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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Neuropathic Pain

edited by

Hiroshi Ueda

and

Norimitsu Morioka

submission deadline 20 Jul 2025 | 9 articles | Viewed by 12999 | Submission Open

Keywords: neuropathic pain; nociplastic pain; fibromyalgia; brain-immune connection; sexual dimorphism; glial cells; lysophosphatidic acid

(This special issue belongs to the Section Cells of the Nervous System)

Signaling Pathways in Endometrial Cancer Cells

edited by

Tomohiko Fukuda

submission deadline 20 Jul 2025 | 2 articles | Viewed by 4652 | Submission Open

Keywords: endometrial cancer; cellular signaling; cell metabolism; DNA damage repair pathway; the PI3K/AKT/mTOR pathway; the RAS/MAPK pathway; molecular classification

(This special issue belongs to the Section Cell Signaling)

Environmental Exposure and Cell Damage

edited by

Paola Piomboni

Alice Luddi

and

Melvin K. S. Leow

submission deadline 20 Jul 2025 | 1 articles | Viewed by 4061 | Submission Open

Keywords: cellular and molecular damage; oxidative stress; environmental effects; endocrine disruptors; lifestyle factors

(This special issue belongs to the Section Cellular Immunology)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 20 Jul 2025 | 4 articles | Viewed by 3956 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Adipose-Derived Stem Cells: Current Applications and Future Directions

edited by

Yasuhito Ishigaki

submission deadline 20 Jul 2025 | 3 articles | Viewed by 3607 | Submission Open

Keywords: cell therapy; regenerative medicine; adipose-derived stem cells (ADSCs); exosome; cytokine

(This special issue belongs to the Section Stem Cells)

Role of Autophagy in Plant Cells

edited by

Alessio Papini

submission deadline 20 Jul 2025 | 2 articles | Viewed by 2274 | Submission Open

Keywords: autophagy; endoplasmic reticulum; TOR; vacuoles; lysosomes; mitochondria; plastids

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases

edited by Xinrui Gui and Jinjun Wu

submission deadline 20 Jul 2025 | 1 articles | Viewed by 982 | Submission Open

Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biophysics)

Host–Microbial Interactions: Second Edition

edited by

Hung-Jen Liu

Brent L. Nielsen

and

Muhammad Munir

submission deadline 20 Jul 2025 | Viewed by 792 | Submission Open

Keywords: virus– host interactions; signaling pathway; virus entry; life cycle

(This special issue belongs to the Section Cellular Immunology)

Glioblastoma: What Do We Know?

edited by

Shan Ping Yu

submission deadline 25 Jul 2025 | 5 articles | Viewed by 14146 | Submission Open

Keywords: carcinoma cell; diagnoses; molecular mechanism; cellular mechanism; signaling pathways; biomarkers; therapeutics

(This special issue belongs to the Section Cells of the Nervous System)

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Jul 2025 | 7 articles | Viewed by 12010 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Neuroinflammation in Brain Health and Diseases

edited by Debashis Dutta and Nemil Bhatt

submission deadline 25 Jul 2025 | 4 articles | Viewed by 4423 | Submission Open

Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics

(This special issue belongs to the Section Cells of the Nervous System)

Regulation of Receptor Tyrosine Kinase Signaling and Its Implication in Cancer

edited by

Zhixiang Wang

submission deadline 25 Jul 2025 | 2 articles | Viewed by 3588 | Submission Open

Keywords: RTKs; EGFR family; PDGFR family; FGF receptor family; VEGFR family; growth factors; phosphorylation; cell signaling; cell cycle; cancer; targeted cancer therapy; the antibody-based cancer therapies; small molecule-based tyrosine kinase inhibitor (TKI)

(This special issue belongs to the Section Cell Signaling)

New Molecular and Computational Approaches to Study Immune and Metabolic Interactions in Cancer Biology

edited by Federica Mornata, Luca De Feo, Rebecca Polidori and

Matteo Brindisi

submission deadline 25 Jul 2025 | Viewed by 366 | Submission Open

Keywords: solid and liquid cancer; cancer metabolism; tumor microenvironment; digital pathology; immunoncology

(This special issue belongs to the Section Cell Methods)

Novel Molecular Targets for the Treatment of Sleep Disorders

edited by

Dae-Wui Yoon

submission deadline 25 Jul 2025 | Viewed by 147 | Submission Open

Keywords: sleep disorders; molecular targets; glymphatic system; neuroinflammation; circadian rhythms; microbiome; biomarkers; pharmacological therapy; gene therapy; neurodegeneration

Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease

edited by

Rebecca Aicheler

and

Richard Webb

submission deadline 25 Jul 2025 | Viewed by 137 | Submission Open

Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health

(This special issue belongs to the Section Cell Signaling)

Recent Developments in Cellular and Molecular Mechanisms and Therapeutic Approaches to Cardiovascular and Metabolic Diseases

edited by

Catherine Yzydorczyk

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1505 | Submission Open

Keywords: cardiometabolic diseases; developmental programming; sexual dimorphism

Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms

edited by Tirthadipa Pradhan-Sundd

submission deadline 30 Jul 2025 | Viewed by 131 | Submission Open

Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells

State-of-the-Art of Cell Cultures in Drug Validation and Toxicity Assessment

edited by

Anna Bassi

and

Stefania Vernazza

submission deadline 31 Jul 2025 | 7 articles | Viewed by 21402 | Submission Open

Keywords: human in vitro models; toxicity testing; drug development; mandatory requirements; regulatory approval; standardization; validation

(This special issue belongs to the Section Cell Methods)

Proteomic Applications in Ageing and Neurodegenerative Conditions

edited by

Thomas Wishart

Rachel A. Kline

and

Dominic Kurian

submission deadline 31 Jul 2025 | 4 articles | Viewed by 16801 | Submission Open

(This special issue belongs to the Section Cell Methods)

Cancer-Associated Fibroblasts: Challenges and Directions

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 31 Jul 2025 | 4 articles | Viewed by 11156 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors

edited by

Yoshimasa Tanaka

submission deadline 31 Jul 2025 | 3 articles | Viewed by 9813 | Submission Open

Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells

(This special issue belongs to the Section Cellular Immunology)

Signaling in Cancer Stem Cells

edited by Upasana Ray

submission deadline 31 Jul 2025 | 3 articles | Viewed by 7207 | Submission Open

Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs

(This special issue belongs to the Section Stem Cells)

Biological Mechanisms in the Treatment of Neuropsychiatric Diseases

edited by Randall D Marshall and Frank S. Menniti

submission deadline 31 Jul 2025 | 5 articles | Viewed by 5787 | Submission Open

Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments

(This special issue belongs to the Section Cellular Pathology)

Cell–Cell Interactome-Based Therapies for Osteosarcoma

edited by

Frédéric Lézot

and Javier Munoz

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4176 | Submission Open

Keywords: osteosarcoma; cell– cell interactions; microenvironment; metastases; resistance; chemotherapy; immune checkpoints

(This special issue belongs to the Section Cell Microenvironment)

Ion Channels in Cancer: An Update

edited by

Michael X. Zhu

and

Yong Zhou

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2425 | Submission Open

Keywords: ion channels; cancer therapy; cancer cell biology; mitogenic signaling; cancer signaling

(This special issue belongs to the Section Cell Proliferation and Division)

Role of Extracellular Matrix in Cancer and Disease

edited by

Maurizio Onisto

Marco Franchi

and

Valentina Masola

submission deadline 31 Jul 2025 | 4 articles | Viewed by 2301 | Submission Open

Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling

(This special issue belongs to the Section Cell Microenvironment)

Neuronal Development and Disease: From Molecular Bases to Neurological Disorders

edited by Ramiro Almeida

submission deadline 31 Jul 2025 | 3 articles | Viewed by 2183 | Submission Open

Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1699 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

Establishment and Characterization of Novel Patient-Derived Cancer Model

edited by

Yuki Yoshimatsu

and

Tadashi Kondo

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1328 | Submission Open

Keywords: patient-derived cancer model; primary tissue culture; cell line; spheroid; organoid; xenograft; PDX; organ-on-a-chip; comparative oncology; precision medicine

Skeletal Muscle: Structure, Physiology and Diseases

edited by

Vincenzo Sorrentino

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1164 | Submission Open

Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging

(This special issue belongs to the Section Tissues and Organs)

The Cell Biology of Heart Disease

edited by Rajeshwary Ghosh and

Samreen Sadaf

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1123 | Submission Open

Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 31 Jul 2025 | 2 articles | Viewed by 1118 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Retinal Pigment Epithelium in Degenerative Retinal Diseases

edited by Jian Liu and Shintaro Horie

submission deadline 31 Jul 2025 | 2 articles | Viewed by 946 | Submission Open

Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers

(This special issue belongs to the Section Cellular Pathology)

Advances in Understanding Skeletal Muscle Metabolism and Regeneration: From Mechanisms to Therapeutics

edited by

Junaith S. Mohamed

submission deadline 31 Jul 2025 | 1 articles | Viewed by 851 | Submission Open

Keywords: skeletal muscle; satellite cells; myoblast; myogenesis; regeneration; mitochondria; metabolism; sarcopenia; cachexia

(This special issue belongs to the Section Tissues and Organs)

Role of Gene Regulation in Neurological Disorders

edited by

Yujing Li

and Yulin Jin

submission deadline 31 Jul 2025 | 1 articles | Viewed by 827 | Submission Open

Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)

(This special issue belongs to the Section Cell and Gene Therapy)

Emerging Topics in Cachexia

edited by Gabriela Salim Ferreira De Castro

submission deadline 31 Jul 2025 | 1 articles | Viewed by 442 | Submission Open

Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers

Therapeutic Applications of Magnetotactic Bacteria and Magnetosomes: State of the Art and Perspectives

edited by

Patrice X. Petit

submission deadline 31 Jul 2025 | Viewed by 323 | Submission Open

Keywords: biomedical applications; biotechnology; magnetite nanocrystals; magnetosomes; magnetotactic bacteria; nanotechnology; nanotargeting

(This special issue belongs to the Section Cellular Biophysics)

Mechanisms That Link Olfactory Perception with Aging in Drosophila

edited by

Tuhin Subhra Chakraborty

, Anindya Ganguly and Jordan A. Munroe

submission deadline 31 Jul 2025 | Viewed by 203 | Submission Open

Keywords: olfaction; aging; neuroscience

(This special issue belongs to the Section Cellular Aging)

Molecular Pathobiology and Drug Targeting Cardiovascular and Kidney Injury in Obesity and Diabetes

edited by Annayya R. Aroor

submission deadline 31 Jul 2025 | Viewed by 162 | Submission Open

Keywords: obesity; hypertension; diabetes; atherosclerosis; cardiorenal metabolic syndrome

(This special issue belongs to the Section Cellular Pathology)

MicroRNAs: Regulators of Cellular Fate

edited by

Hsiuying Wang

submission deadline 31 Jul 2025 | Viewed by 140 | Submission Open

Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker

Advances in the Regulation of Proteins and Genes for Stem Cells

edited by

Bonghee Lee

submission deadline 31 Jul 2025 | Viewed by 137 | Submission Open

Keywords: stem cells; pluripotency; differentiation; diagnosis; therapeutics

(This special issue belongs to the Section Stem Cells)

Role of Mitochondrial Metabolism in Kidney Disease

edited by

Huihui Huang

submission deadline 31 Jul 2025 | Viewed by 132 | Submission Open

Keywords: kidney disease; mitochondria; metabolism

(This special issue belongs to the Section Tissues and Organs)

The Role of Macrophages in Leishmaniasis: Current Perspective

edited by Devki Nandan

submission deadline 31 Jul 2025 | Viewed by 110 | Submission Open

Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Jul 2025 | Viewed by 83 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

Lung Development: Challenges and Opportunities

edited by David Warburton

submission deadline 31 Jul 2025 | Viewed by 76 | Submission Open

Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration

(This special issue belongs to the Section Tissues and Organs)

Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration

edited by Sujoy Bhattacharya

submission deadline 1 Aug 2025 | 2 articles | Viewed by 4218 | Submission Open

Keywords: atrophic age-related macular degeneration; iPSC-derived RPE; animal models

(This special issue belongs to the Section Stem Cells)

Advancements in Cardiac Metabolism

edited by

Michael Dodd

submission deadline 1 Aug 2025 | 1 articles | Viewed by 434 | Submission Open

Keywords: cardiovascular disease; metabolism; fatty acids; heart failure; mitochondrial dysfunction

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular and Molecular Players in Bone Homeostasis

edited by Darja Andreev

submission deadline 1 Aug 2025 | Viewed by 88 | Submission Open

Keywords: bone homeostasis; cellular and molecular mechanisms; bone-related diseases; microenvironmental factors; therapeutic targets

The Dynamic Gut Wall: Innovations and Future Directions in Intestinal Epithelium

edited by

Natalia Soshnikova

and

Christoph Reinhardt

submission deadline 15 Aug 2025 | 1 articles | Viewed by 753 | Submission Open

Keywords: intestinal epithelium; regenerative medicine; stem cells; gut microbiota; epithelial barrier; bioengineering; morphogenetic signaling

Cachexia: Molecular Mechanisms and Treatment Strategies

edited by Zoltán Lohinai

submission deadline 15 Aug 2025 | Viewed by 134 | Submission Open

Keywords: cachexia; cancer metabolism; dietary interventions; inflammation; malnutrition; cachexia biomarkers

(This special issue belongs to the Section Cellular Pathology)

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