Chronic Coronary Syndromes: Cellular Pathways, Comorbidities, and Prognostic Determinants

Dear Colleagues,

Chronic coronary syndromes (CCS) highlight that terminology alone rarely captures the underlying biology of ischemic heart disease. Just as traditional MI categories such as STEMI and NSTEMI do not fully reflect the spectrum of obstructive and non-obstructive pathology, CCS represents a broad and evolving continuum shaped by far more than epicardial stenosis. Microvascular dysfunction, endothelial injury, inflammation, and cardiometabolic comorbidities increasingly determine clinical presentation, progression, and long-term outcomes as our population ages and as diabetes, obesity, and chronic kidney disease reshape the cardiovascular landscape.

This Special Issue aims to feature studies that integrate cellular and molecular mechanisms with clinical expression, risk stratification, and prognosis in CCS. We welcome original research, reviews, and translational or clinical investigations focused on vascular biology, microvascular disease, inflammatory and metabolic pathways, comorbidity interactions, imaging and biomarker development, and emerging therapeutic strategies. By combining perspectives across basic, translational, and clinical science, this issue seeks to move beyond terminology toward a more mechanistic understanding that supports individualized and precise management for patients living with chronic coronary syndromes.

Dr. Chowdhury H. Ahsan
Guest Editor

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