Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response
edited by
submission deadline 31 Jan 2026 | Viewed by 193 | Submission Open
Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors
Examining the Cellular Biology of Adenovirus
edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard
submission deadline 31 Jan 2026 | Viewed by 175 | Submission Open
Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome
The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders
edited by , and Adriana C. E. Graziano
submission deadline 31 Jan 2026 | Viewed by 160 | Submission Open
Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation
(This special issue belongs to the Section Cellular Neuroscience)
Role of Oxidative Stress in Cardiovascular Diseases submission deadline 31 Jan 2026 | Viewed by 133 | Submission Open
Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in the Role of Lipid Signaling in Diseases
edited by and
submission deadline 5 Feb 2026 | Viewed by 258 | Submission Open
Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation
Role of Alpha-Synuclein in Neurodegenerative Diseases
edited by
submission deadline 10 Feb 2026 | 1 articles | Viewed by 1841 | Submission Open
Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases
(This special issue belongs to the Section Cellular Aging)
Decoding Cellular Organization Through Spatial Omics
edited by Elizabeth Neumann
submission deadline 10 Feb 2026 | Viewed by 210 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Exclusive Review Papers in Autophagy—Second Edition
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 21694 | Submission Open
Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades
(This special issue belongs to the Section Autophagy)
Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 15804 | Submission Open
Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 12202 | Submission Open
Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Molecular Therapeutic Advances for Neurodegenerative Diseases
edited by
submission deadline 15 Feb 2026 | 3 articles | Viewed by 6653 | Submission Open
Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders
(This special issue belongs to the Section Cellular Aging)
Spotlight on Natural Killer Cells in Immuno-Oncology submission deadline 15 Feb 2026 | 1 articles | Viewed by 4132 | Submission Open
Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Mechanisms of Tumorigenesis
edited by
submission deadline 15 Feb 2026 | 1 articles | Viewed by 2242 | Submission Open
Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine
Cancers and Metabolic Diseases—the Molecular Players in the Game
edited by
submission deadline 15 Feb 2026 | Viewed by 184 | Submission Open
Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics
GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma
edited by
submission deadline 15 Feb 2026 | Viewed by 162 | Submission Open
Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors
Cellular Mechanisms and Therapies of Hematologic Malignancies
edited by Sayantani Sinha and Stanley Chun-Wei Lee
submission deadline 15 Feb 2026 | Viewed by 131 | Submission Open
Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance
(This special issue belongs to the Section Cellular Pathology)
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease
edited by , , Michy P. Kelly and Leila Gobejishvili
submission deadline 20 Feb 2026 | 17 articles | Viewed by 59115 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications
edited by and Elisabetta Zucchi
submission deadline 20 Feb 2026 | 5 articles | Viewed by 14345 | Submission Open
Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Feb 2026 | 3 articles | Viewed by 9200 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5057 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
T Cells in Inflammation and Cancer
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4269 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Molecular Mechanisms of Leukemias
edited by and Frode Selheim
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2963 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)
(This special issue belongs to the Section Cellular Pathology)
Role of Gene Regulation in Neurological Disorders
edited by and Yulin Jin
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2647 | Submission Open
Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)
(This special issue belongs to the Section Cell and Gene Therapy)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2611 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Transient Receptor Potential (TRP) Channels and Health and Disease
edited by Hiroki Kittaka and Makoto Tominaga
submission deadline 20 Feb 2026 | 4 articles | Viewed by 1989 | Submission Open
Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology
Current Advances in Plant Gene Regulatory Networks submission deadline 20 Feb 2026 | 1 articles | Viewed by 1329 | Submission Open
Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Advances in Molecular Research on Cancer Drug Targets and Drug Resistance
edited by , and Rakesh Kumar Srivastava
submission deadline 20 Feb 2026 | Viewed by 399 | Submission Open
Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers
Elucidating Roles of Cell Adhesion Molecules in Health and Disease
edited by Vladimir Sytnyk and
submission deadline 20 Feb 2026 | Viewed by 247 | Submission Open
Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs(IgSF-CAMs); integrins; cadherins; selectins; proteoglycans
Advances in T Cell Targeting for Cancer Immunotherapy
edited by Ryma Toumi
submission deadline 20 Feb 2026 | Viewed by 203 | Submission Open
Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy
Molecular Cell Biology of T Cells in Cancer and Infectious Diseases
edited by and João Viola
submission deadline 20 Feb 2026 | Viewed by 194 | Submission Open
Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism
(This special issue belongs to the Section Cellular Immunology)
Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications submission deadline 20 Feb 2026 | Viewed by 124 | Submission Open
Keywords: autophagy; pathology; physiology; therapy; methods
(This special issue belongs to the Section Autophagy)
Astrocytes: Roles and Functions in the Brain submission deadline 21 Feb 2026 | Viewed by 174 | Submission Open
Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting
Recent Advances in Regenerative Dentistry—Second Edition
edited by
submission deadline 25 Feb 2026 | 6 articles | Viewed by 28086 | Submission Open
Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking
(This special issue belongs to the Section Tissues and Organs)
Natural Products and Their Derivatives Against Human Disease
edited by
submission deadline 25 Feb 2026 | 6 articles | Viewed by 13924 | Submission Open
Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 3230 | Submission Open
Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease
Research on Extracellular Vesicles in Health and Disease submission deadline 25 Feb 2026 | 1 articles | Viewed by 1346 | Submission Open
Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA
Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs submission deadline 25 Feb 2026 | 1 articles | Viewed by 1071 | Submission Open
Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds
Small Molecule Inhibitors: A New Era in Cancer Treatment
edited by , and Suman Asalla
submission deadline 25 Feb 2026 | 2 articles | Viewed by 1013 | Submission Open
Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance
Remyelination: From Molecular Mechanism to Therapy submission deadline 25 Feb 2026 | 1 articles | Viewed by 833 | Submission Open
Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration
Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives
edited by Peter Van Endert
submission deadline 25 Feb 2026 | 1 articles | Viewed by 392 | Submission Open
Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy
New Trends and Advances in Induced Neural Cells and iPSC Technologies
edited by
submission deadline 25 Feb 2026 | Viewed by 243 | Submission Open
Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling
(This special issue belongs to the Section Cellular Neuroscience)
Molecular and Cellular Mechanisms of Ischemic Stroke
edited by Milani Deb-Chatterji
submission deadline 25 Feb 2026 | Viewed by 185 | Submission Open
Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy
Molecular Mechanisms of Treatment Resistance in Prostate Cancer
edited by
submission deadline 25 Feb 2026 | Viewed by 174 | Submission Open
Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance
The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease submission deadline 26 Feb 2026 | Viewed by 167 | Submission Open
Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling
(This special issue belongs to the Section Tissues and Organs)
Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation
edited by Hari Krishna Reddy Rachamala and
submission deadline 27 Feb 2026 | 1 articles | Viewed by 3145 | Submission Open
Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology
(This special issue belongs to the Section Cell Methods)
Novel Insights into Mechanism and Treatment of Degenerative Disc Disease
edited by Yejia Zhang
submission deadline 27 Feb 2026 | 2 articles | Viewed by 2180 | Submission Open
Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury
(This special issue belongs to the Section Cellular Pathology)
Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders
edited by Mohamed Eldeeb
submission deadline 27 Feb 2026 | 1 articles | Viewed by 2014 | Submission Open
Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration
(This special issue belongs to the Section Mitochondria)
Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets
edited by Saverio Gentile
submission deadline 27 Feb 2026 | Viewed by 159 | Submission Open
Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 27 Feb 2026 | Viewed by 158 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies
edited by Kyle Lauren Poulsen
submission deadline 27 Feb 2026 | Viewed by 150 | Submission Open
Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics
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