Therapeutic Mechanism of Nervous System Inflammation—Second Edition
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 10 December 2025 | Viewed by 1386
Special Issue Editors
Interests: inflammation; microglia; astrocytes; neurodegeneration; Parkinson's disease; neuroinflammation; immune system; brain; inflammatory bowel diseases
Special Issues, Collections and Topics in MDPI journals
Interests: neuroinflammation; signaling; bioactive compounds; evolutionary computational study
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroinflammation is a process involved in various inflammatory cascades in nervous tissues that can result in persistent and chronic apoptotic neuronal cell death, triggering various degenerative disorders of the central nervous system, including neuroinflammatory and neurodegenerative diseases.
Although neuroinflammation is a natural defense mechanism against a variety of pathologic insults within the central nervous system (CNS), excessive inflammatory responses can be harmful. To contain and repair local tissue damage, an immediate anti-inflammatory response is required. CNS-resident cells, such as microglia and astrocytes, along with peripheral immune cells, orchestrate a series of events aimed at functional restoration. If the acute inflammatory event is not resolved, it turns toxic, resulting in progressive CNS degeneration. As a result, the cellular, molecular, and biochemical processes that control inflammation must coexist with the intrinsic CNS repair mechanisms that influence tissue healing.
A better understanding of the inflammatory processes that occur prior to or during CNS damage, as well as the subsequent cascades of inflammatory reactions, could lead to the development of novel treatments.
The goal of this Special Issue is to highlight aspects that could potentially contribute as therapeutic interventions to help resolve CNS inflammation, promote tissue repair, and enable functional recovery after acute injury and infection. Cellular and molecular mechanisms, as well as potential therapeutic targets for inflammatory disorders of the nervous system, will be investigated.
Prof. Dr. Maria Anttonietta Panaro
Dr. Antonia Cianciulli
Guest Editors
Manuscript Submission Information
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Keywords
- neuroinflammation
- neurodegeneration
- therapy
- drug target
- cell signaling
- cells of nervous system
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Related Special Issue
- Therapeutic Mechanism of Nervous System Inflammation in Cells (5 articles)
