Molecular Insight into Immunomodulation by Probiotics and Fermented Food Derivatives

Dear Colleagues,

Immune dysregulation underlies various inflammation, infection and metabolic diseases, while conventional immunomodulatory therapies suffer from poor specificity, side effects and drug tolerance. As promising natural bioactive resources, probiotics and fermented food derivatives exhibit reliable immunomodulatory capacities. Advances in molecular and multi-omics technologies further facilitate the exploration of their underlying immune regulatory mechanisms. This Special Issue focuses on molecular insights into probiotic and fermented food-mediated immunomodulation. It welcomes original research and comprehensive reviews bridging mechanistic findings and translational applications, covering gut-immune axis regulation, immune-related signaling pathways, metabolite structure–function relationships, and novel functional food or therapeutic design. Studies combining in vitro, in vivo and computational multi-omics analyses with mechanistic validation are highly encouraged, aiming to advance targeted immune intervention and infectious disease prevention.

Prof. Dr. Dawei Chen
Dr. Hengxian Qu
Guest Editors

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