Oral Cancer: Prophylaxis, Etiopathogenesis and Treatment, 2nd Edition

Dear Colleagues,

Oral cancer continues to be a leading cause of death worldwide; it is prevalent in developing countries, where regularly smoking, chewing tobacco and betel nuts and consuming alcohol are very common habits. Oral inflammation may also play a role in the pathophysiology of oral cancers due to the involvement of several inflammatory pathways. Moreover, oral squamous cell carcinoma is associated with several oral bacteria and virus carriage. It has been reported that oral cancer patients have significantly higher levels of Candida albicans genotype A strain than noncancer patients. This strain has also been linked to leukoplakic lesions. Immunosuppression has also been linked to the development of oral cancer in patients undergoing bone marrow and renal transplantation. Despite the availability of novel therapeutic options, the 5-year survival rate for oral cancer in most countries remains below 50%. Therefore, effective therapies to prevent the development of oral cancer are required, and potential natural products and phytochemicals are being investigated for use in the treatment of oral diseases. These natural compounds may be supplemented in their natural form or incorporated into bars, powders, liquids, gels, tablets or capsules, toothpaste, mouthwashes, lozenges, oral gels or other pharmaceutical products.

This Special Issue will focus on recent research on etiopathogenesis, biomarkers, natural products with anticancer activity through various mechanisms, and novel pharmaceutical formulations with potential applications in oral cancer prophylaxis and treatment.

You can read the publications in the first volumes of this Special Issue here:

https://www.mdpi.com/journal/cimb/special_issues/U2TX90NIK1

Dr. Violeta Popovici
Dr. Emma Adriana Ozon
Guest Editors

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