Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunoregulation in Cardiovascular Disease
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 4377 | Submission Open
Keywords: cardiovascular disease (CVD); immunoregulation; inflammation; immune cells; immune mediators; immunomodulatory therapies; biomarkers; epigenetics; microbiome; cellular methods/technologies
Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer
edited by Nicola Normanno, and
submission deadline 31 Oct 2026 | 4 articles | Viewed by 4320 | Submission Open
Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence
Novel Immunotherapies for Diffuse Large B-Cell Lymphoma
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 3887 | Submission Open
Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody–drug conjugates; tumor microenvironment; biomarkers; translational research
Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 31 Oct 2026 | 2 articles | Viewed by 3482 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 31 Oct 2026 | 2 articles | Viewed by 2713 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Signalling Mechanisms Regulating Cardiac Fibroblast Function
edited by Haofei Wang and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2680 | Submission Open
Keywords: cardiac fibroblasts; myofibroblast activation; extracellular matrix remodeling; fibrosis; intercellular communication; mechanotransduction; single-cell and spatial insights; regeneration; therapeutic targeting
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2237 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
Molecular Signaling and Mechanism on Vascular Remodeling
edited by and Yitao Huang
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2131 | Submission Open
Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling
Interactions Between Gut Microbiota and Epigenetic Markers in Health and Disease
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1969 | Submission Open
Keywords: gut microbiome; epigenetic marks; cancer; metabolic diseases; neuropsychiatric disorders; inflammatory diseases; infectious diseases; cardiovascular diseases; probiotics; prebiotics
(This special issue belongs to the Section Cell and Gene Therapy)
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1624 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Dictyostelium as a Model in Cell Dynamics and Disease
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 1154 | Submission Open
Keywords: dictyostelium; disease; cell migration; chemotaxis; cytoskeleton; cell mechanics; actin; host-bacteria interaction; cell division
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Idiopathic Pulmonary Fibrosis
edited by and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 851 | Submission Open
Keywords: idiopathic pulmonary fibrosis; fibroblast activation; epithelial–mesenchymal interaction; extracellular matrix remodeling; inflammation; signaling pathways; biomarkers; molecular targets; autophagy; senescence
GABAA Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms
edited by Tingwei Mu and Yajuan Wang
submission deadline 31 Oct 2026 | 1 articles | Viewed by 693 | Submission Open
Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms
Allergy and Immunity
edited by Anish R. Maskey and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 685 | Submission Open
Keywords: allergy; immune regulation; inflammation; epithelial barrier; biomarker; alternate therapy
(This special issue belongs to the Section Cellular Immunology)
Neurotoxicity: Focusing on Molecular and Cellular Mechanisms
edited by , Manuel José Morales and
submission deadline 31 Oct 2026 | Viewed by 472 | Submission Open
Keywords: neurotoxicity; neuroinflammation; neurodegeneration; chemotherapy-induced neuropathy; neuroprotection; neuronal injury
Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine
edited by and Andrea Wittig
submission deadline 31 Oct 2026 | Viewed by 421 | Submission Open
Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers
Mechanobiological Regulation of Fibroblast-to-Myofibroblast Phenotype Transition
edited by Mirko D’urso and
submission deadline 31 Oct 2026 | Viewed by 348 | Submission Open
Keywords: fibroblasts; myofibroblasts; mechanotransduction; extracellular matrix; fibrosis; tissue remodeling; mechanobiology
(This special issue belongs to the Section Cell Microenvironment)
Crosstalk Between Autophagy, Apoptosis and Inflammation submission deadline 31 Oct 2026 | Viewed by 312 | Submission Open
Keywords: autophagy; apoptosis; inflammation; signal transduction; lipid messengers; rheumatic disorders; cancer; neurodegenerative diseases
(This special issue belongs to the Section Autophagy)
Cellular and Molecular Mechanisms of Oocyte Maturation and the Fertilization Process
edited by , Jong Tai Chun, and Bart M. Gadella
submission deadline 31 Oct 2026 | Viewed by 309 | Submission Open
Keywords: oocyte growth; meiotic maturation; sperm capacitation; acrosome reaction; actin; calcium; cortical/zona reaction; polyspermy; cleavage; implantation
(This special issue belongs to the Section Reproductive Cells and Development)
Ovarian Tumors—Molecular Mechanisms, Cellular Dynamics, and Therapeutic Advances
edited by David Schweer, Joel Cardenas and
submission deadline 31 Oct 2026 | Viewed by 303 | Submission Open
Keywords: ovarian tumor biology; cellular signaling networks; genetic and epigenetic regulation; tumor microenvironment; cellular heterogeneity; single-cell and spatial omics; functional genomics; mechanisms of therapeutic resistance
(This special issue belongs to the Section Cellular Pathology)
Autophagy, Mitochondria, and Cell Death in Cancer
edited by Yuchen Lei and
submission deadline 31 Oct 2026 | Viewed by 285 | Submission Open
Keywords: autophagy; cancer; cell death; metabolism; mitochondria
(This special issue belongs to the Section Autophagy)
Colorectal Cancer: Genetics and Molecular Mechanisms submission deadline 31 Oct 2026 | Viewed by 280 | Submission Open
Keywords: colorectal cancer; metastasis ; generation alterations; epigenetic regulation; signal transduction pathways; biomarkers; therapeutic resistance; in vitro and in vivo models; translational research
(This special issue belongs to the Section Tissues and Organs)
Advances in Alcohol-Associated Liver Disease submission deadline 31 Oct 2026 | Viewed by 270 | Submission Open
Keywords: alcohol-associated liver disease (ALD); metabolic and alcohol associated liver disease (MetALD); alcohol-associated hepatitis (AH);steatosis; fibrosis; cirrhosis; portal hypertension; hepatic inflammation; hepatocytes; macrophages; neutrophils; stellate cells
(This special issue belongs to the Section Cellular Pathology)
Nucleic Acids and Their Binding Partners: Structural and Mechanistic Insights
edited by
submission deadline 31 Oct 2026 | Viewed by 260 | Submission Open
Keywords: cryo-EM; NMR; AFM; molecular dynamics; nucleic acids; nucleic acid-protein complexes
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Ion Transporters and Channels in Cellular Homeostasis and Disease
edited by Guanxiao Qi and Raul E. Guzman
submission deadline 31 Oct 2026 | Viewed by 256 | Submission Open
Keywords: patch-clamp recording; ligand-gated channels; ion channel modulators; channel-specific ligands; channelopathies; epilepsy; neurodegenerative disease
Integrating CRISPR-Based Functional Genomics and Multi-Omics to Identify Therapeutic Targets
edited by and David J. Elliott
submission deadline 31 Oct 2026 | Viewed by 230 | Submission Open
Keywords: CRISPR-technology; functional genomics screening; Perturb-seq; multi-omics; disease mechanisms; drug target discovery
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Mechanisms Behind Liver Inherited Metabolic Diseases and Novel Therapeutic Strategies
edited by Sonam Gurung
submission deadline 31 Oct 2026 | Viewed by 202 | Submission Open
Keywords: inherited metabolic liver diseases; urea cycle disorders; hepatic metabolic homeostasis; molecular mechanisms of disease; disease-modifying therapies; monogenic disorders; systems biology approaches; rare diseases
(This special issue belongs to the Section Cellular Pathology)
Microscopy in Decoding Complex Cellular Structures
edited by
submission deadline 31 Oct 2026 | Viewed by 199 | Submission Open
Keywords: correlative microscopy; super resolution microscopy; electron microscopy; 3D reconstruction; cell–cell contact; cell–matrix contact; cell surface; cell signaling; cell microenvironment; cell adhesion; cell junction; cell organelle; organelle maturation; mitochondria; Golgi apparatus; phagosomes; cilia; synapse formation; barrier function; blood–brain barrier; multimodal microscopy; fluorescence microscopy; expansion microscopy; organelle shaping; migrasomes; protozoan; organoid; spheroid
(This special issue belongs to the Section Cell Methods)
Advanced Review Papers in ‘Tissue and Organs’
edited by
submission deadline 31 Oct 2026 | Viewed by 183 | Submission Open
Keywords: tissue biology; organ development and morphogenesis; tissue architecture and organization; stem cells and progenitor cells; tissue regeneration and repair; extracellular matrix; cell–cell communication; cellular microenvironment; tissue remodeling; 3D tissue models and bioengineering
(This special issue belongs to the Section Tissues and Organs)
The Role of Immune Checkpoint Inhibitors Combined with Cancer Vaccines in the Neoadjuvant Setting of Solid Tumors
edited by Yasser Mostafa Kamel and Mahmoud Abdelsalam
submission deadline 31 Oct 2026 | Viewed by 181 | Submission Open
Keywords: neoadjuvant therapy; immune checkpoint inhibitors (ICIs); therapeutic cancer vaccines; early-stage solid tumors; pathologic complete response (pCR); major pathologic response (MPR)
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms of Sperm Capacitation
edited by Patricio J. Morales, and Milene Kong
submission deadline 31 Oct 2026 | Viewed by 177 | Submission Open
Keywords: sperm capacitation; acrosome reaction; protein phosphorylation; calcium signaling; signal transduction; post-translational modifications
(This special issue belongs to the Section Reproductive Cells and Development)
Emerging Trends in Liquid Biopsy: Recent Advances and Challenges
edited by
submission deadline 31 Oct 2026 | Viewed by 177 | Submission Open
Keywords: liquid biopsy; circulating DNA (ctDNA); circulating tumor cells (CTC); blood; biofluid
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Responses to Abiotic and Biotic Stress in Plants
edited by
submission deadline 31 Oct 2026 | Viewed by 163 | Submission Open
Keywords: abiotic stress; biotic stress; plants; stress signaling; plant immunity; gene regulation; plant–microbe interactions; stress physiology; genomics
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
MicroRNAs in Atherosclerosis: Mechanisms, Biomarkers, and Therapeutic Opportunities
edited by Genesio Karere
submission deadline 31 Oct 2026 | Viewed by 156 | Submission Open
Keywords: microRNAs (miRNAs); atherosclerosis and vascular inflammation; endothelial dysfunction; circulating biomarkers; RNA-based therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
Cellular and Molecular Mechanisms in Mammalian Reproduction submission deadline 31 Oct 2026 | Viewed by 156 | Submission Open
Keywords: cell physiology; intra- and extracellular signaling; cell growth and differentiation; cellular immunology; stem cells; autophagy; apoptosis; omics; aging/senescence; cell techniques
(This special issue belongs to the Section Reproductive Cells and Development)
Epigenetic Regulation of Cellular Plasticity in Brain Tumors
edited by and Erina Vlashi
submission deadline 31 Oct 2026 | Viewed by 141 | Submission Open
Keywords: brain tumors; epigenetic modifiers; tumor plasticity; epigenetic heterogeneity; microenvironment-epigenetic interactions; therapy resistance
(This special issue belongs to the Section Cell and Gene Therapy)
Molecular Genetics of Cystic Kidney Disease
edited by and Juliana Galvis
submission deadline 31 Oct 2026 | Viewed by 141 | Submission Open
Keywords: cystic kidney disease; polycystic kidney disease; cilia; PKD1; PKD2; autosomal dominant; renal epithelium; animal models; disease mechanisms; organoids
(This special issue belongs to the Section Cell and Gene Therapy)
Mechanisms of Drug Resistance in Colorectal Cancer
edited by
submission deadline 31 Oct 2026 | Viewed by 120 | Submission Open
Keywords: colorectal cancer; drug resistance; chemotherapy; targeted therapy; tumour microenvironment; cancer stem cells; preclinical models; combination therapy; resistance mechanisms; predictive biomarkers
(This special issue belongs to the Section Cellular Pathology)
Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications
edited by , Shibo Wei and
submission deadline 1 Nov 2026 | 2 articles | Viewed by 2388 | Submission Open
Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism
Role of Inflammasomes in Neurological Disorders submission deadline 1 Nov 2026 | Viewed by 339 | Submission Open
Keywords: inflammasome; pyroptosis; caspase-1; ASC specks; IL-1beta; PANoptosis; CNS injury; neurodegenerative diseases; biomarkers; Alzheimer’s disease; Parkinson’s disease; multiple sclerosis; amyotrophic lateral sclerosis
(This special issue belongs to the Section Cellular Neuroscience)
Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling
edited by
submission deadline 5 Nov 2026 | 3 articles | Viewed by 7595 | Submission Open
Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis
Cancer Stem Cells in Triple-Negative Breast Cancer submission deadline 5 Nov 2026 | Viewed by 533 | Submission Open
Keywords: cancer stem cells; TNBC; signal pathways; epithelial–mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers
Advancements in Research on hiPSC-Derived Cells
edited by Akhilesh Kumar
submission deadline 10 Nov 2026 | 3 articles | Viewed by 10343 | Submission Open
Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering
(This special issue belongs to the Section Stem Cells)
Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies submission deadline 10 Nov 2026 | 2 articles | Viewed by 4552 | Submission Open
Keywords: hematologic diseases; mechanisms; therapies
Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer
edited by , Lin Yuan and Yang Yu
submission deadline 10 Nov 2026 | 3 articles | Viewed by 2762 | Submission Open
Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics
Molecular and Cellular Mechanisms of Heart Regeneration
edited by Mira Pronobis and
submission deadline 10 Nov 2026 | 1 articles | Viewed by 1139 | Submission Open
Keywords: cardiac regeneration; cardiomyocyte proliferation; tissue remodeling; cardiovascular repair; regenerative therapy; cellular plasticity; myocardial infarction; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Methane Biosynthesis
edited by , James Ferry and
submission deadline 10 Nov 2026 | Viewed by 477 | Submission Open
Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases
New Insights into Platelet Physiology and Dysfunction
edited by Serena Valsami and
submission deadline 10 Nov 2026 | Viewed by 217 | Submission Open
Keywords: platelets; platelet function; platelet physiology; platelet dysfunction; platelet disorders; platelet biology; pathophysiology; platelet transfusion; hereditary platelet disorders; acquired platelet disorders
(This special issue belongs to the Section Cells of the Cardiovascular System)
Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases
edited by Qingdong Guan
submission deadline 15 Nov 2026 | 5 articles | Viewed by 18962 | Submission Open
Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells
(This special issue belongs to the Section Cellular Immunology)
Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies
edited by
submission deadline 15 Nov 2026 | 7 articles | Viewed by 10903 | Submission Open
Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
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