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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

edited by

Silvia Peppicelli

and Giulio Menegazzi

submission deadline 30 Sep 2025 | Viewed by 156 | Submission Open

Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance

(This special issue belongs to the Section Cell Microenvironment)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 30 Sep 2025 | Viewed by 146 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 30 Sep 2025 | Viewed by 136 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Biomarkers and Therapeutic Targets in Insulin Resistance

edited by

Mohamed Elrayess

submission deadline 30 Sep 2025 | Viewed by 130 | Submission Open

Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases

(This special issue belongs to the Section Cellular Pathology)

Mitochondria and Peroxisomes–Individual Roles and Delicate Balance of Redox Organelles

edited by

Andreas Till

submission deadline 30 Sep 2025 | Viewed by 93 | Submission Open

Keywords: mitochondria; peroxisomes; redox organelles; oxidative stress; ROS; organelles; neurodegeneration; autophagy; aging; metabolism

Novel Molecular Insight into Congenital Disorders of N-Linked Glycosylation

edited by

Ashutosh Pandey

submission deadline 30 Sep 2025 | Viewed by 81 | Submission Open

Keywords: N-linked glycosylation; CDG; animal models; genetic variants; glycomics; glycoproteomics; pathophysiology

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Sep 2025 | Viewed by 75 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Novel Insights into Molecular Mechanisms and Therapy of Myeloma

edited by

Yusuke Furukawa

and

Jian Wu

submission deadline 5 Oct 2025 | 4 articles | Viewed by 4609 | Submission Open

Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker

(This special issue belongs to the Section Cellular Pathology)

The Interplay of G-Protein-Coupled Receptor Signaling between Humans and Diseases

edited by Victor Garcia

submission deadline 10 Oct 2025 | 1 articles | Viewed by 6418 | Submission Open

Keywords: G-proteins; G-protein-coupled receptors; G-protein-independent signaling; cAMP signals

Study on Immune Activity of Natural Products

edited by Xiu-Min Li

submission deadline 10 Oct 2025 | Viewed by 91 | Submission Open

Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential

Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health

edited by

Chuanjin Wu

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2370 | Submission Open

Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination; ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.

(This special issue belongs to the Section Cellular Pathology)

Ras Family of Genes and Proteins: Structure, Function and Regulation

edited by

Eugenio Santos

Alberto Fernández-Medarde

and Rosula Garcia-Navas

submission deadline 15 Oct 2025 | 2 articles | Viewed by 2313 | Submission Open

Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF

Regulation of the Subcellular Compartmentalization of Signaling Pathways by Post-Translational Modifications

edited by Jürgen Fritsch

submission deadline 15 Oct 2025 | 1 articles | Viewed by 724 | Submission Open

Keywords: phosphorylation; ubiquitination; acetylation; acylation; methylation; sumoylation; glycosylation; neddylation; ribosylation; oxidation; proteolysis

Advances in Understanding Inflammation in Atherosclerosis: From Mechanisms to Therapeutic Targets

edited by Yaw Asare and Michael Lacy

submission deadline 15 Oct 2025 | Viewed by 636 | Submission Open

Keywords: atherosclerosis; inflammatory pathways; monocytes/macrophages; endothelial cells; innate immunity; inflammasome; IL-1β ; cytokines and chemokines; neutrophils; epigenetic mechanisms; adaptive immunity; small-molecule inhibitors; T cells; B cells

(This special issue belongs to the Section Cellular Pathology)

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 15 Oct 2025 | Viewed by 272 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function

edited by

Alessandra Maria Vitale

and

Federica Scalia

submission deadline 15 Oct 2025 | Viewed by 224 | Submission Open

Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 15 Oct 2025 | Viewed by 218 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

AI, CRISPR, and Molecular Mechanisms in Precision Medicine

edited by Karim Daliri

submission deadline 15 Oct 2025 | Viewed by 100 | Submission Open

Keywords: CRISPR; gene therapy; precision medicine

(This special issue belongs to the Section Cell Methods)

Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health

edited by

Aaron C. Brown

submission deadline 15 Oct 2025 | Viewed by 86 | Submission Open

Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines

Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 15 Oct 2025 | Viewed by 78 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Extracellular Vesicles and Exosomes: Novel Insight and Therapeutic Applications in Cancer

edited by Giusi Alberti and

Celeste Caruso Bavisotto

submission deadline 16 Oct 2025 | Viewed by 129 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes (Exos); proteins and miRNA; 2D-EVs and Exos; 3D-EVs and Exos; precision therapy; molecular mechanism; cancer physiology; oncology research

Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses

edited by

Yang D. Teng

submission deadline 20 Oct 2025 | 9 articles | Viewed by 19628 | Submission Open

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Mechanisms of Autism Spectrum Disorder

edited by Tanya Gandhi and

Charles Lee

submission deadline 20 Oct 2025 | 6 articles | Viewed by 13267 | Submission Open

Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies

(This special issue belongs to the Section Cells of the Nervous System)

Therapeutic Targets in Glioblastoma

edited by Candice Mazewski and

Frank Eckerdt

submission deadline 20 Oct 2025 | 5 articles | Viewed by 8773 | Submission Open

Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing

(This special issue belongs to the Section Cells of the Nervous System)

New Trends and Advances in Diagnosis and Prognosis of Head and Neck Cancer from Carcinogenesis to Future Molecular Targeted Therapies: 2nd Edition

edited by

Piotr Cierpikowski

and

Julia Bar

submission deadline 20 Oct 2025 | 4 articles | Viewed by 5318 | Submission Open

Keywords: head and neck cancer; oral cancer; biomarker; prognosis; carcinogenesis; oral premalignant lesions; cancer stem cells; signaling pathways; molecular targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Sperm Biology and Reproductive Health—Second Edition

edited by

Yi-Xun Liu

and

Shou-Long Deng

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2168 | Submission Open

Keywords: spermatogenesis; differentiation of spermatogonial stem cells in vitro; mitosis; meiosis; sperm formation

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1407 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Mechanism of Cell Signaling During Eye Development and Diseases—Second Edition

edited by

Mehrnoosh Saghizadeh Ghiam

and

Vivien Coulson-Thomas

submission deadline 20 Oct 2025 | 1 articles | Viewed by 782 | Submission Open

Keywords: cell signaling; ocular; eye disorders; Wnt signaling; TGF-β

(This special issue belongs to the Section Cell Signaling)

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 20 Oct 2025 | 1 articles | Viewed by 445 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Cell Therapy for Retinal Diseases

edited by

Girish Kumar Srivastava

and

Yogeswaran Lokanathan

submission deadline 20 Oct 2025 | Viewed by 300 | Submission Open

Keywords: retinal diseases; cell therapy; stem cells; retinal regeneration; cell transplantation; gene editing in retinal therapy; tissue engineering; retinal organoids; vision restoration; clinical translation of cell therapy; future directions in retinal regeneration

(This special issue belongs to the Section Tissues and Organs)

Immune Response in HIV Infection, Pathogenesis and Persistence

edited by Suvadip Mallick

submission deadline 20 Oct 2025 | Viewed by 153 | Submission Open

Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints

(This special issue belongs to the Section Cellular Immunology)

New Molecular Insights into Hepatitis and Hepatic Cancer

edited by

Mark A. Feitelson

submission deadline 20 Oct 2025 | Viewed by 120 | Submission Open

Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances

(This special issue belongs to the Section Cellular Pathology)

Autophagy in Neurological Disorders

edited by

Natalia Jimenez-Moreno

and

Ciro Isidoro

submission deadline 20 Oct 2025 | Viewed by 117 | Submission Open

Keywords: autophagy; selective autophagy; neurodegeneration; proteostasis; lysosomes; aging; oxidative stress; aging; biomarkers; pharmacological agents

(This special issue belongs to the Section Cells of the Nervous System)

Cell Death and Its Clearance in Health and Disease

edited by

Turan Tufan

submission deadline 20 Oct 2025 | Viewed by 107 | Submission Open

Keywords: cell death; phagocytosis; immune homeostasis; inflammation

(This special issue belongs to the Section Cellular Pathology)

The Cellular and Molecular Mechanisms of Immunity to Infectious Viruses

edited by

Dimitrios Vlachakis

Tassos Georgakopoulos

and

Marios Agelopoulos

submission deadline 20 Oct 2025 | Viewed by 91 | Submission Open

Keywords: viral infections; immune cell biology; gene expression programs; epigenetics; chromatin architecture; cis-regulatory elements; functional genomics; computational biology applications

(This special issue belongs to the Section Cellular Pathology)

Unraveling Protein–Protein Interactions for Innovative Therapeutics and Nanodelivery

edited by Roberta Montanari and

Alberto Vitali

submission deadline 20 Oct 2025 | Viewed by 62 | Submission Open

Keywords: protein– protein interactions; PPI modulators; nanodelivery; molecular mechanisms

(This special issue belongs to the Section Cellular Biophysics)

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 25 Oct 2025 | 5 articles | Viewed by 10783 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

Adult Stem Cells in Human Disease

edited by Esther Wolfs, Tim Vangansewinkel and

Annelies Bronckaers

submission deadline 25 Oct 2025 | 1 articles | Viewed by 2525 | Submission Open

Keywords: dental pulp stem cells; disease; regenerative medicine; disease modeling

(This special issue belongs to the Section Stem Cells)

3D Cultures and Organ-on-a-Chip in Cell and Tissue Cultures

edited by

Annunziata Mauro

Barbara Barboni

and

Giovanna Della Porta

submission deadline 25 Oct 2025 | 2 articles | Viewed by 1943 | Submission Open

Keywords: three-dimensional cell culture; organ-on-a-chip; tissue engineering; regenerative medicine; drug testing; microfluidics; in vitro models; personalized medicine; cellular interaction; disease modeling

(This special issue belongs to the Section Cell Methods)

Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease

edited by

Ruqayya Afridi

submission deadline 25 Oct 2025 | Viewed by 164 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Anatomy and Function of Sensory Organs and Sensory Tissues

edited by

Frank Schmitz

submission deadline 25 Oct 2025 | Viewed by 124 | Submission Open

Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs

(This special issue belongs to the Section Tissues and Organs)

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Oct 2025 | Viewed by 123 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 30 Oct 2025 | 1 articles | Viewed by 739 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Oct 2025 | 1 articles | Viewed by 555 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Advances in Cellular and Molecular Treatment of Autoimmune Diseases—Second Edition

edited by

Panagiotis Athanassiou

Dimitrios P. Bogdanos

and

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Oct 2025 | Viewed by 220 | Submission Open

Keywords: autoimmune diseases; disease activity; TNFa inhibitors; tocilizumab; infliximab; golimumab; etanercept; JAK inhibitors; cellular targets; molecular targets

(This special issue belongs to the Section Cellular Immunology)

Thirty plus Years’ Journey—Painting the Molecular Picture of E-C Coupling

edited by Jianjie Ma, Long-Sheng Song,

Jingsong Zhou

and

Hua Zhu

submission deadline 30 Oct 2025 | Viewed by 120 | Submission Open

Keywords: E-C coupling; calcium signaling; muscle physiology; cardiovascular disease

New Advances in Cancer Cell Biology: Biomarkers and Therapeutic Targets

edited by

Verena Damiani

submission deadline 30 Oct 2025 | Viewed by 102 | Submission Open

Keywords: cancer; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Immunology)

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 30 Oct 2025 | Viewed by 102 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

Perinatal Brain Injury—from Pathophysiology to Therapy

edited by Cora H.A. Nijboer,

Bobbi Fleiss

and

Ivo Bendix

submission deadline 31 Oct 2025 | 6 articles | Viewed by 11991 | Submission Open

Keywords: preterm birth; perinatal brain injury; infection; inflammation; hypoxia; ischemia; hyperoxia; malnutrition; regenerative therapies; pharmacological intervention; stem cells

(This special issue belongs to the Section Cells of the Nervous System)

Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy

edited by

Grazia Serino

and

Amilcare Barca

submission deadline 31 Oct 2025 | 3 articles | Viewed by 8409 | Submission Open

Keywords: gastrointestinal cancer; gastric cancer; colorectal cancer; esophageal cancer; liver cancer; pancreatic cancer; inflammatory bowel disease; miRNAs; in vitro and in vivo models; molecular networks; molecular pathways; translational medicine; epithelial barrier functions/processes

(This special issue belongs to the Section Cellular Pathology)

Displaying special issue 151-200 on page 4 of 11.

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