, knowledge, attitudes, and practices (KAP) in the Gulf Cooperation Council (GCC) region remain limited. Objectives: The aim of this study was to asse...
On behalf of the EORTC Cutaneous Lymphoma Tumour Group (EORTC-CLTG), we are pleased to present the Abstracts of the EORTC-CLTG Annual Meeting 2026, the European Meeting on Skin Lymphoma and Inflammatory Mimickers, to be held in Berlin, Germany, from...
Dermatology has historically evolved from the observation of visible skin lesions to a complex medical specialty shaped by scientific, institutional, technological, and social transformations. This article aims to analyze the historical trajectory of...
This study aimed to review the scientific literature on dysbiosis characterized by Staphylococcus aureus enrichment and its implications for atopic dermatitis and other dermatoses. A narrative literature review was conducted using the PubMed database...
Acne vulgaris and rosacea are traditionally classified as distinct inflammatory facial dermatoses. Nevertheless, accumulating mechanistic and translational evidence suggests that these conditions share partially overlapping biological domains includi...
Background/Objectives: Onychomycosis is a common fungal nail infection that may contribute to foot morbidity in adults with type 2 diabetes mellitus (T2DM), particularly when neuropathy, peripheral vascular disease, nail dystrophy, local trauma, tine...
Background/Objectives: Metatypical basal cell carcinoma (MTBCC) is a rare and aggressive variant of non-melanoma skin cancer (NMSC) characterised by overlapping histological features of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma...
Background/Objectives: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), originally developed for Type II Diabetes, has become popular for weight loss due to its ability to suppress appetite and promote fat loss. Although semaglutide...
In academic research, reviews serve as a foundational tool for mapping and organizing existing knowledge, evaluating scientific progress in specific domains, and guiding future investigations [...]
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which type 2 immune activation, epidermal barrier dysfunction, microbial dysbiosis, and neurosensory pathways interact to sustain disease activity and symptom burden. Despite major adva...
Introduction: Chronic lymphedema (CL) can lead to infectious complications, skin inflammation, and tumors. Consequently, patients with CL are at increased risk of developing several malignant cutaneous neoplasms, including Kaposi sarcoma, B-cell lymp...
Background: Acne is a common inflammatory dermatosis with well-documented epidemiology in urban populations; however, data from rural sub-Saharan African settings remain limited. Objective: To characterize the demographic profile, clinical subtypes,...
Lichen planus pigmentosus inversus (LIPPI) is a rare variant within the spectrum of lichenoid dermatoses, characterized by sharply demarcated hyperpigmented lesions predominantly affecting intertriginous areas. Its pathogenesis remains incompletely u...
Introduction: High-Intensity Focused Ultrasound (HIFU) is a widely used non-invasive esthetic treatment for facial/neck rejuvenation, inducing thermal coagulation for neocollagenesis. Despite its general safety, its non-optimal application risks neur...
Background/Objectives: Vision Transformers (ViTs) have demonstrated impressive performance in dealing with large-scale natural image datasets. They have started to be used in medical image classification problems as well. However, how they behave und...
Background: Difficult-to-treat anatomical areas in atopic dermatitis (AD), including the head and neck, hands, genital and intertriginous regions, are frequently associated with therapeutic refractoriness, persistent pruritus, and substantial functio...
Emerging research highlights the complex interplay between the gut microbiome, skin health, and environmental exposures, forming what is now recognized as the gut–skin–exposome axis. This narrative review explores the role of gut microbio...
Introduction: Alopecia areata (AA) is a chronic immune-mediated disorder characterized by non-scarring hair loss and a significant psychosocial burden. Ritlecitinib, a selective Janus kinase 3 (JAK3) and tyrosine kinase expressed in hepatocellular ca...
Elderly psoriasis patients (≥65 years) demonstrate mainly preserved but substantially delayed therapeutic responses to IL-17 and IL-23 inhibitors, achieving lower PASI90 rates at early time-points with eventual “catch-up” by week 52, a...
Background: Biotin (vitamin B7) is widely marketed and used as an over-the-counter supplement for hair, skin, and nails, despite uncertainty about its clinical benefit for alopecia and hair growth. While overt biotin deficiency can be associated with...
The skin serves as a primary defensive barrier to protect the body from environmental contaminants, infections and trauma. Unfortunately, skin barrier’s structural and functional integrity can be compromised, disrupted or impaired due to a comb...
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatosis characterized by recurrent nodules, abscesses, and sinus tract formation in intertriginous skin. Although HS is increasingly recognized as an autoinflammatory condition rather than a...
Surgery continues to represent the central curative modality for melanoma despite major advances in systemic immunotherapy and targeted treatments. Contemporary surgical strategies aim to maintain oncologic safety while minimizing functional and aest...
Background: Conventional therapies for moderate-to-severe inflammatory acne include topical agents, systemic antibiotics, hormonal treatments, and oral isotretinoin. However, increasing resistance of Cutibacterium acnes to antibiotics and the potenti...
Sensitive Skin Syndrome (SSS) is a worldwide condition characterized by sensory symptoms such as stinging, burning, and itching, often without visible signs. This pilot study investigated individuals with self-reported SSS, focusing on the specific s...
Background: This study aimed to assess the prevalence of PD-L1 protein expression in dermatofibrosarcoma protuberans (DFSP) to provide insights into the potential use of immune checkpoint inhibitors. Methods: We retrospectively analyzed formalin-fixe...
Introduction: Myxoid liposarcoma (MLPS) is a rare soft tissue sarcoma comprising 5–10% of adult cases, most often in the thigh. Diagnosis is challenging due to nonspecific imaging findings and resemblance to benign lesions. Case Report: A 42-ye...
Rosacea is a chronic skin condition characterized by persistent inflammation, manifesting primarily on the face and causing redness, papules, pustules, and phymatous changes. The etiology of rosacea is multifactorial, with immune system factors playi...
Background/Objectives: Metformin, a widely used antidiabetic drug, has recently gained attention in dermatology due to its pleiotropic effects. Given the high prevalence, chronicity, and therapeutic challenges of several dermatological conditions, th...
Background/Objectives. Ultraviolet B (UVB) radiation is a key etiological factor for skin cancer, inducing oxidative stress, DNA damage and apoptosis. Nicotinamide (NAM), a NAD+ precursor, has shown photoprotective properties, although the mechanisms...
Background/Objectives: Melanoma remains one of the most malignant types of skin cancer with rising incidence numbers, despite the progress made in the prevention and management of the disease. Recent technological advancements, such as developments i...
Background/Aims: This study aimed to undertake a systematic literature review to compare the effectiveness of narrowband UVB (nb-UVB) therapy with Psoralen + UVA (PUVA) or Psoralen + UVB treatments in individuals with vitiligo. Methods: A comprehensi...
Background and Objectives: Merkel cell carcinoma (MCC) is a rare, aggressive, invasive cutaneous neuroendocrine carcinoma. It commonly affects the skin of the extremities and head and neck regions in elderly patients. In situ MMC represents MMC confi...
Background/Objectives: Acute generalized exanthematous pustulosis (AGEP) is a severe drug-induced cutaneous reaction characterized by the abrupt onset of sterile pustules, fever, neutrophilia, and a T cell-mediated type IVd hypersensitivity response....
Background/Objectives: Acne is a common skin condition that is characterized by the manifestation of comedones, erythematous papules, pustules, and nodules over follicular areas. A huge contributing factor in the pathogenesis is colonization by Cutib...
Introduction: Atopic dermatitis (AD) is driven by complex pathways that mediate inflammation and pruritus. The pathophysiology of AD’s disease involves multiple pathways. Interleukin-13 (IL-13) is considered a major cytokine in Th2-type inflamm...
Italian Court of Cassation Ruling Decree 30032 of 30 October 2023 discusses a medical malpractice case concerning the diagnosis of dermatofibrosarcoma protuberans and the alleged diagnostic and therapeutic delay. By examining how the ruling frames th...
Immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 antibodies, have significantly improved outcomes in a variety of solid tumors, including urothelial carcinoma. However, their use is frequently associated with immune-related adverse events...
Linear atrophoderma of Moulin (LAM) is a rare, benign dermatosis characterized by unilateral, hyperpigmented, slightly atrophic plaques distributed along Blaschko’s lines. We report the case of an 18-year-old woman with a four-year history of a...
The human skin microbiome, defined as a multifaceted ecosystem comprising bacteria, fungi, viruses, and mites, plays a pivotal role in maintaining skin homeostasis and regulating immune responses. In recent years, an increasing amount of evidence has...
Background: The lipid components of the skin barrier have the strongest structure when arranged in an orthorhombic packing. This structure can be influenced by the external supply of lipophilic ingredients. While the benefits of ceramide supplementat...
Background: currently, there is a growing trend toward multifunctional cosmetics, which combine several active ingredients in a single product to enhance efficacy and user convenience. As ingredients may influence one another, it is important to stud...
Cutaneous leiomyosarcoma is a rare, malignant tumor that arises from smooth muscle cells, accounting for less than 3% of all cutaneous sarcomas. Our case report details a 63-year-old male patient who presented with a rapidly growing, painful nodule i...
Background/Objectives: Epidermolysis bullosa (EB) is a rare genetic disease often requiring extensive dental interventions. Whole genome sequencing of the oral microbiome may provide essential information on the pathogenic shifts reported in the lite...
Melasma is an acquired hyperpigmentation that is more common in women and mainly affects the face. It can significantly reduce quality of life due to its chronic nature and resistance to treatment. Objectives: This study aimed to compare the clinical...
Background: Melanoma of unknown primary (MUP) is a rare and distinct clinical subtype of metastatic melanoma, in which no identifiable primary tumor is found. The prognosis of MUP compared to melanoma with known primary (MKP) remains unclear, especia...
