Advances in Endoscopic Management of Esophageal Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 1 March 2027 | Viewed by 696
Editors
2. Endoscopy Unit, Teknon Medical Center, Barcelona, Spain
Interests: early gastrointestinal cancer; endoscopic submucosal dissection (ESD); third space endoscopy; esophageal squamous cell carcinoma; Barrett’s esophagus; Barrett’s eradication
Interests: gastrointestinal tumors; medical oncology; esophageal cancer
Special Issue Information
Dear Colleagues,
Endoscopic management has substantially reshaped the therapeutic landscape of esophageal cancer, particularly for early-stage disease. Over the past two decades, the development and refinement of advanced endoscopic resection techniques—most notably endoscopic submucosal dissection (ESD)—have enabled organ-preserving treatment strategies with favorable oncologic outcomes in carefully selected patients without evidence of extraluminal disease. These approaches have markedly reduced the need for surgical esophagectomy in early neoplasia while achieving high rates of en bloc and R0 resection. In selected scenarios, local endoscopic resection followed by structured surveillance has emerged as a potential management strategy when the estimated risk of lymph node metastasis is low or when oncologic outcomes appear comparable to surgical resection. In this context, accumulating evidence suggests that surveillance strategies after complete endoscopic resection may represent a reasonable alternative to immediate surgery in carefully selected cases, including some patients with superficial submucosal invasion (pT1b), provided that risk stratification and follow-up protocols are rigorously applied. Ongoing research continues to refine the criteria that may identify patients who could safely benefit from organ-preserving approaches. Beyond therapeutic resection, the field continues to evolve rapidly through improvements in diagnostic and staging technologies. Advances in high-definition endoscopy, virtual chromoendoscopy, and artificial intelligence-assisted detection and characterization systems are improving lesion recognition and risk stratification. In parallel, endoscopic ablative therapies are expanding the therapeutic armamentarium for Barrett’s esophagus-associated neoplasia. This Special Issue aims to provide an updated overview of recent advances in the endoscopic diagnosis, staging, and treatment of esophageal cancer. We welcome original research articles and reviews addressing innovations in endoscopic techniques, clinical outcomes, training and standardization, and emerging technologies such as robotics and artificial intelligence. By bringing together contributions from leading experts, this Special Issue seeks to highlight current progress and explore future directions in minimally invasive, endoscopy-based management strategies for esophageal neoplasia.
Dr. Hugo Uchima
Dr. Cristina Bugés Sánchez
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- endoscopic submucosal dissection (ESD)
- esophageal squamous cell carcinoma
- Barrett’s esophagus
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