Mitochondria and Peroxisomes–Individual Roles and Delicate Balance of Redox Organelles

Dear Colleagues,

Cellular homeostasis is a key requisite for the cell survival and health of multicellular organisms. In order to guarantee homeostatic conditions, eukaryotic cells are constantly combating intrinsic and extrinsic stress conditions. One prominent example for a potentially deleterious intrinsic stressor is an excess of reactive oxidative species (ROS), leading to cell damage, functional decline, and the possible manifestation or progression of severe disorders such as chronic inflammation, neurodegeneration, or cancer. Two organelles are both the source and sink of ROS: Mitochondria represent the site of ATP production by oxidative phosphorylation (oxPhos), but also contribute to apoptosis execution, metabolism, and immune responses. Peroxisomes are ubiquitous organelles containing a specific set of enzymes involved in fatty acid beta-oxidation, lipid synthesis, and ROS detoxification. Importantly, the dysfunction of these organelles is linked to a variety of devastating diseases.

On occasion of this Special Issue of Cells, I cordially invite you to contribute reviews, comments, or original research articles on various aspects related to the following topic:

“Mitochondria and Peroxisomes–Individual roles and delicate Balance of Redox Organelles”

Articles addressing cellular, biochemical, or general aspects of organelle function or crosstalk are highly welcome. Relevant topics may encompass (but are not limited to) the following:

• Mitochondrial and/or peroxisomal metabolism;
• Cellular bioenergetics;
• Mitochondrial/peroxisomal homeostasis;
• Organelle turnover;
• Molecular mechanisms of ROS generation and detoxification;
• Functional crosstalk between redox organelles;
• Role of redox organelles in chronic inflammation, cancer, neurodegeneration, metabolic syndrome, and aging;
• Therapies or drugs targeting organelle biology;
• Organelle-specific genome editing;
• Mitochondrial DNA variants and their role in human diseases.

Early-stage researchers are especially invited to share their data and opinions. Moreover, if we jointly manage to publish more than 10 papers, this Special Issue may be published in a printed book format.

Dr. Andreas Till
Guest Editor

Manuscript Submission Information

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• mitochondria
• peroxisomes
• redox organelles
• oxidative stress
• ROS
• organelles
• neurodegeneration
• autophagy
• aging
• metabolism