The Role of Mitochondria in Health, Disease, and Ageing
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: 10 July 2026 | Viewed by 11
Special Issue Editors
Interests: mitochondria; protein folding; aggregation; protein quality control and degradation
Interests: lysosomal storage disorders; vesicular trafficking; endosomal sorting; lysosome biogenesis; mitochondrial diseases; autoimmune disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are pivotal regulators of energy production, cellular metabolism, and cell growth, and they also contribute to proteostasis and cellular signaling. Their roles further encompass the regulation of calcium homeostasis, mitochondrial biomolecule synthesis, and the orchestration of different forms of cell death and differentiation. Because of these versatile roles, mitochondrial health is foundational to cellular integrity, and any defects in mitochondrial function underlie a large spectrum of human diseases, ranging from rare, inherited mitochondrial syndromes to common, acquired disorders of aging and metabolism. Advances in understanding mitochondrial function and dysfunction offer unparalleled opportunities to develop mitochondria-targeted therapeutics and interventions to improve patient outcomes.
This Special Issue aims to highlight cutting-edge achievements in mitochondrial research concerning health and disease across various inherited and acquired mitochondrial disorders, as well as in the ageing process. Key themes may include, but are not limited to, the biochemistry and molecular biology of mitochondria, crosstalk between mitochondria and other cellular organelles, the role of mitochondria in aging, molecular mechanisms of mitochondrial dynamics, advances in mtDNA research, oxidative stress and inflammation, mitochondrial metabolic alterations, and new avenues in mitochondrial pathway-targeted therapeutics. We welcome original research, critical reviews, and perspectives that foster new ideas and discoveries in mitochondrial biology and their role in health, disease, and ageing. By bringing together work on both inherited mitochondrial diseases and acquired dysfunctions, this Special Issue aims to define the future directions for mitochondrial research and translational medicine.
Dr. Arunkumar Venkatesan
Prof. Dr. Ritva Tikkanen
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrial dysfunction
- metabolism
- mitochondrial genetics
- aging and senescence
- bioenergetics
- mitophagy
- neurodegeneration
- cardiomyopathy
- metabolic syndrome
- ocular diseases
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