The Role of Hormone Receptors in Cancers
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 December 2025 | Viewed by 26
Special Issue Editors
Interests: androgen receptors; breast cancer; estrogen receptors; iPSC; receptor signaling pathways; triple-negative breast cancer
Interests: neurodegenerative disease; neuropharmacology; signaling pathways
Special Issue Information
Dear Colleagues,
Hormone receptors play a critical role in regulating cellular growth, differentiation, and survival in various tissues. In many cancers, including breast, prostate, endometrial, and thyroid malignancies, hormone receptor signaling pathways are frequently dysregulated, contributing to tumor initiation, progression, and resistance to therapy. Estrogen, androgen, progesterone, and other nuclear receptors have been widely studied, yet the complexity of their crosstalk with intracellular pathways and the tumor microenvironment continues to evolve.
This Special Issue aims to highlight the latest advances in our understanding of how hormone receptors influence cancer biology. We welcome original research articles and reviews that explore the mechanistic roles of hormone receptors, their interactions with co-regulators, post-translational modifications, and their potential as prognostic markers or therapeutic targets. Studies encompassing in vitro experiments, in vivo investigations using animal models, as they collectively contribute to a comprehensive understanding of receptor-mediated pathways. Submissions addressing emerging receptor types, non-genomic actions, receptor isoforms, and resistance mechanisms to endocrine therapy are particularly encouraged. We hope this Special Issue will provide valuable insights into hormone receptor-driven oncogenesis and support the development of innovative strategies for diagnosis, prognosis, and treatment.
We look forward to your contributions to this Special Issue.
Dr. Edris Choupani
Dr. Kambiz Hassanzadeh
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer progression
- endocrine therapy resistance
- estrogen and androgen receptors
- hormone receptors
- nuclear receptors
- receptor signaling pathways
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