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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors

edited by

Yoshimasa Tanaka

submission deadline 15 Feb 2026 | 4 articles | Viewed by 14328 | Submission Open

Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)

edited by

Xiaohong Zhang

submission deadline 15 Feb 2026 | 4 articles | Viewed by 10147 | Submission Open

Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Molecular Therapeutic Advances for Neurodegenerative Diseases

edited by

Vanessa Castelli

submission deadline 15 Feb 2026 | 3 articles | Viewed by 5480 | Submission Open

Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders

(This special issue belongs to the Section Cellular Aging)

Spotlight on Natural Killer Cells in Immuno-Oncology

edited by

Anahid Jewett

and

Kawaljit Kaur

submission deadline 15 Feb 2026 | 1 articles | Viewed by 3638 | Submission Open

Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Mechanisms of Tumorigenesis

edited by

Hengbin Wang

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1855 | Submission Open

Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine

Cancers and Metabolic Diseases—the Molecular Players in the Game

edited by

T.K.S. Kumar

submission deadline 15 Feb 2026 | Viewed by 138 | Submission Open

Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics

GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma

edited by

Thomas Wilkie

submission deadline 15 Feb 2026 | Viewed by 117 | Submission Open

Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors

Cellular Mechanisms and Therapies of Hematologic Malignancies

edited by Sayantani Sinha and Stanley Chun-Wei Lee

submission deadline 15 Feb 2026 | Viewed by 88 | Submission Open

Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance

(This special issue belongs to the Section Cellular Pathology)

Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease

edited by

Paul M. Epstein

Stefan Brocke

, Michy P. Kelly and Leila Gobejishvili

submission deadline 20 Feb 2026 | 17 articles | Viewed by 48583 | Submission Open

Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction

(This special issue belongs to the Section Cell Microenvironment)

Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications

edited by

Ilaria Martinelli

and Elisabetta Zucchi

submission deadline 20 Feb 2026 | 5 articles | Viewed by 11806 | Submission Open

Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Feb 2026 | 3 articles | Viewed by 7675 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

Ovarian Cancer and Endometriosis

edited by

Ji-Hye Ahn

and

Jung-Hye Choi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4200 | Submission Open

Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product

(This special issue belongs to the Section Cellular Pathology)

T Cells in Inflammation and Cancer

edited by

Kihong Lim

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3464 | Submission Open

Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms of Leukemias

edited by

María Hernández Valladares

and Frode Selheim

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2074 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)

(This special issue belongs to the Section Cellular Pathology)

The Cell Biology of Heart Disease

edited by Rajeshwary Ghosh and

Samreen Sadaf

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2045 | Submission Open

Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Role of Gene Regulation in Neurological Disorders

edited by

Yujing Li

and Yulin Jin

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1724 | Submission Open

Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)

(This special issue belongs to the Section Cell and Gene Therapy)

Current Advances in Plant Gene Regulatory Networks

edited by

Laszlo Kozma-Bognar

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1060 | Submission Open

Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

edited by

Yuhao Xie

Concettina La Motta

and Rakesh Kumar Srivastava

submission deadline 20 Feb 2026 | Viewed by 321 | Submission Open

Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Feb 2026 | Viewed by 269 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

Elucidating Roles of Cell Adhesion Molecules in Health and Disease

edited by Vladimir Sytnyk

submission deadline 20 Feb 2026 | Viewed by 191 | Submission Open

Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs（IgSF-CAMs); integrins; cadherins; selectins; proteoglycans

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 20 Feb 2026 | Viewed by 165 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

Advances in T Cell Targeting for Cancer Immunotherapy

edited by Ryma Toumi

submission deadline 20 Feb 2026 | Viewed by 133 | Submission Open

Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy

Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications

edited by

Simone Patergnani

and

Alberto Danese

submission deadline 20 Feb 2026 | Viewed by 87 | Submission Open

Keywords: autophagy; pathology; physiology; therapy; methods

(This special issue belongs to the Section Autophagy)

Astrocytes: Roles and Functions in the Brain

edited by

Victor Huang

and

Rita Raisman-Vozari

submission deadline 21 Feb 2026 | Viewed by 130 | Submission Open

Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 25 Feb 2026 | 6 articles | Viewed by 23626 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

Natural Products and Their Derivatives Against Human Disease

edited by

Mamunur Rashid

submission deadline 25 Feb 2026 | 6 articles | Viewed by 12004 | Submission Open

Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1989 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

Research on Extracellular Vesicles in Health and Disease

edited by

Maria Concetta Cufaro

submission deadline 25 Feb 2026 | 1 articles | Viewed by 837 | Submission Open

Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA

Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs

edited by

Gamaleldin Ibrahim Harisa

submission deadline 25 Feb 2026 | 1 articles | Viewed by 592 | Submission Open

Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds

Remyelination: From Molecular Mechanism to Therapy

edited by

Antonella Ragnini-Wilson

and

Gaetano Barbato

submission deadline 25 Feb 2026 | 1 articles | Viewed by 507 | Submission Open

Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration

Small Molecule Inhibitors: A New Era in Cancer Treatment

edited by

Natarajan Aravindan

Kousalya Lavudi

and Suman Asalla

submission deadline 25 Feb 2026 | Viewed by 250 | Submission Open

Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance

New Trends and Advances in Induced Neural Cells and iPSC Technologies

edited by

Guoqiang Sun

submission deadline 25 Feb 2026 | Viewed by 159 | Submission Open

Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling

(This special issue belongs to the Section Cellular Neuroscience)

Molecular and Cellular Mechanisms of Ischemic Stroke

edited by Milani Deb-Chatterji

submission deadline 25 Feb 2026 | Viewed by 146 | Submission Open

Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy

Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives

edited by Peter Van Endert

submission deadline 25 Feb 2026 | Viewed by 145 | Submission Open

Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy

Molecular Mechanisms of Treatment Resistance in Prostate Cancer

edited by

Christopher J. Ong

submission deadline 25 Feb 2026 | Viewed by 133 | Submission Open

Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance

The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease

edited by

Stacey C. Schutte

Wei-Chih Lien

and

Ching-Yun Chen

submission deadline 26 Feb 2026 | Viewed by 115 | Submission Open

Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling

(This special issue belongs to the Section Tissues and Organs)

Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders

edited by Mohamed Eldeeb

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1674 | Submission Open

Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration

(This special issue belongs to the Section Mitochondria)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1451 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation

edited by Hari Krishna Reddy Rachamala and

Naga Malleswara Rao Nakka

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1258 | Submission Open

Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology

(This special issue belongs to the Section Cell Methods)

Targeting of Cancer Cells with Small Molecule Drugs

edited by

Jannet Kocerha

submission deadline 27 Feb 2026 | Viewed by 121 | Submission Open

Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology

(This special issue belongs to the Section Cellular Pathology)

Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets

edited by Saverio Gentile

submission deadline 27 Feb 2026 | Viewed by 112 | Submission Open

Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment

Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by Kyle Lauren Poulsen

submission deadline 27 Feb 2026 | Viewed by 112 | Submission Open

Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics

Role of Extracellular Matrix in Cancer and Disease

edited by

Maurizio Onisto

Marco Franchi

and

Valentina Masola

submission deadline 28 Feb 2026 | 6 articles | Viewed by 14549 | Submission Open

Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling

(This special issue belongs to the Section Cell Microenvironment)

Signaling in Cancer Stem Cells

edited by Upasana Ray

submission deadline 28 Feb 2026 | 3 articles | Viewed by 14246 | Submission Open

Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs

(This special issue belongs to the Section Stem Cells)

The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications

edited by

Monique Vogel

and

Paul Engeroff

submission deadline 28 Feb 2026 | 3 articles | Viewed by 12391 | Submission Open

Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors

(This special issue belongs to the Section Cellular Immunology)

Cellular Pathology: Emerging Discoveries and Perspectives in the USA

edited by

Mohammed S. Razzaque

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6595 | Submission Open

Keywords: cellular pathology; diseases; mechanisms

(This special issue belongs to the Section Cellular Pathology)

The Potential of Induced Pluripotent Stem Cells

edited by Yun Chang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 5991 | Submission Open

Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials

(This special issue belongs to the Section Stem Cells)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5060 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4413 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3570 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

Displaying special issue 201-250 on page 5 of 13.

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