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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Bases Underlying Early Embryonic Development in Mammals

edited by

Rebeca González Fernández

, Julio Ávila Marrero and Angela Palumbo

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture

(This special issue belongs to the Section Reproductive Cells and Development)

Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis

edited by Xu Jing

submission deadline 31 May 2026 | Viewed by 5 | Submission Open

Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers

(This special issue belongs to the Section Cellular Metabolism)

Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives

edited by

Eléanor Luce

and

Anne Dubart-Kupperschmitt

submission deadline 1 Jun 2026 | 1 articles | Viewed by 745 | Submission Open

Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine

(This special issue belongs to the Section Stem Cells)

Molecular Mechanisms of Fibrosis in Chronic Liver Diseases

edited by

Ahmad Salhab

, Regina Golan-Gerstl and Ihab Ansari

submission deadline 1 Jun 2026 | Viewed by 205 | Submission Open

Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS

Mechanisms, Biomarkers, and Therapeutics of Neurodegeneration

edited by

Xiao Bin

submission deadline 1 Jun 2026 | Viewed by 18 | Submission Open

Keywords: neurodegeneration; biomarkers; mechanistic studies; protein aggregation; protein degradation; neuroinflammation; targeted therapies; genetics; precision medicine

(This special issue belongs to the Section Cellular Neuroscience)

Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by

Abdullah Saeed

submission deadline 5 Jun 2026 | 3 articles | Viewed by 11695 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Novel Insights into Molecular Mechanisms and Therapy of Myeloma

edited by

Yusuke Furukawa

and

Jian Wu

submission deadline 10 Jun 2026 | 7 articles | Viewed by 17985 | Submission Open

Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker

(This special issue belongs to the Section Cellular Pathology)

Advances in Pulmonary Fibrosis

edited by Sergio Piñeiro Hermida

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1296 | Submission Open

Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Cardiac Repair and Regeneration

edited by Mahesh Thirunavukkarasu

submission deadline 10 Jun 2026 | Viewed by 106 | Submission Open

Keywords: cardiac repair and regeneration; cardiomyocyte; cardiac fibrosis; signaling pathways; immune regulation; extracellular vesicles; stem cell therapies; epigenetics; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy

edited by

Frank Schnütgen

submission deadline 10 Jun 2026 | Viewed by 87 | Submission Open

Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities

(This special issue belongs to the Section Cellular Metabolism)

Lipid Mediators in Cardiometabolic Regulation and Disease

edited by Adeniyi Michael Adebesin

submission deadline 10 Jun 2026 | Viewed by 51 | Submission Open

Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins

(This special issue belongs to the Section Cellular Metabolism)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 15 Jun 2026 | 1 articles | Viewed by 3803 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cellular Origin of Glioma: From Triggers to Treatments

edited by Katherine Karakoula

submission deadline 15 Jun 2026 | Viewed by 373 | Submission Open

Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells

Novel Insights into Developing Therapeutic Strategies for Neurological Disorders

edited by

Hui Jin Shin

, Joanna A. Korecka and

Yu-Han Huang

submission deadline 15 Jun 2026 | Viewed by 212 | Submission Open

Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders

Regulation of Hormone Secretion from Islets in Health and Disease

edited by

Md Shahidul Islam

submission deadline 15 Jun 2026 | Viewed by 211 | Submission Open

Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk

Genomics and Cellular Mechanisms in Ovarian Cancer

edited by Hao Huang

submission deadline 15 Jun 2026 | Viewed by 155 | Submission Open

Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Tissues and Organs)

Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics

edited by

Marcel Trautmann

submission deadline 15 Jun 2026 | Viewed by 131 | Submission Open

Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models

Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies

edited by Nai-Yun Sun,

Yoshimasa Tanaka

and

Hsin-Fang Tu

submission deadline 15 Jun 2026 | Viewed by 92 | Submission Open

Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Jun 2026 | 1 articles | Viewed by 4398 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Jun 2026 | 3 articles | Viewed by 3315 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Mechanisms of Antimicrobial Treatment in Human Diseases

edited by

Paolo Gaibani

submission deadline 20 Jun 2026 | 1 articles | Viewed by 3012 | Submission Open

Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits

(This special issue belongs to the Section Cellular Pathology)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1657 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

Progress of Nanoparticles in the Treatment of Cancers

edited by

Mohammad Asif Sherwani

and Nafees Ahamad

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1482 | Submission Open

Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease

edited by

Ruqayya Afridi

submission deadline 20 Jun 2026 | 1 articles | Viewed by 987 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Anatomy and Function of Sensory Organs and Sensory Tissues

edited by

Frank Schmitz

submission deadline 20 Jun 2026 | Viewed by 329 | Submission Open

Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs

(This special issue belongs to the Section Tissues and Organs)

New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Jun 2026 | Viewed by 146 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cellular Neuroscience)

Molecular and Cellular Mechanisms of Insulin Secretion

edited by

Haiqiang Dou

submission deadline 20 Jun 2026 | Viewed by 29 | Submission Open

Keywords: insulin secretion; beta-cells; pancreatic islets; diabetes; exocytosis; Ca2+

(This special issue belongs to the Section Cellular Metabolism)

The Orchestration of Glial Cells in Health and Disease

edited by Keying Zhu

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1410 | Submission Open

Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 25 Jun 2026 | Viewed by 415 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Jun 2026 | Viewed by 263 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies

edited by Kjell Heuser and

Cecilie Nome

submission deadline 25 Jun 2026 | Viewed by 67 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication

The Function of Stem Cells in the Biomedical Applications

edited by Rakesh Kumar Srivastava

submission deadline 25 Jun 2026 | Viewed by 66 | Submission Open

Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery

Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration

edited by Soung-Hoon Lee

submission deadline 25 Jun 2026 | Viewed by 59 | Submission Open

Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology

Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics

edited by Muhammad Soyfoo

submission deadline 25 Jun 2026 | Viewed by 48 | Submission Open

Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease

Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities

edited by Victoria McGilligan

submission deadline 25 Jun 2026 | Viewed by 42 | Submission Open

Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics

The Dual Role of Extracellular Vesicles in Neurodegeneration: Disease Biomarkers and Drug Delivery Platforms Within the Matrix Microenvironment

edited by

Elisa Tonoli

and

Elisabetta Verderio Edwards

submission deadline 25 Jun 2026 | Viewed by 4 | Submission Open

Keywords: extracellular vesicles; neurodegenerative diseases; extracellular matrix; biomarkers; therapeutic applications; drug delivery

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 30 Jun 2026 | 8 articles | Viewed by 36847 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 30 Jun 2026 | 7 articles | Viewed by 12264 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 30 Jun 2026 | 2 articles | Viewed by 10215 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7915 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5646 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5204 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5115 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Study on Immune Activity of Natural Products

edited by Xiu-Min Li

submission deadline 30 Jun 2026 | 3 articles | Viewed by 2987 | Submission Open

Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential

MicroRNAs: Regulators of Cellular Fate

edited by

Hsiuying Wang

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2060 | Submission Open

Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker

Emerging Topics in Cachexia

edited by Gabriela Salim Ferreira De Castro

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1182 | Submission Open

Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 30 Jun 2026 | 1 articles | Viewed by 827 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Jun 2026 | 1 articles | Viewed by 698 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

Extracellular Vesicles and Cell Therapies in Regenerative Nephrology and Urology

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 30 Jun 2026 | 1 articles | Viewed by 662 | Submission Open

Keywords: extracellular vesicles (EVs); microRNA (miRNA); acute kidney injury (AKI); chronic kidney disease (CKD); glomerulonephritis; kidney transplantation; fibrosis; mesenchymal stromal cells (MSCs); engineered EVs; single-cell and spatial omics; machine learning and artificial intelligence; ; precision nephrology; GMP manufacturing; regenerative medicine; biomarkers; artificial intelligence (AI)

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms in Gastrointestinal Diseases

edited by

Shakti Ranjan Satapathy

and

Vikas Yadav

submission deadline 30 Jun 2026 | Viewed by 501 | Submission Open

Keywords: gastrointestinal pathophysiology ; epithelial– mesenchymal transition (EMT) ; inflammation and immune regulation ; tumor microenvironment ; cell signaling pathways ; stem cell biology in GI tract ; molecular biomarkers ; organoids and disease modeling ; microbiome– host interactions ; drug discovery

(This special issue belongs to the Section Tissues and Organs)

Displaying special issue 501-550 on page 11 of 14.

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