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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 5 Jul 2026 | 2 articles | Viewed by 5472 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes

edited by

Michela Corsini

and

Stefania Mitola

submission deadline 8 Jul 2026 | 1 articles | Viewed by 2800 | Submission Open

Keywords: membrane receptors; molecular complex; membrane microdomains

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 10 Jul 2026 | 4 articles | Viewed by 15230 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Advances in Human Pluripotent Stem Cells

edited by

Peggy Arthur

Sangeetha Kandoi

and

Nagavendra Kommineni

submission deadline 10 Jul 2026 | 5 articles | Viewed by 9933 | Submission Open

Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Cellular Signaling Networks in Development, Homeostasis, and Disease

edited by

Ying Xia

Mei Xin

and Chia-Yang Liu

submission deadline 10 Jul 2026 | 3 articles | Viewed by 2245 | Submission Open

Keywords: cell fate determination; cell migration and survival; cell proliferation and differentiation; development and homeostasis; developmental disorders; disease mechanisms; regenerative medicine; signal transduction; signaling crosstalk; spatial transcriptomics

(This special issue belongs to the Section Cell Signaling)

The Role of Mitochondria in Health, Disease, and Ageing

edited by

Arunkumar Venkatesan

and

Ritva Tikkanen

submission deadline 10 Jul 2026 | 2 articles | Viewed by 1628 | Submission Open

Keywords: mitochondrial dysfunction; metabolism; mitochondrial genetics; aging and senescence; bioenergetics; mitophagy; neurodegeneration; cardiomyopathy; metabolic syndrome; ocular diseases

(This special issue belongs to the Section Mitochondria)

Advances in Tissue Engineering Approaches for Bone Repair and Regeneration

edited by

Elaheh Dalir Abdolahinia

submission deadline 10 Jul 2026 | 2 articles | Viewed by 1510 | Submission Open

Keywords: bone tissue engineering; bone regeneration; biomaterials and scaffolds; bone cancer; 3D printing; bioprinting

(This special issue belongs to the Section Tissues and Organs)

Hypoxia and the Immune Landscape in Infection and Cancer

edited by Bernard Burke

submission deadline 10 Jul 2026 | 1 articles | Viewed by 1343 | Submission Open

Keywords: hypoxia; tumor; infection; HIFs; immune checkpoint proteins; immune evasion; metabolic dysregulation; leukocyte recruitment; effector cell function; acidosis

(This special issue belongs to the Section Cellular Immunology)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 10 Jul 2026 | Viewed by 856 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

Chronic Coronary Syndromes: Cellular Pathways, Comorbidities, and Prognostic Determinants

edited by Chowdhury H. Ahsan

submission deadline 10 Jul 2026 | 1 articles | Viewed by 567 | Submission Open

Keywords: chronic coronary syndromes; microvascular dysfunction; endothelial injury; vascular biology; inflammation; cardiometabolic comorbidities; ischemic heart disease; risk stratification; precision cardiology

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Neuro-Immune Axis in Pulmonary Inflammation and Fibrosis

edited by Carlos H. Hiroki

submission deadline 10 Jul 2026 | Viewed by 357 | Submission Open

Keywords: neuroimmune interactions; lung inflammation; lung innervation; neuropeptides; neurotransmitters

(This special issue belongs to the Section Cellular Immunology)

Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights

edited by

Kohji Fukunaga

and

Wenbin Jia

submission deadline 15 Jul 2026 | 3 articles | Viewed by 12779 | Submission Open

Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy

(This special issue belongs to the Section Tissues and Organs)

Inflammation in the Brain: From Molecular and Cellular Mechanisms to Therapeutic Strategies

edited by Sujatha Kannan and

Elizabeth Winans Tucker

submission deadline 15 Jul 2026 | 3 articles | Viewed by 8760 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; immune signaling; neurodegeneration; neuroimmunology; brain injury; therapeutic strategies

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 15 Jul 2026 | 2 articles | Viewed by 6518 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Jul 2026 | 2 articles | Viewed by 2637 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cellular Neuroscience)

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2551 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Recent Progress on Fibrosis and Cardiac Dysfunction

edited by

Tabito Kino

and

Tomoaki Ishigami

submission deadline 15 Jul 2026 | 2 articles | Viewed by 2385 | Submission Open

Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Jul 2026 | 1 articles | Viewed by 2025 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Role of T Cells in Immune Disease Treatment

edited by

Ilan Bank

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1939 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells

(This special issue belongs to the Section Cellular Immunology)

MET: Signaling, Regulation, and Biological Roles

edited by Abdulhameed Al-Ghabkari and William W. Lockwood

submission deadline 15 Jul 2026 | 1 articles | Viewed by 587 | Submission Open

Keywords: MET; HGF (hepatocyte growth factor); MET signaling; receptor tyrosine kinase (RTK); cancer; tumor progression; receptor activation; MET-targeted therapy

(This special issue belongs to the Section Cell Signaling)

Role of Ras-Regulated Signal Pathways

edited by

Takayuki Tsukuba

submission deadline 15 Jul 2026 | Viewed by 583 | Submission Open

Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway

(This special issue belongs to the Section Cell Signaling)

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Jul 2026 | Viewed by 497 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

Role of Hippo Signaling in Cancer

edited by

Dimpi Mukhopadhyay

and

Alessio D'Alessio

submission deadline 15 Jul 2026 | Viewed by 290 | Submission Open

Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis

(This special issue belongs to the Section Cell Signaling)

Skeletal Muscle Plasticity in Health, Aging and Disease

edited by

Junaith S. Mohamed

submission deadline 15 Jul 2026 | Viewed by 211 | Submission Open

Keywords: skeletal muscle; muscle plasticity; muscle regeneration; muscle atrophy; mitochondria; autophagy; non-coding RNAs

(This special issue belongs to the Section Cellular Aging)

Molecular and Cellular Mechanisms of Inherited Retinal Diseases

edited by Holly Yu Chen

submission deadline 15 Jul 2026 | Viewed by 179 | Submission Open

Keywords: inherited retinal diseases; retinal degeneration; retinal organoids; müller glia; retinal pigment epithelium

(This special issue belongs to the Section Cellular Pathology)

Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 20 Jul 2026 | 7 articles | Viewed by 19285 | Submission Open

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 20 Jul 2026 | 9 articles | Viewed by 16586 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 20 Jul 2026 | 4 articles | Viewed by 9343 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jul 2026 | 7 articles | Viewed by 9048 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Jul 2026 | 2 articles | Viewed by 6134 | Submission Open

Keywords: adipocyte differentiation, progenitors, and stem cells; adipokines, myokines, hepatokines, cytokines, cellular signaling, and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics, genomics, metabolomics, other ‘omics’ technologies; metabolic syndrome, obesity, insulin resistance, cancer

(This special issue belongs to the Section Tissues and Organs)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 20 Jul 2026 | 4 articles | Viewed by 3332 | Submission Open

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor–immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment

edited by Shashi Anand

submission deadline 20 Jul 2026 | 1 articles | Viewed by 776 | Submission Open

Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance

(This special issue belongs to the Section Cellular Metabolism)

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Jul 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Epigenetic and Metabolic Regulation of Cancer—2nd Edition

edited by

Jung-Hyun Kim

and

Ming Tan

submission deadline 20 Jul 2026 | 1 articles | Viewed by 432 | Submission Open

Keywords: cancer; epigenetic; transcription; chromatin; tumor metabolism; immunometabolism

(This special issue belongs to the Section Cellular Metabolism)

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and

Hami Hemati

submission deadline 20 Jul 2026 | Viewed by 384 | Submission Open

Keywords:

Substance Use

Alcohol

Immunity

Inflammation

Hematopoietic stem and progenitor cells

Monocytes

Neutrophils

Macrophages

T cells

Cellular and Molecular Research of Plant-Derived Exosomes

edited by Mukesh Kumar Sriwastva

submission deadline 20 Jul 2026 | Viewed by 307 | Submission Open

Keywords: plant-derived exosomes; extracellular vesicles; exosome isolation and characterization; cross-kingdom communication; therapeutic applications; biomolecule cargo (proteins, RNAs, lipids); plant exosome-like nanoparticles; drug delivery systems

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular Mechanisms and Targeting Strategies of the Blood–Brain Barrier

edited by Kasandra Bélanger

submission deadline 20 Jul 2026 | Viewed by 253 | Submission Open

Keywords: blood–brain barrier; homeostasis; neurovascular unit; drug delivery; neurorological disorders; BBB integrity; permeability; molecular pathways

(This special issue belongs to the Section Cellular Neuroscience)

Bioactive Compounds in the Management of Neurodegenerative Diseases

edited by Melania Ruggiero and

Maria Antonietta

submission deadline 20 Jul 2026 | Viewed by 251 | Submission Open

Keywords: bioactive compounds; neurodegenerative diseases; neuroprotection; neuroinflammation; oxidative stress; neurogenesis; astrocytes reprogramming

(This special issue belongs to the Section Cellular Neuroscience)

Applications of Nanotechnology and Molecular Imaging in Cancer

edited by

Zheng-Rong Lu

and Victoria Laney

submission deadline 20 Jul 2026 | Viewed by 199 | Submission Open

Keywords: contrast agents and mechanisms; probes; molecular imaging; longitudinal imaging; tumor microenvironment; nanomaterials; cell signaling; cancer therapy; intracellular pathways; imaging-guided treatment

A New Frontier for Cancer Diagnosis and Therapy

edited by

Concettina La Motta

Md Manirujjaman

and

A.S.M. Waliullah

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1627 | Submission Open

Keywords: cancer diagnosis; precision oncology; liquid biopsy; molecular biomarkers; immunotherapy; targeted therapy; nanomedicine; multi-omics; artificial intelligence; tumor heterogeneity

(This special issue belongs to the Section Cellular Immunology)

Novel Molecular Targets for the Treatment of Sleep Disorders

edited by

Dae-Wui Yoon

submission deadline 25 Jul 2026 | Viewed by 490 | Submission Open

Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration

Molecular Regulation of Trophoblast Invasion in Placental Function and Pregnancy Disorders

edited by Mirjana Nacka-Aleksić

submission deadline 25 Jul 2026 | Viewed by 246 | Submission Open

Keywords: trophoblast invasion; preeclampsia; placenta accreta; human trophoblast stem cells

(This special issue belongs to the Section Reproductive Cells and Development)

Harnessing the Immune System: Emerging Therapeutic Strategies in Cancer

edited by Kishan Shamjibhai Italiya

submission deadline 25 Jul 2026 | Viewed by 195 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; adoptive cell therapy; cancer vaccines; T cell therapy; immuno-oncology; tumor immune evasion; immune modulation; antitumor immunity

(This special issue belongs to the Section Cellular Immunology)

Applications of Proteomics in Human Diseases and Treatments

edited by

Giovanni Cuda

and

Marco Gaspari

submission deadline 30 Jul 2026 | 3 articles | Viewed by 4058 | Submission Open

Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics

(This special issue belongs to the Section Cell Methods)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 30 Jul 2026 | 1 articles | Viewed by 2684 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Toxicology in Cells: Cellular Mechanisms, Molecular Responses, and Modern Models

edited by Maria Jurczuk and

Patrice X. Petit

submission deadline 30 Jul 2026 | 2 articles | Viewed by 1921 | Submission Open

Keywords: cellular toxicology; oxidative stress; apoptosis; autophagy; biomarkers; nanotoxicology; organ-on-chip; toxicogenomics; epigenetic regulation; mitochondrial dysfunction

New Advances in Immunomodulation Using Biomaterials

edited by