Non-Coding RNAs in Bone Tumors: Pathogenesis, Diagnostic Biomarkers, and Therapeutic Perspectives
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: 28 February 2027 | Viewed by 176
Editor
Special Issue Information
Dear Colleagues,
Non-coding RNA (ncRNA) interactions have increasingly been associated with the hallmarks of cancer in recent years. An explosion of studies investigating ncRNAs and their role in oncology has been observed over the past decade. In line with this development, the role of ncRNAs at multiple levels—including pathogenesis, diagnostics, prognosis, and therapeutic implications—has gained substantial recognition and has also been increasingly explored in the realm of bone tumors. To date, the vast majority of ncRNA research in bone tumors has focused on highly malignant osteosarcoma. Recent reviews have highlighted the importance of ncRNAs in the molecular pathogenesis of osteosarcoma. Furthermore, the feasibility of ncRNA expression patterns for the differential diagnosis of osteosarcoma has been evaluated in comparison with conventional histopathological methods. Considerable attention has been directed toward miRNA-based cancer therapeutics. However, clinically established ncRNA-based therapies remain limited also in malignant bone tumors, likely due to factors such as drug resistance and the complex, multifaceted roles of ncRNAs in cancer biology.
Given that protein-coding genes account for only approximately 1.8% of the human genome, it is not surprising that emerging evidence suggests that alterations in non-coding genomic regions—particularly those involving ncRNAs—may hold significant potential for advancing bone tumor oncology in the future. Accordingly, this Special Issue will focus on the role of ncRNAs in improving our understanding of the pathogenesis, differential diagnosis, prognosis, and therapeutics of bone tumors.
Prof. Dr. Albert Roessner
Guest Editor
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Keywords
- bone tumors
- non-coding RNAs
- pathogenesis
- biomarkers
- non-coding RNA therapeutics
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