DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 15 December 2025 | Viewed by 567
Special Issue Editors
Interests: diabetes and metabolism; epigenetic mechanisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
DNA methylation is a fundamental epigenetic modification that regulates gene expression, maintains genomic stability, and orchestrates crucial developmental and cellular processes. Alterations in DNA methylation patterns have been increasingly implicated in the initiation and progression of a wide range of human diseases, including cancers, neurological disorders, autoimmune conditions, and metabolic syndromes. Recent advances in high-throughput sequencing, single-cell epigenomics, and functional studies have greatly expanded our understanding of the dynamic and context-dependent nature of DNA methylation, revealing its pivotal role as an interface between genetic predisposition and environmental influences.
This Special Issue aims to highlight the latest discoveries in the field of DNA methylation as it pertains to human health and disease. We welcome submissions of original research articles and comprehensive reviews that explore molecular mechanisms, the contribution of methylation to disease pathogenesis, the development of methylation-based biomarkers, and emerging therapeutic strategies targeting the epigenome. Studies employing innovative technologies or providing new conceptual insights into the regulation and function of DNA methylation are particularly encouraged.
Dr. Michele Longo
Dr. Jyotirmoy Das
Guest Editors
Manuscript Submission Information
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Keywords
- DNA methylation
- epigenetics
- diseases
- biomarkers
- functional analysis
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