Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms Underlying Inflammatory Pain
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1400 | Submission Open
Keywords: molecular mechanisms; inflammatory pain; nociception; neuronal sensitization; neuroimmune interactions
Mechanisms Underlying Cell Growth and Development
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1170 | Submission Open
Keywords: cell growth; cell development; cell differentiation; cell cycle; mitosis; meiosis; molecular rearrangements; chromosomes; gene expression
Spatial Biology: Decoding Cellular Complexity in Tissues submission deadline 30 Apr 2026 | 1 articles | Viewed by 965 | Submission Open
Keywords: spatial biology; spatial tissue profiling; proteomics; transcriptomics; cell and tissue
(This special issue belongs to the Section Tissues and Organs)
Autophagy in Neurological Disorders submission deadline 30 Apr 2026 | 1 articles | Viewed by 532 | Submission Open
Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents
(This special issue belongs to the Section Cellular Neuroscience)
Role of Gamma Delta T Cells in Immunotherapy
edited by and Wenwei Tu
submission deadline 30 Apr 2026 | Viewed by 411 | Submission Open
Keywords: gamma delta T cells; adoptive cell therapy; chimeric antigen receptors; bispecific antibodies; cancer immunotherapy; tumor microenvironment; phosphoantigens; butyrophilin 2A1/3A1; virus infection; multidrug-resistant bacteria; extracellular vesicles
(This special issue belongs to the Section Cellular Immunology)
Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 396 | Submission Open
Keywords: autoimmune diseases; immune cells; lymphocytes; antigen-presenting cells; natural killer cells; innate lymphoid cells; epigenetic modifications; autoimmunity
(This special issue belongs to the Section Cellular Immunology)
Advances in Bacterial Cell Biophysics: Metabolic Engineering and Host Interactions
edited by Shahid Khan
submission deadline 30 Apr 2026 | Viewed by 390 | Submission Open
Keywords: bacterial cell biophysics; mechanical properties; biophysical techniques; host interactions; metabolic engineering
Synaptic Dysregulation in Nervous System Disorders
edited by Pragya Goel
submission deadline 30 Apr 2026 | Viewed by 334 | Submission Open
Keywords: synapses; synaptic transmission; synaptic plasticity; neurodegeneration; neuropsychiatric disorders; neurodevelopmental diseases
(This special issue belongs to the Section Cellular Neuroscience)
Novel Therapies and Biomarkers for Rare Diseases
edited by Reena Kartha
submission deadline 30 Apr 2026 | Viewed by 274 | Submission Open
Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine
Advances in Liquid Biopsy for Early Detection and Monitoring of Cancer
edited by Nicola Normanno, and
submission deadline 30 Apr 2026 | Viewed by 226 | Submission Open
Keywords: ctDNA; circulating tumor cells; microRNAs; exosomes; methylation; fragmentomics; early detection; minimal residual disease; artificial intelligence
Interleukin-1 Signaling in Cancer: Novel Mechanisms and Therapeutic Opportunities
edited by Afshan Fathima Nawas and
submission deadline 30 Apr 2026 | Viewed by 223 | Submission Open
Keywords: interleukin-1 signaling; tumor microenvironment; inflammatory pathways; cytokine networks; cancer cell proliferation; epigenetic regulation in cancer; non-coding RNAs; immune modulation; cancer metabolism
The Role of Integrins and Small GTPases in Health and Disease
edited by
submission deadline 30 Apr 2026 | Viewed by 185 | Submission Open
Keywords: cell signaling; integrins; cell adhesion; integrins diseases; infectious diseases
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Apr 2026 | Viewed by 177 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Kidney Development: Cellular and Molecular Insights submission deadline 30 Apr 2026 | Viewed by 126 | Submission Open
Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation
Glycosylation and Glycoproteins in Human Disease
edited by and
submission deadline 30 Apr 2026 | Viewed by 122 | Submission Open
Keywords: glycobiology; glycosylation; glycoproteins; glycolipids; glycan biomarkers; congenital disorders of glycosylation (cdg); immune modulation; glycan profiling; glycoengineering; host– pathogen interactions; therapeutic glycoproteins; bioorthogonal chemistry
Advances in Neuropathology: Cellular, Molecular and Precision Mechanisms in Neurodegenerative Diseases submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open
Keywords: neurodegeneration; Alzheimer's disease; Parkinson's disease; glial cells; synaptic dysfunction; protein aggregation; lysosomal function; autophagy; precision medicine
Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies submission deadline 30 Apr 2026 | 1 articles | Viewed by 116 | Submission Open
Keywords: hematologic diseases; mechanisms; therapies
Advancing Breast Cancer Research: Multi-Omics, AI, and Emerging Cellular Mechanisms
edited by Rahul Sanawar, and Satheesh Kumar Sengodan
submission deadline 30 Apr 2026 | Viewed by 110 | Submission Open
Keywords: breast cancer; cancer stem cells; cell plasticity; immune evasion; drug resistance; tumor microenvironment; non-coding RNAs; circulating tumor cells (CTC); circulating tumor DNA (ctDNA); exosomes; signaling pathways (e.g.; PI3K/AKT; MAPK); targeted therapy; immunotherapy
Noncoding RNAs: Immunity, Mechanisms, and Biomarker Potential
edited by
submission deadline 30 Apr 2026 | Viewed by 107 | Submission Open
Keywords: noncoding RNAs (ncRNAs); MicroRNAs (miRNAs); long noncoding RNAs (lncRNAs); circular RNAs (circRNAs); immune regulation; tumor microenvironment; immune checkpoints; cancer immunotherapy; liquid biopsy biomarkers; immune evasion
Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression submission deadline 30 Apr 2026 | Viewed by 105 | Submission Open
Keywords: cancer progression; cell death; senescence; cancer therapy
Molecular Signaling and Mechanism on Vascular Remodeling
edited by Ki Ho Park and Yitao Huang
submission deadline 30 Apr 2026 | Viewed by 100 | Submission Open
Keywords: vascular diseases; atherosclerosis; aneurysm; intimal hyperplasia; vascular remodeling; cellular mechanisms; cellular signaling
New Therapeutic Approaches to Cardiac Repair
edited by Dinakar Iyer
submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open
Keywords: cardiac regeneration; CRISPR/base editing; mRNA therapeutics; circular RNA (circRNA); lipid nanoparticles (LNPs); engineered exosomes/extracellular vesicles; direct cardiac reprogramming; engineered heart muscle/3D cardiac patches; myocardial infarction repair; translational cardiology
Mechanisms and Therapies of Cell Death Pathways
edited by and Deniz Gulfem Ozturk
submission deadline 30 Apr 2026 | Viewed by 76 | Submission Open
Keywords: cell death; mitochondrial regulation; BCL-2 family; non-apoptotic cell death; cell death pathways interactions; small molecules; therapeutic strategy; therapy resistance
(This special issue belongs to the Section Cellular Pathology)
Post-Transcriptional Control of Stem Cell Fate and Neural Development
edited by
submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open
Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology
(This special issue belongs to the Section Stem Cells)
Exploiting Stem Cell Pathways for Immune Protection
edited by
submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open
Keywords: stem cell; immune tolerance; immune modulation; autoimmunity; immunosuppression; immunotherapy; immune escape; immune evasion; immune privilege; stemness
Lipoprotein and Cardiovascular Diseases Therapy
edited by Verity Ramirez and Wenliang Song
submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open
Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanism of Endocrine Therapy Resistance in Breast Cancer
edited by and Clodia Osipo
submission deadline 1 May 2026 | Viewed by 61 | Submission Open
Keywords: estrogen receptor; endocrine resistance; mechanism of action; predictive biomarkers; signal transduction; novel therapeutics; drug sequencing; drug targets; pathological findings
(This special issue belongs to the Section Cellular Pathology)
Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling
edited by Joaquim Gea Guiral
submission deadline 10 May 2026 | 2 articles | Viewed by 1959 | Submission Open
Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis
LPS-Induced Inflammatory Diseases
edited by and
submission deadline 10 May 2026 | Viewed by 569 | Submission Open
Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer
edited by , Lin Yuan and Yang Yu
submission deadline 10 May 2026 | Viewed by 133 | Submission Open
Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics
Retinal Disorders: Cellular Mechanisms and Targeted Therapies
edited by
submission deadline 15 May 2026 | 5 articles | Viewed by 11917 | Submission Open
Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics
(This special issue belongs to the Section Cellular Pathology)
Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling
edited by Jianjie Ma, Long-Sheng Song, and
submission deadline 15 May 2026 | 3 articles | Viewed by 2602 | Submission Open
Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease
Mechanisms and Therapies in Chronic Pain
edited by Nikesh Kunder and June Bryan I. de la Peña
submission deadline 15 May 2026 | 1 articles | Viewed by 1577 | Submission Open
Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management
(This special issue belongs to the Section Cellular Pathology)
Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae
edited by and Hisao Moriya
submission deadline 15 May 2026 | 2 articles | Viewed by 1145 | Submission Open
Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Placenta in Tissue Engineering and Regeneration
edited by
submission deadline 15 May 2026 | Viewed by 233 | Submission Open
Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration
The Metabolic Interactions and Pathways in Cancers
edited by Mohamed Elgendy
submission deadline 15 May 2026 | Viewed by 207 | Submission Open
Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy
Molecular and Translational Advances in Metastatic Breast Cancer Research
edited by
submission deadline 15 May 2026 | Viewed by 118 | Submission Open
Keywords: metastatic breast cancer; tumor microenvironment; therapeutic resistance; immunotherapy; targeted therapy; cancer biomarkers; personalized medicine; translational oncology; circulating tumor cells; molecular mechanisms of metastasis
The Role of Light in Ocular Health and Disease
edited by Krisztina Valter, and
submission deadline 15 May 2026 | Viewed by 111 | Submission Open
Keywords: light; photobiology; light exposure; circadian rhythms; vision; light-induced retinal damage; phototoxicity; photoprotection; retinal degeneration; light modulation; oxidative stress; light therapy; photobiomodulation; blue light effects; Protective wavelengths; harmful wavelengths; ocular phototransduction; light-based therapeutics
Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma
edited by , Patricia L Sullivan and Jeremy J Reynolds
submission deadline 15 May 2026 | Viewed by 101 | Submission Open
Keywords: chordoma; targeted therapy; brachyury; tumor microenvironment; epigenetics; immunotherapy; biomarkers; drug resistance; translational oncology; radiation resistance
Conditional Programming of Cells, Advanced Computational Methods, and Intelligent Systems in Prostate Cancer Research
edited by Ahmed Fadiel
submission deadline 15 May 2026 | Viewed by 71 | Submission Open
Keywords: prostate cancer; conditional programming; cellular reprogramming; computational biology; cell-state transitions; lineage plasticity; tumor microenvironment; ex vivo models; machine learning
Advances in Spermatogenesis—Second Edition
edited by and Changmin Niu
submission deadline 15 May 2026 | Viewed by 26 | Submission Open
Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular Advances in Prenatal Exposure to Environmental Toxicants submission deadline 20 May 2026 | 4 articles | Viewed by 13487 | Submission Open
Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes
Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition submission deadline 20 May 2026 | 6 articles | Viewed by 9564 | Submission Open
Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β
(This special issue belongs to the Section Cell Signaling)
Recent Advances in the Study of Tau Protein
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 4785 | Submission Open
Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions
(This special issue belongs to the Section Cellular Neuroscience)
Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery
edited by Roberta Montanari and
submission deadline 20 May 2026 | 1 articles | Viewed by 3541 | Submission Open
Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms
(This special issue belongs to the Section Cellular Biophysics)
The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses submission deadline 20 May 2026 | 3 articles | Viewed by 2874 | Submission Open
Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications
(This special issue belongs to the Section Cellular Pathology)
Heparanase and Heparanase-2: Function, Regulation, Signaling, and Disease submission deadline 20 May 2026 | 1 articles | Viewed by 1747 | Submission Open
Keywords: heparanase (Hpa1); heparanase-2 (Hpa2); tumor microenvironment; extracellular matrix; tumor progression; tumor suppression; metastatic niche; glycocalyx; immune cells; inflammation
(This special issue belongs to the Section Cell Signaling)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1567 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies
edited by , and Íñigo Casafont
submission deadline 20 May 2026 | Viewed by 318 | Submission Open
Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy
(This special issue belongs to the Section Cellular Metabolism)
New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets
edited by
submission deadline 20 May 2026 | Viewed by 242 | Submission Open
Keywords: cancer; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Immunology)
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