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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis

edited by

Francesc Mitjans

submission deadline 10 Dec 2025 | 2 articles | Viewed by 4764 | Submission Open

Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody

(This special issue belongs to the Section Cell Microenvironment)

Therapeutic Mechanism of Nervous System Inflammation—Second Edition

edited by

Maria Anttonietta Panaro

and

Antonia Cianciulli

submission deadline 10 Dec 2025 | 1 articles | Viewed by 2621 | Submission Open

Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system

(This special issue belongs to the Section Cellular Neuroscience)

Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma

edited by

Swapan K. Ray

submission deadline 15 Dec 2025 | 21 articles | Viewed by 76707 | Submission Open

Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities

(This special issue belongs to the Section Cellular Neuroscience)

New Advances in Neuroinflammation

edited by

John W. Chen

and Michael Breckwoldt

submission deadline 15 Dec 2025 | 14 articles | Viewed by 63383 | Submission Open

Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging

(This special issue belongs to the Section Cellular Neuroscience)

Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities

edited by

Vasily M. Studitsky

submission deadline 15 Dec 2025 | 5 articles | Viewed by 9837 | Submission Open

Keywords: DNA damage; DNA repair; epigenetics; chromatin; remodeling

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications

edited by

Michele Longo

and

Jyotirmoy Das

submission deadline 15 Dec 2025 | 3 articles | Viewed by 6547 | Submission Open

Keywords: DNA methylation; epigenetics; diseases; biomarkers; functional analysis

(This special issue belongs to the Section Cellular Pathology)

Mitochondria and Metabolism in Cancer Stem Cells (CSCs)

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 15 Dec 2025 | 2 articles | Viewed by 4508 | Submission Open

Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches

(This special issue belongs to the Section Stem Cells)

Physics of Cancer: How Mechanobiology Drives Cancer Progression

edited by

Claudia Tanja Mierke

submission deadline 15 Dec 2025 | 1 articles | Viewed by 2486 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

Hormone Receptors in Cancers: From Molecular Insights to Clinical Applications

edited by

Edris Choupani

and Kambiz Hassanzadeh

submission deadline 15 Dec 2025 | 1 articles | Viewed by 876 | Submission Open

Keywords: cancer progression; endocrine therapy resistance; estrogen and androgen receptors; hormone receptors; nuclear receptors; receptor signaling pathways

Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition

edited by

Zhuo Wang

submission deadline 15 Dec 2025 | 1 articles | Viewed by 608 | Submission Open

Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition

(This special issue belongs to the Section Tissues and Organs)

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Dec 2025 | Viewed by 395 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cellular Neuroscience)

The Symphony of Nature—the Precision of Life’s Regulation

edited by Weiguang Wang and Baocheng Liu

submission deadline 15 Dec 2025 | Viewed by 131 | Submission Open

Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding

(This special issue belongs to the Section Cell Methods)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 16 Dec 2025 | Viewed by 171 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular Mechanisms of Cognitive Function and Dysfunction

edited by

Parasuraman Padmanabhan

Balázs Gulyás

and

Domokos Máthé

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5937 | Submission Open

Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy

(This special issue belongs to the Section Cellular Neuroscience)

Physiology of Telocytes

edited by

Catalin G. Manole

and Mihail E. Hinescu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 5062 | Submission Open

Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine

(This special issue belongs to the Section Cellular Pathology)

Metabolic Hallmarks in Cancer

edited by

Michael Lisanti

, Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3580 | Submission Open

Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions

(This special issue belongs to the Section Cellular Metabolism)

Advances in Human Pluripotent Stem Cells

edited by

Peggy Arthur

Sangeetha Kandoi

and

Nagavendra Kommineni

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2983 | Submission Open

Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets

edited by

Laura Jiménez Sánchez

and María Martín Estebané

submission deadline 20 Dec 2025 | Viewed by 328 | Submission Open

Keywords: microglia; inflammation; neural damage; mitochondria; potential targets

(This special issue belongs to the Section Cellular Aging)

Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders

edited by

Shenzhao Lu

submission deadline 20 Dec 2025 | Viewed by 255 | Submission Open

Keywords: development; neurological disease; cancer; genetic; epigenetic

Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions

edited by

Atefeh Rabiee

submission deadline 20 Dec 2025 | Viewed by 204 | Submission Open

Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function

Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids

edited by

Joanna Romanek

and Sylwia Orczewska-Dudek

submission deadline 20 Dec 2025 | Viewed by 181 | Submission Open

Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress

Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies

edited by Xiangguo Shi

submission deadline 20 Dec 2025 | Viewed by 173 | Submission Open

Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution

(This special issue belongs to the Section Cellular Pathology)

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Dec 2025 | Viewed by 140 | Submission Open

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2568 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Advances in Molecular Genomics and Pathology of Cancers

edited by

Muhammad Kibriya

submission deadline 25 Dec 2025 | Viewed by 267 | Submission Open

Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches

edited by

Neeraj Soni

submission deadline 25 Dec 2025 | Viewed by 172 | Submission Open

Keywords: chronic pain; synaptic plasticity; circuit dysfunction

(This special issue belongs to the Section Cellular Pathology)

Role of T Cells in Immune Disease Treatment

edited by

Ilan Bank

submission deadline 25 Dec 2025 | Viewed by 131 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells

(This special issue belongs to the Section Cellular Immunology)

Host Immunity to Bacterial Infections

edited by Karine Gloux

submission deadline 26 Dec 2025 | Viewed by 363 | Submission Open

Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration

edited by

Guoping Fan

submission deadline 28 Dec 2025 | 1 articles | Viewed by 1787 | Submission Open

Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling

(This special issue belongs to the Section Cellular Neuroscience)

Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights

edited by

Kohji Fukunaga

and

Wenbin Jia

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6529 | Submission Open

Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy

(This special issue belongs to the Section Tissues and Organs)

Fertility Disorders in Testes and Ovaries

edited by

Paweł Kordowitzki

and Joanna Kochan

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1604 | Submission Open

Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF

(This special issue belongs to the Section Tissues and Organs)

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 30 Dec 2025 | Viewed by 805 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions

Emerging Roles of Glial Cells in Human Health and Disease

edited by

Dan Frenkel

and

Menachem Hanani

submission deadline 31 Dec 2025 | 10 articles | Viewed by 45904 | Submission Open

Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia

(This special issue belongs to the Section Cellular Neuroscience)

Gene Therapy for Rare Diseases

edited by

Cord Brakebusch

submission deadline 31 Dec 2025 | 7 articles | Viewed by 40628 | Submission Open

Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses

edited by

Yang D. Teng

submission deadline 31 Dec 2025 | 9 articles | Viewed by 26475 | Submission Open

(This special issue belongs to the Section Cellular Neuroscience)

New Insights into Vascular Biology in Health and Disease

edited by Bashir M. Rezk

submission deadline 31 Dec 2025 | 6 articles | Viewed by 19401 | Submission Open

Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization

(This special issue belongs to the Section Cells of the Cardiovascular System)

Biological Mechanisms in the Treatment of Neuropsychiatric Diseases

edited by Randall D Marshall and Frank S. Menniti

submission deadline 31 Dec 2025 | 6 articles | Viewed by 17822 | Submission Open

Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms of Anti-Cancer Therapies

edited by Ilgen Mender and

Kazuyuki Kitatani

submission deadline 31 Dec 2025 | 8 articles | Viewed by 16029 | Submission Open

Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 31 Dec 2025 | 7 articles | Viewed by 14960 | Submission Open

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration

edited by

Philippe Hernigou

submission deadline 31 Dec 2025 | 7 articles | Viewed by 12669 | Submission Open

Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique

(This special issue belongs to the Section Cellular Pathology)

Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience

edited by Howard Prentice and

Jang-Yen Wu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9249 | Submission Open

Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise

edited by

Eugenia Murawska-Ciałowicz

Ana Filipa Silva

and

Gilmara Gomes De Assis

submission deadline 31 Dec 2025 | 2 articles | Viewed by 9187 | Submission Open

Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases

edited by Sara Spinelli,

Alessia Remigante

and

Rossana Morabito

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8401 | Submission Open

Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules

(This special issue belongs to the Section Cellular Pathology)

Ageing and Neurodegenerative Diseases, Second Edition

edited by Feng Wang and

Antonella Caccamo

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8197 | Submission Open

Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling

(This special issue belongs to the Section Cellular Pathology)

Signaling Pathways and Mechanisms in Cancer Therapy Resistance

edited by

Natarajan Aravindan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8174 | Submission Open

Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies

(This special issue belongs to the Section Cellular Pathology)

Redox and Metabolic Profile of Cancer

edited by

Bato Korac

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8049 | Submission Open

Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria

(This special issue belongs to the Section Cellular Metabolism)

Mechanisms of Immune Responses and Therapy

edited by

Zhuang Wang

and

Bernhard Ryffel

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7654 | Submission Open

Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Cell Biology: State of the Art and Perspectives in Italy 2025

edited by

Vincenzo Carafa

submission deadline 31 Dec 2025 | 1 articles | Viewed by 7628 | Submission Open

Keywords: cell biology; physiology; molecular biology

Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders

edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and

Verónica Pérez de la Cruz

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6649 | Submission Open

Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism

(This special issue belongs to the Section Cell Signaling)

Cellular and Molecular Mechanisms of Liver Diseases

edited by Jieyun Jiang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5793 | Submission Open

Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms

(This special issue belongs to the Section Cellular Pathology)

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